Open Respiratory Archives最新文献

{"title":"Feasibility and Safety of Intercostal Cryoneurolysis During Pleuroscopy: A Novel Analgesic Approach Using a 1.7 mm Cryoprobe","authors":"Sammy Onyancha ,&nbsp;Isabelle Dettmer ,&nbsp;Njuxhersa Maloku ,&nbsp;Gernot Rohde","doi":"10.1016/j.opresp.2025.100463","DOIUrl":"10.1016/j.opresp.2025.100463","url":null,"abstract":"<div><h3>Introduction</h3><div>Pleuroscopy is a minimally invasive and highly effective procedure used for diagnosing pleural diseases. Despite its utility, pain during and after the procedure can be significant. Traditional analgesic approaches, including systemic opioids and local anaesthetics albeit potent, may provide incomplete pain relief and can be associated with side effects. Cryoneurolysis has emerged as a feasible analgesic technique in general surgery. However, an equivalent treatment modality has yet to be established for pleuroscopy.</div></div><div><h3>Objectives</h3><div>To investigate the safety and feasibility of cryoneurolysis in pleuroscopy performed using a 1.7<!--> <!-->mm cryoprobe via a semi-rigid pleuroscope.</div></div><div><h3>Materials and methods</h3><div>We conducted a prospective, single-centre observational study on 43 patients who underwent pleuroscopy at our institution between January 2024 and December 2024, of which 25 received cryoneurolysis. Pain levels were assessed using a Numeric Rating Scale (NRS) immediately post-procedure and at 24 and 72<!--> <!-->h. Complications and long-term adverse events were documented.</div></div><div><h3>Results</h3><div>NRS scores after cryoneurolysis showed successful pain management both immediately post-procedure (mean NRS: 3.1) and at subsequent time points (24<!--> <!-->h: 2.0; 72<!--> <!-->h: 1.5). No major complications, such as major haemorrhage or nerve injury leading to persistent deficits, were observed. Minor complications occurred in 2 patients, who experienced a transient numbness immediately post-procedure. Analgesic requirements were lower than the control group, with 68% of patients requiring only mild oral analgesics post-procedurally.</div></div><div><h3>Conclusion</h3><div>The use of cryoneurolysis during pleuroscopy appears to be a feasible, safe, and effective technique for pain management. However, further studies with larger cohorts are warranted to validate the findings.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 4","pages":"Article 100463"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life in Patients With Type 2 Inflammatory Asthma","authors":"Iñigo Ojanguren ,&nbsp;Isam Alobid ,&nbsp;Virginia Rodríguez-Vázquez ,&nbsp;Víctor Reyes ,&nbsp;Miriam Espinosa ,&nbsp;África Luca de Tena ,&nbsp;Irantzu Muerza ,&nbsp;Enrique Gómez de la Fuente","doi":"10.1016/j.opresp.2025.100461","DOIUrl":"10.1016/j.opresp.2025.100461","url":null,"abstract":"<div><h3>Introduction</h3><div>Asthma is a heterogeneous disease that often coexists with type 2 inflammatory (T2i) conditions in many individuals with severe asthma, leading to heightened exacerbations that diminish their quality of life (QoL). Despite this, there is a noticeable scarcity of QoL assessment tools specifically designed for individuals with T2i-related asthma.</div></div><div><h3>Objectives</h3><div>To analyse the asthma subset of T2i patients, derived from a survey conducted by the patient-driven T2i Network Project, aimed at identifying common drivers and challenges related to the QoL of T2i patients.</div></div><div><h3>Material and methods</h3><div>An anonymous online survey was distributed through eight Spanish patient associations. It comprised 29 questions about the patient's sociodemographic characteristics and several self-reported questions about the diagnosis, QoL measures, the severity of the disease, use of healthcare resources, and quality of care.</div></div><div><h3>Results</h3><div>The T2i asthma sub-analysis included 180 participants; 93% self-reported their disease severity as moderate-to-severe, 85% affected by one or more coexisting T2i diseases. An increase in the self-perceived severity was associated with higher self-perceived intensity, lack of control, and persistence of symptoms, with a stronger impact on total QoL. Asthma participants expressed a great impact on all the measured dimensions of the QoL.</div></div><div><h3>Conclusions</h3><div>The results demonstrate unmet needs and important difficulties for asthma T2i patients, either as the only condition or with other T2i conditions, and underscore the need for innovative approaches to improve their QoL. Most of this subset of patients perceive their condition as severe and experience self-perceived intense and limiting symptoms, which constantly worsen and persist over time.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 4","pages":"Article 100461"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestión eficiente de agendas de asma grave","authors":"Ignacio Dávila ,&nbsp;José Ángel Carretero Gracia ,&nbsp;Pilar Cebollero ,&nbsp;José Luis Izquierdo Alonso ,&nbsp;Eva Martínez-Moragón ,&nbsp;Concepción Morales-García ,&nbsp;Gerardo Pérez Chica ,&nbsp;Santiago Quirce ,&nbsp;Juan José Soler-Cataluña ,&nbsp;Marta Viñas","doi":"10.1016/j.opresp.2025.100456","DOIUrl":"10.1016/j.opresp.2025.100456","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100456"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Degree of Adherence to Recommendations From the Spanish Consensus on the Reduction of Oral Corticosteroid Use in Asthma Patients: A Questionnaire-based Observational Study","authors":"Javier Domínguez-Ortega ,&nbsp;Xavier Muñoz Gall ,&nbsp;Julio Delgado Romero ,&nbsp;Francisco Casas-Maldonado ,&nbsp;Marina Blanco-Aparicio","doi":"10.1016/j.opresp.2025.100452","DOIUrl":"10.1016/j.opresp.2025.100452","url":null,"abstract":"<div><h3>Introduction</h3><div>The Spanish consensus on the reduction of oral corticosteroid (OCS) use in asthma management was recently published to address the issue of OCS overuse in this area. This study evaluates the degree of awareness and implementation of this consensus by healthcare professionals.</div></div><div><h3>Methods</h3><div>A longitudinal study was conducted with a survey completed by pulmonologists and allergists in 2 rounds conducted 6 months apart. Key metrics included OCS prescribing rates, adherence to recommendations, and other clinician-reported practices.</div></div><div><h3>Results</h3><div>Both rounds were completed by 112 and 115 participants, respectively, with equal representation from allergists and pulmonologists. Most (91.1%) were familiar with the consensus, and 58.0% rated their knowledge as high. Fifty-three percent reported increased knowledge after 6 months. Regarding OCS dosing, 70.5% in the first round and 66.1% in the second round considered 5<!--> <!-->mg/day of prednisone to be low-dose therapy. A majority routinely calculated annual OCS doses, with a notable rise in the use of digital tools for dose calculations. Most clinicians favored 5–7 days for short OCS courses and supported the use of biologics for patients with uncontrolled severe asthma on maintenance OCS.</div></div><div><h3>Conclusions</h3><div>These findings suggest a notable reduction in OCS use and improved adherence to asthma management guidelines following the publication of the Spanish consensus. Repeated educational interventions appear effective in modifying prescribing behaviors and optimizing asthma care.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100452"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence Update on the Efficacy of Cytisinicline by Treatment Regimen: A Rapid Review","authors":"Raúl Majo García ,&nbsp;María Guadalupe Espinosa Villoria ,&nbsp;María Nélida Fernández-Martínez ,&nbsp;Alfonso Díaz Madero ,&nbsp;María Isabel Pérez Martín ,&nbsp;Daniel Fernández-García","doi":"10.1016/j.opresp.2025.100472","DOIUrl":"10.1016/j.opresp.2025.100472","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100472"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compilation of Harm: Tobacco, Chronic Obstructive Pulmonary Disease, and Mucus Plugs. Systematic Review of the Literature and Meta-Analysis","authors":"José Ignacio de Granda-Orive ,&nbsp;Daniel López-Padilla ,&nbsp;Adolfo Alonso-Arroyo ,&nbsp;Rafael Aleixandre-Benavent ,&nbsp;Segismundo Solano-Reina ,&nbsp;Carlos Rábade-Castedo ,&nbsp;Miguel Jiménez-Gómez ,&nbsp;Carlos A. Jiménez-Ruiz","doi":"10.1016/j.opresp.2025.100479","DOIUrl":"10.1016/j.opresp.2025.100479","url":null,"abstract":"<div><h3>Introduction</h3><div>In COPD patients, mucus plugs are associated with lower lung function, worse quality of life, higher all-cause mortality, and a higher rate of exacerbations. The aim of the study was to determine whether subjects with COPD with a higher cumulative smoking history, such as current smokers, have a higher mucus plug score compared to former and never smokers with COPD.</div></div><div><h3>Material and methods</h3><div>We have carried out a systematic review of the literature (SRL) and a meta-analysis (MA).</div></div><div><h3>Results</h3><div>Nine articles were finally included in the SRL, and 6 of them were part of the MA. We found that subjects who had never smoked had a lower rate of mucus plugs when compared to active and ex-smokers (OR 0.08 [CI 95% 0.06, 0.12]). When comparing subjects with and without mucus plugs between current smokers vs. ex-smokers, we found that ex-smokers had a higher rate of mucus plugs than current smokers (OR 1.12 [CI 95% 1.02, 1.24]). When comparing subjects without mucus plugs or with a low mucus plug score (0–2) with a high mucus plug score (&gt;3) between current smokers vs. ex-smokers, we found that ex-smokers had a higher mucus plug score than current smokers (OR 1.19 [CI 95% 1.08, 1.32]).</div></div><div><h3>Conclusions</h3><div>We found that subjects who have never smoked have a lower rate of mucus plugs than those who have smoked and that ex-smokers with COPD have a higher rate of mucus plugs than current smokers with COPD. Quitting smoking is the most significant modifiable risk factor for COPD.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100479"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestión de riesgos en la realización de pruebas de función pulmonar pospandemia","authors":"Luis Puente Maestu ,&nbsp;Juana M. Martínez Llorens ,&nbsp;José Luis Valera Felices ,&nbsp;Yolanda Torralba García ,&nbsp;Marian Gimeno Peribáñez ,&nbsp;Eusebi Chiner ,&nbsp;Roberto Cabestre ,&nbsp;Juan Rodríguez Hermosa ,&nbsp;Raúl Godoy Mayoral ,&nbsp;Celeste Marcos ,&nbsp;Ana Balaña Corberó ,&nbsp;Carlos Almonacid","doi":"10.1016/j.opresp.2025.100459","DOIUrl":"10.1016/j.opresp.2025.100459","url":null,"abstract":"<div><div>This document is a detailed proposal addressing the management of spirometry and other pulmonary function tests in the post-COVID-19 pandemic context in Spain. The introduction discusses how the pandemic has affected the performance of these essential tests and underscores the need for a pragmatic assessment of risks and benefits, given that the absence of pulmonary function studies may lead to significant diagnostic and therapeutic errors.</div><div>The section on the epidemiological situation in Spain highlights that the WHO no longer considers COVID-19 a public health emergency of international concern, reflecting the reduced severity of the disease due to high vaccination coverage and the characteristics of circulating variants.</div><div>The regulatory framework states that the Health Institute Carlos III has defined a new epidemiological surveillance strategy aimed at restoring social and healthcare normality. A ministerial order issued by the Ministry of Health is mentioned, which lifts the mandatory use of facemasks in certain settings, in alignment with the strategy to return to normalcy.</div><div>The proposal provides an in-depth analysis of the infectious risk to healthcare workers and patients in pulmonary function laboratories, concluding that current practices —along with the use of surgical masks and viral filters— minimize the generation and transmission of infectious aerosols.</div><div>Detailed recommendations are provided for risk management, including architectural controls, administrative measures, hygiene practices, and personal protective protocols, with the goal of safeguarding both healthcare professionals and patients.</div><div>The cited bibliography reinforces the scientific evidence base underlying the proposed recommendations and demonstrates a careful and deliberate approach to the safe and efficient reintroduction of spirometry and other pulmonary function tests into routine healthcare.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100459"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Outdoor Air Pollutants on Asthma: A Narrative Review","authors":"David Espejo ,&nbsp;Vicente Plaza ,&nbsp;Santiago Quirce ,&nbsp;Juan Antonio Trigueros ,&nbsp;Xavier Muñoz","doi":"10.1016/j.opresp.2025.100448","DOIUrl":"10.1016/j.opresp.2025.100448","url":null,"abstract":"<div><div>Asthma is a chronic lung disease affecting individuals across all age groups, contributing to significant morbidity and mortality. Exposure to air pollutants is a major factor in both the development and exacerbation of asthma symptoms. This study reviewed the impact of key air pollutants, including nitrogen dioxide (NO₂), particulate matter with a diameter ≤2.5<!--> <!-->μm (PM_2.5) or ≤10<!--> <!-->μm (PM₁₀), and ozone (O₃), on asthma outcomes. Our analysis of 20 studies showed significant associations between exposure to these pollutants and increased asthma incidence and prevalence, particularly in children. Specifically, pollutants such as elemental carbon (EC), benzene, NO₂, PM₁₀, and sulfur dioxide (SO₂) were found to be significantly associated with asthma development in children, while NO₂ and PM_2.5 were linked to asthma exacerbations in both children and adults. Additionally, hospitalizations and emergency room visits were positively correlated with exposure to PM_2.5 and O₃ in both children and adults, and the elderly showed significant associations with O₃ exposure. Although asthma-related mortality was not directly linked to specific pollutants, a few studies indicated a broader association between exposure to pollutants like NO₂ and PM_2.5 and increased overall mortality. These findings highlight the importance of reducing exposure to outdoor air pollutants to mitigate asthma risk and improve public health outcomes, particularly in vulnerable populations like children and the elderly.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100448"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long Term Effectiveness of Mepolizumab in the Treatment of Chronic Eosinophilic Pneumonia","authors":"María Longás ,&nbsp;Cindy S. Aponte ,&nbsp;Daniel Laorden ,&nbsp;David Romero ,&nbsp;Santiago Quirce ,&nbsp;Rodolfo Álvarez-Sala ,&nbsp;on behalf of ASMAGRAVE-HULP Group","doi":"10.1016/j.opresp.2025.100462","DOIUrl":"10.1016/j.opresp.2025.100462","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100462"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaping With or Without Nicotine is Always Addictive","authors":"Carlos Andrés Jimenez-Ruiz ,&nbsp;Mina Gaga ,&nbsp;Jose Ignacio de Granda-Orive","doi":"10.1016/j.opresp.2025.100478","DOIUrl":"10.1016/j.opresp.2025.100478","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100478"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}