Luis Pérez-de Llano , Mª Gema Bonilla , Elisa Luzon , Francisco Ramos-Lima , Juan Carlos Miralles
{"title":"What We Know to Date About Early Treatment With Biologics in Severe Asthma: A Scoping Review About the Use of Biologics in Severe Asthma and Possible Parallels With Early Rheumatoid Arthritis","authors":"Luis Pérez-de Llano , Mª Gema Bonilla , Elisa Luzon , Francisco Ramos-Lima , Juan Carlos Miralles","doi":"10.1016/j.opresp.2025.100418","DOIUrl":"10.1016/j.opresp.2025.100418","url":null,"abstract":"<div><h3>Introduction</h3><div>Theoretically, an early intervention with biologics in severe asthma (SA) patients may attenuate inflammatory processes and potentially halt disease progression and remodeling. Changing the approach to a more preventive one could alter the course of the disease, avoid its progression, and improve the likelihood of achieving clinical remission. The aims of this study were to gather scientific evidence on this topic, to draw a parallel between SA and rheumathoid arthritis (RA) and to analyze the potential benefits of establishing early treatment in SA.</div></div><div><h3>Material and methods</h3><div>A systematic scoping review, conducted in accordance with the methodological guidance of the Arksey and O’Malley framework and focusing on early treatment intervention with biological drugs in SA and RA is presented.</div></div><div><h3>Results</h3><div>Evidence supports the early intervention with biologics in RA to improve outcomes. Evidence regarding early intervention with biologics in SA is scarce. To date, the literature reviewed suggests that better clinical condition of the patient and more preserved lung function at the onset of biological treatment, together with a shorter duration of asthma, are associated with better response to biologics.</div></div><div><h3>Conclusions</h3><div>Data suggests that the more preventive approach may lead to improved results. The scarcity of scientific evidence highlights the importance of pursuing this line of research.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100418"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan Agüero , Juan Luis García-Rivero , Beatriz Abascal , Carlos Antonio Amado , Ignacio Fernandez-Olmo , Miguel Santibáñez , on behalf of the group of researchers of the ASTHMA-FENOP study
{"title":"FeNO Stability in Repeated Measurements in Asthma Patients During Three Consecutive Days","authors":"Juan Agüero , Juan Luis García-Rivero , Beatriz Abascal , Carlos Antonio Amado , Ignacio Fernandez-Olmo , Miguel Santibáñez , on behalf of the group of researchers of the ASTHMA-FENOP study","doi":"10.1016/j.opresp.2025.100417","DOIUrl":"10.1016/j.opresp.2025.100417","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100417"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raúl Majo García , María Nélida Fernández-Martínez , Andrea Crespo Sedano , María Guadalupe Espinosa Villoria , Esther Alonso Sastre , Daniel Fernández-García
{"title":"Effectiveness of Cytisinicline Treatment in Hospital Smoking Units","authors":"Raúl Majo García , María Nélida Fernández-Martínez , Andrea Crespo Sedano , María Guadalupe Espinosa Villoria , Esther Alonso Sastre , Daniel Fernández-García","doi":"10.1016/j.opresp.2025.100414","DOIUrl":"10.1016/j.opresp.2025.100414","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100414"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eva Maria Gómez Pedrajas , Johanny Vargas Rodriguez , Catia Caneiras , Sagrario Mayoralas Alises , Salvador Díaz Lobato
{"title":"The Impact of Social Work on the Management of Chronic Respiratory Diseases","authors":"Eva Maria Gómez Pedrajas , Johanny Vargas Rodriguez , Catia Caneiras , Sagrario Mayoralas Alises , Salvador Díaz Lobato","doi":"10.1016/j.opresp.2025.100415","DOIUrl":"10.1016/j.opresp.2025.100415","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100415"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Rábade-Castedo , Maribel Cristóbal Fernández , Carlos A. Jiménez-Ruiz
{"title":"El cigarrillo electrónico: una alternativa errónea para reducir los daños del tabaco","authors":"Carlos Rábade-Castedo , Maribel Cristóbal Fernández , Carlos A. Jiménez-Ruiz","doi":"10.1016/j.opresp.2025.100416","DOIUrl":"10.1016/j.opresp.2025.100416","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100416"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan Marco Figueira Gonçalves , Javier de Miguel Díez , Bernardino Alcázar Navarrete , Pere Almagro Mena , María Belén Alonso-Ortiz , Ana Balañá Corberó , Miriam Barrecheguren , Roberto Cabestre García , Enrique Cases Viedma , Pilar Cejudo Ramos , Alberto Fernández-Villar , Rafael Golpe , Milagros Iriberri Pascual , José Luis López-Campos , Jesús Molina París , David de la Rosa-Carrillo , Javier Sayas Catalán , Marc Miravitlles , COPD-Avanz Working Group
{"title":"Delphi Consensus on the Management of Patients With Advanced COPD: COPD-Avanz Working Group","authors":"Juan Marco Figueira Gonçalves , Javier de Miguel Díez , Bernardino Alcázar Navarrete , Pere Almagro Mena , María Belén Alonso-Ortiz , Ana Balañá Corberó , Miriam Barrecheguren , Roberto Cabestre García , Enrique Cases Viedma , Pilar Cejudo Ramos , Alberto Fernández-Villar , Rafael Golpe , Milagros Iriberri Pascual , José Luis López-Campos , Jesús Molina París , David de la Rosa-Carrillo , Javier Sayas Catalán , Marc Miravitlles , COPD-Avanz Working Group","doi":"10.1016/j.opresp.2025.100411","DOIUrl":"10.1016/j.opresp.2025.100411","url":null,"abstract":"<div><h3>Introduction</h3><div>To reach a multidisciplinary consensus on the management of patients with advanced COPD using Delphi methodology.</div></div><div><h3>Material and methods</h3><div>A multidisciplinary committee of experts (Pneumology, Physiotherapy, Internal Medicine, Physical Medicine and Rehabilitation, Primary Care, and Nursing) developed a 105-item questionnaire to be agreed by a panel of experts grouped into the following topics: (1) Definition of advanced COPD patients; (2) Management of dyspnoea in patients with advanced COPD; (3) Prevention and recovery of exacerbation in patients with advanced COPD; and (4) Dealing with disease progression.</div></div><div><h3>Results</h3><div>After two rounds, consensus was reached on 77.1% of the items. The definition proposed for advanced COPD and agreed by 91.5% of the panellists stated: “COPD patient with FEV<sub>1</sub> <!--><<!--> <!-->50% and at least two of the following criteria: dyspnoea mMRC 3–4, chronic respiratory insufficiency, and limitation in basic activities of daily living”. Other relevant agreements were: the use of opioids, pulmonary rehabilitation and respiratory physiotherapy, or home high-flow therapy and long-term oxygen therapy for the improvement of dyspnoea; the role of comorbidities assessment; the inclusion of these patients in respiratory rehabilitation programmes; the use of inhaled antibiotic treatment in chronic bronchial infection by <em>Pseudomonas aeruginosa</em> in the prevention and recovery of exacerbations; and the criteria for lung transplantation or augmentation therapy in patients with advanced COPD and severe α1-antitrypsin deficiency.</div></div><div><h3>Conclusions</h3><div>In this document, a broad panel of experts reached a high degree of consensus on the definition of advanced COPD as well as on its approach. The information provided by this consensus is intended to assist the clinician in the identification of these patients as well as to provide guidance on their management.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100411"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vicente Plaza , Francisco Casas-Maldonado , Borja G. Cosío , Juan Luis García-Rivero , Ruperto González-Pérez , Eva Martínez Moragón , Álvaro Moreno-Ancillo , Abel Pallarés-Sanmartín , Jacinto Ramos , Serafín Sánchez , Javier Domínguez-Ortega
{"title":"Severe Asthma Management in Spain: A Survey-Based National Study. Is it Time for a National Asthma Plan?","authors":"Vicente Plaza , Francisco Casas-Maldonado , Borja G. Cosío , Juan Luis García-Rivero , Ruperto González-Pérez , Eva Martínez Moragón , Álvaro Moreno-Ancillo , Abel Pallarés-Sanmartín , Jacinto Ramos , Serafín Sánchez , Javier Domínguez-Ortega","doi":"10.1016/j.opresp.2025.100408","DOIUrl":"10.1016/j.opresp.2025.100408","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100408"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}