Open Respiratory Archives最新文献

Trends and Characteristics of Retracted Articles in the Smoking Field: An Observational Study 吸烟领域撤回文章的趋势和特征：一项观察性研究

Open Respiratory Archives Pub Date : 2025-10-01 DOI: 10.1016/j.opresp.2025.100496

José Ignacio de Granda-Orive , Carlos A. Jiménez-Ruiz , Rafael Aleixandre-Benavent , Daniel López-Padilla , Carlos Rábade-Castedo , Miguel Jiménez-Gómez , Adolfo Alonso-Arroyo

{"title":"Trends and Characteristics of Retracted Articles in the Smoking Field: An Observational Study","authors":"José Ignacio de Granda-Orive , Carlos A. Jiménez-Ruiz , Rafael Aleixandre-Benavent , Daniel López-Padilla , Carlos Rábade-Castedo , Miguel Jiménez-Gómez , Adolfo Alonso-Arroyo","doi":"10.1016/j.opresp.2025.100496","DOIUrl":"10.1016/j.opresp.2025.100496","url":null,"abstract":"<div><h3>Objective</h3><div>The aim was to examine reasons for retraction and rates of article retraction in the field of smoking.</div></div><div><h3>Material and methods</h3><div>We conducted an observational study and searched the largest database of articles that have been retracted.</div></div><div><h3>Results</h3><div>We found 83 papers that were retracted from 1988 to 2024. According to the type of document (documents typologies), the majority were original articles (74 papers). The 83 documents have been retracted in 65 different journals. The retracted papers’ citation counts were examined by searching Web of Science (WoS) and Scopus, and we have observed that a quarter (26.5%) of the 68 articles available in the WoS database had increased their citations, despite the fact that they were retracted works. The reasons for retraction were unreliable, inconsistent, erroneous, or missing data or an incorrect conclusion; duplication of previously published articles; duplication of images into the articles or in previous articles; conflicts of interest; the ethical/plagiarism policy and authorship issues concerns; fake peer reviews; data falsification/data error; articles retracted at the authors’ request; and unknown causes of retraction and journal publisher's error.</div></div><div><h3>Conclusions</h3><div>Unreliable, inconsistent, inaccurate, or missing data; an incorrect conclusion; or duplication/already published articles; duplication of images; and conflicts of interest are the main causes of retractions. Retracted articles have been increasing in number over the years, and additionally, the amount of time that passes between an article's publication and retraction is getting shorter. We verify that retracted articles indeed continue to gain citations after the retraction, some even more than before.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 4","pages":"Article 100496"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the Interaction Between Premature Ageing in HIV and COPD Using Epigenetic Clocks: A Case–Control Study Protocol 利用表观遗传时钟了解HIV早衰与COPD之间的相互作用：一项病例对照研究方案

Open Respiratory Archives Pub Date : 2025-10-01 DOI: 10.1016/j.opresp.2025.100489

Meritxell Gavalda , Rebecca Rowena Pena , Francisco Fanjul , Jose Luisa Valera , Borja G. Cosio , Ernest Sala , Marta Gonzalez-Freire , Melchor Riera

{"title":"Understanding the Interaction Between Premature Ageing in HIV and COPD Using Epigenetic Clocks: A Case–Control Study Protocol","authors":"Meritxell Gavalda , Rebecca Rowena Pena , Francisco Fanjul , Jose Luisa Valera , Borja G. Cosio , Ernest Sala , Marta Gonzalez-Freire , Melchor Riera","doi":"10.1016/j.opresp.2025.100489","DOIUrl":"10.1016/j.opresp.2025.100489","url":null,"abstract":"<div><h3>Objectives</h3><div>Our project aims to study premature ageing in people living with HIV and COPD. We hypothesize that the chronic inflammation associated with both conditions accelerates the ageing process. HIV infection has undergone a significant paradigm shift in recent years, transitioning from a rapidly fatal disease to a chronic condition. People living with HIV experience more comorbidities (cardiovascular events, osteoporosis, cancer, neurodegenerative diseases, …) at a younger age. This phenomenon, often referred to as ‘premature ageing,’ is associated with chronic inflammation and epigenetic changes. Epigenetic clocks, composite markers based on DNA methylation alterations, have emerged as valuable tools for predicting biological age as they predict mortality better than chronological age. These alterations are described both systemically and at the pulmonary level and are related to a higher prevalence of chronic obstructive pulmonary disease (COPD) and worsened respiratory function.</div></div><div><h3>Material and methods</h3><div>To achieve this, we will perform a case–control study analysing epigenetic clocks and comparing four different groups: healthy control subjects, patients living with HIV without COPD, COPD patients without HIV, and patients with both HIV and COPD.</div></div><div><h3>Conclusions</h3><div>We hypothesise that patients with both COPD and HIV will exceed the cumulative ageing effect of each condition separately, which suggests a multiplicative effect of ageing between HIV and COPD. Should our hypothesis be supported, it could justify a re-evaluation and potential modification of current screening protocols for COPD in HIV patients or the implementation of case-finding strategies.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 4","pages":"Article 100489"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145227028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Bronchoscopic Intratumoral Injection in Lung Cancer: Current Advances, Challenges, and Opportunities for Resource-Limited Settings 支气管镜下肿瘤内注射治疗肺癌：资源有限环境下的当前进展、挑战和机遇

Open Respiratory Archives Pub Date : 2025-10-01 DOI: 10.1016/j.opresp.2025.100490

Dimas Bayu Firdaus , Oea Khairsyaf , Russilawati

{"title":"Therapeutic Bronchoscopic Intratumoral Injection in Lung Cancer: Current Advances, Challenges, and Opportunities for Resource-Limited Settings","authors":"Dimas Bayu Firdaus , Oea Khairsyaf , Russilawati","doi":"10.1016/j.opresp.2025.100490","DOIUrl":"10.1016/j.opresp.2025.100490","url":null,"abstract":"<div><div>Lung cancer remains the leading cause of cancer-related deaths globally, with a high burden in Southeast Asia, including Indonesia. Conventional treatments, including surgery, radiotherapy, and systemic chemotherapy, are often limited by patient factors such as multifocal disease, poor pulmonary reserve, or central airway obstruction. This review explores bronchoscopic intratumoral injection as a novel, localized therapeutic strategy and assesses its feasibility in resource-limited settings. We conducted a narrative synthesis of recent literature on bronchoscopic intratumoral injection techniques, therapeutic agents, clinical outcomes, and implementation challenges. Additional focus was placed on the Indonesian healthcare context, particularly the infrastructure in West Sumatra. Bronchoscopic intratumoral injection delivers chemotherapeutic, immunologic, or gene-based agents directly into tumors using flexible bronchoscopy, including transbronchial needle injection, endobronchial ultrasound-guided injection, and cone-beam computed tomography. This approach achieves high local drug concentrations with minimal systemic toxicity, shifting the paradigm toward immune modulation and durable tumor control. Clinical outcomes include improved airway patency, lung function, symptom relief, and survival in patients ineligible for standard therapies. Feasibility in Indonesia is supported by existing clinical resources and agent availability. Despite challenges, such as limited access to advanced imaging, specialized equipment, and skilled personnel, bronchoscopic intratumoral injection may represent a promising investigational strategy in selected cases. Further research is warranted before routine clinical implementation can be contemplated. Strategies such as structured training and regional collaboration can bridge implementation gaps, aligning innovation with equitable lung cancer care in developing countries.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 4","pages":"Article 100490"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Avoidable Mortality Burden Attributable to PM2.5 in Madrid (Spain) 马德里（西班牙）PM2.5可避免的死亡率负担

Open Respiratory Archives Pub Date : 2025-10-01 DOI: 10.1016/j.opresp.2025.100494

Ángel López-Encuentra , Esther Gil Cid , Víctor Abraira , Luis Miguel Pozo Coronado , on behalf of the Coordinadora Vecinal Distrito Latina (COVELA), the Asociación Madres por el Clima Lourdes

{"title":"Avoidable Mortality Burden Attributable to PM2.5 in Madrid (Spain)","authors":"Ángel López-Encuentra , Esther Gil Cid , Víctor Abraira , Luis Miguel Pozo Coronado , on behalf of the Coordinadora Vecinal Distrito Latina (COVELA), the Asociación Madres por el Clima Lourdes","doi":"10.1016/j.opresp.2025.100494","DOIUrl":"10.1016/j.opresp.2025.100494","url":null,"abstract":"<div><div>The World Health Organization (WHO) established in 2021 an annual health limit of 5μg/m<sup>3</sup> for outdoor PM2.5 concentrations (cPM2.5). Our objective was to evaluate the health impact of cPM2.5 in two locations of a large city during 2023. In the first study (South; more socially vulnerable), the 5μg/m<sup>3</sup> limit was exceeded 70% of the time. Additionally, 26% of the values were above 15μg/m<sup>3</sup>. In the second study (Central), this limit (5μg/m<sup>3</sup>) was exceeded 99% of the time, and 64% of the values were above 15μg/m<sup>3</sup>. Based on data from both locations (1,149,930 inhabitants over the age of 25), annual lung cancer mortality ranged from 23 to 38 cases (6.7%–8.7%), while mortality from non-communicable diseases ranged from 700 to 854 cases (10.7%–12.3%). The avoidable burden of mortality attributable to annual PM2.5 concentrations justifies the urgent need for their drastic reduction as a public health policy.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 4","pages":"Article 100494"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Equity in Respiratory Health: Actionable Recommendations for Spain 呼吸健康的公平性：对西班牙的可行建议

Open Respiratory Archives Pub Date : 2025-10-01 DOI: 10.1016/j.opresp.2025.100487

Carlos Almonacid , Joan B. Soriano , M. Guadalupe Fontán , Beatriz González López-Valcárcel , Carmen Hernández , Rafael Manzanera , Remedios Martel , Mariano Pastor , Virginia Rodríguez , Isabel Urrutia , Raquel Varas-Doval , Eusebi Chiner

{"title":"Equity in Respiratory Health: Actionable Recommendations for Spain","authors":"Carlos Almonacid , Joan B. Soriano , M. Guadalupe Fontán , Beatriz González López-Valcárcel , Carmen Hernández , Rafael Manzanera , Remedios Martel , Mariano Pastor , Virginia Rodríguez , Isabel Urrutia , Raquel Varas-Doval , Eusebi Chiner","doi":"10.1016/j.opresp.2025.100487","DOIUrl":"10.1016/j.opresp.2025.100487","url":null,"abstract":"<div><div>Chronic respiratory diseases are a major public health burden, affecting over 7 million people in Spain and representing the third leading cause of death. Conditions such as chronic obstructive pulmonary disease, asthma, and lung cancer are heavily influenced by social and environmental determinants, including socioeconomic status, air quality, and smoking. Moreover, the increasingly aging Spanish population and persistent urban pollution levels further expand the burden of these diseases. This article underscores the urgent need to address inequities in respiratory healthcare through comprehensive policy action. To this end, we herein propose measures such as strengthening primary care to ensure early diagnosis, enhancing coordination between community pharmacy, primary and hospital care, incorporating specialised roles such as continuity-of-care nurses, prioritising access to cost-effective innovative treatments, promoting healthy environments, and reinforcing anti-smoking initiatives. We also advocate for inclusion of social determinants of health indicators in electronic health records and for development of patient education programmes. Tackling respiratory health disparities requires targeted strategies that involve all healthcare and social stakeholders to optimise resource use and improve the quality of life of patients with respiratory diseases in Spain.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 4","pages":"Article 100487"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145227029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traducción estandarizada al castellano del cuestionario King's Brief Interstitial Lung Disease (K-BILD) Traducción estandarizada al castellano del cutionario King's Brief间质性肺病（K-BILD）

Open Respiratory Archives Pub Date : 2025-10-01 DOI: 10.1016/j.opresp.2025.100491

Gianluca Cotta , Ana Alonso , Anna Feliu , Patricia Peñacoba , Irene Martin , Surrinder Birring , Diego Castillo

引用次数: 0

Spain's Sarcoidosis Mortality: An Evolving Public Health Challenge 西班牙结节病死亡率：不断演变的公共卫生挑战

Open Respiratory Archives Pub Date : 2025-10-01 DOI: 10.1016/j.opresp.2025.100495

Lucia Cayuela , Anna Michela Gaeta , Victoria Achaval Rodríguez , Sara Cabrera Fernández , Aurelio Cayuela

{"title":"Spain's Sarcoidosis Mortality: An Evolving Public Health Challenge","authors":"Lucia Cayuela , Anna Michela Gaeta , Victoria Achaval Rodríguez , Sara Cabrera Fernández , Aurelio Cayuela","doi":"10.1016/j.opresp.2025.100495","DOIUrl":"10.1016/j.opresp.2025.100495","url":null,"abstract":"<div><h3>Objective</h3><div>To comprehensively analyze national trends in sarcoidosis mortality in Spain between 1999 and 2023, with a focus on demographic differences and changes over time.</div></div><div><h3>Material and methods</h3><div>This nationwide ecological study analyzed death registry data for sarcoidosis (ICD-10 code D86) from the Spanish National Institute of Statistics. Age-standardized mortality rates (ASMRs) were calculated by sex and age. Joinpoint regression assessed temporal trends and annual percentage changes (APCs).</div></div><div><h3>Results</h3><div>Spain recorded 1053 sarcoidosis deaths between 1999 and 2023, with women accounting for 61.8%. Overall deaths rose, peaking at 72 in 2022. Mortality was heavily concentrated among those aged≥65 years (75.8% of deaths). Age-specific mortality rates were negligible under 35, increasing markedly with age. Comparing 1999–2003 and 2019–2023 revealed rising mortality, especially among older adults; for example, men aged 70–74 saw rates increase from 1.22 to 4.06 per million, and women aged 80–84 from 3.24 to 8.40 per million. The male-to-female mortality ratio shifted over time, indicating a growing relative burden among men in several age groups. Joinpoint analysis showed steady ASMR increases: men's overall APC was +4.20%, driven by a 5.81% rise among those ≥65 years, while women's APC was +1.24%, primarily among those ≥65 years.</div></div><div><h3>Conclusions</h3><div>Sarcoidosis mortality in Spain has risen substantially over 25 years, particularly among older adults and men. These findings underscore the need for targeted management and public health interventions focused on Spain's ageing population.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 4","pages":"Article 100495"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fixed Airflow Limitation in Severe Asthma: Rethinking the Role of Small Airway Disease 严重哮喘的固定气流限制：重新思考小气道疾病的作用

Open Respiratory Archives Pub Date : 2025-09-04 DOI: 10.1016/j.opresp.2025.100483

Miguel Jiménez-Gómez , Ismael García-Moguel , Rocío Magdalena Díaz-Campos

引用次数: 0

Foreign Body Granulomatous Reaction Mimicking Tumor Recurrence After Lung Cancer Surgery: A Case Series 肺癌手术后异体肉芽肿反应模拟肿瘤复发：一个病例系列

Open Respiratory Archives Pub Date : 2025-09-03 DOI: 10.1016/j.opresp.2025.100481

Marc Paredes , Domingo Madera , Marta Plana Pes , Pere Trias Sabrià , Lara Pijuan , Cruz García , Carlos Déniz , Rosa López Lisbona

{"title":"Foreign Body Granulomatous Reaction Mimicking Tumor Recurrence After Lung Cancer Surgery: A Case Series","authors":"Marc Paredes , Domingo Madera , Marta Plana Pes , Pere Trias Sabrià , Lara Pijuan , Cruz García , Carlos Déniz , Rosa López Lisbona","doi":"10.1016/j.opresp.2025.100481","DOIUrl":"10.1016/j.opresp.2025.100481","url":null,"abstract":"<div><div>Mechanical hemostatic agents, such as oxidized cellulose (Willocell©), are frequently used in thoracic surgery. Although considered safe, they can induce granulomatous reactions that mimic tumor recurrence. In this retrospective study, we analyzed patients from the Hospital Universitari de Bellvitge (July 2024–March 2025) who underwent EBUS due to lymphadenopathies with increased SUV on PET-FDG following surgery for lung cancer. Nine patients, who had undergone anatomical lung resections (VATS or RATS), presented with suspicious lymphadenopathies ipsilateral to the surgical site. EBUS-TBNA revealed no malignancy but showed amorphous material compatible with a foreign body reaction attributable to Willocell©. Only one patient was diagnosed with tumor recurrence.</div><div>This case series underscores the importance of maintaining a broad differential diagnosis when evaluating potential causes of increased metabolic activity on PET/CT scans, as its specificity is limited. EBUS-TBNA proves to be a key tool for achieving an accurate diagnosis in these scenarios.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 4","pages":"Article 100481"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual Navigation Technology for the Functional Restoration of Anastomosis in Oncologic Pulmonary Surgery 虚拟导航技术在肿瘤肺外科吻合功能恢复中的应用

Open Respiratory Archives Pub Date : 2025-09-03 DOI: 10.1016/j.opresp.2025.100482

Pedro Juan Rodríguez Martín, Laura Martínez Vega, Felipe Cristóbal Andreo García

{"title":"Virtual Navigation Technology for the Functional Restoration of Anastomosis in Oncologic Pulmonary Surgery","authors":"Pedro Juan Rodríguez Martín, Laura Martínez Vega, Felipe Cristóbal Andreo García","doi":"10.1016/j.opresp.2025.100482","DOIUrl":"10.1016/j.opresp.2025.100482","url":null,"abstract":"<div><div>A 44-year-old woman, former smoker, underwent apical segmentectomy of the right lower lobe in 2015 for a typical carcinoid tumor (1.5cm, Ki 67<2%, T1aN0M0R1). In 2024, follow-up CT revealed a suspicious lesion, and PET scan confirmed a 13mm nodule (SUVmax 6). In January 2025, she had an extended right lower lobectomy with bronchoplasty. Weeks later, flexible bronchoscopy showed reduced bronchial lumen, partially visualizing the middle lobe bronchi (ML). Two months post-surgery, due to increasing dyspnea, an almost complete distal stenosis of the intermediate bronchus was discovered, preventing access to the ML. After unsuccessful balloon dilation and anatomical uncertainty, the procedure was stopped. CT with 3D reconstruction (<em>Fujifilm Synapse 3D software)</em> and virtual bronchoscopy navigation (VBN) was performed with this planner. Guided by VBN, biopsies and successful balloon dilation reopened the ML bronchial orifice. The case highlights the value of VBN and 3D reconstruction for planning and guiding complex endoscopic procedures.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 4","pages":"Article 100482"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0