Open Respiratory Archives最新文献

{"title":"Expert Consensus on Single-Inhaler Triple Therapy for the Treatment of Asthma in Adult Patients","authors":"Carolina Cisneros Serrano ,&nbsp;Eva Martínez Moragón ,&nbsp;Alicia Padilla-Galo ,&nbsp;Cleofé Fernández Aracil ,&nbsp;Andrea Trisán Alonso ,&nbsp;Gerardo Pérez Chica ,&nbsp;Ana Pueyo Bastida ,&nbsp;Auxiliadora Romero Falcón ,&nbsp;José Ángel Carretero-Gracia ,&nbsp;José Gregorio Soto-Campos ,&nbsp;Members of the Validation Task Force","doi":"10.1016/j.opresp.2025.100442","DOIUrl":"10.1016/j.opresp.2025.100442","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite existing guidelines, many patients with asthma do not achieve adequate control of their disease. This is largely due to low adherence to inhaled therapy. Single-inhaler administration may improve this and other aspects of asthma therapy, such as cost-effectiveness. The aim of this study is to gather the opinions of a panel of experts on single-inhaler triple therapy (SITT) for the treatment of asthma in adult patients.</div></div><div><h3>Material and methods</h3><div>A recommendation task force reviewed the available evidence and formulated 45 statements divided into 5 sections: efficacy, cost-effectiveness, therapeutic adherence, safety, and patient satisfaction. A validation task force of 71 experts evaluated these recommendations using the 2-round Delphi technique. Panellists rated their agreement with each statement on a 9-point scale.</div></div><div><h3>Results</h3><div>Consensus was achieved in 42 of the 45 statements. Panellists broadly agreed that SITT improves lung function, reduces exacerbations, is cost-effective, and promotes therapeutic adherence. The safety of TT was considered favourable, even in patients with cardiovascular comorbidities. The panellists also agreed on the importance of evaluating patient satisfaction with the inhaler. However, no consensus was reached regarding the suitability of TT as a first-line treatment, nor on whether TT is more beneficial than up-dosing ICS in patients with a low inflammatory profile currently receiving dual therapy. Additionally, panellists did not agree on whether sick leave due to respiratory causes was associated with greater adherence to TT.</div></div><div><h3>Conclusions</h3><div>The consensus indicates that SITT is considered an effective, safe option for the treatment of asthma that improves therapeutic adherence and patient satisfaction. Further real-world studies are needed to evaluate its implementation in different clinical contexts.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100442"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple Therapy in Asthma","authors":"Cleofé Fernández Aracil ,&nbsp;María del Mar García Ródenas ,&nbsp;Luis Manuel Hernández Blasco","doi":"10.1016/j.opresp.2025.100439","DOIUrl":"10.1016/j.opresp.2025.100439","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100439"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Cavitary Pulmonary Aspergillosis","authors":"Maria Mercedes Morante Tinoco ,&nbsp;Julia Montero de Miguel ,&nbsp;Itziar Fernández Ormaechea","doi":"10.1016/j.opresp.2025.100436","DOIUrl":"10.1016/j.opresp.2025.100436","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100436"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home Respiratory Therapies in Patients With Obstructive Sleep Apnea: A Value-based Care Model in Spain","authors":"Irene Cano-Pumarega ,&nbsp;Candela Caballero-Eraso ,&nbsp;Valentín Cabriada ,&nbsp;Mar Mosteiro ,&nbsp;Juan Fernando Masa ,&nbsp;Ferran Barbé","doi":"10.1016/j.opresp.2025.100427","DOIUrl":"10.1016/j.opresp.2025.100427","url":null,"abstract":"<div><div>This document proposes a value-based care model to improve adherence and health outcomes in patients with obstructive sleep apnea (OSA) treated with CPAP. The current care model for OSA management adopts a uniform, volume-based approach for all patients, limiting personalized care and reducing service quality without providing objective outcome data. The value-based care model proposed here focuses on guiding all interventions towards improving treatment adherence, aiming to enhance health outcomes by increasing patients’ quality of life and comfort with treatment. Key strategies to be implemented include education and support programs at the beginning of treatment, enhancing comfort in mask use, telemonitoring of adherence, patient involvement in the treatment progress, patient stratification based on adherence, and identifying individuals who may benefit from alternative treatments. A results-based funding model is also recommended to optimize resource allocation. Expected outcomes from these measures include a reduction in home visits and in-person consultations for stable patients, fewer non-adherent patients, more optimally treated patients, and overall improvements in treatment quality and effectiveness. Key indicators to evaluate the success of this approach include quality of life (measured through quality-of-life questionnaires), adherence levels (via telemonitoring), and CPAP comfort. Collectively, these strategies allow for a comprehensive approach, optimizing resources and ensuring personalized care that improves the experience and outcomes of OSA patients.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100427"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Structured Self-Management Intervention to Improve Quality of Life in Individuals With Chronic Obstructive Pulmonary Disease (AMPOC Study)","authors":"Maite López Luque ,&nbsp;Marta Chuecos Molina ,&nbsp;Guadalupe Ortega Cuelva ,&nbsp;M. Jesús Vázquez López ,&nbsp;Francisco Orfila Pernas ,&nbsp;Nina Granel Giménez ,&nbsp;Esther Ruiz Rodríguez ,&nbsp;M. Ángeles Santos Santos ,&nbsp;Adrià Almazor Sirvent ,&nbsp;Antonio Vallejo Domingo ,&nbsp;Toni López Ruiz ,&nbsp;Purificación Jordana Ferrando","doi":"10.1016/j.opresp.2025.100426","DOIUrl":"10.1016/j.opresp.2025.100426","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to compare the effectiveness of a structured self-management program in patients with moderate–severe COPD followed up for 12 months, in improving quality of life, dyspnea, inhaler adherence, anxiety, and depression, compared to standard practice.</div></div><div><h3>Material and methods</h3><div>This was a multicenter randomized clinical trial involving 115 patients, 59 in the intervention group and 56 in the control group. Participants from 16 primary care centers in Barcelona, Spain, were allocated consecutively and in a blinded manner to the intervention and control groups in stages. Professionals received training in behavioral change techniques. The intervention consisted of four 20-min sessions conducted at 14-day intervals, covering topics such as COPD knowledge, smoking, inhaler use, physical activity, nutrition, breathing, exacerbations, vaccinations, work and environmental conditions, leisure, sexuality, daily activities, anxiety, and depression.</div></div><div><h3>Results</h3><div>A total of 102 patients completed the study, 50 in the intervention group and 52 in the control group. Differences between the intervention and control groups in quality of life, dyspnea, inhaler adherence, smoking, anxiety, and depression were not significant.</div></div><div><h3>Conclusion</h3><div>In patients with moderate–severe COPD, a structured self-management intervention in primary care is not more effective than standard care in improving quality of life, dyspnea, inhaler adherence, anxiety, and depression.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100426"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of the EDADES 2024 Survey: More Data for Concern Than for Satisfaction","authors":"M. Cristóbal-Fernández ,&nbsp;C.A. Jimenez-Ruiz ,&nbsp;J.I. de Granda-Orive","doi":"10.1016/j.opresp.2025.100435","DOIUrl":"10.1016/j.opresp.2025.100435","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100435"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumocystis jirovecii Pneumonia as an Unusual Presentation of De Novo Acute Myeloid Leukemia","authors":"Stephany Ivonne Briones Alvarado,&nbsp;Angelica María Quito Parra,&nbsp;Gabriella Manzanares Cavin,&nbsp;Manuel Mor Martínez,&nbsp;Rafael Gregorio Marulanda Melo","doi":"10.1016/j.opresp.2025.100428","DOIUrl":"10.1016/j.opresp.2025.100428","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100428"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Evidence on the Usefulness of Potential Therapies in the Prevention of COPD Exacerbations: Beyond the Use of Bronchodilator Therapy and Inhaled Corticosteroids","authors":"Juan Marco Figueira-Gonçalves ,&nbsp;Francisco Javier Callejas-González ,&nbsp;Rafael Golpe ,&nbsp;Luis Máiz-Carro ,&nbsp;Marta Marín-Oto ,&nbsp;Javier de Miguel-Díez ,&nbsp;Guillermo Samuel Loscertales-Vacas ,&nbsp;José María Tordera-Mora ,&nbsp;Álvaro Hurtado-Fuentes","doi":"10.1016/j.opresp.2025.100438","DOIUrl":"10.1016/j.opresp.2025.100438","url":null,"abstract":"<div><div>Prevention of exacerbations is a key objective in chronic obstructive pulmonary disease (COPD) management. The adverse effects of an exacerbation include a negative impact on patient quality of life and symptoms, an accelerated rate of decline in lung function, hospital admissions, and increased mortality. Clinical guidelines related to COPD management recommend smoking cessation and inhaled therapy (bronchodilators with or without corticosteroids) as the mainstay for these patients. Apart from the above-mentioned treatment, other potential therapies, such as mucolytic agents, antibiotics (oral or inhaled), phosphodiesterase-4 inhibitors or vaccination, are available and have been shown to reduce the incidence of exacerbations. In this brief narrative review, we will examine the efficacy of various treatments for preventing COPD exacerbations, beyond the use of bronchodilator therapy and inhaled corticosteroids.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100438"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of the Respiratory Intermediate Care Unit in Interstitial Lung Disease Exacerbations: A Bridge to Lung Transplantation","authors":"Ainhoa Izquierdo Pérez ,&nbsp;Silvia Aguado Ibáñez ,&nbsp;Sonia Salinas Castillo ,&nbsp;Gabriela Pombo Lacaba ,&nbsp;Enrique Rodríguez Rubio ,&nbsp;Rosalia Laporta Hernández ,&nbsp;Beatriz Jara Chinarro ,&nbsp;Carlos Almonacid Sánchez","doi":"10.1016/j.opresp.2025.100432","DOIUrl":"10.1016/j.opresp.2025.100432","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aims to describe the clinical features, hospital management, and outcomes of patients with interstitial lung disease (ILD) and acute respiratory failure (ARF) admitted to the respiratory intermediate care units (RICUs).</div></div><div><h3>Material and methods</h3><div>An observational study was conducted on ILD patients admitted to the RICU between June 1, 2021, and May 30, 2024. Main variables analysed included demographics, non-invasive respiratory support (NIRS) types, ILD-related variables, lung transplant outcomes, and survival rates.</div></div><div><h3>Results</h3><div>Of the 401 patients admitted, 51 (13%) had ILD, of whom 34 (67%) were male. Idiopathic pulmonary fibrosis (IPF) was the most common condition (33%), and high-flow oxygen therapy (HFOT) was the primary treatment (94%). Infection (29%) and disease progression (36%) were the main hospitalization causes. Of the 27 patients (53%) evaluated for transplantation, 18 (36%) underwent a lung transplant, with 5 (28%) directly transplanted from the RICU and 55% (<em>N</em> <!-->=<!--> <!-->15) were added to the emergency-driven list. Overall survival rates for ICU-eligible patients were 89% at one month, 77% at six months, and 72% at one year, while non-ICU eligible had lower survival probabilities of 31%, 13%, and 13%, respectively.</div></div><div><h3>Conclusions</h3><div>The RICU should be considered a bridge therapy for patients who are ICU candidates and eligible for lung transplant during ILD exacerbations, potentially reducing ICU admissions. However, patients who are not ICU candidates face high short- and medium-term mortality risks. The significance of this study highlights the need to establish a specific RICU admission protocol for patients experiencing ILD exacerbations.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100432"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Whole Lung Lavage in a Patient With Lipoid Pneumonia","authors":"Marc Paredes ,&nbsp;Mari Paz Fuset-Cabanes ,&nbsp;Lara Pijuan ,&nbsp;Roger Llatjós ,&nbsp;Marta Diez-Ferrer ,&nbsp;Belén Del Río ,&nbsp;Sandra Orozco ,&nbsp;Vanesa Vicens-Zygmunt","doi":"10.1016/j.opresp.2025.100421","DOIUrl":"10.1016/j.opresp.2025.100421","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100421"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}