Open Respiratory Archives最新文献

{"title":"Discovering Treatable Traits in Asthma: Toward More Precise Treatment","authors":"Raquel García Hernáez , María Victoria García-Gallardo Sanz , Francisco Javier González Barcala","doi":"10.1016/j.opresp.2025.100451","DOIUrl":"10.1016/j.opresp.2025.100451","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100451"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positioning of EBUS-guided Cryobiopsy in the Diagnosis of Mediastinal Lesions: A First Approach","authors":"Selene Cuenca Peris , Monica Bauza , Elsie Daviana Meneses Petersen , Paola Alessandra Benini Padilla , Raquel Martínez Tomás , Andrés Briones Gómez , Mireya Prieto Rodríguez , Enrique Cases Viedma","doi":"10.1016/j.opresp.2025.100447","DOIUrl":"10.1016/j.opresp.2025.100447","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100447"},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations and Challenges in Intermediate Respiratory Care Units. Integration and Planning Within the Hospital System: A Regional Perspective From Castilla-La Mancha","authors":"Raúl Hidalgo Carvajal , Ángel Ortega González , Raúl Godoy Mayoral , Francisco Javier Agustín Martínez , Olga Mediano San Andrés","doi":"10.1016/j.opresp.2025.100446","DOIUrl":"10.1016/j.opresp.2025.100446","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100446"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges of the New Spanish Guideline for Treatment of COPD (GesEPOC 2025)","authors":"Marc Miravitlles","doi":"10.1016/j.opresp.2025.100445","DOIUrl":"10.1016/j.opresp.2025.100445","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100445"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophil and Cationic Protein Levels in Patients Treated With Dupilumab: A Real-Life Study","authors":"María Alejandra Castillo , Jorge Correa-Borit , Daniel Laorden , Fiorella Adrianzen , Elena Villamañán , David Romero , Santiago Quirce , Javier Domínguez-Ortega","doi":"10.1016/j.opresp.2025.100444","DOIUrl":"10.1016/j.opresp.2025.100444","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100444"},"PeriodicalIF":0.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Bronchoscopic Lung Volume Reduction With Endobronchial Valves: A Systematic Review and Meta-analysis","authors":"Julia Díaz-Miravalls ,&nbsp;Alejandro Romero-Linares ,&nbsp;Miguel Jiménez-Gómez ,&nbsp;Eduardo Catalinas-Muñoz ,&nbsp;José Ignacio De Granda-Orive ,&nbsp;Alberto Caballero-Vázquez ,&nbsp;Pedro Romero-Palacios ,&nbsp;Bernardino Alcázar-Navarrete","doi":"10.1016/j.opresp.2025.100443","DOIUrl":"10.1016/j.opresp.2025.100443","url":null,"abstract":"<div><h3>Introduction</h3><div>Emphysema is a phenotype of chronic obstructive pulmonary disease (COPD) that causes air trapping and lung hyperinflation and, consequently, dyspnea, reduced exercise tolerance, and poor health-related quality of life. Several randomized controlled clinical trials have shown that bronchoscopic lung volume reduction (BLVR) with endobronchial valves (EBV) achieves clinically relevant improvements in dyspnea, pulmonary function, exercise capacity and quality of life 12 months after valve implantation in patients with heterogeneous emphysema without collateral ventilation. The goal of our meta-analysis is to examine the efficacy and safety of BLRV in patients with COPD.</div></div><div><h3>Material and methods</h3><div>A literature search was performed with PubMed, Embase and Cochrane to identify randomized controlled trials on BLVR with endobronchial valves published from 2005 onwards.</div></div><div><h3>Results</h3><div>Nine studies with a total of 1352 patients were included; 827 received EBV therapy and 525 standard of care (SOC) medications. The first group showed statistically significant improvements in forced expiratory volume in 1 second (FEV1), Saint George Respiratory Questionnaire (SGRQ) score, modified medical research council (mMRC) dyspnea scale, and 6-minute walk distance (6MWD), and a statistically significant reduction in residual volume (RV). The incidence of pneumothorax and exacerbations in the EBV arm increase significantly, and there were no significant difference between mortality rates.</div></div><div><h3>Conclusions</h3><div>Patients with heterogeneous emphysema and no collateral ventilation showed significant improvements in lung function, exercise capacity, dyspnea score, and health-related quality of life after BLVR-EBV, although the risk of exacerbations and pneumothorax in the first 6 months increased compared with the group receiving standard care.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100443"},"PeriodicalIF":0.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert Consensus on Single-Inhaler Triple Therapy for the Treatment of Asthma in Adult Patients","authors":"Carolina Cisneros Serrano ,&nbsp;Eva Martínez Moragón ,&nbsp;Alicia Padilla-Galo ,&nbsp;Cleofé Fernández Aracil ,&nbsp;Andrea Trisán Alonso ,&nbsp;Gerardo Pérez Chica ,&nbsp;Ana Pueyo Bastida ,&nbsp;Auxiliadora Romero Falcón ,&nbsp;José Ángel Carretero-Gracia ,&nbsp;José Gregorio Soto-Campos ,&nbsp;Members of the Validation Task Force","doi":"10.1016/j.opresp.2025.100442","DOIUrl":"10.1016/j.opresp.2025.100442","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite existing guidelines, many patients with asthma do not achieve adequate control of their disease. This is largely due to low adherence to inhaled therapy. Single-inhaler administration may improve this and other aspects of asthma therapy, such as cost-effectiveness. The aim of this study is to gather the opinions of a panel of experts on single-inhaler triple therapy (SITT) for the treatment of asthma in adult patients.</div></div><div><h3>Material and methods</h3><div>A recommendation task force reviewed the available evidence and formulated 45 statements divided into 5 sections: efficacy, cost-effectiveness, therapeutic adherence, safety, and patient satisfaction. A validation task force of 71 experts evaluated these recommendations using the 2-round Delphi technique. Panellists rated their agreement with each statement on a 9-point scale.</div></div><div><h3>Results</h3><div>Consensus was achieved in 42 of the 45 statements. Panellists broadly agreed that SITT improves lung function, reduces exacerbations, is cost-effective, and promotes therapeutic adherence. The safety of TT was considered favourable, even in patients with cardiovascular comorbidities. The panellists also agreed on the importance of evaluating patient satisfaction with the inhaler. However, no consensus was reached regarding the suitability of TT as a first-line treatment, nor on whether TT is more beneficial than up-dosing ICS in patients with a low inflammatory profile currently receiving dual therapy. Additionally, panellists did not agree on whether sick leave due to respiratory causes was associated with greater adherence to TT.</div></div><div><h3>Conclusions</h3><div>The consensus indicates that SITT is considered an effective, safe option for the treatment of asthma that improves therapeutic adherence and patient satisfaction. Further real-world studies are needed to evaluate its implementation in different clinical contexts.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100442"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple Therapy in Asthma","authors":"Cleofé Fernández Aracil ,&nbsp;María del Mar García Ródenas ,&nbsp;Luis Manuel Hernández Blasco","doi":"10.1016/j.opresp.2025.100439","DOIUrl":"10.1016/j.opresp.2025.100439","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100439"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Cavitary Pulmonary Aspergillosis","authors":"Maria Mercedes Morante Tinoco ,&nbsp;Julia Montero de Miguel ,&nbsp;Itziar Fernández Ormaechea","doi":"10.1016/j.opresp.2025.100436","DOIUrl":"10.1016/j.opresp.2025.100436","url":null,"abstract":"","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 3","pages":"Article 100436"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home Respiratory Therapies in Patients With Obstructive Sleep Apnea: A Value-based Care Model in Spain","authors":"Irene Cano-Pumarega ,&nbsp;Candela Caballero-Eraso ,&nbsp;Valentín Cabriada ,&nbsp;Mar Mosteiro ,&nbsp;Juan Fernando Masa ,&nbsp;Ferran Barbé","doi":"10.1016/j.opresp.2025.100427","DOIUrl":"10.1016/j.opresp.2025.100427","url":null,"abstract":"<div><div>This document proposes a value-based care model to improve adherence and health outcomes in patients with obstructive sleep apnea (OSA) treated with CPAP. The current care model for OSA management adopts a uniform, volume-based approach for all patients, limiting personalized care and reducing service quality without providing objective outcome data. The value-based care model proposed here focuses on guiding all interventions towards improving treatment adherence, aiming to enhance health outcomes by increasing patients’ quality of life and comfort with treatment. Key strategies to be implemented include education and support programs at the beginning of treatment, enhancing comfort in mask use, telemonitoring of adherence, patient involvement in the treatment progress, patient stratification based on adherence, and identifying individuals who may benefit from alternative treatments. A results-based funding model is also recommended to optimize resource allocation. Expected outcomes from these measures include a reduction in home visits and in-person consultations for stable patients, fewer non-adherent patients, more optimally treated patients, and overall improvements in treatment quality and effectiveness. Key indicators to evaluate the success of this approach include quality of life (measured through quality-of-life questionnaires), adherence levels (via telemonitoring), and CPAP comfort. Collectively, these strategies allow for a comprehensive approach, optimizing resources and ensuring personalized care that improves the experience and outcomes of OSA patients.</div></div>","PeriodicalId":34317,"journal":{"name":"Open Respiratory Archives","volume":"7 2","pages":"Article 100427"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}