Problems of Endocrinology最新文献_第2页

Errors in radiation diagnosis of pituitary adenomas 垂体腺瘤放射诊断的错误

Problems of Endocrinology Pub Date : 2019-10-06 DOI: 10.14341/probl11692

I. Dedov, A. I. Bukhman, V. G. Shlykova

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A rare case of pseudohypoparathyroidism 假性甲状旁腺功能减退1例

Problems of Endocrinology Pub Date : 2019-10-06 DOI: 10.14341/probl11704

V. Gubkina, T. Kamynina, E. Kornilova, A. Dreval

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The functional state of the thyroid system of children exposed in utero as a result of the Chernobyl disaster 由于切尔诺贝利灾难，子宫内暴露的儿童甲状腺系统的功能状态

Problems of Endocrinology Pub Date : 2019-10-06 DOI: 10.14341/probl11698

S. I. Sychik, A. Stozharov, B. K. Voronetskiy

{"title":"The functional state of the thyroid system of children exposed in utero as a result of the Chernobyl disaster","authors":"S. I. Sychik, A. Stozharov, B. K. Voronetskiy","doi":"10.14341/probl11698","DOIUrl":"https://doi.org/10.14341/probl11698","url":null,"abstract":"A cohort of children exposed in utero after the Chernobyl accident is formed (n=422). Individual absorbed dose (AD) for the fetal thyroid was estimated from direct measurements of dose power for the maternal thyroid and was 0.01-4.5 Gy. The mean AD for the thyroid of pregnant women was 24.09+1.17 sGy, that of prenatally exposed children 44.74+2.58 sGy. Thyroid status of 195 exposed children and 220 controls is examined. Thyroid hormones were radioimmunoassayed and measured by enzyme immunoassay using standard diagnostic kits. Serum triiodothyronine concentrations were significantly increased in prenatally exposed children of both sexes (p<0.05 for boys and p<0.01 for girls). Serum thyroxin and thyroxin-binding globulin (TBG) levels were decreased in exposed boys in comparison with the control (p<0.05). In exposed girls thyroxin levels were virtually normal, but there was a tendency to an increase of thyroglobulin (t=1.6) and to a decrease of TBG (t= 1.7) in comparison with the control. The mean TBG concentration in the serum was below the norm in both groups. The results can be indicative of thyroid dysfunction in remote periods after prenatal exposure to radioactive iodine.","PeriodicalId":342539,"journal":{"name":"Problems of Endocrinology","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130971059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the possible participation of phosphatidylinositol-3-kinase in activation by insulin and epidermal growth factor phospholipase c, hydrolyzing glycosylphosphatidylinositol 磷脂酰肌醇-3激酶可能参与胰岛素和表皮生长因子磷脂酶c活化、水解糖基磷脂酰肌醇

Problems of Endocrinology Pub Date : 2019-10-06 DOI: 10.14341/probl11707

A. Krivtsov, V. Tkachuk

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Treatment of diffuse euthyroid goiter in children 儿童弥漫性甲状腺功能正常甲状腺肿的治疗

Problems of Endocrinology Pub Date : 2019-10-06 DOI: 10.14341/probl11697

T. Taranushenko, A. Panfilov, S. Dogadin

{"title":"Treatment of diffuse euthyroid goiter in children","authors":"T. Taranushenko, A. Panfilov, S. Dogadin","doi":"10.14341/probl11697","DOIUrl":"https://doi.org/10.14341/probl11697","url":null,"abstract":"High prevalence of diffuse euthyroid goiter and inefficiency of conservative treatment aimed at normalization of thyroid volume necessitate search for optimal methods of treatment. \u0000Results of thyroxin and potassium iodide (antistrumin) therapy of 110 children with diffuse toxic goiter, living in a region with medium-grave iodine deficiency, are analyzed. The diagnosis was verified by clinical data, ultrasonic examinations, and hormone measurements. \u0000Changes in the volume of the thyroid under the effect of thyroxin and antistrumin therapy could be variously directed: the involved thyroid might enlarge, shrink, or not change at all. Therapeutic effects of thyroxin and antistrumin on the degree of thyroid decrease and incidence of positive results after 6-month therapy were virtually the same. \u0000Thyroxin in a daily dose of 2.0-2.5 xg/kg promoted a decrease and normalization of the thyroid size. Efficacy of thyroxin significantly increased if it was used longer than for 6 months. \u0000Potassium iodide (antistrumin) in a weekly dose of 2000 pg (equivalent to daily 200 pg iodine) led to decrease of goiter size and normalization of the thyroid volume. The best results were observed after a no more than 6-month course of treatment. A longer course brought about a tendency to a higher incidence of untoward effects (enlargement of the thyroid).","PeriodicalId":342539,"journal":{"name":"Problems of Endocrinology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131852743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune polyglandular syndromes 自身免疫性多腺综合征

Problems of Endocrinology Pub Date : 2019-10-06 DOI: 10.14341/probl11708

V. Fadeev, I. Shevchenko, G. Melnichenko

引用次数: 0

The first experience of laser spectroscopy in the surgical treatment of thyroid diseases 激光光谱学在甲状腺疾病手术治疗中的首次经验

Problems of Endocrinology Pub Date : 2019-10-06 DOI: 10.14341/probl11694

Vetshev Ps, Chilingaridi Ke, Ippolitov Li, S. Harnas, Loshchenov Vb, Gabaidze Di, A. Y. Duplik

{"title":"The first experience of laser spectroscopy in the surgical treatment of thyroid diseases","authors":"Vetshev Ps, Chilingaridi Ke, Ippolitov Li, S. Harnas, Loshchenov Vb, Gabaidze Di, A. Y. Duplik","doi":"10.14341/probl11694","DOIUrl":"https://doi.org/10.14341/probl11694","url":null,"abstract":"For assessing the efficacy of intraoperative laser autofluorescent spectroscopy (IOLAS), 46 patients with thyroid diseases of different etiology are examined. The patients ’ aged varied from 30 to 65 years. The following morphological types of diseases were observed: benign nodular formations in 42 patients, thyroid cancer in 4, papillary TINO MO in 2, and follicular cancer TINO MO in 2 cases. Out of benign formations, 36 were multinodular colloid goiter and 6 follicle-cell adenomas. As a result of using IOLAS, thyroid cancer was diagnosed during surgery in 8 (17.4%) out of 36 patients with multinodular colloid goiter; this diagnosis necessitated more extensive intervention than was planned: subtotal resection had to be extended to thyroidectomy. In all the cases IOLAS data were confirmed by urgent and later planned histological analyses. Due to this method, no reoperations were needed, which previously had to be performed because of the data of planned histological analysis, and therefore, the probable complications of reoperations were prevented. Our data indicate that IOLAS more accurately identifies the type and morphology of thyroid involvement and helps choose adequate volume of intervention. The first experience with laser fluorescent study as optic biopsy holds good promise as regards improvement of intraoperative rapid diagnosis of thyroid diseases.","PeriodicalId":342539,"journal":{"name":"Problems of Endocrinology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122525198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The nature of psychological changes in patients with insulin-dependent diabetes mellitus after learning self-control 胰岛素依赖型糖尿病患者学习自我控制后心理变化的性质

Problems of Endocrinology Pub Date : 2019-10-06 DOI: 10.14341/probl11691

A. Dreval, Y. Redkin, I. V. Misnikova

{"title":"The nature of psychological changes in patients with insulin-dependent diabetes mellitus after learning self-control","authors":"A. Dreval, Y. Redkin, I. V. Misnikova","doi":"10.14341/probl11691","DOIUrl":"https://doi.org/10.14341/probl11691","url":null,"abstract":"Time course of psychological status of diabetics during automonitoring training is analyzed. Seventeen patients with insulin-dependent diabetes mellitus aged 15-43 years with disease standing of 1-17 years were followed up, who were never trained automonitoring before. Two control groups were not trained, which helped assess the results from different viewpoints. The levels of depression, anxiety, energy, positive sensations, total well-being, satisfaction with treatment, subjective perception of hypoglycemic reactions, and subjective perception of hyperglycaemia were assessed using special questionnaires. Compensation of diabetes was improved both in the main and control groups. Psychological status of diabetics improved after training: levels of depression and anxiety decreased, levels of energy, psychological well-being, and general psychological status increased (p<0.05). In the controls all the above parameters were unchanged over the period of hospitalization. The incidence of subjective perception of hyperglycaemia decreased in trained patients (p<0.05) but not in the controls. The data indicate that the program of diabetic training can be recommended as a method for improving the efficacy of treatment as regards both metabolism compensation and improvement of the psychological status of patients.","PeriodicalId":342539,"journal":{"name":"Problems of Endocrinology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133894220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Modern problems of thyroidology 现代甲状腺问题

Problems of Endocrinology Pub Date : 2019-10-06 DOI: 10.14341/probl11690

V. Kandror

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The use of the HELPER device for determining infrared radiation of the skin in the diagnosis of diabetic angiopathies 在糖尿病血管病变的诊断中使用HELPER装置来测定皮肤的红外辐射

Problems of Endocrinology Pub Date : 2019-09-23 DOI: 10.14341/probl199844210-12

E. Zhuk

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