Problems of Endocrinology最新文献_第8页

Pharmacotherapy of obesity: what’s new? 肥胖的药物治疗:有什么新进展?

Problems of Endocrinology Pub Date : 2018-10-06 DOI: 10.14341/PROBL9315

E. Troshina, E. Ershova

引用次数: 6

Statin administration is associated with higher IGF-1 levels in patients without diabetes mellitus 他汀类药物与非糖尿病患者较高的IGF-1水平相关

Problems of Endocrinology Pub Date : 2018-10-06 DOI: 10.14341/PROBL8759

O. Shpagina, I. Bondarenko, G. Kolesnikova

{"title":"Statin administration is associated with higher IGF-1 levels in patients without diabetes mellitus","authors":"O. Shpagina, I. Bondarenko, G. Kolesnikova","doi":"10.14341/PROBL8759","DOIUrl":"https://doi.org/10.14341/PROBL8759","url":null,"abstract":"Background: Research makes it clear that the IGF-1 level correlates with cardiovascular disease, chronic heart failure, and mortality. Yet, little is known about the effect of statins on IGF-1. \u0000Aims: to evaluate the effect of statin treatment on IGF-1 and its association with a cardiovascular risk. \u0000Material and methods: The study included 115 patients (mean age, 55.8±6.1 years) who either were overweight or had mild obesity (body mass index 28.6±3.8 kg/m2) without diabetes. Group 1 consisted of 70 patients with verified coronary artery disease receiving statin therapy; group 2 included 45 healthy subjects. Coronary angiography and treadmill test were used to diagnose coronary artery disease. Impaired glucose tolerance and total cholesterol, triglycerides, LPHD, LPLD, fibrinogen, and IGF-1 levels were evaluated in all the subjects. Heart chamber geometry was assessed by echocardiography. \u0000Results: The IGF-1 level was significantly higher in group 1 compared to the control group (196 and 167 ng/ml, respectively; р=0.014). Serum levels of IGF-1 were associated with duration of statin therapy (R=0.311; p=0.000), stage of hypertension (R=0.187; p=0.04), fibrinogen (R=0.274; p=0.033), TG (R=0.316; p=0.006), total cholesterol (R=–0.213; p=0.016), LPLD (R=–0.184; p=0.038), smoking (R=0.3; p=0.009), ejection fraction (R=0.298; p=0.041), end-diastolic volume (R=0.422; p=0.036), end-systolic volume (R=0.407; p=0.042), end-diastolic dimension (R=0.27; p=0.014), interventricular septal thickness (R=0.247; p=0.02), and left ventricular posterior wall thickness (R=0.258; p=0.019). Rosuvastatin dose positively correlated with the IGF-1 level (R=0.521; p=0.028). \u0000Conclusions: Statin administration is associated with higher IGF-1 levels in patients without diabetes. High IGF-1 level correlates with the risk factors of coronary artery disease: hypertension, lipid profile, and fibrinogen level and has an adverse effect on chronic heart failure by altering the cardiac remodeling.","PeriodicalId":342539,"journal":{"name":"Problems of Endocrinology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124996140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Dynamic monitoring of iodine sufficiency in Belarus: results and problems 白俄罗斯碘充足的动态监测:结果和问题

Problems of Endocrinology Pub Date : 2018-07-17 DOI: 10.14341/PROBL8686

T. Mokhort, N. Kolomiets, S. Petrenko, E. Fedorenko, A. Mokhort

{"title":"Dynamic monitoring of iodine sufficiency in Belarus: results and problems","authors":"T. Mokhort, N. Kolomiets, S. Petrenko, E. Fedorenko, A. Mokhort","doi":"10.14341/PROBL8686","DOIUrl":"https://doi.org/10.14341/PROBL8686","url":null,"abstract":"The strategy for elimination of iodine deficiency in the population was developed and implemented in the Republic of Belarus. It is based on acceptance of recommendations that iodized salt is a unique source of iodine support. Currently, adequate iodine consumption is achieved. The prevalence of thyroid gland diseases caused by iodine deficiency was significantly decreased. In 2013, the International Council for Control of Iodine Deficiency Disorders (ICCIDD), a global non-profit non-governmental organization established to eliminate iodine deficiency and its negative consequences, published the results of iodine status assessment in the world. According to these data, the Republic of Belarus provides adequate iodine intake. In 2016, Iodine Global Network published maps characterizing iodine supply for the two main categories — school-age children and pregnant females. These data have confirmed that the Republic of Belarus refers to countries with sufficient iodine consumption according to the results of subnational studies. Despite the achieved successes, new issues are raised: quality of iodine sufficiency monitoring, risks of excessive salt intake, and need for new approaches to diagnosing thyroid pathology due to iodine deficiency.","PeriodicalId":342539,"journal":{"name":"Problems of Endocrinology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134184130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Glucokinase activators — a promising class of antidiabetic drugs 葡萄糖激酶激活剂——一类很有前途的抗糖尿病药物

Problems of Endocrinology Pub Date : 2018-07-17 DOI: 10.14341/PROBL8747

A. Spasov, Спасов Александр Алексеевич, V. Kosolapov, Косолапов Вадим Анатольевич, D. Babkov, Бабков Денис Александрович, O. Mayka, Майка Ольга Юрьевна

引用次数: 0

Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: a case report 长链3-羟基酰基辅酶a脱氢酶缺乏症1例

Problems of Endocrinology Pub Date : 2018-07-17 DOI: 10.14341/probl8636

E. Khramova, E. Khorosheva, O. Perfilova

{"title":"Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: a case report","authors":"E. Khramova, E. Khorosheva, O. Perfilova","doi":"10.14341/probl8636","DOIUrl":"https://doi.org/10.14341/probl8636","url":null,"abstract":"Long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) is an autosomal recessive mitochondrial fatty acid beta-oxidation disorder with variable presentation including lack of energy (lethargy), low blood sugar (hypoglycemia), weak muscle tone (hypotonia), hepatic steatosis, and hypocarnitinemia. In this report, we describe a 9-month-old male patient who suffered from recurrent hypoglycemia with hypoglycemic convulsions, vomiting, and neurological regression since the age of 4 months. The patient presented with hypotonia, motor delay, hepatomegaly, protein-energy malnutrition (BMI SDS — 2.8). Biochemical tests demonstrated hypoglycemia (2.5 mmol/l), elevated lactate, creatine phosphokinase, and aminotransferases. There were also increased concentrations of long-chain acylcarnitine and 3-hydroxyacylcarnitine as well as a dramatic decrease in the carnitine level. Digestive tract malformations, endocrinopathies, and degenerative diseases of the nervous system were excluded hydroxyacyl-CoA dehydrogenase (HADHA) gene)testing revealed a homozygous mutation p.Glu474Gln. This confirmed the diagnosis of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. Diet correction by adding medium chain triglycerides, compensation of carnitine deficiency, and symptomatic therapy made it possible to avoid fatal metabolic crises and manage neurological regression. Early detection, diagnosis, and treatment of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency may improve clinical outcomes.","PeriodicalId":342539,"journal":{"name":"Problems of Endocrinology","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121826887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The peculiarities of self in young patients with type 1 diabetes mellitus 年轻1型糖尿病患者的自我特点

Problems of Endocrinology Pub Date : 2018-07-17 DOI: 10.14341/probl8249

A. A. Fedorova, E. Shishkina, Vitaliy S. Kablukov

{"title":"The peculiarities of self in young patients with type 1 diabetes mellitus","authors":"A. A. Fedorova, E. Shishkina, Vitaliy S. Kablukov","doi":"10.14341/probl8249","DOIUrl":"https://doi.org/10.14341/probl8249","url":null,"abstract":"The problem of the influence of self on human behavior is one of the major focuses of psychologists. However, the problem of self-identification of patients with somatic diseases, in particular type 1 diabetes mellitus, still remains poorly understood. \u0000Aim: the study aim was to investigate the characteristics of self-evaluation in young patients with type 1 diabetes mellitus. \u0000Material and methods. The theoretical and methodological basis of the study was the concept by V.V. Stolin (1985) and the theory of self by S.R. Pantileev (1989). We used the self-attitude assessment (SAA) method by S.R. Pantileev, personal differentia method adapted at the Bekhterev Research Institute; and self-esteem scale test by M. Rosenberg. The study included 60 subjects allocated into two groups: 30 patients with type 1 diabetes mellitus, a mean age of 22.5 years (18 to 25 years) and a mean disease duration of 5 years; 30 healthy subjects with a mean age of 21.5 years (18 to 25 years). \u0000Results. Patients with type 1 diabetes, unlike healthy subjects, had a low level of self-evaluation; they had the most pronounced negative emotional attitude to their Self, which reflected a low level of self-acceptance and comprise. Patients with type 1 diabetes had the level of self-esteem lower than that in healthy subjects. They were characterized by the presence of internal conflicts, disagreement with oneself, and excessive soul-searching and reflection. They considered themselves as the source of their failures. \u0000Conclusions. The results indicate the distinct differences in the structure of Self between type 1 diabetes patients and healthy subjects.","PeriodicalId":342539,"journal":{"name":"Problems of Endocrinology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129100524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The rare form of congenital adrenal hyperplasia caused by an autosomal dominant form of STAR deficiency 罕见的先天性肾上腺增生是由常染色体显性的STAR缺陷引起的

Problems of Endocrinology Pub Date : 2018-07-17 DOI: 10.14341/probl8644

N. Kalinchenko, G. Chistousova, V. Petrov, E. V. Vasiliev, A. Tiulpakov

引用次数: 1

Characteristics of primary hyperparathyroidism in young patients 年轻患者原发性甲状旁腺功能亢进的特点

Problems of Endocrinology Pub Date : 2018-07-17 DOI: 10.14341/probl9399

E. Mamedova, N. Mokrysheva, L. Rozhinskaya

引用次数: 5

Molecular genetic factors in the development of papillary thyroid cancer in the Kazakh population 哈萨克族人群甲状腺乳头状癌发生的分子遗传因素

Problems of Endocrinology Pub Date : 2018-05-31 DOI: 10.14341/probl8691

M. Espenbetova, N. Glushkova, A. Krykpayeva

{"title":"Molecular genetic factors in the development of papillary thyroid cancer in the Kazakh population","authors":"M. Espenbetova, N. Glushkova, A. Krykpayeva","doi":"10.14341/probl8691","DOIUrl":"https://doi.org/10.14341/probl8691","url":null,"abstract":"Introduction. In the last decade several population studies on the association of the genes NKX2-1 and FOXE1 with sporadic papillary thyroid cancer were conducted. In the Kazakh population of similar work to date were not conducted. The aim of this study was to study the genetic association of the FOXE1 (rs9655313) and NKX2-1 (rs944289) oncomarkers with papillary thyroid cancer in the Kazakh population. \u0000Materials and methods. We conducted a case-control study that allows us to retrospectively evaluate the association of NKX2-1 and FOXE1 genes and papillary thyroid cancer. \u0000Results. The frequency distribution of FOXE1 rs965513 polymorphism in the group of papillary thyroid cancer and the control group detected by healthy individuals was significantly different (χ2 = 100.09, D.f. = 2, p = 0.000). In the group of cases, the AA genotype (17.5%) was in three times more often compared with the control group (5.1%). The GG variant had a lower frequency in the group of persons of papillary thyroid cancer (37.9%) against the control group (61.4%), the odds ratio (OR) in the FOXE1 rs965513 group was 2.367. The distribution of the NKX2-1 (rs944289) polymorphism frequencies in the compared groups of values were significantly different (χ2 = 100.09, D.f. = 2, p = 0.000). In the group of cases, the genotype of TT (30.5%) against the control group (20.7%) was 1.5 times more common. The SS variant had a lower frequency of occurrence in the group of persons of papillary thyroid cancer (19.8%) against the control group (28.9%), OR in NKX2-1 (rs944289) group was 1.46. \u0000Conclusion. Carrying out screening for carriers of FOXE1 rs965513 and NKX2-1 (rs944289) can become an effective means of early diagnosis with a high frequency of its spread and associations with cases of papillary thyroid cancer in the Kazakh population.","PeriodicalId":342539,"journal":{"name":"Problems of Endocrinology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126416216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0