Egyptian Journal of Bronchology最新文献

{"title":"Unveiling the hidden causes: the crucial role of fiber optic bronchoscopy in diagnosing non-resolving pneumonia - a prospective study conducted in a tertiary care hospital of north India","authors":"Amir Abdullah Dar, Syed Mudasir Qadri, Saleem Javaid Wani, Ghulam Nabi Dhobi, Vivek Kumar, Nazia Mehfoz, Sonaullah Shah, Fayaz Ahmad Bhat","doi":"10.1186/s43168-025-00411-4","DOIUrl":"https://doi.org/10.1186/s43168-025-00411-4","url":null,"abstract":"Abstract Introduction Non-resolving pneumonia (NRP) poses a significant diagnostic challenge, often requiring advanced investigations for accurate identification of underlying causes. Fiber-optic bronchoscopy (FOB), along with bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBLB), is increasingly recognized for its diagnostic utility. Patients and methods This prospective observational study was designed to evaluate the role of FOB in determining the aetiology of NRP among patients at a tertiary care hospital in Kashmir. It was conducted on 70 patients diagnosed with NRP between December 2018 and November 2020. Clinical, radiological, and microbiological investigations were performed, followed by FOB. Findings from BAL and TBLB were analyzed to determine diagnostic outcomes. Results The mean age of participants was 55.9 ± 17 years, with males comprising 58.6%. Pulmonary tuberculosis (38.6%) was the most common etiology, followed by malignancy (24.3%), bacterial pneumonia (20%), and fungal pneumonia (8.5%). Squamous cell carcinoma (20%) was the predominant malignancy, especially in smokers. The overall diagnostic yield of FOB was 91.4%. No major procedural complications were reported. Conclusion FOB, combined with BAL and TBLB, is a highly effective diagnostic tool for NRP, offering valuable insights into infectious and non-infectious etiologies. It is particularly beneficial for diagnosing pulmonary tuberculosis and centrally located malignancies, highlighting its significance in improving patient outcomes. This study emphasizes the importance of a comprehensive diagnostic approach in cases of NRP, especially in resource-limited settings.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ejb.springeropen.com/counter/pdf/10.1186/s43168-025-00411-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147899952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air under pressure: a case report on tension pneumomediastinum arising from traumatic injury","authors":"Udvass Kumar Kotokey","doi":"10.1186/s43168-024-00338-2","DOIUrl":"https://doi.org/10.1186/s43168-024-00338-2","url":null,"abstract":"Abstract Background Tension pneumomediastinum (TPM) is a rare but critical condition characterized by the accumulation of air in the mediastinum, leading to increased intrathoracic pressure and cardiovascular compromise. This case report is novel due to the rarity of TPM arising from blunt chest trauma and the necessity for emergent surgical intervention after initial conservative management failed. Case presentation A 63-year-old male presented with severe chest pain and dyspnea following a high-impact motor vehicle collision. Initial assessment revealed tachypnea, tachycardia, and hypotension, along with extensive subcutaneous emphysema over the chest and neck. Imaging confirmed pneumomediastinum and bilateral pneumothoraxes, consistent with TPM. Despite initial management with high-flow oxygen and bilateral chest tube insertion, the patient’s condition deteriorated, necessitating emergent mediastinal decompression via an anterior subxiphoid incision. This intervention resulted in immediate hemodynamic improvement. Conclusions This case underscores the importance of recognizing TPM in patients with chest trauma and highlights the need for prompt surgical intervention in cases of hemodynamic instability. Early and accurate diagnosis and timely surgical management are crucial for improving patient outcomes in TPM.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147918478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of atypical pneumonia by chest ultrasonography","authors":"Ahmed Sameh Sayed, Mona Mansour Ahmed, Khaled Mohamed Wagih, Haytham Samy Diab, Ahmed Mohamed Hussein","doi":"10.1186/s43168-023-00239-w","DOIUrl":"https://doi.org/10.1186/s43168-023-00239-w","url":null,"abstract":"Abstract Background Patients with pneumonia exhibit similar clinical presentations despite having different causative organisms; thus, a rapid and easy test is needed to differentiate between the diseases. Here, we use lung ultrasound to discriminate between causative organisms in correlation with other diagnostic modalities. Methods This descriptive cross-sectional study was carried out on 67 patients diagnosed with atypical pneumonia admitted at Ain-Shams University hospitals in the period from July 2019 to June 2021. Study population was divided into three groups according to the causative agent based on the results of PCR: Group 1 included 23 patients (influenza A), group 2 included 30 patients (COVID-19), and group 3 included 14 patients (atypical organisms). Included patients underwent lung ultrasound scan via a 12-zone scanning protocol and CT scan with 24 h in between. The present study was approved by the ethical committee at our institution. Results The mean age ranged from 39.93 ± 19.26 SD to 60.3 ± 13.02 SD years; 64.17% of them were males. There was also a highly statistically significant difference between the three groups as regard B-lines and thickened pleural line being higher among group 2; 100% of cases had B-lines in their chest ultrasound assessment, while thickened pleural line was found in 53.3% of cases. Dynamic air bronchogram was found with higher percentage in group 3 (71.4%) with a highly significant association. Higher mean Soldati score was associated with more severe disease among cases with viral pneumonia. Conclusions Lung ultrasound may be used as an aiding tool to estimate the etiology of atypical pneumonia. It can be useful during pandemics of acute respiratory diseases for rapid triage and stratification of patients as through calculation of modified Soldati score and detection of the most common finding. Also, modified Soldati score correlates with disease severity.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135342363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of high flow nasal canula in patients with mild hypercapnia","authors":"Mohammed A. Ibrahim, Magdy Emara, Mohammed Shehta","doi":"10.1186/s43168-023-00243-0","DOIUrl":"https://doi.org/10.1186/s43168-023-00243-0","url":null,"abstract":"Abstract Context High flow nasal canula is usually used for management of acute hypoxemic failure; however, it may have a potential therapeutic benefits in hypercapnia as it can alter tidal volume, end expiratory volume, positive end expiratory pressure, and respiratory rate. Aim Evaluate safety and efficacy of application HFNC (high flow nasal canula) for patients with mild hypercapnia. Settings and design A prospective interventional study. Patients and methods Over six months, thirty eight patients were enrolled, with mild hypercapnia and PH level not less 7.30 and PaCo2 not more 60 mmhg; with applying HFNC, serial checking of arterial blood gases was done. Checkpoints were at 2 h, 12 h, 24 h, and 48 h post application of HFNC. HFNC can be shifted to NIV or invasive MV at any time whenever indicated. Results Primary pulmonary disorder was chronic obstructive pulmonary disorder in (22 patients) and (16 patients) had interstitial lung disease. For PH in overall, mean values had changed from 7.33 until reached 7.37 at 48 h post HFNC with calculation of P value at each checkpoint from baseline value; significant changes were recorded at 24 h and 48 h post HFNC application. A similar observation was observed for PaCO2. No significant changes were observed at any checkpoint for HCO3. Conclusion High flow nasal canula is safe in cases with mild hypercapnia with a considerable success rate and a proven high efficacy. Trial registration Clinicaltrials.gov/NCT05948527, Registered 14 July 2023—Retrospectively registered, https://www.clinicaltrials.gov/NCT05948527 .","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":"3 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135345880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of comorbid pulmonary disease on COVID-19 disease severity and outcome: a retrospective cohort study","authors":"Sally Magdy, Reem Elkorashy, Eman Hany Elsebaie, Hebatallah Hany Assal, Hoda M. Abdel-Hamid","doi":"10.1186/s43168-023-00240-3","DOIUrl":"https://doi.org/10.1186/s43168-023-00240-3","url":null,"abstract":"Abstract Background Identifying patients with comorbid pulmonary disease may guide prognosis and aid in developing strategies regarding who would benefit the most from vaccines. This study was designed to clarify the influence of comorbid lung disease on COVID-19 severity and outcome. Methods This is a retrospective cohort analysis of 587 COVID-19 patients. The clinical, laboratory, and imaging data and comorbidities as reported by the patients were obtained from the Kasr Alainy Hospital medical records. Also, data regarding whether the patient is hospitalized or not, the length of hospital stay, complications, and mortality are gathered from the records. Results The patients’ mean ages are 51 ± 15 years (63.9% are males with the remaining 36.1% which are females). Patients with chronic comorbid pulmonary diseases represented 113 patients among the whole study population. with the COPD being 11.4%. Patients with comorbid lung diseases associated or not with other comorbidities were at higher risk of acquiring severe COVID-19 and had higher complication and mortality rates compared to patients without comorbidities ( p-value < 0.001 ). Patients with preexisting diabetes, hypertension, COPD, and chronic kidney disease have a significantly higher risk of severe infection ( p-value < 0.001 , 0.001 , 0.001 , < 0.001 ), complications ( p-value 0.038 , 0.005 , < 0.001 , < 0.001 ), and mortality ( p-value 0.021 , 0.001 , < 0.001 , < 0.001 ), respectively. Conclusion This study provides a better understanding of COVID-19 patients with comorbid lung disease and highlights the importance of the data deduced from our study and similar studies in aiding the designation of vaccination programs for those patients if needed.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":"201 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135475656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging changes of oil aspiration over time in children: a case series","authors":"Masoud Mahdavi Rashed, Mojtaba Haji Hosseini, Behnam Beizae, Seyed Ali Alamdaran, Anahita Alizadeh, Seyed Javad Seyedi, Ehsan Hassannejad, Nahid Tavakolizadeh","doi":"10.1186/s43168-023-00242-1","DOIUrl":"https://doi.org/10.1186/s43168-023-00242-1","url":null,"abstract":"Abstract Background Oil aspiration pneumonia is an uncommon form of lung disease due to aspiration or inhalation of oil-containing products. The present study reports the changes process of radiological findings over time in four children. Case presentation For 2 years, four cases (17 months until 3.5 years) with aspiration oil-containing (petroleum or benzene) products were referred to a tertiary center, Akbar Children’s Hospital, Mashhad Medical University of Science. They presented with respiratory distress and fever. The radiography, low-dose CT scan, and ultrasound findings were evaluated. Assessment of serial imaging findings in our patients shows decreased volume, ground glass opacity, and septal thickening in the lower lobes of the lungs are a predominant pattern in the first and second days. Consolidation and nodular opacity appear after 48 h. In the second week, the nodular pattern (fluid-filled pneumatoceles) is the main pattern and persists for 1 month. CT scan images showed that opaque nodules are actually fluid-filled pneumatoceles. Finally, air-filled pneumatoceles gradually appeared from the third week and disappeared in 6–8 months. Conclusion Our results show that four radiological phases of oil pneumonia, including ground glass opacities, segmental consolidation, fluid-filled pneumatoceles (nodule), and finally air-filled pneumatoceles, could be seen in radiography, CT scan, and ultrasound.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":"6 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135479593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic yield of combined ultrasound-guided fine needle aspiration and core needle biopsy versus either technique alone in peripheral lung and pleural lesions","authors":"Rania Ahmed Sweed, Yehia Mohamed Khalil, Hany Amin Sharawy, Eman Sheta Ali Gawdat Alsawy, Mina Botros","doi":"10.1186/s43168-023-00233-2","DOIUrl":"https://doi.org/10.1186/s43168-023-00233-2","url":null,"abstract":"Abstract Introduction Ultrasound (US) has become an integral tool for chest assessment as it provides crucial information on pleural pathologies and peripherally located lung lesions. Aim To assess the diagnostic yield of combined fine needle aspiration (FNAB) and core needle biopsy (CNB) versus each technique ultrasound-guided in peripheral lung and pleural lesions. Methodology The present study enrolled 30 patients presenting to Alexandria Main University Hospital, with CT scans showing undiagnosed peripheral lung or parietal pleural lesions with or without effusion. A full ultrasound chest assessment was done covering 12 regions. Assessment of the lesion of interest, vascularity was assessed via color Doppler, locating the safest entry site. Real-time US-guided FNAB was done using a spinal needle 22 gauge. Then real-time US-guided CNB using 18 gauge Trucut needle in the same setting. Duration and complications of each procedure were reported. In FNAB, three smears were prepared, fixed in alcohol, and stained with hematoxylin and eosin stain. The remaining sample was fixed in formalin and centrifuged to prepare cell blocks. On the other hand, Trucut needle biopsy specimens were fixed in formalin and processed as paraffin-embedded blocks. Immunohistochemical staining was done. The results were classified into four categories (inadequate, negative, suspicious, and positive for malignancy. Results The diagnostic yield of combined techniques was 96.7% versus 63.3% using FNAB and 96.7% using CNB. The sensitivity of FNAB was 86% while CNB was 95%. The specificity and positive predictive value of both methods were 100%. The negative predictive value of FNAB was 57% versus 80% for CNB in peripheral lung lesions. Duration of US-guided CNB was statistically significantly longer than that of FNAB in both peripheral lung and pleural lesions. No major complications were reported using either technique. Conclusion Combined FNAB and CNB were not superior to CNB alone regarding diagnostic yield but were superior to FNAB. Ultrasound-guided CNB has a superior diagnostic yield over FNAB, with no statistically significant difference regarding associated complications, both techniques are safe. FNAB provided sufficient material for ancillary molecular testing.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":"4 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135635161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the early returns of robotic-assisted bronchoscopy in a patient population at high risk for cancer: factors associated with a diagnostic procedure and pathologic outcomes","authors":"Rami Naaman, Christopher M. Kapp, Odile David, Kevin Kovitz, Benjamin Aronson, Kevin Haas","doi":"10.1186/s43168-023-00238-x","DOIUrl":"https://doi.org/10.1186/s43168-023-00238-x","url":null,"abstract":"Abstract Background Lung cancer remains the most common cause of cancer-related deaths in the USA. Successful implementation of lung cancer screening programs has led to increased detection of peripheral pulmonary lesions (PPL). Robotic-assisted bronchoscopy (RB) is a relatively novel tool used to safely diagnose PPN. Additionally, with the developing precision of personalized medicine and targeted therapy, obtaining adequate tissue for next-generation sequencing (NGS) has become critical to optimizing the medical management of lung cancer. Our aim is to assess the diagnostic yield of RB, identify patient and procedure characteristics associated with performing a diagnostic biopsy, and evaluate the adequacy of tumor cellularity for biomarker identification. Results We performed a retrospective observational study consecutively enrolling 54 adult patients who underwent RB between January 2022 and March 2023. Records were reviewed for medical comorbidities and smoking status. PPL characteristics included size, location, presence of a bronchus sign on mapping computed tomography (CT) scans, distance from airway and pleura on CT, and days between obtaining CT and the bronchoscopy. Procedural factors included the radial endobronchial ultrasound (r-EBUS) view obtained and the sampling method(s) with which a diagnosis was achieved. Records were reviewed for final pathology and the need for further procedures to establish a diagnosis. Samples that yielded non-small cell lung cancer (NSCLC) were sent for an NGS panel if deemed adequate. The panels were reviewed to identify potentially actionable mutations. Multivariable logistic regression was performed to assess patients and lesions characteristics associated with a diagnostic biopsy. We sampled 56 lesions, 45 (80.4%) were from current or former smokers. The overall diagnostic yield was 73.2% and 68.9% for nodules less than 3 cm. Lesions size ranged from 8 mm nodules to 70 mm masses, with an average size 20.3 mm. Mean nodule size from diagnostic procedures was 21.5 mm and 16.9 mm from non-diagnostic ones ( p = 0.04). Logistic regression analysis showed that the presence of a bronchus sign was associated with a diagnostic procedure (OR 19.4, p = 0.023), while lack of a r-EBUS view predicted a non-diagnostic bronchoscopy (OR 0.02, p = 0.013). 28 diagnostic biopsies (68.3%) yielded NSCLC and of the 25 cases that we followed, 22 samples (88%) were adequate for NGS. Conclusions The presence of a bronchus sign on CT and obtaining r-EBUS view during RB were associated with a higher diagnostic yield. RB successfully sampled PPL with adequate tumor cellularity for NGS.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":"8 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135635321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The yield of rigid thoracoscopy in patients of undiagnosed exudative pleural effusion and comparison of pleural fluid and thoracoscopic findings between tuberculosis and malignancy","authors":"Hemant Kumar, Mohammad Arif, Sachin Kumar, Ved Prakash, Ajay Kumar Verma, Chanchal Rana, Saumya Shukla, R. A. S. Kushwaha","doi":"10.1186/s43168-023-00237-y","DOIUrl":"https://doi.org/10.1186/s43168-023-00237-y","url":null,"abstract":"Abstract Background Medical thoracoscopy is an essential tool in the evaluation of patients with pleural effusion who remain undiagnosed despite a thorough pleural fluid workup. Malignancy and tuberculosis are the two most common etiologies in such patients having completely different prognoses. Therefore, correct diagnosis is very important before starting treatment. This study was planned to study the yield of rigid thoracoscopy in such patients and to observe its associated complications. Furthermore, the difference in the profile of patients with malignancy and tuberculosis was also evaluated. Methods This was a single-center, exploratory, observational study done between 1st May 2021 to 31st December 2022. Patients with undiagnosed exudative pleural effusion defined as exudative pleural effusions as per Light’s criteria with negative Gene X pert and twice negative pleural fluid cytology for malignancy, underwent rigid thoracoscopy for confirmation of their diagnosis. Results A total of 160 patients, who fulfilled our inclusion criteria, were included in our study. Male to female ratio was 1.25:1, with a mean age of 57.3 years. The most common etiology observed was malignancy, seen in 120 out of 160 patients (75%), followed by tuberculosis, which was seen in 27 (17%) patients. A final diagnosis could be made in 158 patients, giving a diagnostic yield of 98.8%. 11.8% showed procedure-related complications without any mortality. Conclusion Rigid medical thoracoscopy has a very high diagnostic yield with few complications. A significant proportion of patients with straw-colored effusion can present with malignancy and vice versa. A few with ADA above 40 were diagnosed as having malignancy. Therefore, tissue-based biopsy with thoracoscopy can be easily performed to make a correct diagnosis with huge future implications in such patients.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":"47 24","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135820323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, physiological, and radiological different phenotypes of COPD patients","authors":"Islam Galal, Zeinab Rabie, Shazly Ahmed, Ahmed Hamdy Mhsb, Samah Kotb","doi":"10.1186/s43168-023-00232-3","DOIUrl":"https://doi.org/10.1186/s43168-023-00232-3","url":null,"abstract":"Abstract Background COPD is a heterogeneous lung disorder with multiple phenotypes and endotypes. This study aimed to identify the diverse clinical, physiological, and radiological phenotypes of COPD. Moreover, to provide whether there was a possible relation between FEV1%, FVC%, and FEV1/FVC ratio, [both before and after broncho-dilation with the diameters of the airway at three diverse levels throughout both inspiratory and expiratory phases of respiration]. Results This study included 50 cases, that were classified according to the radiological phenotypes into 5 groups [29 cases (58%) were mild [centrilobular emphysema) CLE)], 8 cases (16%) were moderate CLE, 5 cases (10%) were [confluent emphysema (CON)], 5 cases (10%) were [advanced destructive emphysema (ADE)] and 3 cases (6%) were [para septal emphysema (PSE)]. There was no considerable variance in the frequency of COPD clinical phenotypes among the diverse radiological phenotypes. There was a moderate positive correlation between the predicted FEV1% and the corresponding inter-luminal diameter at the selected levels (RB1, and LB3) in the inspiratory phase of respiration ( P < 0.001 and p = 0.001 respectively) ( r = 0.58, 0.46 respectively). and there was a moderate positive correlation in the expiratory phase of respiration between the predicted FEV1% and the equivalent inter-luminal diameter at the selected levels (RB1, and LB3) ( P < 0.001 respectively) ( r = 0.62, 0.51 respectively). Conclusions We confirmed that COPD is a highly heterogeneous illness, with multiple diverse clinical, physiological, and radiological phenotypes. Furthermore, HRCT can well be allied with pulmonary function tests (PFT).","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135367010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}