非covid -19社区获得性肺炎的急性期反应物

IF 1 Q4 RESPIRATORY SYSTEM
Yosri Akl, Ahmed Elkomy, Eman Kamal Ibrahim
{"title":"非covid -19社区获得性肺炎的急性期反应物","authors":"Yosri Akl, Ahmed Elkomy, Eman Kamal Ibrahim","doi":"10.1186/s43168-023-00234-1","DOIUrl":null,"url":null,"abstract":"Abstract Background Acute phase reactants (APR) are markers of inflammation that could be applied for the assessment of community-acquired pneumonia (CAP) severity in association with various pneumonia severity scores. So, the aim of the study was to assess levels of APR such as total leucocytic count (TLC), platelets, neutrophils, neutrophils-to-lymphocyte ratio (NLR), CRP, D-dimer, ferritin, and ESR in patients with CAP and to correlate between their values and disease severity. Methodology The study included 51 patients diagnosed as non-COVID-19 (CAP). Patients were classified into two groups group A (pneumonia only) and group B (pneumonia complicated with empyema/complicated para-pneumonic effusion). All patients underwent clinical evaluation, CURB65, radiological assessment, and blood sampling to measure APR. Results The mean age of patients was 47 ± 17 years. The main symptoms were productive cough (90.2%) and Fever (92.2%).TLC, platelets, neutrophils, CRP, D-dimer, ferritin, and ESR were elevated than normal values. Significant positive correlations were found between the duration of fever and CRP, D-dimer, and ferritin with p values = 0.024, 0.012, and 0.034 respectively. Significant positive correlations were found between CURB65 and both CRP and ferritin with p values = 0.007 and 0.020. A significant increase in platelet count and ESR values was found in group B than in group A. Conclusion APR are important markers that can be used in the assessment of CAP in collaboration with clinical evaluation and severity scores. CRP, D-dimer, and ferritin were positively correlated with CURB65, while ESR and platelets could be considered predictors of the development of complications. Trial registration Retrospectively registered, registration number NCT05926089 , date of registration is 06/29/2023.","PeriodicalId":34128,"journal":{"name":"Egyptian Journal of Bronchology","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Acute phase reactants in non-COVID-19 community-acquired pneumonia\",\"authors\":\"Yosri Akl, Ahmed Elkomy, Eman Kamal Ibrahim\",\"doi\":\"10.1186/s43168-023-00234-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Background Acute phase reactants (APR) are markers of inflammation that could be applied for the assessment of community-acquired pneumonia (CAP) severity in association with various pneumonia severity scores. So, the aim of the study was to assess levels of APR such as total leucocytic count (TLC), platelets, neutrophils, neutrophils-to-lymphocyte ratio (NLR), CRP, D-dimer, ferritin, and ESR in patients with CAP and to correlate between their values and disease severity. Methodology The study included 51 patients diagnosed as non-COVID-19 (CAP). Patients were classified into two groups group A (pneumonia only) and group B (pneumonia complicated with empyema/complicated para-pneumonic effusion). All patients underwent clinical evaluation, CURB65, radiological assessment, and blood sampling to measure APR. Results The mean age of patients was 47 ± 17 years. The main symptoms were productive cough (90.2%) and Fever (92.2%).TLC, platelets, neutrophils, CRP, D-dimer, ferritin, and ESR were elevated than normal values. Significant positive correlations were found between the duration of fever and CRP, D-dimer, and ferritin with p values = 0.024, 0.012, and 0.034 respectively. Significant positive correlations were found between CURB65 and both CRP and ferritin with p values = 0.007 and 0.020. A significant increase in platelet count and ESR values was found in group B than in group A. Conclusion APR are important markers that can be used in the assessment of CAP in collaboration with clinical evaluation and severity scores. CRP, D-dimer, and ferritin were positively correlated with CURB65, while ESR and platelets could be considered predictors of the development of complications. Trial registration Retrospectively registered, registration number NCT05926089 , date of registration is 06/29/2023.\",\"PeriodicalId\":34128,\"journal\":{\"name\":\"Egyptian Journal of Bronchology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2023-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Egyptian Journal of Bronchology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s43168-023-00234-1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian Journal of Bronchology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s43168-023-00234-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0

摘要

背景急性期反应物(Acute phase reactants, APR)是炎症标志物,可与各种肺炎严重程度评分相关,用于评估社区获得性肺炎(community-acquired pneumonia, CAP)严重程度。因此,本研究的目的是评估CAP患者的APR水平,如总白细胞计数(TLC)、血小板、中性粒细胞、中性粒细胞与淋巴细胞比率(NLR)、CRP、d -二聚体、铁蛋白和ESR,以及它们的值与疾病严重程度之间的相关性。方法本研究纳入51例诊断为非covid -19 (CAP)的患者。患者分为两组:A组(仅为肺炎)和B组(肺炎合并脓胸/合并肺旁积液)。所有患者均进行了临床评估、CURB65、放射学评估和采血测量apr。结果患者平均年龄为47±17岁。主要症状为咳咳(90.2%)和发热(92.2%)。TLC、血小板、中性粒细胞、CRP、d -二聚体、铁蛋白和ESR均高于正常值。c反应蛋白(CRP)、d -二聚体(D-dimer)、铁蛋白(feritin)与发热持续时间呈正相关,p值分别为0.024、0.012、0.034。CURB65与CRP、铁蛋白均呈显著正相关,p值分别为0.007、0.020。B组患者血小板计数和ESR值均明显高于A组。结论APR可与临床评价和病情严重程度评分协同评价CAP。CRP、d -二聚体和铁蛋白与CURB65呈正相关,而ESR和血小板可被认为是并发症发生的预测因子。回顾性注册,注册号NCT05926089,注册日期为2023年6月29日。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acute phase reactants in non-COVID-19 community-acquired pneumonia
Abstract Background Acute phase reactants (APR) are markers of inflammation that could be applied for the assessment of community-acquired pneumonia (CAP) severity in association with various pneumonia severity scores. So, the aim of the study was to assess levels of APR such as total leucocytic count (TLC), platelets, neutrophils, neutrophils-to-lymphocyte ratio (NLR), CRP, D-dimer, ferritin, and ESR in patients with CAP and to correlate between their values and disease severity. Methodology The study included 51 patients diagnosed as non-COVID-19 (CAP). Patients were classified into two groups group A (pneumonia only) and group B (pneumonia complicated with empyema/complicated para-pneumonic effusion). All patients underwent clinical evaluation, CURB65, radiological assessment, and blood sampling to measure APR. Results The mean age of patients was 47 ± 17 years. The main symptoms were productive cough (90.2%) and Fever (92.2%).TLC, platelets, neutrophils, CRP, D-dimer, ferritin, and ESR were elevated than normal values. Significant positive correlations were found between the duration of fever and CRP, D-dimer, and ferritin with p values = 0.024, 0.012, and 0.034 respectively. Significant positive correlations were found between CURB65 and both CRP and ferritin with p values = 0.007 and 0.020. A significant increase in platelet count and ESR values was found in group B than in group A. Conclusion APR are important markers that can be used in the assessment of CAP in collaboration with clinical evaluation and severity scores. CRP, D-dimer, and ferritin were positively correlated with CURB65, while ESR and platelets could be considered predictors of the development of complications. Trial registration Retrospectively registered, registration number NCT05926089 , date of registration is 06/29/2023.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Egyptian Journal of Bronchology
Egyptian Journal of Bronchology RESPIRATORY SYSTEM-
自引率
7.70%
发文量
56
审稿时长
9 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信