高流量鼻导管治疗轻度高碳酸血症的安全性和有效性

IF 1 Q4 RESPIRATORY SYSTEM
Mohammed A. Ibrahim, Magdy Emara, Mohammed Shehta
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引用次数: 0

摘要

高流量鼻导管通常用于治疗急性低氧血症衰竭;然而,它可能对高碳酸血症有潜在的治疗益处,因为它可以改变潮气量、呼气末容积、呼气末正压和呼吸速率。目的评价高流量鼻导管治疗轻度高碳酸血症的安全性和有效性。背景与设计一项前瞻性介入研究。在6个月的时间里,38例患者入组,轻度高碳酸血症,PH值不低于7.30,PaCo2不高于60mmhg;应用HFNC进行了动脉血气的连续检测。检查点分别在应用HFNC后2小时、12小时、24小时和48小时。HFNC可以在任何时候转移到NIV或侵入性MV,只要有指示。结果原发性肺疾病为慢性阻塞性肺疾病22例,间质性肺疾病16例。总体而言,PH在HFNC后48小时的平均值从7.33变化到7.37,每个检查点的P值从基线值计算;在应用HFNC后24 h和48 h记录了显著变化。PaCO2也有类似的观察结果。在HCO3的任何检查点均未观察到显著变化。结论高流量鼻导管治疗轻度高碳酸血症是安全的,成功率高,疗效好。试验注册Clinicaltrials.gov/NCT05948527, 2023年7月14日注册,回顾性注册https://www.clinicaltrials.gov/NCT05948527。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Safety and efficacy of high flow nasal canula in patients with mild hypercapnia
Abstract Context High flow nasal canula is usually used for management of acute hypoxemic failure; however, it may have a potential therapeutic benefits in hypercapnia as it can alter tidal volume, end expiratory volume, positive end expiratory pressure, and respiratory rate. Aim Evaluate safety and efficacy of application HFNC (high flow nasal canula) for patients with mild hypercapnia. Settings and design A prospective interventional study. Patients and methods Over six months, thirty eight patients were enrolled, with mild hypercapnia and PH level not less 7.30 and PaCo2 not more 60 mmhg; with applying HFNC, serial checking of arterial blood gases was done. Checkpoints were at 2 h, 12 h, 24 h, and 48 h post application of HFNC. HFNC can be shifted to NIV or invasive MV at any time whenever indicated. Results Primary pulmonary disorder was chronic obstructive pulmonary disorder in (22 patients) and (16 patients) had interstitial lung disease. For PH in overall, mean values had changed from 7.33 until reached 7.37 at 48 h post HFNC with calculation of P value at each checkpoint from baseline value; significant changes were recorded at 24 h and 48 h post HFNC application. A similar observation was observed for PaCO2. No significant changes were observed at any checkpoint for HCO3. Conclusion High flow nasal canula is safe in cases with mild hypercapnia with a considerable success rate and a proven high efficacy. Trial registration Clinicaltrials.gov/NCT05948527, Registered 14 July 2023—Retrospectively registered, https://www.clinicaltrials.gov/NCT05948527 .
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来源期刊
Egyptian Journal of Bronchology
Egyptian Journal of Bronchology RESPIRATORY SYSTEM-
自引率
7.70%
发文量
56
审稿时长
9 weeks
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