慢性阻塞性肺病患者的临床、生理和放射学不同表型

IF 1 Q4 RESPIRATORY SYSTEM
Islam Galal, Zeinab Rabie, Shazly Ahmed, Ahmed Hamdy Mhsb, Samah Kotb
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引用次数: 0

摘要

背景COPD是一种具有多种表型和内源性的异质性肺疾病。本研究旨在确定慢性阻塞性肺病不同的临床、生理和放射学表型。此外,提供FEV1%、FVC%和FEV1/FVC比值[支气管扩张前后与呼吸的吸气期和呼气期三个不同水平的气道直径之间是否存在可能的关系]。结果本组50例患者,根据影像学表型分为5组[轻度[小叶中心肺气肿]29例(58%),中度[CLE] 8例(16%),[融合性肺气肿(CON)] 5例(10%),[晚期破坏性肺气肿(ADE)] 5例(10%),[间隔旁肺气肿(PSE)] 3例(6%)]。在不同的放射学表型中,COPD临床表型的频率没有显著差异。预测的FEV1%与呼吸吸气期选定水平(RB1和LB3)对应的腔内直径呈中度正相关(P <0.001, p = 0.001) (r = 0.58, 0.46)。预测的FEV1%与所选水平(RB1和LB3)下的等效腔内直径在呼气期存在中度正相关(P <0.001) (r = 0.62, 0.51)。结论:我们证实慢性阻塞性肺病是一种高度异质性的疾病,具有多种不同的临床、生理和放射学表型。此外,HRCT可以很好地与肺功能检查(PFT)结合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical, physiological, and radiological different phenotypes of COPD patients
Abstract Background COPD is a heterogeneous lung disorder with multiple phenotypes and endotypes. This study aimed to identify the diverse clinical, physiological, and radiological phenotypes of COPD. Moreover, to provide whether there was a possible relation between FEV1%, FVC%, and FEV1/FVC ratio, [both before and after broncho-dilation with the diameters of the airway at three diverse levels throughout both inspiratory and expiratory phases of respiration]. Results This study included 50 cases, that were classified according to the radiological phenotypes into 5 groups [29 cases (58%) were mild [centrilobular emphysema) CLE)], 8 cases (16%) were moderate CLE, 5 cases (10%) were [confluent emphysema (CON)], 5 cases (10%) were [advanced destructive emphysema (ADE)] and 3 cases (6%) were [para septal emphysema (PSE)]. There was no considerable variance in the frequency of COPD clinical phenotypes among the diverse radiological phenotypes. There was a moderate positive correlation between the predicted FEV1% and the corresponding inter-luminal diameter at the selected levels (RB1, and LB3) in the inspiratory phase of respiration ( P < 0.001 and p = 0.001 respectively) ( r = 0.58, 0.46 respectively). and there was a moderate positive correlation in the expiratory phase of respiration between the predicted FEV1% and the equivalent inter-luminal diameter at the selected levels (RB1, and LB3) ( P < 0.001 respectively) ( r = 0.62, 0.51 respectively). Conclusions We confirmed that COPD is a highly heterogeneous illness, with multiple diverse clinical, physiological, and radiological phenotypes. Furthermore, HRCT can well be allied with pulmonary function tests (PFT).
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来源期刊
Egyptian Journal of Bronchology
Egyptian Journal of Bronchology RESPIRATORY SYSTEM-
自引率
7.70%
发文量
56
审稿时长
9 weeks
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