C2PAC指数在脓毒症致凝血病(SIC)中的诊断价值

IF 1 Q4 RESPIRATORY SYSTEM
Mohamed Shaaban Mousa, Salwa Hassan Ahmed, Fatma Abdel Wahab Abdel Maksoud, Soliman Belal Soliman, Ahmed A. Tantawy
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All patients were subjected to assessment of C lectin domain family 2 receptor (sCLEC2), by enzyme-linked immunosorbent assay ELIZA kit, then C2PAC index (a ratio of soluble type C lectin-like receptor 2 level sCLEC-2 and platelet count) was calculated using the platelet count. Results Our study demonstrated that sCLEC-2 levels and C2PAC in group I were higher than in group II ( p value < 0.001), and Klebsiella was the most common organism detected in ICU septic patients; detected in 25 patients (44.6%), there is a statistical significance ( p value 0.045) between sCLEC2 levels and streptococcal infections. It was detected also that the SIC group was 17 patients (30.4%) and the sepsis without coagulopathy group was 39 patients (69.6%). Compared with the sepsis without coagulopathy group, the SIC group was significantly older and had a significantly higher SOFA score, sCLEC-2 levels, and C2PAC index. 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引用次数: 0

摘要

研究C2PAC指数(可溶性C型凝集素样受体2水平scec2与血小板计数的比值)在脓毒症诱导的凝血病中的潜在作用,并探讨将该指数作为脓毒症和脓毒症诱导的凝血病的早期预测指标的可能性。方法病例对照研究共86例,分为2组:I组为病例组,56例败血症或感染性休克患者;II组为对照组,30例性别、年龄相匹配的健康人。所有患者均采用elisa试剂盒检测C凝集素结构域家族2受体(sCLEC2)水平,并用血小板计数计算C2PAC指数(可溶性C凝集素样受体2水平scec2与血小板计数之比)。结果I组scec2水平和C2PAC水平均高于II组(p值<0.001),克雷伯菌是ICU脓毒症患者中最常见的微生物;25例(44.6%)患者中,sCLEC2水平与链球菌感染之间有统计学意义(p值0.045)。SIC组17例(30.4%),无凝血功能障碍脓毒症组39例(69.6%)。与无凝血功能障碍的脓毒症组相比,SIC组明显衰老,SOFA评分、sclc -2水平和C2PAC指数明显升高。最后,C2PAC作为脓毒症致凝血病的诊断和预后指标具有很高的统计学意义<0. 001. 结论C2PAC指数可作为脓毒症致凝血功能障碍的准确标志物,其敏感性(82.4%)高于scecc -2(58.8%),且两者的特异性相同(89.7%)。C2PAC指数是预测SIC进展的有效指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The diagnostic role of C2PAC index in cases of sepsis-induced coagulopathy (SIC)
Abstract Background To study the potential role of the C2PAC index (a ratio of soluble type C lectin-like receptor 2 level sCLEC-2 and platelet count) in sepsis-induced coagulopathy with the possibility of using this index as an early predictor in sepsis and sepsis-induced coagulopathy. Methods Our case–control study included a total of 86 participants divided into 2 groups: group I is the case group consisting of 56 patients of sepsis or septic shock and group II (control group) of 30 healthy persons: sex and age-matched healthy individuals. All patients were subjected to assessment of C lectin domain family 2 receptor (sCLEC2), by enzyme-linked immunosorbent assay ELIZA kit, then C2PAC index (a ratio of soluble type C lectin-like receptor 2 level sCLEC-2 and platelet count) was calculated using the platelet count. Results Our study demonstrated that sCLEC-2 levels and C2PAC in group I were higher than in group II ( p value < 0.001), and Klebsiella was the most common organism detected in ICU septic patients; detected in 25 patients (44.6%), there is a statistical significance ( p value 0.045) between sCLEC2 levels and streptococcal infections. It was detected also that the SIC group was 17 patients (30.4%) and the sepsis without coagulopathy group was 39 patients (69.6%). Compared with the sepsis without coagulopathy group, the SIC group was significantly older and had a significantly higher SOFA score, sCLEC-2 levels, and C2PAC index. Lastly, the strong potentiality of using C2PAC as a diagnostic and prognostic marker for sepsis-induced coagulopathy with high statistical significance < 0. 001. Conclusions C2PAC index can be validated as an accurate marker of sepsis-induced coagulopathy with higher sensitivity when using the C2PAC index (82.4%) than using sCLEC-2 (58.8%) and both have the same specificity (89.7%). The C2PAC index is a useful predictor of SIC progression.
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来源期刊
Egyptian Journal of Bronchology
Egyptian Journal of Bronchology RESPIRATORY SYSTEM-
自引率
7.70%
发文量
56
审稿时长
9 weeks
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