Theoretical and Natural Science最新文献_第2页

Explore the impact of free sulfur dioxide on red and white wine 探索游离二氧化硫对红葡萄酒和白葡萄酒的影响

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/45/20240422

Yuyang Tian, Jiahuizi Peng, Xinyue Li, Sirui Wang

{"title":"Explore the impact of free sulfur dioxide on red and white wine","authors":"Yuyang Tian, Jiahuizi Peng, Xinyue Li, Sirui Wang","doi":"10.54254/2753-8818/45/20240422","DOIUrl":"https://doi.org/10.54254/2753-8818/45/20240422","url":null,"abstract":"Today, red and white wine are essential symbols that motivate the worlds economy and are cultural symbols. Thus, the taste and process of alcohol during fermentation have become highly evocative to producers today. In this way, this article focuses on the effect of free sulfur dioxide on the concentration of fixed and volatile acids since fixed and volatile acids have a high impact on the taste of red and white wine, according to scientific research. This article also focuses on the PH value of both wines to investigate whether the free sulphate dioxide has a positive effect on the PH acidity of red and white wine. By paying attention to the acidity, the producers can further investigate the health impact of both wines and provide better choices and plans for the consumers. Using Cortezs data, this article matches the linear regression model to compare the fixed and volatile groups between red and white wine. PH values of both wines are also laid out in the final linear regression model group. The linear regression model tests the difference between free sulfur dioxides effects on the two wine categories. Lastly, the RMSE value has been used to test whether the result is reliable.","PeriodicalId":341023,"journal":{"name":"Theoretical and Natural Science","volume":"3 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141801794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

APOE4, activation of latent form HSV-1, A beta accumulation and AD progression APOE4、激活潜伏型 HSV-1、A beta 积累和注意力缺失症的进展

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/44/20240488

Weiqi Mo

引用次数: 0

Investigation of traditional Chinese medicine for cancer treatment: Signaling pathways and anti-tumor microenvironment 中药治疗癌症的研究：信号通路和抗肿瘤微环境

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/44/20240410

Mengqi He, Yi Liao

引用次数: 0

Cellular nature of major depressive disorder and alcohol use disorder comorbidity: An overview 重度抑郁障碍和酒精使用障碍合并症的细胞本质：综述

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/45/20240681

Humiao Dong, Ziao Zhang, Yutong Chen, Yuhan Shao, Ziqi Huang

{"title":"Cellular nature of major depressive disorder and alcohol use disorder comorbidity: An overview","authors":"Humiao Dong, Ziao Zhang, Yutong Chen, Yuhan Shao, Ziqi Huang","doi":"10.54254/2753-8818/45/20240681","DOIUrl":"https://doi.org/10.54254/2753-8818/45/20240681","url":null,"abstract":"The co-occurrence of alcohol use disorders and depression is increasing in our society due to their wide prevalence. Both alcohol use disorders (AUD) and depression increase susceptibility to disability and mortality, and their symptoms are closely linked to the brains reward circuits. While the pathogenesis of AUD and depression is well-researched, the mechanism of comorbidities remains a challenge. Individuals with depression may use alcohol for self-medication, leading to the formation of AUD over time. Abrupt cessation of alcohol consumption in individuals with long-term AUD can result in neurotransmitter abnormalities and an elevated risk of depression or relapse. This review primarily focuses on basic research and summarizes neurotransmitters such as GABA, glutamate, dopamine, norepinephrine, and 5-HT in relation to Major Depressive Disorder and AUD. Currently, the effectiveness of treatment for comorbidities is not clearly evident. Our goal is to comprehensively explore the cellular attributes associated with these comorbidities in order to identify new avenues for therapeutic interventions.","PeriodicalId":341023,"journal":{"name":"Theoretical and Natural Science","volume":"111 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141802157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Singular value decomposition: A useful technique for image denoising 奇异值分解：一种有用的图像去噪技术

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/39/20240610

Kejia Xing

引用次数: 0

Research progress of PD-1/PD-L1 inhibitors combined with other drugs in the treatment of tumors PD-1/PD-L1 抑制剂与其他药物联合治疗肿瘤的研究进展

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/44/20240484

Shuaichen Zhou

{"title":"Research progress of PD-1/PD-L1 inhibitors combined with other drugs in the treatment of tumors","authors":"Shuaichen Zhou","doi":"10.54254/2753-8818/44/20240484","DOIUrl":"https://doi.org/10.54254/2753-8818/44/20240484","url":null,"abstract":"Cancer as the first killer of the influence of human life and health, researcher use a variety of ways to cure cancer, but has been no effective treatment, along with the innovation of new biotechnology, researcher discovered the cancer cells rely on the Warburg effect in the human body metabolism. And understanding the PD-1L receptor on the surface of tumor cells can help tumor cells to achieve immune escape, which is not easy to be recognized and killed by the PD-1 receptor on the surface of immune cells. After understanding this process, researchers have developed PD-1/PD-L1 receptor inhibitors to help cure cancer by targeting this mechanism, which is also part of immunotherapy. Among the drugs on the market today, it has been confirmed that PD-1/PD-L1 is effective in the treatment of non-solid tumors and a small number of solid tumors. However, because of the characteristics of most solid tumors, PD-1/PD-L1 is limited to play a role, so researchers try to develop PD-1/PD-L1 combined with other drugs to treat more solid tumors. In the literature cited in this article, it can be seen that the combination of PD-1/PD-L1 with other drugs is effective, but the adverse reactions will also increase. This article will discuss the effectiveness of PD-1/PD-L1 combined with other drugs in detail.","PeriodicalId":341023,"journal":{"name":"Theoretical and Natural Science","volume":"13 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141799078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The number of Hamiltonian cycles in groups of Symmetry 对称组中的哈密顿周期数

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/43/20240756

Zixia Jiang

引用次数: 0

Dark matter and its candidate particles 暗物质及其候选粒子

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/43/20240925

Yuhan Zhang, Zidong Zeng

引用次数: 0

Assessment of cellular signaling pathways in cancer: Targeting aberrant kinases and phosphatases for personalized therapy 评估癌症的细胞信号通路：针对异常激酶和磷酸酶进行个性化治疗

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/45/20240611

WangHao Mao

{"title":"Assessment of cellular signaling pathways in cancer: Targeting aberrant kinases and phosphatases for personalized therapy","authors":"WangHao Mao","doi":"10.54254/2753-8818/45/20240611","DOIUrl":"https://doi.org/10.54254/2753-8818/45/20240611","url":null,"abstract":"Cancer is a group of diseases where cell proliferation is uncontrolled leading to formation of tumors which can spread to other parts of the body in a process called metastasis. With a mortality of about ten million deaths each year, cancer is responsible for one in six deaths which makes it one of the leading health problems worldwide. Because of this it is necessary for scientists to research cancer thoroughly to stop this problem as soon as possible. Cellular signaling pathways regulate cell proliferation, depending on the ligand that binds to cells it can lead to cell growth or apoptosis. So if a mutation happens in one of these pathways it can lead to serious problems such as the constant activation of the pathway causing uncontrolled cell growth and thus, cancer. In this review, I will focus on the aberrant kinases and phosphatases describing their pathways with detail and seeing how to target these mutations using combinatorial therapy with signal-transduction inhibitors to try to stop the pathogenesis of cancer. So far, there is no known cure for cancer and only some treatments in phase III are available. Trying to cure cancer is very complex, especially in cancer treatment as each patient may have genetic variations, the molecular profile of the tumor, and other unique biological characteristics, herein, personalized therapy based on different patients situation to increase treatment effectiveness while minimizing side effects. In this review, we intend to elucidate the significance of targeting aberrant kinases and phosphatases in the pathogenesis of cancer.","PeriodicalId":341023,"journal":{"name":"Theoretical and Natural Science","volume":"56 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141799885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between screen usage and two core symptom changes in children with autism during Covid-19: A study in Italy Covid-19 期间屏幕使用与自闭症儿童两种核心症状变化之间的关系：意大利研究

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/45/20240516

Yihan Luo, Jiayi Cui

引用次数: 0