Research progress of PD-1/PD-L1 inhibitors combined with other drugs in the treatment of tumors

Cancer as the first killer of the influence of human life and health, researcher use a variety of ways to cure cancer, but has been no effective treatment, along with the innovation of new biotechnology, researcher discovered the cancer cells rely on the Warburg effect in the human body metabolism. And understanding the PD-1L receptor on the surface of tumor cells can help tumor cells to achieve immune escape, which is not easy to be recognized and killed by the PD-1 receptor on the surface of immune cells. After understanding this process, researchers have developed PD-1/PD-L1 receptor inhibitors to help cure cancer by targeting this mechanism, which is also part of immunotherapy. Among the drugs on the market today, it has been confirmed that PD-1/PD-L1 is effective in the treatment of non-solid tumors and a small number of solid tumors. However, because of the characteristics of most solid tumors, PD-1/PD-L1 is limited to play a role, so researchers try to develop PD-1/PD-L1 combined with other drugs to treat more solid tumors. In the literature cited in this article, it can be seen that the combination of PD-1/PD-L1 with other drugs is effective, but the adverse reactions will also increase. This article will discuss the effectiveness of PD-1/PD-L1 combined with other drugs in detail.