Theoretical and Natural Science最新文献

Evaluation of Chinese herbal medicine's neuroprotective effects: Regulation for neurological disorders 评估中药的神经保护作用：调节神经系统疾病

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/44/20240413

Qiuyu Niu

引用次数: 0

Numerical methods base on trinomial trees for option pricing 基于三叉树的期权定价数值方法

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/43/20240890

Zijun Zhang

引用次数: 0

Research on multi-path optimization problem based on particle swarm optimization algorithm 基于粒子群优化算法的多路径优化问题研究

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/43/20240857

Jianxu Zhou

引用次数: 0

Discovery of genes prominent in ADHD and SUDs: A meta-analysis and review 发现多动症和药物依赖性障碍的主要基因：荟萃分析和综述

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/45/20240532

Yaqing Gao, Chen Sang, Guotai Shen, Yuan Xu

{"title":"Discovery of genes prominent in ADHD and SUDs: A meta-analysis and review","authors":"Yaqing Gao, Chen Sang, Guotai Shen, Yuan Xu","doi":"10.54254/2753-8818/45/20240532","DOIUrl":"https://doi.org/10.54254/2753-8818/45/20240532","url":null,"abstract":"Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neuropsychiatric condition characterized by symptoms of inattention, hyperactivity, and impulsivity, with a high prevalence among school-aged children. Substance Use Disorders (SUDs) are often comorbid with ADHD, yet the genetic linkages between these two disorders are not well understood. This study aims to fill the research gap by performing a meta-analysis on seven existing Genome-Wide Association Studies (GWAS) datasets using PLINK 1.9 software to explore the genetic commonalities between ADHD and SUDs. Prior studies have identified separate genetic markers for each disorder, but comprehensive research examining the overlap between these two conditions remains scarce. Our meta-analysis identified multiple significant Single Nucleotide Polymorphisms (SNPs) and associated genes that are relevant to both ADHD and SUDs. These genes exhibited significant p-values, underlining their potential role in the comorbid genetic landscape of these conditions. The findings of this study provide novel insights into the shared genetic etiology of ADHD and SUDs and suggest promising avenues for future research and potential therapeutic interventions.","PeriodicalId":341023,"journal":{"name":"Theoretical and Natural Science","volume":"38 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141800012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altering adult Hippocampal Neurogenesis in the dentate gyrus through varying glucocorticoid receptor concentrations 通过改变糖皮质激素受体浓度改变齿状回中的成年海马神经发生

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/44/20240459

Minheng Cui

{"title":"Altering adult Hippocampal Neurogenesis in the dentate gyrus through varying glucocorticoid receptor concentrations","authors":"Minheng Cui","doi":"10.54254/2753-8818/44/20240459","DOIUrl":"https://doi.org/10.54254/2753-8818/44/20240459","url":null,"abstract":"Adult Hippocampal Neurogenesis, short for AHN, is an essential yet foundational process of producing new nerve cells in the dentate gyrus of the hippocampus. It is a fact that increasing AHN will enhance peoples ability to learn, memorize, regulate mood, etc. Therefore, scientists strive to pursue the factors which influence AHN. Until now, research had proved that GR activity is associated with the degree of AHN. Additionally, a high GR activity will potentially reduce the level of ANH and an optimal level of GR activity will create the optimized level of AHN. Consequently, how a low level of GR activity will possibly influence AHN will be examined in this paper. For Experiment 1, the GR antagonist reduces the GR activity in 8-year-old male mice: C57BL/6 and BrdU highlights the newly generated neurons in the dentate gyrus. As an ideal result compared to the control group, low GR activity will lead to a decrease in the AHN. For Experiment 2, 3 minor experiments will be constructed to test the GR activity and AHN of the mice in 3 different conditions (low, controllable, and uncontrollable stress). And Nanobit Assay that is separately attached to the GR and the ligands will present fluorescent when combined. Additionally, the method of CRISPR-CAS9 is used to knock down either GR or GR when the other one is measured, and BrdU is also used to light up the neurons to measure the degree of AHN. The ideal result will present a number greater than 1 for the ratio between GR/GR and AHN decreases for the low-stress group and uncontrollable-stress group. Oppositely, the ratio will be smaller than 1 for the controllable stress group, meaning AHN increases. Conclusively, the output will demonstrate a reversed U shape with the x-axis being the level of GR activity and the y-axis presenting the level of AHN. Despite the experiments that have proceeded on mice, the significance of them is people will have certain references to the influences of AHN to prevent those conditions or stress which will negatively affect AHN.","PeriodicalId":341023,"journal":{"name":"Theoretical and Natural Science","volume":"40 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141800394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of smoking on lung cancer: A causal inference approach 吸烟对肺癌的影响：因果推理方法

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/44/20240424

Ziyang Qiu, Tianyi Ge, Zhaopeng Zhang, Zhenchen Lu, Louis Cao

引用次数: 0

Innovations in combating antimicrobial resistance: Unveiling nanotechnology, gene technology, and molecular diagnostics 对抗抗菌药耐药性的创新：揭开纳米技术、基因技术和分子诊断技术的神秘面纱

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/44/20240442

Jiayang Qiu

引用次数: 0

mRNA therapeutics in diseases: Light inspect into a new horizon 疾病中的 mRNA 疗法：开拓新视野

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/44/20240857

Yanhui Li

{"title":"mRNA therapeutics in diseases: Light inspect into a new horizon","authors":"Yanhui Li","doi":"10.54254/2753-8818/44/20240857","DOIUrl":"https://doi.org/10.54254/2753-8818/44/20240857","url":null,"abstract":"An in-depth analysis of messenger RNA (mRNA) therapeutics and their potential to treat a wide range of diseases is provided in this thorough review paper. mRNA therapy has a great deal of potential for treating various terminal illnesses. By introducing mRNA as a vaccine or therapeutic agent, recent developments in biotechnology and molecular medicine have made it possible to produce almost any functional protein or peptide in the human body. This offers a unique chance to prevent and treat various challenging illnesses, many of which have genetic roots. Moreover, the utilization of in vitro transcribed mRNA has brought about a revolution in the production process, rendering it more efficient, adaptable, customizable, and cost-effective when compared to traditional methods. For a long time, researchers have aspired to enhance various aspects of mRNA, including its stability, immunogenicity, translation efficiency, and delivery systems, with the aim of achieving an efficient and secure means of delivering mRNA. In this comprehensive review, we will delve into the essence of mRNA and mRNA-based therapies, encompassing their fundamental principles, methods of production, diverse applications, outcomes, and constraints. We will underscore the importance of optimizing mRNA and its delivery systems to ensure the success of mRNA therapy, all while addressing the pivotal challenges and prospects in the battle against cancer and COVID-19.","PeriodicalId":341023,"journal":{"name":"Theoretical and Natural Science","volume":"12 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141801005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analysis of the gut-brain axis and mental disorder 肠脑轴与精神障碍的元分析

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/44/20240773

Hanmo Yang, Shuran Zhang

{"title":"Meta-analysis of the gut-brain axis and mental disorder","authors":"Hanmo Yang, Shuran Zhang","doi":"10.54254/2753-8818/44/20240773","DOIUrl":"https://doi.org/10.54254/2753-8818/44/20240773","url":null,"abstract":"The gut-brain axis refers to the bidirectional information communication network between the brain and the gut. Microbiome and gut-brain axis have been implicated in mental disorders and have become the focus of neuroscience research. A meta-analysis was conducted to summarize the evidence regarding this link. A filtering search was performed using Hollis, PubMed, and Google Scholar to identify considered studies and trials. A keyword search identified 5500 articles. Seven provided analytically valuable and eligible data and were finally included for consideration and analysis. The data offered relevant studies on depression or anxiety, Schizophrenia, and Alzheimer's disease. Of the seven papers, four used correlational analysis (n=952) on depression and anxiety, two (n=384) on Schizophrenia, and one (n=80) on Alzheimers disease. These correlation analyses were designed to investigate the differences in gut microbial abundance between normal individuals and patients with mental disorders. In addition, three studies (n=314) identified a causal link by comparing the changes in mental health status by altering or influencing the gut microbiota. These causal analyses aimed to explore the differences in gut microbial abundance before and after the onset of mental disorders. In this case, mental illnesses were 2.8 to 14 times higher in the experimental groups than in the control groups. The findings support the hypothesis that the health of the gut-brain axis (microbial abundance) is inversely correlated to the incidence of many psychological disorders. However, how the gut-brain axis facilitates the pathogenesis of mental disorders remains to be further studied.","PeriodicalId":341023,"journal":{"name":"Theoretical and Natural Science","volume":"24 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141801362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in tacrine for Alzheimers disease 他克林治疗阿尔茨海默病的进展

Theoretical and Natural Science Pub Date : 2024-07-26 DOI: 10.54254/2753-8818/44/20240946

Wenting Li

引用次数: 0