Radiation Medicine and Protection最新文献

{"title":"Advances in radiation-induced heart disease diagnosis and treatment","authors":"Kaixuan Wang ,&nbsp;Cong Ye ,&nbsp;Lan Luo ,&nbsp;Chen Yan","doi":"10.1016/j.radmp.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.radmp.2024.04.003","url":null,"abstract":"<div><p>Over the past decades, the survival rates of patients with cancer have significantly increased owing to advancements in cancer treatment strategies. Radiotherapy has become an indispensable treatment modality for thoracic tumors. While it offers benefits in treating or even potentially curing cancer, thoracic radiotherapy exposes neighboring heart tissues to ionizing radiation, elevating the risk of radiation-induced heart disease (RIHD). Despite improvements in radiotherapy techniques that have reduced the incidence of RIHD, complete avoidance of heart radiation exposure remains a challenge. Cohort studies involving atomic bomb survivors and individuals with occupational radiation exposure, even at relatively low doses, have reported a significant increase in RIHD risks. The pathological mechanisms underlying RIHD have been extensively reviewed. At present, imaging techniques and traditional cardiac biomarkers are the primary methods to diagnose RIHD, with ongoing efforts to explore additional promising markers for predicting and monitoring RIHD. Moreover, traditional and novel therapeutic strategies are being actively explored to prevent or alleviate RIHD. Insights gained from therapeutic advancements in other organ systems or heart diseases caused by different factors can provide valuable ideas for RIHD management. This review discusses the recent advancements in the diagnosis and treatment of RIHD.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 2","pages":"Pages 83-89"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000285/pdfft?md5=17a3a783a1fa002a96c4a0fcc391e1cf&pid=1-s2.0-S2666555724000285-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141303573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-electrocardiography-gated dual-energy cardiac CT angiography for assessment of left atrial appendage thrombus","authors":"Feifei Zhang,&nbsp;Tian Jiang,&nbsp;Ruigang Xie,&nbsp;Jiliang Zhang,&nbsp;Minghua Sun,&nbsp;Yinghui Ge","doi":"10.1016/j.radmp.2024.03.004","DOIUrl":"10.1016/j.radmp.2024.03.004","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the diagnosis value of a low dose, dual-energy cardiac computed tomography angiography (CTA) with non-electrocardiography-gated (non-ECG-gated) in detecting left atrial appendage (IAA) thrombus.</p></div><div><h3>Methods</h3><p>Consecutive patients with atrial fibrillation who underwent cardiac CTA protocol (dual-energy scan for arterial phase and conventional scan for delayed phase) were prospectively enrolled. LAA lesions were proved by clinical comprehensive diagnosis, the final study included 18 cases with LAA thrombus and 48 cases with circulatory stasis. Quantitative parameters derived from dual-energy images were measured for the LAA lesions, including the conventional CT attenuation value (CT value), iodine concentration (IC), normalized iodine concentration (NIC), effective atomic number values (Zeff) and energy spectrum curve slope (Slope). The differences between LAA thrombus group and circulatory stasis group were compared by independent sample <em>t</em>-test or Wilcoxon rank sum test regarding to the normality test. The diagnosis performance of the dual-energy parameters was assessed using receiver operating characteristic (ROC) curve analysis and area under curve (AUC).</p></div><div><h3>Results</h3><p>All the dual-energy parameters were demonstrated significantly difference between LAA thrombus and circulatory stasis group (<em>P</em>＜0.05), and showed better diagnostic performance than the conventional CT value. ROC analysis revealed IC was the most predictive parameter with AUC equal to 0.836. The radiation dose in the arterial phase was (2.64 ​± ​0.66) mSv.</p></div><div><h3>Conclusion</h3><p>Dual-energy CTA scanning shows convincing diagnostic performance in detecting left atrial appendage thrombus with lower radiation dose, and may help reduce the need for delayed phase scan.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 2","pages":"Pages 118-123"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266655572400025X/pdfft?md5=667b6e15636487605f5f1aa325113235&pid=1-s2.0-S266655572400025X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bcl-xL regulates radiation-induced ferroptosis through chaperone-mediated autophagy of GPX4 in tumor cells","authors":"Jing Han ,&nbsp;Ruru Wang ,&nbsp;Bin Chen ,&nbsp;Feng Xu ,&nbsp;Liangchen Wei ,&nbsp;An Xu ,&nbsp;Lijun Wu ,&nbsp;Guoping Zhao","doi":"10.1016/j.radmp.2024.03.003","DOIUrl":"10.1016/j.radmp.2024.03.003","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the role and the molecular mechanisms of apoptotic signaling in ferroptosis to regulate tumor radiosensitivity.</p></div><div><h3>Methods</h3><p>Reactive oxygen species (ROS) and lipid peroxide levels were detected in Mouse embryonic fibroblasts(MEFs) with Bcl-xL or Mcl-1 deficiency induced by erastin. Colony formation, ROS, lipid peroxidation and the transcription/translation levels of PTGS2 were measured in Bcl-xL knockdown tumor cells induced by 5 ​Gy γ-rays or co-treated with ferrostatin-1 (Ferr-1). The protein levels of LPCAT3, ACSL4 and PEBP1 in Bcl-xL knockout MEF cells were evaluated in Bcl-xL knockout MEF cells post-radiation. Moreover, the interaction of heat shock protein 90 (HSP90) with Bcl-xL, GPX4, or LAMP2A was detected by protein mass spectrometry and immunoprecipitation assays.</p></div><div><h3>Results</h3><p>Manipulating Bcl-xL levels facilitated radiation-induced ferroptosis by augmenting the enzymatic oxidation of polyunsaturated fatty acids (PUFAs) and enhancing chaperone-mediated autophagy (CMA) of glutathione peroxidase 4 (GPX4) (MEF cell line: <em>t</em>=4.540, <em>P</em>＜0.01; A549 ​cell line: <em>t</em>=56.16, <em>P</em>＜0.0001; <em>t</em>=4.885, <em>P</em>＜0.01; HCT116 ​cell line: <em>t</em>=14.75, <em>P</em>＜0.01; <em>t</em>=7.363, <em>P</em>＜0.05). Downregulating Bcl-xL expression promoted the activity of acyl-CoA synthetase long-chain family member 4 (ACSL4), thus increasing the enzymatic oxidation of PUFAs (<em>t</em>=4.258, <em>P</em>＜0.01). Moreover, depletion of Bcl-xL expedited the CMA process targeting GPX4 by facilitating the association of GPX4 with heat shock protein 90 (HSP90) and LAMP2A following radiation exposure. Subsequent degradation of GPX4 led to the accumulation of lipid peroxides, ultimately triggering ferroptosis.</p></div><div><h3>Conclusions</h3><p>Our study provides initial insights into the regulatory role of Bcl-xL in ferroptosis and underscores the potential of targeting Bcl-xL as a promising therapeutic strategy for cancer by modulating both apoptotic and ferroptotic pathways.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 2","pages":"Pages 90-99"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000248/pdfft?md5=9e4fe81d7fc078e70bbb93ae8eeb68cb&pid=1-s2.0-S2666555724000248-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of therapeutic agents for breast cancer with potentially radiosensitizing properties","authors":"Zhongwei Zhang ,&nbsp;David Lim ,&nbsp;Zhihui Feng","doi":"10.1016/j.radmp.2024.03.002","DOIUrl":"10.1016/j.radmp.2024.03.002","url":null,"abstract":"<div><p>Breast cancer is the most frequently diagnosed malignant tumor in women worldwide and the leading cause of cancer death. Radiotherapy for breast cancer is readily accepted and widely used in clinical practice. Potential limitations with radiotherapy include treatment resistance, side effects, and complications caused by high doses of irradiation. The search has been on to locate an efficacious radiosensitizer. This review summarizes six currently approved pharmaceuticals that have also been investigated for off-label use as radiosensitizers in breast cancer.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 2","pages":"Pages 75-82"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000224/pdfft?md5=f3ef8f8c2f0646a57ff1e08ee3c2ac6c&pid=1-s2.0-S2666555724000224-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulator of G protein signaling 20 contributes to radioresistance of non-small cell lung cancer cells by suppressing pyroptosis","authors":"","doi":"10.1016/j.radmp.2024.05.008","DOIUrl":"10.1016/j.radmp.2024.05.008","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the potential role of the regulator of G protein signaling 20 (RGS20) in radioresistance of non-small cell lung cancer (NSCLC).</p></div><div><h3>Methods</h3><p>A total of 35 lung adenocarcinoma (LUAD) patients from The Cancer Genome Atlas (TCGA), who underwent radiotherapy, were enrolled and divided into radiosensitive (<em>n</em> ​= ​16) and radioresistant (<em>n</em> ​= ​19) groups based on clinical prognosis. The expression and prognosis of RGS20 were analyzed by Gene Expression Profiling Interactive Analysis (GEPIA) database. A radioresistant cell line (A549R) was constructed by irradiating A549 ​cells with 6 ​Gy X-rays for 10 fractions. Cell survival was measured by colony formation assay. The regulatory effect of RGS20 on pyroptosis were verified by LDH release and Western blot assay, and the underlying mechanism was investigated by transfecting RGS20 siRNA and applying a GSDMD inhibitor).</p></div><div><h3>Results</h3><p>A total of 2,181 differentially expressed genes (DEGs) were identified by analyzing the data of radiosensitive and radioresistant individuals from the TCGA-LUAD dataset. These DEGs were enriched in G alpha (z) signalling events analyzed by Reactome database. RGS20 exhibited significant upregulation among the DEGs, and its higher expression predicted poor prognosis in LUAD patients. In vitro, the expression of RGS20 protein was increased by irradiation in A549 ​cells, whereas it remained at much high levels in A549R cells regardless of irradiation. After irradiation, the expressions of pyroptosis-related proteins were significantly increased in A549 cells (<em>P</em> ＜ 0.05), with no significant changes were observed in A549R cells. Treatment with LDC7559 significantly reduced LDH release (<em>P</em> ＜ 0.01) and improved the survival rate of irradiated A549 cells (<em>P</em> ＜ 0.01). Furthermore, knockdown of RGS20 gene in A549R cells significantly increased LDH release (<em>P</em> ＜ 0.001) and enhanced radiosensitivity (<em>P</em> ＜ 0.01), while LDC7559 administration reversed LDH release (<em>P</em> ＜0.01) and radiation-induced cell death increased by siRGS20 (<em>P</em> ＜0.05). Meantime, the increased expression level of GSDMD-NT was observed in A549 and A549R cells transfected with siRGS20 (<em>P</em> ＜ 0.05).</p></div><div><h3>Conclusion</h3><p>RGS20 contributes to the radioresistance of NSCLC cells, which might be a potential target for NSCLC radiotherapy.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 3","pages":"Pages 178-184"},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000364/pdfft?md5=198de5f8faa72149980075ef3d725c91&pid=1-s2.0-S2666555724000364-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141132429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of radiotherapy and diagnosis resources allocation in Shanghai, China","authors":"","doi":"10.1016/j.radmp.2024.05.006","DOIUrl":"10.1016/j.radmp.2024.05.006","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the equity of medical resources in radiotherapy and diagnosis in Shanghai, China, based on population, geography, and economic factors.</p></div><div><h3>Methods</h3><p>Data on medical resources including institutions, equipment, and staff in radiotherapy/diagnosis were collected from all 16 districts of Shanghai, China in 2022. Separate data were collected for institutions and devices in CT. The Gini coefficient (<em>G</em>) and Lorenz curves were used to assess fairness based on population and geography, while the Theil index (<em>T</em>) was employed to evaluate health equity based on economic factors. Health resource agglomeration degree (HRAD) and population agglomeration degree (PAD) were utilized to analyze the equity and accessibility of medical resources considering both population and geography.</p></div><div><h3>Results</h3><p>In 2022, Shanghai had a total of 992 institutions, 4,925 devices, and 10,282 personnel in radiotherapy and diagnosis. Additionally, there were 381 institutions conducting CT examinations and 776 CT machines in Shanghai. The Gini coefficients for institutions, devices, and personnel in radiotherapy and diagnosis based on population ranged from 0.2 to 0.4, while for CT, the Gini coefficients for institutions and devices ranged from 0.2 to 0.4. When considering geography, all Gini coefficients were greater than 0.5. The results of the Theil index indicated that inequities in distribution may be influenced by economic factors. The HRAD and PAD revealed disparities in the accessibility of institutions, devices, and personnel in radiotherapy/diagnosis and CT in Shanghai.</p></div><div><h3>Conclusions</h3><p>Inequities in the distribution of institutions, equipment, and personnel for radiotherapy/diagnosis and CT were observed in Shanghai in 2022, both geographically and economically. There is a critical need to enhance the allocation of resources for radiological equipment and personnel and to establish a scientifically robust urban resource planning framework.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 3","pages":"Pages 207-212"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000340/pdfft?md5=e16f30772f607934c1092b3bb1a022f5&pid=1-s2.0-S2666555724000340-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141056042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"scRNA-seq transcriptomic profiling of irradiated mouse skin reveals altered cell types, pathways, and cell-cell interactions","authors":"","doi":"10.1016/j.radmp.2024.05.005","DOIUrl":"10.1016/j.radmp.2024.05.005","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the substantial changes in cell types, pathways, and cell-cell interactions occurring in the irradiation-induced alopecia and dermatitis (IRIAD) mouse model and to identify potential targets for patients experiencing skin adverse reactions to radiotherapy.</p></div><div><h3>Methods</h3><p>Mice were irradiated at 15 ​Gy, targeting the head and neck region. After a 14-day interval, living cells were extracted from both wild-type (WT) mice and irradiated mice for single-cell RNA sequencing (scRNA-seq). The scRNA-seq data, retrieved from the GEO database (GSE201447), underwent stringent quality control using the Seurat (v4.3.0) R package. Cell type annotation relied on previously reported typical markers and CellMarker 2.0. Differentially expressed genes were calculated to perform gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Cell-cell interactions were evaluated using the Cellchat R package.</p></div><div><h3>Results</h3><p>The application of single-cell RNA sequencing (scRNA-seq) enabled a comprehensive characterization of the intricate cellular composition of both wild-type (WT) and irradiated mice skin. Remarkably, cells within irradiated mice skin exhibited a significant alteration in the intensity of cell-cell interactions compared to their wild-type counterparts. This change in interaction intensity was observed across various cell types, including fibroblast cells, endothelial cells, and dendritic cells. Importantly, these \"interacting cells\" shared common signaling pathways, notably the upregulation of the IL-17 pathway following irradiation.</p></div><div><h3>Conclusions</h3><p>The modification of intercellular communication induced by irradiation primarily involves fibroblast cells, endothelial cells, and various types of immune cells. This investigation provides a novel perspective on potential targets and holds promise for enhancing the clinical management of IRIAD.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 3","pages":"Pages 185-193"},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000339/pdfft?md5=93996f6cc8e740c3c16f99c19f4879b8&pid=1-s2.0-S2666555724000339-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141057872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronomodulated chemotherapy for locoregionally advanced nasopharyngeal carcinoma: A phase II randomized controlled trial","authors":"Xiaoxiao Chen ,&nbsp;Feng Jin ,&nbsp;Weili Wu ,&nbsp;Yuanyuan Li ,&nbsp;Jinhuan Long ,&nbsp;Xiuling Luo ,&nbsp;Xiuyun ,&nbsp;Juan Li ,&nbsp;Pengxin Zhang ,&nbsp;Mang Zhang","doi":"10.1016/j.radmp.2024.01.001","DOIUrl":"10.1016/j.radmp.2024.01.001","url":null,"abstract":"<div><h3>Objective</h3><p>To validate the safety and efficacy of chronochemotherapy for locoregionally advanced nasopharyngeal carcinoma (NPC).</p></div><div><h3>Methods</h3><p>Participants for this phase II randomized controlled trial were recruited from the Department of Head and Neck Oncology at the Affiliated Cancer Hospital of Guizhou Medical University. Patients enrolled (128 in total, 112 in the final analysis) between April 1, 2017, and February 28, 2018, were randomly divided into the chronochemotherapy and conventional chemotherapy groups. In the chronochemotherapy group, docetaxel was intravenously administered between 3:30 a.m. and 4:30 a.m. on day 1, followed by intravenous administration of cisplatin between 10:00 a.m. and 10:00 p.m. from day 1to day 5. In addition, 5-fluorouracil was administered through a continuous intravenous pump between 10:00 p.m. and 10:00 a.m. (2nd day) from day 1 to day 5. In the conventional chemotherapy group, docetaxel (on day 1), cisplatin (on day 2), and 5-fluorouracil (from day 1 to day 5, 120 ​h in total) were administered without time-specific constraints. Both groups underwent intensity-modulated radiation therapy with 6-MV X-rays. The gross target volume (GTV) comprised the nasopharyngeal GTV and cervical lymph node GTV. The primary endpoint was immune function, quantified by measuring dendritic cell and lymphocyte subsets, whereas the secondary endpoints were therapeutic efficacy and incidence of adverse events. Pearson Chi-square test was applied to compare total events between the groups, Mann-Whitney <em>U</em> test was used to compare the DC subsets and toxicities, and Wilcoxon signed-rank test ​was used to compare the continuous variables between the two groups.</p></div><div><h3>Results</h3><p>Chronochemotherapy preserved immune function, as evidenced by elevated levels of myeloid dendritic cells (<em>P</em> ​= ​0.394) and higher CD4/CD8 ratio (<em>P</em> ​= ​0.781). No significant difference in overall response rate, measured as the sum of complete and partial response rates, was observed between the groups (<em>P</em> ​= ​0.711). A reduction in the incidence of vomiting (<em>P</em> ​= ​0.002), stomatitis (<em>P</em> ​= ​0.028), and mucositis (<em>P</em> ​= ​0.028) was observed in the chronochemotherapy group. Leukopenia incidence rate was 83.3 ​% and 92.3 ​% in the chronochemotherapy and conventional chemotherapy groups, respectively (<em>P</em> ​= ​0.232).</p></div><div><h3>Conclusions</h3><p>In patients with locoregionally advanced NPC, the overall response rate of chronochemotherapy is comparable to that of conventional chemotherapy; however, chronochemotherapy shows fewer adverse events.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 1","pages":"Pages 43-48"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000017/pdfft?md5=595883f09c7d8d76ddd1b76e9ff0b452&pid=1-s2.0-S2666555724000017-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance tests of a portable thyroid radioiodine meter","authors":"Zeshu Li ,&nbsp;Zhijie Yang ,&nbsp;Fei Tuo ,&nbsp;Shuo Wang ,&nbsp;Qianqian Zhou ,&nbsp;Juncheng Liang","doi":"10.1016/j.radmp.2024.02.002","DOIUrl":"10.1016/j.radmp.2024.02.002","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the effectiveness of a portable thyroid radioiodine meter in on-site monitoring to enhance the monitoring precision of radioiodine inhaled by nuclear medicine staff and patients.</p></div><div><h3>Methods</h3><p>A portable thyroid radioiodine meter was developed to measure the ¹³¹I activity in the thyroid. Performance tests of the portable thyroid radioiodine meter were conducted using calibration sources and testing methodologies adhering to national metrological standards.</p></div><div><h3>Results</h3><p>The thyroid radioiodine meter exhibited integral non-linearity, 8-h measurement stability, measurement linearity, and an energy resolution of 0.42%, 1.05%, 1.56%, and 7.11%, respectively for ¹³⁷Cs at 661.66 ​keV. Additionally, its minimum detectable activity for ¹³¹I at 364.49 ​keV was approximately 22 Bq (10 ​min).</p></div><div><h3>Conclusion</h3><p>The developed thyroid radioiodine meter features elevated performance and great potential for application in nuclear medicine and monitoring of responses to nuclear or radiological emergencies.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 1","pages":"Pages 53-58"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000042/pdfft?md5=5c420579f044ef0186d9423aed45557f&pid=1-s2.0-S2666555724000042-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139818513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the effect of Fresh Air Ventilation system for reducing indoor 222Rn","authors":"Yanchao Song ,&nbsp;Dexing Lian ,&nbsp;Hongxing Cui ,&nbsp;Changsong Hou ,&nbsp;Yunyun Wu","doi":"10.1016/j.radmp.2024.02.001","DOIUrl":"10.1016/j.radmp.2024.02.001","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the reduction effect for the indoor ²²²Rn (Rn) by Fresh Air Ventilation (FAV) system, a novel commercial ventilation device in China.</p></div><div><h3>Methods</h3><p>The indoor concentrations of Rn and its decay products (RnD) in three residential rooms, two in Beijing and one in Hefei city, Anhui province, before and after FAVS functioned were measured using an active continuous method. The air exchange rate was monitored by measuring CO₂ concentration using the tracer gas method.</p></div><div><h3>Results</h3><p>In the three rooms, the FAVS reduced the Rn concentrations from (162 ​± ​80) Bq/m³ to (63 ​± ​22) Bq/m³ and decreased the RnD concentrations from (64 ​± ​35) Bq/m³ to (13 ​± ​6) Bq/m³ on average, a decrease of (59 ​± ​25)% in the Rn concentrations and a drop of (77 ​± ​18)% in the RnD concentrations. Considering dose conversion factors of Rn and RnD, FAVS decreased the exposure dose by (76 ​± ​20)%. Besides, FAVS increased the air exchange rates from 0.17 h⁻¹ to 0.56 h⁻¹ on average.</p></div><div><h3>Conclusions</h3><p>FAVS can effectively reduce indoor Rn and RnD concentrations by improving the air exchange, serving as a valuable supplement to existing radon mitigation methods, especially in extreme climates.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 1","pages":"Pages 49-52"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000030/pdfft?md5=53fee3d2e53826c1be3639751d0a7186&pid=1-s2.0-S2666555724000030-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139892838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}