Radiation Medicine and Protection最新文献

{"title":"A summary of UNSCEAR evaluation on medical exposure to ionizing radiation and call for more representative data","authors":"Jing Chen","doi":"10.1016/j.radmp.2023.12.001","DOIUrl":"10.1016/j.radmp.2023.12.001","url":null,"abstract":"<div><p>The annex A of the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2020/2021 Report presented a comprehensive global estimate of frequencies and doses from medical exposure to ionizing radiation, their distribution and trends for the period 2009–2018. The annex considered four general categories of medical practice using ionizing radiation: (a) diagnostic radiology, including dental radiology and computed tomography, (b) interventional radiology (image-guided interventional procedures), (c) nuclear medicine, and (d) radiation therapy. In the period 2009–2018, about 4.2 billion medical radiological examinations were performed annually, resulting in an annual effective dose of 0.57 ​mSv per caput. The use of computed tomography has continued to grow and the contribution from interventional radiology has increased rapidly in recent years. The annual number of radionuclide therapy treatments has increased by 60% since the UNSCEAR 2008 Report, while the number of courses of radiation therapy has increased by 22%. Medical exposure remains by far the largest human-made source of radiation exposure to the public. The Committee's evaluation relies on the collection of up-to-date and representative exposure data from all Member States of the United Nations. Future exposure survey should be more relevant and useful and adapted to changing data sources and changing uses of radiation across the world.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 1","pages":"Pages 7-10"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555723000734/pdfft?md5=6c7ae545414d134aaae5d6e3dce820de&pid=1-s2.0-S2666555723000734-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139193171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel traditional Chinese medicine combination for radiation","authors":"Ming Shang ,&nbsp;Yicheng Ke ,&nbsp;Jiangyun Liu ,&nbsp;Zhifei Cao ,&nbsp;Liying Zhang ,&nbsp;Wenyang Zhang ,&nbsp;Weiwei Pei ,&nbsp;Guangming Zhou ,&nbsp;Yongqi Liu","doi":"10.1016/j.radmp.2024.02.004","DOIUrl":"https://doi.org/10.1016/j.radmp.2024.02.004","url":null,"abstract":"<div><h3>Objective</h3><p>To formulate an efficacious radioprotective combination of Chinese medicines with minimal toxicity.</p></div><div><h3>Methods</h3><p>Aqueous and alcoholic extracts from 38 traditional Chinese herbs were prepared. To produce drug-containing sera, rats received six doses of each extract <em>via</em> oral gavage at 12-h intervals. Subsequently, human lung epithelial BEAS-2B cells were cultured in these drug-containing sera. The cell viability was assessed after different doses of irradiation to identify the radioprotective effects of Chinese herbal extracts. The efficacy of a selected Chinese herbal extract combination was further confirmed through cell viability analysis <em>via in vitro</em> colony formation and survival rate assessments in C57BL/6 mice post-irradiation.</p></div><div><h3>Results</h3><p>Extracts from <em>Angelicae Sinensis Radix</em> (<em>ASR</em>; two extracts), <em>Citri Reticulatae Pericarpium (CRP), Platycladi Cacumen (PC)</em>, <em>Schisandrae chinensis Fructus (SF)</em>, <em>Scutellariae Radix (SR)</em>, and <em>Glycyrrhizae Radix et Rhizome</em> (<em>GRR</em>) demonstrated radioprotective effects. The combination of the seven Chinese herbal extracts notably increased the survival and viability of the BEAS-2B cells exposed to varying doses of X-rays. Moreover, the group of mice receiving Chinese medicine combination and irradiation exhibited prolonged survival after exposure to 6.5 ​Gy X-rays with a median survival of （14 ​± ​2）d compared to （11 ​± ​2）d in the irradiated group without the herbal treatment. Additionally, the Chinese medicine combination group displayed a significantly higher 28 ​d survival rate (30%) compared to the irradiation-only group (16.6%, <em>P</em> ​&lt; ​0.05).</p></div><div><h3>Conclusion</h3><p>The novel combination of Chinese herbal extracts from <em>ASR</em>, <em>CRP</em>, <em>PC</em>, <em>SF</em>, <em>SR</em>, and <em>GRR</em> has the potential for radiation protection applications.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 1","pages":"Pages 37-42"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000066/pdfft?md5=60c7ecbf1e8b36edfeca786e3074542f&pid=1-s2.0-S2666555724000066-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140164088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The DNA damage and regulatory strategy in hematopoietic stem cells after irradiation exposure: Progress and challenges","authors":"Yanying Liu ,&nbsp;Naicheng Chen ,&nbsp;Fang Chen ,&nbsp;Hao Zeng ,&nbsp;Lijing Yang ,&nbsp;Junping Wang ,&nbsp;Mengjia Hu","doi":"10.1016/j.radmp.2023.12.002","DOIUrl":"10.1016/j.radmp.2023.12.002","url":null,"abstract":"<div><p>The hematopoietic system is susceptible to ionizing radiation (IR), which can cause acute hematopoietic failure or long-term myelosuppression. As the most primitive cells of the hematopoietic hierarchy, hematopoietic stem cells (HSCs) maintain lifelong hematopoietic homeostasis and promote hematopoietic regeneration during stress. Numerous studies have shown that nuclear and mitochondrial genomes are the main targets of radiation injury in HSCs. More importantly, the damage of DNA may trigger a series of biological responses that largely determine HSC fate following IR exposure. Although some essential pathways and factors involved in DNA injury and damage in HSCs have been revealed, a comprehensive understanding of the biological effects of radiation on HSCs still needs to be improved. This review focuses on recent insights into the molecular mechanisms underlying DNA damage and repair in HSCs after IR. Then summarize corresponding regulatory measures, which may provide a reference for further research in this field.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 1","pages":"Pages 16-23"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555723000746/pdfft?md5=58dc3b40f85e7de4e88ebc3b01c1ab4b&pid=1-s2.0-S2666555723000746-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139187883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A summary of UNSCEAR evaluation on occupational exposure to ionizing radiation and call for more representative data in broader range of occupational sectors","authors":"Jing Chen","doi":"10.1016/j.radmp.2023.12.003","DOIUrl":"10.1016/j.radmp.2023.12.003","url":null,"abstract":"<div><p>The annex D of the United Nations Scientific Committee on the Effects of Atomic Radiation （UNSCEAR） 2020/2021 Report presented a comprehensive global estimate of occupational exposure to ionizing radiation. The worldwide annual number of workers exposed to natural and human-made sources of ionizing radiation was estimated to be approximately 24 million in the period 2010–2014. About 52% of those were employed in the sectors that involve exposure to natural sources of radiation. The worldwide average annual effective dose for all workers during the period 2010–2014 was estimated to be around 1.2 ​mSv – about two thirds of the value estimated for the period 1995–1999. The annual effective dose was estimated to be around 2.0 ​mSv for workers exposed to natural sources and 0.5 ​mSv for workers exposed to human-made sources. The overriding limitation of current evaluation was the low rate of participation by United Nations Member States in providing occupational exposure monitoring data, especially data from non-nuclear sectors and occupational sectors involving naturally occurring radioactive materials. As the assessment of the worldwide occupational exposure is a complex task, the Committee relies on the collection of up-to-date data on occupational exposure from United Nations Member States in a broad range of occupational sectors, and continues collaboration with international organizations.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 1","pages":"Pages 11-15"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555723000758/pdfft?md5=c25034890d7c4c16a12bc811b830f39d&pid=1-s2.0-S2666555723000758-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139195345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer's disease and low-dose radiation therapy: A new hope","authors":"Neal E. Dunlap ,&nbsp;Robert P. Friedland ,&nbsp;Lu Cai","doi":"10.1016/j.radmp.2024.01.002","DOIUrl":"10.1016/j.radmp.2024.01.002","url":null,"abstract":"<div><p>The concept of low-dose radiation (LDR)-induced hormetic responses was initially observed approximately 70 years ago and systematically reviewed along with the discovery of LDR-induced adaptive responses in a cytogenetic <em>in vitro</em> study in 1980s. By the end of the 1990s, discussions regarding the potential applications of LDR-induced hormesis and adaptive responses for preventing or treating chronic diseases, such as Alzheimer’s disease (AD) had taken place. Until 2016, reports on radiotherapy for the subjects with AD and for genetic AD model mice were published. Subsequently, several preclinical studies with animal models of AD and clinical studies in AD subjects were conducted. A significant milestone was achieved with the online availability of a new Systematic Review based on qualified publications from these preclinical and clinical studies. This mini-review provides a concise historical introduction to LDR-induced hormesis and adaptive responses with discussion of AD radiotherapy with either LDR or relatively high dose radiation. Highlights of this Systematic Review cover promising outcomes, challenges, and new questions, followed by discussion of potential mechanisms.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 1","pages":"Pages 1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000029/pdfft?md5=fc9674fbbc28b82c92bc8af171c88402&pid=1-s2.0-S2666555724000029-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139880257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploiting the unique interaction characteristics of fast neutrons for improved cancer therapy: A radiobiological perspective","authors":"Festo Kiragga,&nbsp;Konstantin Brazovskiy","doi":"10.1016/j.radmp.2023.12.004","DOIUrl":"10.1016/j.radmp.2023.12.004","url":null,"abstract":"<div><p>Fast neutrons have sufficient energy to liberate recoil protons, alpha particles, and other products when they interact with the nuclei of the target material through scattering and absorption processes. Physical interactions with biological tissues occur mainly with hydrogen nuclei and as the protons interact with the hydrogen in tissues, they create dense ionization chains along their tracks thus depositing energy. Fast neutron therapy was pioneered by Robert Stone in 1938 a few years after the discovery of the neutron. Its main advantage is the limited sensitivity to hypoxia and treatment of slow-growing tumors hence better local control. This is where photon therapy has yet to have much success. Energy deposition by fast neutrons in living tissues is higher than in conventional radiotherapy using mega voltage (MV) photon beams. This higher energy deposition gives fast neutrons a higher relative biological effectiveness (RBE) in dealing with certain tumors. Fast neutrons also have a higher linear energy transfer (LET) and can reach deep-sited tumors better than photon therapy. The main challenge with Fast neutron therapy has been extreme toxicity in late-reacting tissues. Overall, fast neutron therapy holds potential for the treatment of certain tumors by leveraging the unique interaction characteristics of fast neutrons with biological tissues. This review therefore intends to bring this uniqueness to light to enhance the understanding of the radiobiological properties of fast neutrons and the advantages associated with its therapy.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 1","pages":"Pages 24-29"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266655572300076X/pdfft?md5=8c0678a50adb5b7c173eb0d673d995be&pid=1-s2.0-S266655572300076X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139125223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"YWHAZ gene contributes to the radioresistance of oral squamous cell carcinoma cells","authors":"Songling Hu ,&nbsp;Cong Chen ,&nbsp;Hengheng Chen ,&nbsp;Xin Yu ,&nbsp;Xiaofei Li ,&nbsp;Yang Bai ,&nbsp;Chunlin Shao","doi":"10.1016/j.radmp.2024.02.005","DOIUrl":"https://doi.org/10.1016/j.radmp.2024.02.005","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the contribution of YWHAZ gene on the radioresistance and metastasis ability of oral squamous cell carcinoma (OSCC) cells.</p></div><div><h3>Methods</h3><p>The relationship between the expression level of YWHAZ gene and the survival of head and neck squamous cell carcinoma (HNSC) patients was analyzed using Gene Expression Profiling Interactive Analysis (GEPIA) database. A radioresistance cell line (CAL-27R) was constructed by irradiating CAL-27 ​cells with fractional doses. Cell survival was measured by colony formation assay. Cell migration and invasion were detected by transwell assay. The formation of γH2AX foci was detected by immunofluorescence assay. The protein expressions were detected by Western blot assay. In some experiments, CAL-27R cells were effectively transferred with siRNA YWHAZ (siYWHAZ).</p></div><div><h3>Results</h3><p>GEPIA database showed that the expression level of YWHAZ in HNSC tumors was higher than that in adjacent normal tissues, and the HNSC patients with higher level of YWHAZ had a shorter survival. <em>In vitro</em> experiments demonstrated that the expression of YWHAZ protein in CAL-27 ​cells was lower than HSC-3 ​cells (<em>t</em> ​= ​18.89, <em>P</em> ​&lt; ​0.01) and radioresistant CAL-27R cells (<em>t</em> ​= ​25.70, <em>P</em> ​&lt; ​0.01). Knockdown of YWHAZ gene significantly increased radiation-induced cell killing effect, apoptosis induction, and γH2AX foci formation in CAL-27R and HSC-3 cells. Moreover, siRNA YWHAZ transfection also reduced the invasion and migration abilities of the irradiated CAL-27R [(<em>t</em> ​= ​21.09, <em>P</em>&lt;0.01 (migration); <em>t</em> ​= ​6.16, <em>P</em>&lt;0.05 (invasion)] and HSC-3 ​cells [(<em>t</em> = 34.53, <em>P</em> &lt; 0.001 (migration); <em>t</em> ​= ​4.92, <em>P</em> ​&lt; ​0.05 (invasion)] and attenuated radiation-induced expressions of metastasis-related proteins.</p></div><div><h3>Conclusion</h3><p>YWHAZ contributes to the radioresistance of oral squamous cells and thus it may applicable to be a potential target for OSCC radiotherapy.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 1","pages":"Pages 30-36"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000078/pdfft?md5=1c6ce5286911c99a1e86ada6597e6db8&pid=1-s2.0-S2666555724000078-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140164080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomography-based delta-radiomics enabling early prediction of short-term responses to concurrent chemoradiotherapy for patients with non-small cell lung cancer","authors":"Fengqin Zhou ,&nbsp;Jianping Bi ,&nbsp;Shen Wu ,&nbsp;Yi Ding ,&nbsp;Jun Chen ,&nbsp;Mengting Yuan ,&nbsp;Yaoyao He ,&nbsp;Guang Han ,&nbsp;Zilong Yuan","doi":"10.1016/j.radmp.2023.10.002","DOIUrl":"10.1016/j.radmp.2023.10.002","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the potential of computed tomography (CT)-based delta-radiomics in predicting early short-term responses to concurrent chemoradiotherapy for patients with non-small cell lung cancer (NSCLC), in order to determine the optimal time point for the prediction.</p></div><div><h3><em>M</em>ethods</h3><p>A total of 20 patients with pathologically confirmed NSCLC were prospectively enrolled in this study, who did not receive surgical treatment between February 2021 and February 2022. For each case, a total of 1,210 radiomic features (RFs) were extracted from both planning CT (pCT) images along with each of the subsequent three weeks of CT images. Effective ΔRFs were selected using intra-class correlation coefficient (ICC) analysis, Pearson's correlation, ANOVA test (or Mann-Whitney <em>U</em>-test), and univariate logistic regression. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to evaluate the potential to predict short-term responses of different time points.</p></div><div><h3>Results</h3><p>Among the 1,210 ΔRFs for 1–3 weeks, 121 common features were retained after processing using ICC analysis and Pearson's correlation. These retained features included 54 and 58 of all time points that differed significantly between the response and non-response groups for the first and third months, respectively (<em>P</em> ​&lt; ​0.05). After univariate logistic regression, 11 and 44 features remained for the first and third months, respectively. Finally, eight ΔRFs (<em>P</em> ​&lt; ​0.05, AUC ​= ​0.77–0.91) that can discriminate short-term responses in both at 1 and 3 months with statistical accuracy were identified.</p></div><div><h3>Conclusion</h3><p>CT-based delta-radiomics has the potential to provide reasonable biomarkers of short-term responses to concurrent chemoradiotherapy for NSCLC patients, and it can help improve clinical decisions for early treatment adaptation.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 4","pages":"Pages 227-235"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555723000540/pdfft?md5=6fd526953af19bce707bea7b42e02754&pid=1-s2.0-S2666555723000540-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135605710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical prospect of FLASH radiotherapy","authors":"Jiyuan Liu,&nbsp;Guangming Zhou,&nbsp;Hailong Pei","doi":"10.1016/j.radmp.2023.10.005","DOIUrl":"10.1016/j.radmp.2023.10.005","url":null,"abstract":"<div><p>FLASH radiotherapy (FLASH-RT) is a new strategy for tumor treatment with an ultra-high dose rate of more than 40 ​Gy/s. Compared with conventional radiotherapy (CONV-RT), FLASH-RT has no different inhibitory effects on tumors but less damage to normal tissues, which is called the “spare” effect. The “spare” effect triggers our exploration of the great prospect of subverting conventional radiotherapy and its intricate mechanisms. Mitochondrial homeostasis, the immune microenvironment, or DNA integrity may potentially represent the primary breakthrough direction in understanding the mechanisms. Concurrently, it is imperative to advance timely clinical translation efforts. Clinical trials of FLASH-RT have progressed to Phase II in both the United States and Switzerland, with current findings suggesting that FLASH-RT achieves comparable efficacy to CONV-RT while mitigating side effects in select cancer cell types. While summarizing the existing FLASH experiments, this paper emphasizes the significance of clinical transformation and the challenges that will be faced and proposes possible solutions.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 4","pages":"Pages 190-196"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555723000576/pdfft?md5=9ad27495afcbe4277488319946afe9ef&pid=1-s2.0-S2666555723000576-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135963638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances of radiotherapy combined with targeted therapy for nasopharyngeal carcinoma","authors":"Xiaoyan Xu ,&nbsp;Hengzhao Zhuang ,&nbsp;Yijun Xu ,&nbsp;Zhongxu Xing ,&nbsp;Yang Jiao ,&nbsp;Lili Wang","doi":"10.1016/j.radmp.2023.10.001","DOIUrl":"10.1016/j.radmp.2023.10.001","url":null,"abstract":"<div><p>Nasopharyngeal carcinoma is insidious at onset, prone to lymph node metastasis, and has a high rate of locally advanced disease at initial diagnosis. Radiotherapy combined with chemotherapy is the main treatment for locally advanced nasopharyngeal carcinoma, but local recurrence and distant metastasis often lead to treatment failure, of which radioresistance caused by radiotherapy may be one of the reasons. Targeted therapy can selectively inhibit tumor proliferation and metastasis, and patients can achieve long-term survival benefits with low toxic and side effects. Targeted therapy involves a variety of tumor mechanisms, in which combination with radiotherapy may improve radioresistance and the efficacy of radiotherapy. In this review, the advantages and research progress of targeted therapy combined with radiotherapy for nasopharyngeal carcinoma were discussed.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 4","pages":"Pages 197-203"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555723000539/pdfft?md5=196d565d1df6d5800148cc3985e07d8c&pid=1-s2.0-S2666555723000539-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135605454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}