Radiation Medicine and Protection最新文献

{"title":"Attenuation properties of 3D-printed materials for an Ir-192 high dose rate source using Valencia skin applicators","authors":"Jie Zhang ,&nbsp;Wenjun Zhang ,&nbsp;Bo Yang ,&nbsp;Zhequn Liu ,&nbsp;Lang Yu ,&nbsp;Jie Qiu ,&nbsp;Fuquan Zhang","doi":"10.1016/j.radmp.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.radmp.2023.07.001","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the physical properties of commonly used 3D-printed materials and the dose attenuation around a high-dose-rate ¹⁹²Ir source, in order to provide a reference for selecting appropriate 3D-printed materials for brachytherapy.</p></div><div><h3>Methods</h3><p>Fifteen 3D-printed materials (12 non-metallic material and 3 metallic material) were assessed. Each material was fabricated into a wafer with a diameter of 30 ​mm and thickness of 3 ​mm using 3D printing. The CT number of each material was measured, and attenuation measurements were conducted with a Valencia skin applicator and well-type ionization chamber. ¹⁹²Ir was used as the radioactive source, and the attenuated ionization charges were normalized against that obtained in the presence of a solid water phantom at the same depth.</p></div><div><h3>Results</h3><p>The CT number of nylon was (−7.78 ​± ​3.36) HU, closest to water among all materials. The CT numbers of the other 11 non-metallic materials were below 300 HU. Moreover, the CT number of the Al alloy was (1,350.89 ​± ​374.55) HU, while the CT numbers of the Ti alloy and stainless steel exceeded 2,976 HU, reaching the upper limit of the CT number range. The results of the attenuation measurements were normalized with the solid water phantom. The average attenuation coefficients of a polyamide, epoxy resin, photosensitive resin, carbon fiber, silica gel, Al alloy, Ti alloy, and stainless steel were 1.003, 0.994, 0.992, 0.995, 0.995, 0.967, 0.939, and 0.866, respectively.</p></div><div><h3>Conclusions</h3><p>Among the common 3D-printed materials with a density similar to that of water, nylon exhibited the best performance, while the metallic materials caused significant dose attenuation and exhibited CT number distortion. As a result, care should be taken when metallic materials are used as 3D-printed materials for brachytherapy.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 3","pages":"Pages 145-149"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49705862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic analysis of acute radiation-induced rectal injury in rats","authors":"Yue Zhu ,&nbsp;Jun Dai ,&nbsp;Xiaopeng Xu ,&nbsp;Yi Gao ,&nbsp;Weidong Shen ,&nbsp;Shuyu Zhang ,&nbsp;Pengfei Liu","doi":"10.1016/j.radmp.2023.08.003","DOIUrl":"10.1016/j.radmp.2023.08.003","url":null,"abstract":"<div><h3>Objective</h3><p>To comprehensively elucidate overall protein alterations associated with acute radiation-induced rectal injury in rats.</p></div><div><h3>Methods</h3><p>A rat model of acute radiation-induced rectal injury was established by irradiating rectal segments with a single dose of 17.5 ​Gy X-rays. These segments were then collected at 7 d and 10 ​d post-irradiation. Tandem mass tag-based quantitative proteomic analysis was then performed.</p></div><div><h3>Results</h3><p>65,526 peptides were identified, corresponding to 8,088 proteins. Hematoxylin-eosin staining revealed characteristic epithelial cell degeneration and necrosis, intestinal gland atrophy and dilatation, and interstitial inflammatory cell infiltration. Inflammation was more pronounced in the 10 d irradiation group than in the 7 d irradiation group. Overall, 127 up- and 108 downregulated proteins were identified at 7 d post-irradiation, and 122 up- and 44 downregulated proteins were identified at 10 d post-irradiation. Notably, 17 up- and 6 downregulated proteins were consistently co-expressed at both time points. The expression of three of these proteins was validated via real-time quantitative PCR: polypeptide YY (Pyy), thymidylate synthase (Tyms), and tetraspanin (CD9). Tyms transcript levels were significantly higher in irradiated rectal tissues (<em>P</em> ​&lt; ​0.05). Pyy transcript levels were significantly higher at both time points (<em>P</em> ​&lt; ​0.05). Finally, CD9 mRNA expression was significantly lower in both the 7 d and 10 d irradiation groups (<em>P</em> ​&lt; ​0.05).</p></div><div><h3>Conclusions</h3><p>The potential targets were found to prevent and treat acute radiation-induced rectal injury in clinical practice.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 3","pages":"Pages 117-124"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43059927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between IDEAL-IQ MRI fat fraction quantification and pelvic bone marrow reserve function in concurrent chemoradiotherapy for cervical cancer","authors":"Xiaomin Wen ,&nbsp;Qinghua Qin ,&nbsp;Yanling Wu ,&nbsp;Zhouyu Li ,&nbsp;Xinglong Yang ,&nbsp;Jinquan Liu ,&nbsp;Ling Lin ,&nbsp;Mingyi Li","doi":"10.1016/j.radmp.2023.08.002","DOIUrl":"10.1016/j.radmp.2023.08.002","url":null,"abstract":"<div><h3>Objective</h3><p>To analyze the association between iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantification sequence (IDEAL-IQ) magnetic resonance imaging (MRI) of bone marrow fat fraction and bone marrow reserve function during concurrent chemoradiotherapy for cervical cancer.</p></div><div><h3>Methods</h3><p>The study retrospectively analyzed twenty-six patients with stage IB1 to IVA cervical cancer treated between February 2020 and November 2020. All patients received concurrent chemoradiotherapy that included platinum alone or combined paclitaxel and platinum. Pelvic IDEAL-IQ MRI (plain and enhanced) was performed before and after treatment. Regions of interest, including the fifth lumbar vertebra, sacrum, ilium, ischium, and femoral neck, were manually delineated, and the bone marrow fat fraction was measured. Peripheral blood cell counts were recorded during treatment, and the relationship between the fat fraction values and changes in the blood cell counts was explored.</p></div><div><h3>Results</h3><p>IDEAL-IQ MRI bone marrow fat fraction was associated with platelet nadir and platelet decline during treatment. The average pelvic bone marrow fat fraction before chemoradiotherapy was moderately negatively correlated with platelet count nadir during concurrent chemoradiotherapy (<em>r</em> ​= ​−0.450, <em>P</em> ​= ​0.021). The change in average pelvic bone marrow fat fraction through chemoradiotherapy was moderately positively correlated with the degree of thrombocytopenia (<em>r</em> ​= ​0.399, <em>P</em> ​= ​0.044).</p></div><div><h3>Conclusion</h3><p>Bone marrow fat content quantified by IDEAL-IQ was associated with platelet count nadir and the degree of thrombocytopenia in patients with cervical cancer undergoing concurrent chemoradiotherapy.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 3","pages":"Pages 136-144"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46217785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuation properties of 3D-printed materials for an Ir-192 HDR source using Valencia skin applicators","authors":"Jie Zhang, Wenjun Zhang, Bo Yang, Zhequn Liu, Lang Yu, J. Qiu, Fuquan Zhang","doi":"10.1016/j.radmp.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.radmp.2023.07.001","url":null,"abstract":"","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47858775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The radioresistant and survival mechanisms of Deinococcus radiodurans","authors":"Feng Liu ,&nbsp;Nuomin Li ,&nbsp;Yongqian Zhang","doi":"10.1016/j.radmp.2023.03.001","DOIUrl":"10.1016/j.radmp.2023.03.001","url":null,"abstract":"<div><p><em>Deinococcus radiodurans</em> (<em>D. radiodurans</em>) is distinguished by the most radioresistant organism ever known, and can tolerate extreme environments such as ionizing radiation, ultraviolet radiation, oxidation, and desiccation. <em>D. radiodurans</em> is an important model for studying DNA damage/repair and redox regulation upon high dose ionizing radiation. How <em>D. radiodurans</em> response and repair ROS-induced oxidative damage remains a subject of ongoing investigation. This review provides an overview of the radioresistance characteristics of <em>D. radiodurans</em>. Among them, the DNA damage repair pathway and high-efficiency antioxidant defense system are summarized in detail. Furthermore, a novel model that protects the cell against the ionizing radiation is proposed. This review also discusses the potential application , future challenges and directions in advancing towards <em>D. radiodurans</em> studies.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 2","pages":"Pages 70-79"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49585363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of occupational exposure in medical practice in Gabon during 2013–2020","authors":"P. Ondo Meye ,&nbsp;S.Y. Loemba Mouandza ,&nbsp;G.B. Dallou ,&nbsp;Y. Omon ,&nbsp;B.C. Mabika Ndjembidouma ,&nbsp;C. Chaley ,&nbsp;G.H. Ben-Bolie","doi":"10.1016/j.radmp.2023.03.004","DOIUrl":"10.1016/j.radmp.2023.03.004","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate whole-body, extremity and eye-lens occupational dose equivalents of ionizing radiation to Occupationally Exposed Workers (OEWs) in Gabon, monitored by the national Individual Monitoring Service (IMS), in the medical practice.</p></div><div><h3>Methods</h3><p>A total of 816 dose records for 205 OEWs were evaluated. Doses were collected for an eight-year period, from 2013 to 2020. Twelve public and private hospitals were involved, including a cancer centre where radiotherapy (RT) and nuclear medicine (NM) procedures are regularly performed. OEWs were monitored, on a monthly or quarterly basis, for whole-body dose and extremity dose using an optically stimulated luminescence (OSL) dosimeter worn on the torso or the wrist, as appropriate. Eye-lens dose was estimated from whole-body dose results.</p></div><div><h3>Results</h3><p>The whole-body dose distribution was skewed and the zero dose was associated with a probability of 47%. Some recorded doses were associated with estimated X-ray energies above those typically encountered in diagnostic radiology, thus suggesting that some doses attributed to workers and believed to be due to X-rays may in fact be due to background radiation (false positive dose records). For the period 2013–2020, annual doses to OEWs in diagnostic radiology (DR), NM and RT departments were 0.40 ​mSv, 0.38 ​mSv and 0.09 ​mSv, respectively. For the same period, the mean annual extremity and eye-lens doses were 0.78 ​mSv (range: 0–5.24 ​mSv) and 0.35 ​mSv (range: 0–3.74 ​mSv), respectively.</p></div><div><h3>Conclusion</h3><p>With little effort by the national IMS and the regulatory body, annual whole-body doses to workers can be kept well below 6 ​mSv, thus efficiently contributing to the optimization of worker's protection. However, extremity doses may in fact be greater than those reported for OEWs in the NM department. Finally, eye-lens doses were well below the new annual dose limit of 20 ​mSv, thus demonstrating that, in the current situation, OEWs in the NM department do not require routine eye lens dose monitoring. Rather, whole-body dose may be used as an indicator of eye-lens dose.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 2","pages":"Pages 109-115"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44456913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inorganic imaging nanoprobes for breast cancer diagnosis","authors":"Qi Guo ,&nbsp;Maosen Hong ,&nbsp;Tong Wu ,&nbsp;Lei Chen ,&nbsp;Guangxin Duan ,&nbsp;Jianfeng Zeng ,&nbsp;Ximing Wang ,&nbsp;Ling Wen ,&nbsp;Chunhong Hu","doi":"10.1016/j.radmp.2023.05.004","DOIUrl":"10.1016/j.radmp.2023.05.004","url":null,"abstract":"<div><p>Breast cancer is one of the most prevalent cancers worldwide, and early diagnosis and screening are vital to its successful treatment. Although medical imaging methods can assist in the early detection of breast cancer, imaging methods that are currently used for clinical diagnosis have drawbacks, such as low sensitivity and accuracy. Contrast agents are often used in diagnostic imaging to address these drawbacks. Nanocontrast agents have attracted considerable attention in recent years due to their unique physicochemical characteristics. Among these agents, inorganic nanoprobes have been substantially developed through improvements in synthesis techniques and pairings with other organic molecules. This paper mainly summarizes the specific applications of inorganic nanoprobes in the magnetic resonance imaging, fluorescence imaging, radionuclide imaging, and bimodal/multimodal imaging of breast cancer.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 2","pages":"Pages 80-85"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46814974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular proteomic profiling of esophageal epithelial cells cultured under physioxia or normoxia reveals high correlation of radiation response","authors":"Hui Luo ,&nbsp;Yanan Sun ,&nbsp;Liuxiang Wang ,&nbsp;Ran Zhao ,&nbsp;Beggs James","doi":"10.1016/j.radmp.2023.03.002","DOIUrl":"10.1016/j.radmp.2023.03.002","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the radiation response and proteomic profiling of esophageal epithelial cells cultured under physioxia and normoxia.</p></div><div><h3>Methods</h3><p>The human immortalized normal esophageal epithelial cell line SHEE cells were cultured under normoxia (21%) and physioxia (4%), respectively. A clonogenic assay was performed to evaluate the radiation response of SHEE cells. Cellular proteomic profiling of SHEE cells maintained under physioxia and normoxia was conducted to determine the differentially expressed proteins. Then, the identified differentially expressed proteins were validated by Western blot.</p></div><div><h3>Results</h3><p>SHEE cells exposed to normoxia showed an increased radiation response compared to physioxia (irradiation dose ≥10 ​Gy, <em>P&lt;</em> 0.05). Over 1200 non-redundant proteins were identified in the collected samples. Protein expression was compared between physioxia and normoxia, 42 proteins were downregulated and 45 proteins upregulated, in which oxidative phosphorylation was the most significantly enriched pathway. When cells were cultured under normoxia conditions, the induction of antioxidant genes appeared to contribute to form a phenotype adapted to the environment with high oxygen-content. Further analysis validated NRF2, BIP, VCP, SOD1, and YAP1 were the key regulators of this phenotype.</p></div><div><h3>Conclusions</h3><p>Compared with physioxia, normoxic cell culture condition can enhance the radiation response. This study could stimulate <em>in vivo</em> microenvironment, and provide a basis for radiation-induced normal tissue damage.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 2","pages":"Pages 86-92"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46176876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages of nasogastric tube feeding during neoadjuvant concurrent chemoradiotherapy for esophageal cancer: A retrospective study","authors":"Jie Dong ,&nbsp;Qingwu Du ,&nbsp;Tian Zhang ,&nbsp;Xi Chen ,&nbsp;Wencheng Zhang ,&nbsp;Yajun Chen ,&nbsp;Yaqi Zeng ,&nbsp;Chunlei Li ,&nbsp;Yueying Li ,&nbsp;Yujie Wang ,&nbsp;Kun Wang ,&nbsp;Qingsong Pang","doi":"10.1016/j.radmp.2023.05.003","DOIUrl":"10.1016/j.radmp.2023.05.003","url":null,"abstract":"<div><h3>Objective</h3><p>To compare the effects of oral intake and nasogastric tube (NG) feeding on nutritional status, complications and survival during neoadjuvant chemoradiotherapy for esophageal squamous-cell carcinoma (ESCC) patients.</p></div><div><h3>Methods</h3><p>A total of 61 ​ESCC cases treated with neoadjuvant chemoradiotherapy from December 2018 to March 2020 were enrolled, including (38 in oral intake group, and 22 in NG feeding group. Disease characteristics and baseline nutritional markers were collected in both groups. Nutritional status, complication and completion rate of chemoradiotherapy in both groups were evaluated.</p></div><div><h3>Results</h3><p>Compared with the oral intake group, patients in the NG feeding group had a later T stage (<em>P</em> ​= ​0.027) and clinical stage (<em>P</em> ​= ​0.014). The levels of energy intake (<em>P</em> ​= ​0.033), serum prealbumin (<em>P</em> ​&lt; ​0.001), albumin (<em>P</em> ​= ​0.017) and hemoglobin (<em>P</em> ​= ​0.015) before treatment in NG group were significantly lower than those in oral intake group. Furthermore, patient-generated subjective global assessment (PG-SGA) score (<em>P</em> ​= ​0.016) and the levels of serum C-reactive protein (<em>P</em> ​= ​0.014) of NG feeding group were significantly higher than those of oral intake group. However, at the end of treatment, PG-SGA scores were increased in oral intake group and decreased in NG feeding group. In addition, the NG feeding group had a lower incidence of grade ≥2 esophagitis (<em>P</em> ​= ​0.037), and higher completion rate of chemotherapy compared with oral intake group (<em>P</em> ​= ​0.034). Meanwhile, the proportion of parenteral nutrition (<em>P</em> ​= ​0.008) and anti-inflammatory (<em>P</em> ​= ​0.022) treatment in NG feeding group was significantly lower than that in oral intake group. Although patients in the NG feeding group had a worse prognosis, there were no statistically significant differences in overall survival (OS) and progression-free survival (PFS) between the two groups (<em>P</em> ​&gt; ​0.05).</p></div><div><h3>Conclusions</h3><p>As a safe and effective enteral nutrition approach to improving nutrition, nasogastric tube feeding could increase treatment completion rate and reduce the incidence of ≥ grade 2 esophagitis reaction during neoadjuvant chemoradiotherapy.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 2","pages":"Pages 98-103"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41283530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the PARP inhibitor Niraparib on the radiosensitivity of human lung and cervical cancer cells","authors":"Yue Feng ,&nbsp;Shiyi Pi ,&nbsp;Yuwei Li ,&nbsp;Yu Zhang ,&nbsp;Hongwei Zeng ,&nbsp;Xiangyu E. ,&nbsp;Yang Zhang ,&nbsp;Jingping Yu","doi":"10.1016/j.radmp.2023.05.002","DOIUrl":"10.1016/j.radmp.2023.05.002","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the effect of Niraparib, a clinically approved PARP inhibitor on the radiosensitivity of human lung and cervical cancer cells, and preliminarily explore the underlying mechanism.</p></div><div><h3>Methods</h3><p>The human lung cancer cell line A549 and human cervical cancer cell line Siha were both treated with Niraparib for 1 ​h, or X-ray irradiation with 4 ​Gy, or Niraparib for 1 ​h combined with X-ray irradiation with 4 ​Gy. The effect was examined via measurements of cell proliferation by the cell counting kit-8 assay, and cell viability was detected by clone formation assays. Cell apoptosis and cell cycle distribution were investigated by flow cytometry.</p></div><div><h3>Results</h3><p>In human lung and cervical cancer cell lines, Niraparib combined with radiation therapy significantly inhibited cell proliferation. The proportion of apoptotic cells in cell lines treated with Niraparib plus radiation (the combination group) was significantly higher compared with control, radiation, and Niraparib groups (<em>P</em> ​&lt; ​0.05). Additionally, the proportion of A549 ​cells in the G₂/M phase was significantly increased in the combination group compared with the radiation group (<em>P</em> ​&lt; ​0.05).</p></div><div><h3>Conclusion</h3><p>PARP inhibitor Niraparib increases the radiosensitivity of tumorcells, promotes their apoptosis, and induces cell cycle redistribution. The possible mechanism is associated with the inhibition of radiation-induced DNA damage repair.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 2","pages":"Pages 93-97"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42910308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}