Radiation Medicine and Protection最新文献

{"title":"Biophoton signaling in mediation of cell-to-cell communication and radiation-induced bystander effects","authors":"Jian Tong","doi":"10.1016/j.radmp.2024.06.004","DOIUrl":"10.1016/j.radmp.2024.06.004","url":null,"abstract":"<div><p>This paper presents a comprehensive overview of the historical trajectory and development in biophoton studies over the past 100 years, with a particular focus on the recent progress regarding the pivotal role of biophoton in mediating radiation-induced bystander effects (RIBE). The exploration of biophoton mystery starts from the initial observation of mitogenetic radiation and continues to develop to the contemporary science of biophotonics. The properties and underlying mechanisms of biophoton emission are described with illustrative examples from diverse biological systems such as plants, animals and humans. The conclusive evidence of cell-to-cell communication facilitated by biophoton signaling is presented, followed by an elaborate interpretation of potential mechanisms through which biophoton mediates RIBE. The engagement of mitochondria and exosomes in this process is extensively clarified, by highlighting their significant roles in biophoton-mediated RIBE. The advances in biophoton research in respect of bystander response to ionizing radiation may offer profound insights into radiobiology and provide for possible future applications as well in radiation medicine and protection.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 3","pages":"Pages 145-160"},"PeriodicalIF":0.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000546/pdfft?md5=735d55048ac5fd2f33369180b18c61af&pid=1-s2.0-S2666555724000546-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of bioinformatics databases and tools in radiation biology","authors":"","doi":"10.1016/j.radmp.2024.06.002","DOIUrl":"10.1016/j.radmp.2024.06.002","url":null,"abstract":"<div><p>Bioinformatics has become increasingly integral to radiation biology, also known as radiobiology, providing substantial support through data storage, conversion, visualization, and sharing. This review aims to deepen understanding of bioinformatics application in radiobiology by introducing key databases and analytical tools in radiobiology, including general bioinformatics databases, radiobiology-specific databases, data processing tools, and statistical analysis tools for differentially expressed genes (DEGs) and LC/MS analysis. This review also discusses bioinformatics applications in radiobiological fields, such as radioresistance and immune cell enrichment. Despite these advances, challenges such as data interoperability remain. Methods and projects to address these issues, such as GeCo and GMQL, are also examined.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 3","pages":"Pages 165-169"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000522/pdfft?md5=2d9d5caefb88b1e417f08754cc8b301e&pid=1-s2.0-S2666555724000522-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141408024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A population level study on smoking and radon induced adenocarcinoma and small-cell carcinoma among males and females in Canada","authors":"","doi":"10.1016/j.radmp.2024.06.001","DOIUrl":"10.1016/j.radmp.2024.06.001","url":null,"abstract":"<div><h3>Objective</h3><p>To assess if there is a relationship between residential radon exposure and two lung cancer histological types, small-cell carcinoma (diagnosed in people with a smoking history) and adenocarcinoma (the most commonly diagnosed histologic type in people who have never smoked) among males and females in Canada.</p></div><div><h3>Methods</h3><p>With survey data of long-term radon measurements in residential homes, long-term averaged tobacco consumption rates in the units of cigarettes per day per person and long-term averaged age-standardized lung cancer incidence rates at provincial level, simple linear fitting (ANOVA linear regression) was applied in this study to determine the effect on lung cancer induction by smoking and exposure to indoor radon, and to assess if there is a relationship between residential radon exposure and lung cancer histological types.</p></div><div><h3>Results</h3><p>Lung cancer incidence rates correlate very well with the tobacco consumption rates (<em>P</em> ​&lt; ​0.05). However, females appear to be more likely than males to develop lung cancer at a given amount of cigarette consumption. For both small-cell carcinoma and adenocarcinoma, a statistically significant correlation between incidence rate and mean radon concentration was observed for females, the correlation was much stronger for adenocarcinoma (<em>P</em> ​= ​0.0057) than small-cell carcinoma (<em>P</em> ​= ​0.0483). However, there was no such correlation for males.</p></div><div><h3>Conclusion</h3><p>It is possible that female non-smokers are more susceptible to radon-induced lung cancer, and the joint effect of radon exposure and tobacco smoking may be worse in female smokers compared to males, such that higher incidence rate of adenocarcinoma among females compared to males were observed in recent decades, even though females never smoked more than males.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 3","pages":"Pages 170-177"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000510/pdfft?md5=8ff8cd6f1c20bb420e0a4ccd99107ceb&pid=1-s2.0-S2666555724000510-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141396565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-ionizing radiation-induced cellular senescence and age-related diseases","authors":"Haiying Wang,&nbsp;Jian Tong,&nbsp;Yi Cao","doi":"10.1016/j.radmp.2024.04.002","DOIUrl":"10.1016/j.radmp.2024.04.002","url":null,"abstract":"<div><p>Cellular senescence has emerged as an important contributor to aging and age-related diseases. Non-ionizing radiation (NIR), including ultraviolet radiation and electromagnetic fields, has been increasingly recognized as a key inducer of premature senescence. In this review, we discuss the molecular mechanisms of NIR-induced cellular senescence and its effects on aging and age-related diseases. We also summarize the modulation strategies for NIR-induced cellular senescence. A better understanding of the complex relationship between non-ionizing radiation, cellular senescence and age-related pathology may lead to interventions to ameliorate radiation damage and delay aging. Further research is still needed to elucidate the precise mechanisms, dose-response effects, and to develop protective strategies against radiation-induced senescence.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 2","pages":"Pages 68-74"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000273/pdfft?md5=9af5ec13cca6dc1bc81b0498a8ccc5db&pid=1-s2.0-S2666555724000273-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140787059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HyperArc performance in radiotherapy and its correlations with number and volume of multiple brain metastases","authors":"Hongtao Chen,&nbsp;Zihuang Li,&nbsp;Guixiang Liao,&nbsp;Lijun Wang,&nbsp;Xiaonian Deng,&nbsp;Heli Zhong","doi":"10.1016/j.radmp.2024.05.004","DOIUrl":"10.1016/j.radmp.2024.05.004","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the performance and advantages of HyperArc for radiotherapy of multiple brain metastases with dosimetric parameters with respect to coplanar volumetric modulated arc radiotherapy (c-VMAT), and characterize implicit correlations between tumor features and dosimetric parameters.</p></div><div><h3>Methods</h3><p>This retrospective study involved 40 patients with multiple brain metastases (4–16 tumors, 12.8–240.8 cm³) who received simultaneous radiotherapy at the Department of Radiation Oncology, Shenzhen People's Hospital from January 2019 to December 2022. Both HyperArc and c-VMAT plans were designed by the same and qualified physicist using the Eclipse system with Truebeam. A single isocenter and a 6 ​MV flattening filter-free (6FFF) photon beam were used for radiotherapy of multiple brain metastases in each plan. Dosimetric parameters of tumors and organs at risk (OARs) were compared between HyperArc and c-VMAT plans. Correlations between tumor features (number and volume) and dosimetric parameters were revealed and analyzed. Furthermore, monitor units (MUs) of both plan types were recorded to assess rays utilization and delivery efficiency.</p></div><div><h3>Results</h3><p>Compared to c-VMAT plans, HyperArc plans achieved higher maximum dose (<em>D</em>_max) (5.23%, <em>t</em> ​= ​7.87, <em>P</em> ​&lt; ​0.01), but lower minimum dose (<em>D</em>_min) (3.94%, <em>t</em> ​= ​−2.12, <em>P</em> ​= ​0.04) and mean dose (<em>D</em>_mean) (1.05%, <em>t</em> ​= ​−3.29, <em>P</em> &lt; ​0.01) for planning gross tumor volumes (PGTVs). The conformity index (CI), homogeneity index (HI), gradient index (GI) and R₅₀_% of PGTVs with HyperArc were better than those with c-VMAT, with the improvements of 20.78%, 1.68%, 19.83% and 36.20%, respectively (<em>P</em> ​&lt; ​0.01). The dosimetric parameters of OARs were significantly improved in HyperArc plans compared to c-VMAT plans. Specifically, the <em>D</em>_max and the <em>D</em>_mean to the brainstem decreased by 16.14% and 11.37%, respectively. The <em>D</em>_max for eye_L decreased by 16.88%, for eye_R decreased by 11.67%, for optical nerve_L decreased by 12.56 ​%, and for chiasm decreased by 18.12%. Few correlations were observed between the differences of CI/HI/GI/R₅₀_% and the number of PGTVs between the two plan types. Whereas, regression analysis indicated that the differences of CI/ GI/ R₅₀_% were negatively correlated with the volume of PGTVs, respectively. Moreover, although HyperArc plans reduced the MUs by 4.74 ​% compared to c-VMAT, no significant difference was observed (<em>P</em> ​&gt; ​0.05).</p></div><div><h3>Conclusions</h3><p>This study demonstrates the promising performance of HyperArc for radiotherapy of multiple brain metastases, including better dose conformity for the tumors, more rapid dose drop and less dose spillage ","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 2","pages":"Pages 139-144"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000327/pdfft?md5=9756f327828bbaf08c3737544fba9530&pid=1-s2.0-S2666555724000327-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141028983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation protection knowledge and practices among Moroccan dentists: A cross-sectional study","authors":"Naoual Elmorabit ,&nbsp;Majdouline Obtel ,&nbsp;Mohamed Azougagh ,&nbsp;Oumkeltoum Ennibi","doi":"10.1016/j.radmp.2024.03.001","DOIUrl":"10.1016/j.radmp.2024.03.001","url":null,"abstract":"<div><h3>Objective</h3><p>To analyze the current status of knowledge and practices among the Moroccan dentists in the region of Rabat-Salé-Kenitra, towards radiation protection.</p></div><div><h3>Methods</h3><p>This is a cross-sectional study based on a questionnaire related to knowledge and practice regarding radiation protection of patients and dental staff from April to June 2022. The study sample included 325 dentists practicing in the Rabat-Salé-Kénitra region. The target population consisted of all dentists working in public, semi-public and private workplaces.</p></div><div><h3>Results</h3><p>96.6% of dentists were aware of radiation protection. However, nearly 35% were aware of ALARA (as low as reasonably achievable) principle and 73.9% thought that dental X-rays are harmful. 63.6%of subjects used digital image receptor. Only 16.7% of them used a film holder and more than 60% didn't follow the position and distance rule. The median knowledge score was 7 [5, 9], and there was a statistically significant difference according to dentist qualification (<em>P</em> ​= ​0.007), dental radiation protection continuous training (<em>P</em> ​&lt; ​0.0001), age (<em>P</em> = ​0.007) and years of experience (<em>P</em> ​= ​0.039). The median practice score was 5 [4, 6] and there was a statically significance association according to workplace setting (<em>P</em> ​= ​0.001). There was a significant positive relationship between knowledge score and practice score (<em>r</em> ​= ​0.24, <em>P</em>&lt;0.0001). Dentist qualification (<em>OR</em> 0.51, 95%<em>CI</em>: 0.27–0.94, <em>P</em> ​= ​0.03) and continuous training (<em>OR</em> 2.40, 95%<em>CI</em>: 1.47–3.93, <em>P</em>&lt;0.0001) were significant predictors of knowledge, while workplace setting (<em>OR</em> 0.54, 95%<em>CI</em>: 0.32–0.93, <em>P</em> ​= ​0.027) and knowledge score (<em>OR</em> 1.24, 95%<em>CI</em>: 1.12–1.38, <em>P&lt;</em>0.0001) were predictors of practices.</p></div><div><h3>Conclusion</h3><p>Improving dentists' knowledge of radiation protection measures and tools as well as dose reduction techniques could increase their safe practices in dental radiology.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 2","pages":"Pages 131-138"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000212/pdfft?md5=457743697810a3d1f1568879a59f4710&pid=1-s2.0-S2666555724000212-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140280452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey of current practices in the management of cervical cancer by Moroccan radiotherapists","authors":"Bouchra Amaoui ,&nbsp;Slimane Semghouli ,&nbsp;Hanane El Kacemi ,&nbsp;Issam Lalya ,&nbsp;Nadia Benchekroune ,&nbsp;Fatima Safini ,&nbsp;Sanae Abbaoui","doi":"10.1016/j.radmp.2024.04.001","DOIUrl":"10.1016/j.radmp.2024.04.001","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the applicability degree of the international guidelines by Moroccan radiotherapists, in order to improve the management of cervical cancer (CC), since CC is the second most common cancer for women in Morocco.</p></div><div><h3>Methods</h3><p>This cross-sectional study was carried out using a questionnaire sent online to Moroccan radiotherapists. The questionnaire covered participants' characteristics, initial assessment and treatment preparation, techniques and indications for radiotherapy and brachytherapy, dose and indications, as well as on the protocol adopted in the intermediate stages and the location of adjuvant treatments and assessments' follow-up.</p></div><div><h3>Results</h3><p>74 radiotherapists out of 300 have responded to the survey. Only 27.0% of practitioners reported discussing patient records systematically in a multidisciplinary consultation meeting (MCM). For the initial assessment, 77.0% requested pelvic magnetic resonance imaging (MRI). It is significantly less requested in regional oncology centers (ROCs) than in university hospital centers (UHCs) or the private sector (<em>P</em> ​&lt; ​0.001). Furthermore, Clinicians in ROCs do not have access to new techniques of radiotherapy. In 83.8% of cases, the most prescribed radiotherapy protocols were 45–46 ​Gy in 1.8–2 ​Gy per fraction. Three-dimensional gynaecological brachytherapy high-throughput dose guided by dosimetric scanner was available in 75.5% of structures while interstitial gynaecological brachytherapy was only available in 23% of centers. The two most prescribed dose protocols were 4 ​× ​7 ​Gy and 3 ​× ​7 ​Gy in 74.4% and 21.6% of cases, respectively. Finally, monitoring during the first two years was based mainly on pelvic MRI (82.2%) while PET/CT was recommended by only less than 10%.</p></div><div><h3>Conclusions</h3><p>The findings obtained show that our radiotherapists generally comply with international guidelines for the cervical cancer management. However, they should still enhance their practices for the first staging evaluation, the use of systematic MCMs, the doses and treatment techniques used, and the follow-up evaluation.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 2","pages":"Pages 124-130"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000261/pdfft?md5=d2f54fba9abae3e69e924c78e371b1b3&pid=1-s2.0-S2666555724000261-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140777309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of mitophagy in head and neck squamous cell carcinoma: Prognosis and immune insights","authors":"Qin Ding ,&nbsp;Wei Liu ,&nbsp;Junping Pan ,&nbsp;Lihua Wang ,&nbsp;Wenquan Hong ,&nbsp;Sunqin Cai ,&nbsp;Xin Chen ,&nbsp;Duanyu Lin ,&nbsp;Sufang Qiu","doi":"10.1016/j.radmp.2024.05.003","DOIUrl":"10.1016/j.radmp.2024.05.003","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the correlation between mitophagy and the tumor microenvironment (TME) in patients with head and neck squamous cell carcinoma (HNSCC), with an aim to enhance therapeutic efficacy for HNSCC.</p></div><div><h3>Methods</h3><p>A machine learning-based multigene prognostic signature was developed based on mitophagy-related differentially expressed genes (MRGs) identified in The Cancer Genome Atlas cohort. This signature was correlated with the TME using gene set enrichment analysis. The association between this prognostic signature and various immunological features of the TME was explored, including status of tumor-infiltrating immune cells, expression of immune checkpoint molecules, and the immunoscore. Immunohistochemistry validated the expression of hub gene CSNK2A2 and assessed its relationship with immunomarker expression. Quantitative PCR validated CSNK2A2 knockdown in HNSCC cell lines. Functional experiments including Transwell assays to determine cell migration and invasion, Cell Counting Kit 8 assay, and 5-ethynyl-2-deoxyuridine assay were performed to confirm the role of CSNK2A2 in HNSCC. Finally, a subcutaneous xenograft model was generated in C3H mice to validate our findings.</p></div><div><h3>Results</h3><p>The MRG-based prognostic signature showed excellent predictive performance. High-risk patients had significantly shorter progression-free and overall survival (<em>P</em> ​&lt; ​0.0001) than low-risk patients. CD8+ T cell infiltration was lower in high-risk groups, whereas low-risk groups showed higher immunological marker expression. Thus, the low-risk HNSCC subtype may benefit from immune therapy, while high-risk subtypes may benefit from chemotherapy (<em>P</em> ​&lt; ​0.001). CSNK2A2 was highly expressed and strongly correlated with CD8 and PD-L1 based on immunohistochemistry of the HNSCC tissue microarray. CSNK2A2 knockdown reduced cell migration, invasion, and proliferation, and arrested cells in G₁ phase. <em>In vivo</em>, it led to slower tumor growth and smaller tumor volumes.</p></div><div><h3>Conclusion</h3><p>We established a potential prognostic signature that could improve HNSCC management in the future. CSNK2A2 may be a new biomarker to predict immunotherapy efficacy in HNSCC.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 2","pages":"Pages 100-112"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000315/pdfft?md5=dfb195821f34983da2220f71027b923b&pid=1-s2.0-S2666555724000315-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141031122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of severe radiation proctitis with high dosage of vitamin C in combination with cyclooxygenase-2 inhibitor","authors":"Han Wu ,&nbsp;Miaomiao Liu ,&nbsp;Huangang Jiang ,&nbsp;Hui Xu ,&nbsp;Jin Peng ,&nbsp;Jing Dai ,&nbsp;Fuxiang Zhou","doi":"10.1016/j.radmp.2024.05.002","DOIUrl":"10.1016/j.radmp.2024.05.002","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the new treatment strategies for radiation proctitis, which is the most common complication of pelvic tumor malignancies.</p></div><div><h3>Methods</h3><p>Four cases of patients with severe radiation proctitis were treated with high-dosage vitamin C (V_C, 12–24 ​g/d, iv) combined with cyclooxygenase-2 (cyclooxygenase-2, COX-2) inhibitors.</p></div><div><h3>Results</h3><p>For these four cases, the diarrhea, hematochezia, tenesmus, pain, and other symptoms were significantly improved. The edema of the rectal wall is also significantly improved in the imaging review.</p></div><div><h3>Conclusion</h3><p>The high-dosage V_C combined with the treatment of severe radiation proctitis is safe and effective.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 2","pages":"Pages 113-117"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000303/pdfft?md5=75df23389406a12728d33973385ae015&pid=1-s2.0-S2666555724000303-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141039541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus on radiotherapy combined with immunotherapy for esophageal cancer (2024 edition)","authors":"Professional Committee of Radiation Oncology, China Anti-Cancer Association ,&nbsp;Branch of Radiation Oncology, Chinese Medical Association,&nbsp;Branch of Radiation Oncology Treatment Physician, Chinese Medical Doctor Association","doi":"10.1016/j.radmp.2024.02.003","DOIUrl":"10.1016/j.radmp.2024.02.003","url":null,"abstract":"<div><p>Radiotherapy represents an essential treatment approach for esophageal cancer. Over recent years, immunotherapy combined with chemotherapy has become the first-line standard treatment for patients with advanced esophageal cancer. Several phase III studies on immunotherapy combined with radiotherapy for locally advanced esophageal cancer are currently underway. Sufficient evidence-based medical data are urgently needed to support the integration of immunotherapy and chemoradiotherapy as a new treatment strategy for patients with locally advanced esophageal cancer. This consensus, formulated based on the latest study results, in-depth research, and thorough discussions, provides a comprehensive set of recommendations. The document extensively covers treatment strategies and evaluation methods for radiotherapy combined with immunotherapy across patients with operable esophageal cancer, inoperable locally advanced esophageal cancer, and advanced esophageal cancer. Moreover, common complications and radiation-related issues associated with radiotherapy combined with immunotherapy are discussed, serving as clinical guidance. Our expert group comprised members from the Professional Committee of Radiation Oncology, China Anti-Cancer Association, the Branch of Radiation Oncology, Chinese Medical Association, and the Branch of Radiation Oncology Treatment Physician, Chinese Medical Doctor Association.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 2","pages":"Pages 59-67"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000054/pdfft?md5=519fb604d3aac6fbeed74aa6d1620ac0&pid=1-s2.0-S2666555724000054-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140274228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}