{"title":"Non-ionizing radiation-induced cellular senescence and age-related diseases","authors":"Haiying Wang, Jian Tong, Yi Cao","doi":"10.1016/j.radmp.2024.04.002","DOIUrl":null,"url":null,"abstract":"<div><p>Cellular senescence has emerged as an important contributor to aging and age-related diseases. Non-ionizing radiation (NIR), including ultraviolet radiation and electromagnetic fields, has been increasingly recognized as a key inducer of premature senescence. In this review, we discuss the molecular mechanisms of NIR-induced cellular senescence and its effects on aging and age-related diseases. We also summarize the modulation strategies for NIR-induced cellular senescence. A better understanding of the complex relationship between non-ionizing radiation, cellular senescence and age-related pathology may lead to interventions to ameliorate radiation damage and delay aging. Further research is still needed to elucidate the precise mechanisms, dose-response effects, and to develop protective strategies against radiation-induced senescence.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"5 2","pages":"Pages 68-74"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555724000273/pdfft?md5=9af5ec13cca6dc1bc81b0498a8ccc5db&pid=1-s2.0-S2666555724000273-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiation Medicine and Protection","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666555724000273","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Health Professions","Score":null,"Total":0}
引用次数: 0
Abstract
Cellular senescence has emerged as an important contributor to aging and age-related diseases. Non-ionizing radiation (NIR), including ultraviolet radiation and electromagnetic fields, has been increasingly recognized as a key inducer of premature senescence. In this review, we discuss the molecular mechanisms of NIR-induced cellular senescence and its effects on aging and age-related diseases. We also summarize the modulation strategies for NIR-induced cellular senescence. A better understanding of the complex relationship between non-ionizing radiation, cellular senescence and age-related pathology may lead to interventions to ameliorate radiation damage and delay aging. Further research is still needed to elucidate the precise mechanisms, dose-response effects, and to develop protective strategies against radiation-induced senescence.
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