Radiation Medicine and Protection最新文献

{"title":"A brief summary of UNSCEAR evaluation on public exposure to ionizing radiation and research needs","authors":"Jing Chen","doi":"10.1016/j.radmp.2026.04.009","DOIUrl":"10.1016/j.radmp.2026.04.009","url":null,"abstract":"<div><div>The United Nations Scientific Committee on the Effects of Atomic Radiation (in short UNSCEAR) has regularly updated its evaluation on population exposure levels to ionizing radiation since 1958. With more broadly available data and modified analysis methodologies, the Scientific Committee published its most recently updated evaluation of public exposure to ionizing radiation, the UNSCEAR 2024 Report, Annex B. The annex was based mainly on data submitted by 61 United Nations Member States to the UNSCEAR Public Exposure Survey for the period 2007–2020 and compiled from published peer reviewed literature and international organizations. The updated evaluation provided a clearer and more globally representative picture of the radiation doses that people receive in their daily lives from both natural and human-made sources of radiation. It demonstrated that natural background radiation remains the dominant source of public exposure, and confirmed that the public exposure to human-made sources is only a small portion of the public exposure to ionizing radiation and this small portion continues to decline. The major limitation of current evaluation was the low rate of participation by United Nations Member States in providing national representative data, and lack of discharge data from facilities and activities of industries involving naturally occurring radioactive materials. As the assessment of the worldwide public exposure is a complex task, there is the need to continue the development of data inventories and methodologies, and the collaboration with international organizations.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 3","pages":"Pages 119-123"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148214694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk perceptions and acceptance of nuclear power among nuclear emergency reserve personnel","authors":"Lingxuan Ma ,&nbsp;Cuiping Lei ,&nbsp;Long Yuan ,&nbsp;Huifang Chen ,&nbsp;Ximing Fu","doi":"10.1016/j.radmp.2026.04.001","DOIUrl":"10.1016/j.radmp.2026.04.001","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate nuclear and radiation risk perceptions and attitudes toward nuclear energy development among nuclear emergency reserve personnel (NERP), in order to enhance their comprehensive nuclear emergency response capabilities.</div></div><div><h3>Methods</h3><div>An on-site survey was conducted on 1513 NERP from provincial-level institutions and those within 50 km of nuclear power plants in Liaoning, Jiangsu, Shandong, and Hainan provinces, China. Data were collected from <span><span>www.wjx.cn</span><svg><path></path></svg></span>, a widely used online survey platform in China. Intergroup comparisons of scores or ratings were conducted using the Kruskal-Wallis <em>H</em> test. Associations between risk-benefit and trust ratings, knowledge awareness and sociodemographic characteristics, and acceptance and relevant factors were analyzed using Spearman's correlation, linear regression and logistic regression, respectively. The priority of influencing factors was determined using classification and regression tree (CART) analysis.</div></div><div><h3>Results</h3><div>A total of 49.06%‒75.43% of NERP possessed nuclear and radiation knowledge. Higher educational levels and professional titles were significantly positively correlated with awareness rates of nuclear and radiation knowledge. Compared with physicians, nurses, management service personnel, and firefighters, demonstrated significantly lower awareness rates (<em>β</em> = −12.39% to −4.59%, <em>P</em> &lt; 0.05). Support for local nuclear power plant construction was significantly lower than that for national projects. Acceptance of the national and local nuclear power plant construction was associated with gender, nuclear radiation knowledge, risk and benefit assessments, and trust (<em>OR</em> = 0.14−3.21, <em>P</em> &lt; 0.05). Benefit assessment was the primary factor for national nuclear power plant construction, whereas risk assessment was the key determinant for local projects.</div></div><div><h3>Conclusions</h3><div>Inadequate nuclear and radiation knowledge and the “not in my backyard (NIMBY)\" phenomenon among NERP are notable concerns. Targeted and systematic knowledge training and regular emergency drills are essential for NERP. Public communication should be strengthened to clarify nuclear energy risks and benefits, enhance trust in official information, and increase its proportion in public information.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 3","pages":"Pages 143-150"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148214721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the fabrication of hydrogels and their applications in radiation medicine and protection","authors":"Wenjie Ma ,&nbsp;Tianyu Wang ,&nbsp;Douglas Bosco Aidoo ,&nbsp;Jiaxin Ren ,&nbsp;Shaoyi Lai ,&nbsp;Yujiao Jiang ,&nbsp;Yifan Liu ,&nbsp;Minoo Zohdi ,&nbsp;Liang Sun ,&nbsp;Xiaju Cheng ,&nbsp;Ling Wen ,&nbsp;Mutian Hua ,&nbsp;Lijun Wu ,&nbsp;Shuwang Wu","doi":"10.1016/j.radmp.2026.04.008","DOIUrl":"10.1016/j.radmp.2026.04.008","url":null,"abstract":"<div><div>Nuclear science and technology bring significant benefits to medicine, energy, and industry, but also pose risks of environmental contamination and radiation injury. Hydrogels, owing to their ease of preparation, excellent biocompatibility, stimulus responsiveness, wearability, and tunable properties, have emerged as promising platforms for addressing radiation-related challenges. This review summarizes the key properties and preparation methods of hydrogels, with particular emphasis on their synthesis under radiation conditions. It then highlights recent advances in radiation detection using hydrogels, their performance in radiation shielding—especially as flexible composite materials—and their therapeutic applications in treating radiation-induced skin, intestinal, and lung injuries, while briefly discussing potential extensions to other critical organs such as bone marrow and brain. Finally, the review outlines future prospects, focusing on the design of integrated hydrogel platforms that combine real-time monitoring, effective shielding, and targeted therapy, aiming toward closed-loop management of radiation risks.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 3","pages":"Pages 176-184"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148214724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Dose investigation and local diagnostic reference levels for intraoral dental radiography in Beijing, China” [Radiat Medicine Protection 7 (2026) 48–53]","authors":"Jinping Cao ,&nbsp;Hui Xu ,&nbsp;Xian Xue ,&nbsp;Zechen Feng ,&nbsp;Baorong Yue","doi":"10.1016/j.radmp.2026.03.003","DOIUrl":"10.1016/j.radmp.2026.03.003","url":null,"abstract":"","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 3","pages":"Pages 185-186"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148214725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of knowledge, attitudes, and practices about radiation protection and safety among radiology and operating room personnel","authors":"Abdullah Taher Naji,&nbsp;Marwah Abdullah Alhelali,&nbsp;Thana M. Abu-hadi","doi":"10.1016/j.radmp.2026.03.005","DOIUrl":"10.1016/j.radmp.2026.03.005","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the knowledge, attitudes, and practices (KAP) of radiology and operating room personnel regarding radiation protection and safety.</div></div><div><h3>Methods</h3><div>An institution-based cross-sectional study was conducted to assess the KAP of Yemeni staff members in radiology departments and operating rooms representing various public and private institutions throughout Yemeni cities, the data collection was carried out via a Google form-based questionnaire disseminated to 315 individuals. A total of 256 valid responses were received with response rate of 81.27%.</div></div><div><h3>Results</h3><div>The results indicated inadequate knowledge with an overall mean score of (3.547/10). On the other hand, the respondents had positive attitudes (3.895/5), and moderate adherence to practice (3.406/5) toward radiation protection and safety. There were no significant differences in knowledge and practices scores by sex, however, while the attitude dimension score exhibited statistically significant differences (<em>U</em> = 6878, <em>P&lt;</em>0.05). Additionally, significant differences were observed between the occupations (<em>H</em> = 28.949, <em>P&lt;</em>0.05) and education levels of the respondents (<em>H</em> = 11.137, <em>P&lt;</em>0.05). Furthermore, the findings highlighted the positive impact of educational interventions (radiation safety training/lectures) on the total knowledge, attitude and practice scores (all <em>P&lt;</em>0.05) regarding radiation protection. The respondents' attitudes score correlated moderately with their practice compliance score connected to radiation protection (<em>r</em> = 0.48, <em>P&lt;</em>0.05). Moreover, the respondents addressed the shortage of radiation protection equipment (66.02%), and policies/management support (64.45%), as the most common barriers that limit their compliance with radiation protection and safety practices. In addition, they recommended providing sufficient resources (81.25%), establishing a radiation safety culture (76.95%), and providing periodic training programs to improve radiation protection practices (69.92%). These outcomes emphasize the necessity of specific educational intervention and organizational dedication to enhance radiation safety culture in Yemen.</div></div><div><h3>Conclusion</h3><div>The findings highlight the critical need for effective management support, sustained institutional commitment, and targeted educational actions at the university level and through ongoing training to improve radiation protection awareness and behaviours among healthcare workers in medical radiation environments.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 106-113"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessment of radon-induced lung cancer risk with decreasing smoking prevalence in Canada","authors":"Jing Chen","doi":"10.1016/j.radmp.2026.02.002","DOIUrl":"10.1016/j.radmp.2026.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>To re-assess the risk of radon-induced lung cancer with more recent and significantly reduced tobacco smoking rates in Canada.</div></div><div><h3>Methods</h3><div>Based on the radon distribution characteristics obtained from the cross-Canada radon survey and with the EPA/BEIR VI risk model as well as the same model parameters used in previous study, Canadian population risk for radon-induced lung cancer was re-assessed with Canadian age-specific smoking prevalence data of ever smokers in 2022 and Canadian age-specific mortality rates averaged over five years from 2019 to 2022.</div></div><div><h3>Results</h3><div>In the past 20 years from 2002 to 2022, the rates of ever-smokers among Canadians aged 15 and older dropped by 44% for males and by 42% for females. As a result, the baseline risks of lung cancer decreased by 14% for males and 10% for females. The re-evaluation indicates that 12% of lung cancer deaths among Canadian males and 13% of lung cancer deaths among Canadian females are attributable to indoor radon exposure, significantly lower than 16% of radon-induced lung cancer deaths among Canadians as estimated previously.</div></div><div><h3>Conclusions</h3><div>This re-assessment updated the estimates of radon-induced lung cancer in Canada. The study estimated that the success of tobacco control program over time (more than 40% reduction in percentage of ever-smokers in Canadian population in the past two decades) could result in 4% less radon-induced lung cancer deaths in males and 3% less in females.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 95-99"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescription tradeoff decision support for pancreas stereotactic body radiation therapy: From templates to artificial intelligence models","authors":"Yibo Xie ,&nbsp;Manisha Palta ,&nbsp;Ruilin Li ,&nbsp;Wentao Wang ,&nbsp;Qiuwen Wu ,&nbsp;Yaorong Ge ,&nbsp;Q. Jackie Wu ,&nbsp;Yang Sheng","doi":"10.1016/j.radmp.2026.03.004","DOIUrl":"10.1016/j.radmp.2026.03.004","url":null,"abstract":"<div><h3>Objective</h3><div>To develop an artificial intelligence (AI) driven plan tradeoff decision making assistant for radiation oncologists<strong>.</strong></div></div><div><h3>Methods</h3><div>A user interface (UI) was developed to integrate the assistant with the treatment planning system to facilitate prescription decision process. The assistant is powered by a machine learning core which was trained to learn the balance between planning target volume (PTV) coverage and organs-at-risk (OAR) sparing. A group of 98 pancreatic stereotactic body radiation therapy (SBRT) cases were retrospectively included for this study. The clinical plan's PTV coverage was compared against the model predicted value. A 10-fold cross validation was performed for all cases. The comparison was further analyzed in detail for three attending physicians. Cases with large discrepancy were identified and analyzed, and a replan was created to evaluate the achievability of the prediction.</div></div><div><h3>Results</h3><div>The clinical plan PTV <em>V</em>_100% was (87.7 ± 14.5)% while the model predicted value was (90.5 ± 9.6)%. Model agreement discrepancy was observed between attending physicians. Among all 98 cases, 9 were identified with large variation from the model prediction. For the replans, an average of 15.3% improvement was achieved over the original clinical plan, while OARs constrains were met.</div></div><div><h3>Conclusions</h3><div>The assistant's decision provides decent plan quality guidance for prescription drafting. It could provide valuable input prior to treatment planning and save valuable dosimetrist team and radiation oncologist effort. It could further provide valuable insight for resident education and training.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 88-94"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cranial radiation-induced abscopal effects drive time-dependent testicular injury in mice","authors":"Ling Guo ,&nbsp;Liyuan Liu ,&nbsp;Tongzhou Qin ,&nbsp;Guiqiang Zhou ,&nbsp;Jiangyi Li ,&nbsp;Yuxin Wang ,&nbsp;Yan Zhou ,&nbsp;Xixi Yang ,&nbsp;Jing Li ,&nbsp;Guirong Ding","doi":"10.1016/j.radmp.2026.02.001","DOIUrl":"10.1016/j.radmp.2026.02.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To investigate the time-dependent progression of cranial radiation-induced testicular injury in mice, focusing on apoptotic pathways and brain-testis axis involvement.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Male mice were randomly divided into sham irradiation group (sham) and cranial irradiation group (IR) with 36 mice in each group. The IR group received a single dose of 20 Gy cranial X-ray irradiation, while peripheral organs were shielded. Assessments of body weight, testis weight, and sperm parameters were conducted at 1, 2, and 4 weeks post-irradiation. Histological changes and apoptosis were evaluated via H&amp;E staining and TUNEL assay, respectively. Cell-specific markers SOX9, WT1, SYCP3 and PRND were quantified by qRT-PCR, while apoptotic proteins Bcl-2, Bax and Cleaved-caspase 3 were examined by Western blot. Serum levels of brain injury biomarkers NSE and S100B were measured using ELISA.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Compared with sham group, IR mice displayed distinct, time-dependent testicular and systemic alterations. At 1 week post-irradiation, no obvious testicular structural damage was observed, but significant reductions in body and testis weight were accompanied by elevated serum NSE (142.1 ± 16.5 &lt;em&gt;vs.&lt;/em&gt; 102.1 ± 3.6&lt;em&gt;, t =&lt;/em&gt; 7.1&lt;em&gt;, P &lt; 0.05&lt;/em&gt;) and S100B ( 178.2 ± 23.8 &lt;em&gt;vs&lt;/em&gt;. 123.9 ± 11.5, &lt;em&gt;t&lt;/em&gt; = 6.2, &lt;em&gt;P &lt;&lt;/em&gt; 0.05). At 2 weeks post-irradiation, disorganized spermatogonial stem cells (SSCs), downregulated SYCP3 and PRND expression, and a marked increase in sperm abnormalities were evident (52.45 ± 3.35 &lt;em&gt;vs&lt;/em&gt;. 33.46±6.05, &lt;em&gt;t&lt;/em&gt; = 7.77, &lt;em&gt;P &lt;&lt;/em&gt; 0.05), alongside sustained weight loss and persistent elevation of NSE (128.6±3.2 &lt;em&gt;vs.&lt;/em&gt;110.6 ± 2.8&lt;em&gt;, t =&lt;/em&gt;12.8 &lt;em&gt;, P &lt; 0.05&lt;/em&gt;) and S100B levels (163.1 ± 5.9 &lt;em&gt;vs.&lt;/em&gt; 131.5 ± 10.9, &lt;em&gt;t&lt;/em&gt; = 7.8, &lt;em&gt;P &lt;&lt;/em&gt; 0.05). At 4 weeks post-irradiation, severe testicular atrophy manifested, characterized by reduced seminiferous tubule diameter, further increased sperm abnormalities (64.61 ± 8.18 &lt;em&gt;vs.&lt;/em&gt; 42.64 ± 3.13 , &lt;em&gt;t&lt;/em&gt; = 7.10, &lt;em&gt;P &lt;&lt;/em&gt; 0.05), decreased sperm counts (&lt;em&gt;vs.&lt;/em&gt; 3.08 ± 1.36 &lt;em&gt;vs.&lt;/em&gt; 8.55 ± 2.05, &lt;em&gt;t&lt;/em&gt; = 6.30, &lt;em&gt;P &lt;&lt;/em&gt; 0.05), upregulated Cleaved-caspase 3 protein expression (1.75 ± 0.15 &lt;em&gt;vs.&lt;/em&gt; 1.00 ± 0.21, &lt;em&gt;t&lt;/em&gt; = 7.10, &lt;em&gt;P &lt;&lt;/em&gt; 0.05), TUNEL-positive cells localized to spermatogonial stem cells (SSCs) niches. Concurrently, SOX9 (2.12 ± 0.96 &lt;em&gt;vs&lt;/em&gt;. 1.00 ± 0.31) and WT1 (2.51 ± 1.34 &lt;em&gt;vs&lt;/em&gt;. 1.00 ± 0.57) mRNA levels were significantly upregulated (&lt;em&gt;t&lt;/em&gt; = 2.72, 2.55, &lt;em&gt;P &lt;&lt;/em&gt; 0.05). Persistent reductions in body and testis weight, as well as sustained elevations in NSE and S100B, were observed throughout the study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Cranial radiation induces progressive, time-dependent testicular injury in mice via mechanisms mediated by the brain-testis axis, primari","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 55-62"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of 238U and 232Th in commonly consumed foods in East China","authors":"Ning Guo ,&nbsp;Maomao Guo ,&nbsp;Yuhan Xie ,&nbsp;Fuyou Fan ,&nbsp;Yanqin Ji","doi":"10.1016/j.radmp.2026.04.003","DOIUrl":"10.1016/j.radmp.2026.04.003","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the activity concentrations of naturally occurring radionuclides ²³⁸U and ²³²Th in commonly consumed foods from East China and to evaluate the associated dietary exposure and potential radiological health risk to the general population.</div></div><div><h3>Methods</h3><div>A total of 61 food items belonging to 10 major dietary categories were collected from local markets in a region of East China, pretreated by drying, homogenization, and acid digestion, and analyzed for ²³⁸U and ²³²Th using inductively coupled plasma mass spectrometry (ICP-MS). Activity concentrations were calculated and used to assess distribution patterns and inter-element correlations across food groups. The annual committed effective dose from dietary intake was estimated based on measured concentrations and regional consumption data.</div></div><div><h3>Results</h3><div>Both ²³⁸U and ²³²Th were widely detected in the analyzed food samples, with activity concentrations ranging from 11 to 4514 and 7 to 1649 mBq/kg (dry weight), respectively. A significant positive correlation between the two radionuclides indicates a common natural origin. Clear food-type dependence was observed, with vegetables and legumes showing relatively higher ²³⁸U levels and elevated ²³⁸U/²³²Th ratios, while aquatic products and fruits exhibited lower ratios. The annual committed effective doses from dietary intake were estimated at 0.54 μSv/year for ²³⁸U and 1.90 μSv/year for ²³²Th, which are several orders of magnitude below the recommended public exposure limit of 1 mSv/year.</div></div><div><h3>Conclusion</h3><div>The results provide baseline information on the occurrence of naturally occurring radionuclides in commonly consumed foods and indicate that current dietary intake levels pose negligible radiological risk to the general population. These findings support the continued monitoring of natural radionuclides in food to ensure food safety and public health protection.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 100-105"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrin beta-1 as a critical gene in radiation-induced injury: Bioinformatic and experimental verification","authors":"Rongbing Yu ,&nbsp;Ruling Liu ,&nbsp;Ning Xiao ,&nbsp;Xinyu Min ,&nbsp;Keer Jiang ,&nbsp;Xiangyu Meng ,&nbsp;Xiaoying Li ,&nbsp;Jinlei Zhu ,&nbsp;Hu Liu ,&nbsp;Cheng Zhang ,&nbsp;Xuefei Yuan ,&nbsp;Bailong Li","doi":"10.1016/j.radmp.2026.04.002","DOIUrl":"10.1016/j.radmp.2026.04.002","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To investigate the role of integrin beta-1 (Itgb1) in radiation-induced tissue injury and elucidate its underlying molecular mechanisms.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Differentially expressed genes associated with radiation injury were identified from the Gene Expression Omnibus (GEO) microarray database through bioinformatics analysis, followed by enrichment analysis to determine core hub genes. &lt;em&gt;In vitro&lt;/em&gt;, Itgb1 was silenced using siRNA transfection in human chronic myeloid leukemia K562 and mouse alveolar epithelial MLE-12 cells. Protein expression was assessed by Western blot, while cell proliferation, apoptosis, and reactive oxygen species (ROS) levels were quantified by flow cytometry following Itgb1 inhibition. &lt;em&gt;In vivo&lt;/em&gt;, C57BL/6 mice were divided into 4 experimental groups (&lt;em&gt;n&lt;/em&gt; = 5 per group): Control (intraperitoneal injection of PBS without irradiation), RGD (intraperitoneal injection of RGD 10 mg/kg without irradiation), IR + PBS (8 Gy &lt;sup&gt;60&lt;/sup&gt;Co γ-ray total body irradiation with PBS), and IR + RGD (intraperitoneal injection of RGD 10 mg/kg, 2 h prior to 8 Gy &lt;sup&gt;60&lt;/sup&gt;Co γ-ray total body irradiation). Bronchoalveolar lavage fluid (BALF) was collected for macrophage analysis. Lung and intestine tissues were subjected to hematoxylin-eosin (H&amp;E) staining and immunofluorescence (IF) examination. Peripheral blood samples were analyzed to evaluate hematopoietic function.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Bioinformatics analysis identified Itgb1 as a hub gene in radiation-induced injury. Western blot analysis demonstrated significant upregulation of Itgb1 protein following irradiation. In K562 cells, Itgb1 expression peaked at 12 h post-irradiation (&lt;em&gt;t =&lt;/em&gt; 3.07, &lt;em&gt;P&lt;/em&gt; &lt; 0.01) and declined by 24 h, whereas MLE-12 cells exhibited sustained elevation at both time points (&lt;em&gt;t&lt;/em&gt; = 10.44, &lt;em&gt;P&lt;/em&gt; &lt; 0.0001). Itgb1 silencing significantly exacerbated radiation-induced cellular damage. In K562 cells, knockdown reduced S-phase proliferation from 52.49% to 36.41% (&lt;em&gt;t&lt;/em&gt; = 9.64, &lt;em&gt;P&lt;/em&gt; &lt; 0.01), increased apoptosis (&lt;em&gt;t&lt;/em&gt; = 11.36, &lt;em&gt;P&lt;/em&gt; &lt; 0.001), and elevated ROS levels (&lt;em&gt;t&lt;/em&gt; = 3.62, &lt;em&gt;P&lt;/em&gt; &lt; 0.05). Comparable effects were observed in MLE-12 cells: reduced proliferation (46.82% to 37.98%, &lt;em&gt;t&lt;/em&gt; = 12.78, &lt;em&gt;P&lt;/em&gt; &lt; 0.0001), enhanced apoptosis (&lt;em&gt;t&lt;/em&gt; = 10.16, &lt;em&gt;P&lt;/em&gt; &lt; 0.0001), and increased ROS (&lt;em&gt;t&lt;/em&gt; = 5.58, &lt;em&gt;P&lt;/em&gt; &lt; 0.0001). &lt;em&gt;In vivo&lt;/em&gt;, Itgb1 inhibition aggravated radiation-induced pulmonary, intestinal and hematopoietic injuries, characterized by increased inflammatory infiltration, alveolar septal thickening, and decreased peripheral blood cell counts (&lt;em&gt;t&lt;/em&gt; = 2.34, &lt;em&gt;P&lt;/em&gt; &lt; 0.01). These findings indicate that Itgb1 functions as a protective factor against radiation injury.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;This study elucidates Itgb1 critical radioprotective rol","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 63-72"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}