IEEE Open Journal of Engineering in Medicine and Biology最新文献

{"title":"Microbubble Contrast Agents Improve Detection of Active Hemorrhage","authors":"Scott Schoen Jr;Alexis Prasov;Ion Candel;Saaid Arshad;Mark Ottensmeyer;Theodore T. Pierce;Laura J. Brattain;Brian A. Telfer;Anthony E. Samir","doi":"10.1109/OJEMB.2024.3414974","DOIUrl":"10.1109/OJEMB.2024.3414974","url":null,"abstract":"Assessment of trauma-induced hemorrhage with ultrasound is particularly challenging outside of the clinic, where its detection is crucial. The current clinical standard for hematoma detection – the focused assessment with sonography of trauma (FAST) exam – does not aim to detect ongoing blood loss, and thus is unable to detect injuries of increasing severity. To enhance detection of active bleeding, we propose the use of ultrasound contrast agents (UCAs), together with a novel flow phantom and contrast-sensitive processing techniques, to facilitate efficient, practical characterization of internal bleeding. Within a the custom phantom, UCAs and processing techniques enabled a significant enhancement of the hemorrhage visualization (mean increase in generalized contrast-to-noise ratio of 17%) compared to the contrast-free case over a range of flow rates up to 40 ml/min. Moreover, we have shown that the use of UCAs improves the probability of detection: the area under the receiver operating characteristic curve for a flow rate of 40 ml/min was 0.99, compared to 0.72 without contrast. We also demonstrate how additional processing of the spatial and temporal information further localizes the bleeding site. UCAs also enhanced Doppler signals over the non-contrast case. These results show that specialized nonlinear processing (NLP) pipelines together with UCAs may offer an efficient means to improve substantially the detection of slower hemorrhages and increase survival rates for trauma-induced injury in pre-hospital settings.","PeriodicalId":33825,"journal":{"name":"IEEE Open Journal of Engineering in Medicine and Biology","volume":"5 ","pages":"877-884"},"PeriodicalIF":2.7,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10561886","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141948750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel CPAP Device With an Integrated Oxygen Concentrator for Low Resource Countries: In Vitro Validation and Usability Test in Field","authors":"Poletto Sofia;Zannin Emanuela;Ghilotti Emanuele;Putoto Giovanni;Ichto Jerry;Lochoro Peter;Obizu Moses;Okori Samuel;Corno Matteo;Dellacà Raffaele","doi":"10.1109/OJEMB.2024.3413574","DOIUrl":"https://doi.org/10.1109/OJEMB.2024.3413574","url":null,"abstract":"<italic>Goal:</i>\u0000 To develop and validatea novel neonatal non-invasive respiratory support device prototype designed to operate in low-resource settings. \u0000<italic>Methods:</i>\u0000 The device integrates a blower-based ventilator and a portable oxygen concentrator. A novel control algorithm was designed to achieve the desired fraction of inspired oxygen (FiO\u0000₂\u0000) while minimizing power consumption. The accuracy of the delivered FiO\u0000₂\u0000 and the device power consumption were evaluated in vitro, and a formative usability test was conducted in a rural hospital in Uganda. \u0000<italic>Results:</i>\u0000 The agreement between the set and delivered FiO2 was high (limit of agreement:−5.6 ÷ 3.8%). For FiO2 below 60%, the control algorithm reduced the power drain by 50%. The device was also appreciated by intended users. \u0000<italic>Conclusion:</i>\u0000 The prototype proved effective in delivering oxygen-enriched continuous positive airway pressure in the absence of compressed air and oxygen, holding promise for a sustainable and effective implementation of neonatal respiratory support in low-resource settings.","PeriodicalId":33825,"journal":{"name":"IEEE Open Journal of Engineering in Medicine and Biology","volume":"5 ","pages":"498-504"},"PeriodicalIF":2.7,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10555147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141435290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer-Aided Intra-Operatory Positioning of an MRgHIFU Applicator Dedicated to Abdominal Thermal Therapy Using Particle Swarm Optimization","authors":"Yacine M'Rad;Caecilia Charbonnier;Marcelo Elias de Oliveira;Pauline Coralie Guillemin;Lindsey Alexandra Crowe;Thibaud Kössler;Pierre-Alexandre Poletti;Sana Boudabbous;Alexis Ricoeur;Rares Salomir;Orane Lorton","doi":"10.1109/OJEMB.2024.3410118","DOIUrl":"https://doi.org/10.1109/OJEMB.2024.3410118","url":null,"abstract":"Purpose: Transducer positioning for liver ablation by magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) is challenging due to the presence of air-filled organs or bones on the beam path. This paper presents a software tool developed to optimize the positioning of a HIFU transducer dedicated to abdominal thermal therapy, to maximize the treatment's efficiency while minimizing the near-field risk. Methods: A software tool was developed to determine the theoretical optimal position (TOP) of the transducer based on the minimization of a cost function using the particle swarm optimization (PSO). After an initialization phase and a manual segmentation of the abdomen of 5 pigs, the program randomly generates particles with 2 degrees of freedom and iteratively minimizes the cost function of the particles considering 3 parameters weighted according to their criticality. New particles are generated around the best position obtained at the previous step and the process is repeated until the optimal position of the transducer is reached. MR imaging data from \u0000<italic>in vivo</i>\u0000 HIFU ablation in pig livers was used for ground truth comparison between the TOP and the experimental position (EP). Results: As compared to the manual EP, the rotation difference with the TOP was on average −3.1 ± 7.1° and the distance difference was on average −7.1 ± 5.4 mm. The computational time to suggest the TOP was 20s. The software tool is modulable and demonstrated consistency and robustness when repeating the calculation and changing the initial position of the transducer.","PeriodicalId":33825,"journal":{"name":"IEEE Open Journal of Engineering in Medicine and Biology","volume":"5 ","pages":"524-533"},"PeriodicalIF":2.7,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10549770","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of a Continuous Subcutaneous Insulin Infusion (CSII) Pump With Acoustic Volume and Flow Sensing in Simulated High-Consequence Situations","authors":"Robert D. Butterfield;Nathaniel M. Sims","doi":"10.1109/OJEMB.2024.3408092","DOIUrl":"https://doi.org/10.1109/OJEMB.2024.3408092","url":null,"abstract":"<italic>Goal:</i>\u0000 An insulin pump's failure to deliver insulin in the right amount at the right time is a preventable cause of hospitalization. We evaluated key performance metrics of a novel insulin pump that prevents “silent insulin non-delivery” caused by blockage, delivery of air and site leakage. This is accomplished via an acoustic sensor that measures the volume of insulin delivered with each pulse in real-time. \u0000<italic>Methods:</i>\u0000 We tested long and short-term flow accuracy, occlusion-detection time and pressure, and air management of the new device (ND) versus 3 U.S. commercial insulin pumps (CIPs) using standardized methods. \u0000<italic>Results:</i>\u0000 The ND outperformed CIPs on long-term basal flow rate error. Occlusion detection was 5 to 22.5 times faster depending on the basal rate and resulted in significantly lower (2 to 5x) pressures at time of occlusion. With air included in the drug reservoir, the tested CIPs can infuse air without detection, while the ND prevented air delivery without interruption. \u0000<italic>Conclusions:</i>\u0000 Bench tests of the ND versus 3 commercially available pumps showed improved occlusion detection and air management without flow performance tradeoffs. Additionally, the lower delivery pressure measured at time of occlusion suggests a substantially lower potential for site leakage at both basal and bolus rates. These enhancements combine to decrease the likelihood of silent insulin non-delivery.","PeriodicalId":33825,"journal":{"name":"IEEE Open Journal of Engineering in Medicine and Biology","volume":"5 ","pages":"593-599"},"PeriodicalIF":2.7,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10547403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141965146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guest Editorial Introduction to the Special Section on Invisible Sensing: Radar-Based Biomonitoring","authors":"Bjoern M. Eskofier;Martin Vossiek","doi":"10.1109/OJEMB.2024.3409086","DOIUrl":"10.1109/OJEMB.2024.3409086","url":null,"abstract":"","PeriodicalId":33825,"journal":{"name":"IEEE Open Journal of Engineering in Medicine and Biology","volume":"5 ","pages":"678-679"},"PeriodicalIF":2.7,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10547285","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141948751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulation Improves Stress Urinary Incontinence-Like Deficits in Female Rabbits","authors":"F. S. Rahman;Z. Yousuf;F. Castelán;M. Martínez-Gómez;Y. M. Akay;P. Zimmern;M. Akay;M. I. Romero-Ortega","doi":"10.1109/OJEMB.2024.3408454","DOIUrl":"10.1109/OJEMB.2024.3408454","url":null,"abstract":"<italic>Objective:</i>\u0000 Stress urinary incontinence (SUI) affects a third of the female population and is characterized by involuntary urine leakage during abdominal efforts such as sneezing, laughing, or coughing. Acute neuromodulation of the bulbospongiosus nerve (BsN) was shown to increase bladder efficiency in aged and multiparous rabbits. This study investigates the efficacy of sub-chronic BsN neuromodulation in alleviating SUI-like deficits in mature multiparous rabbits, characterized by increased urine leakage and reduced leak point pressure\u0000<italic>. Results:</i>\u0000 Using the voiding spot assay, we observed a 40% reduction in urine leakage events after 30 days of BsN stimulation, which correlated with a 60% increase in daily micturition volume, a 10-fold increase in voided volume, and improvements in voiding efficiency and leak point pressure compared to negative control animals. \u0000<italic>Conclusion:</i>\u0000 In multiparous rabbits, BsN neuromodulation improves important SUI-like metrics including bladder capacity and urethral closure, supporting the use of this bioelectronic modality as treatment for SUI.","PeriodicalId":33825,"journal":{"name":"IEEE Open Journal of Engineering in Medicine and Biology","volume":"6 ","pages":"10-19"},"PeriodicalIF":2.7,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10545601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141969750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of Radar-Based Gait Parameter Estimation Techniques for Fall Risk Assessment","authors":"Sevgi Z. Gurbuz;Mohammad Mahbubur Rahman;Zahra Bassiri;Dario Martelli","doi":"10.1109/OJEMB.2024.3408078","DOIUrl":"10.1109/OJEMB.2024.3408078","url":null,"abstract":"Current methods for fall risk assessment rely on Quantitative Gait Analysis (QGA) using costly optical tracking systems, which are often only available at specialized laboratories that may not be easily accessible to rural communities. Radar placed in a home or assisted living facility can acquire continuous ambulatory recordings over extended durations of a subject's natural gait and activity. Thus, radar-based QGA has the potential to capture day-to-day variations in gait, is time efficient and removes the burden for the subject to come to a clinic, providing a more realistic picture of older adults’ mobility. Although there has been research on gait-related health monitoring, most of this work focuses on classification-based methods, while only a few consider gait parameter estimation. On the one hand, metrics that are accurately and easily computable from radar data have not been demonstrated to have an established correlation with fall risk or other medical conditions; on the other hand, the accuracy of radar-based estimates of gait parameters that are well-accepted by the medical community as indicators of fall risk have not been adequately validated. This paper provides an overview of emerging radar-based techniques for gait parameter estimation, especially with emphasis on those relevant to fall risk. A pilot study that compares the accuracy of estimating gait parameters from different radar data representations – in particular, the micro-Doppler signature and skeletal point estimates – is conducted based on validation against an 8-camera, marker-based optical tracking system. The results of pilot study are discussed to assess the current state-of-the-art in radar-based QGA and potential directions for future research that can improve radar-based gait parameter estimation accuracy.","PeriodicalId":33825,"journal":{"name":"IEEE Open Journal of Engineering in Medicine and Biology","volume":"5 ","pages":"735-749"},"PeriodicalIF":2.7,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10546280","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141948752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles","authors":"Yan Xiao;Lixia Yang;Yicong Wang;Yu Wang;Yuning Chen;Wenhan Lu;Zhenle Pei;Ruonan Zhang;Yao Ye;Xiaowei Ji;Suying Liu;Xi Dong;Yonghua Xu;Yi Feng","doi":"10.1109/OJEMB.2024.3391939","DOIUrl":"10.1109/OJEMB.2024.3391939","url":null,"abstract":"<italic>Objective:</i>\u0000 A biological system's internal morphological structure or function can be changed as a result of the mechanical effect of focused ultrasound. Pulsed low-intensity focused ultrasound (LIFU) has mechanical effects that might induce follicle development with less damage to ovarian tissue. The potential development of LIFU as a non-invasive method for the treatment of female infertility is being considered, and this study sought to explore and confirm that LIFU can activate ovarian follicles. \u0000<italic>Results:</i>\u0000 We found a 50% increase in ovarian weight and in the number of mature follicles on the ultrasound-stimulated side with pulsed LIFU and intraperitoneal injection of 10 IU PMSG in 10-day-old rats. After ultrasound stimulation, the PCOS-like rats had a decrease in androgen levels, restoration of regular estrous cycle and increase in the number of mature follicles and corpora lutea, and the ratio of M1 and M2 type macrophages was altered in antral follicles of PCOS-like rats, consequently promoting further development and maturation of antral follicles. \u0000<italic>Conclusion:</i>\u0000 LIFU treatment could trigger actin changes in ovarian cells, which might disrupt the Hippo signal pathway to promote follicle formation, and the mechanical impact on the ovaries of PCOS-like rats improved antral follicle development.","PeriodicalId":33825,"journal":{"name":"IEEE Open Journal of Engineering in Medicine and Biology","volume":"5 ","pages":"316-329"},"PeriodicalIF":5.8,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10508955","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140803921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On-Demand Gait-Synchronous Electrical Cueing in Parkinson's Disease Using Machine Learning and Edge Computing: A Pilot Study","authors":"Ardit Dvorani;Constantin Wiesener;Christina Salchow-Hömmen;Magdalena Jochner;Lotta Spieker;Matej Skrobot;Hanno Voigt;Andrea Kühn;Nikolaus Wenger;Thomas Schauer","doi":"10.1109/OJEMB.2024.3390562","DOIUrl":"10.1109/OJEMB.2024.3390562","url":null,"abstract":"<italic>Goal:</i>\u0000 Parkinson's disease (PD) can lead to gait impairment and Freezing of Gait (FoG). Recent advances in cueing technologies have enhanced mobility in PD patients. While sensor technology and machine learning offer real-time detection for on-demand cueing, existing systems are limited by the usage of smartphones between the sensor(s) and cueing device(s) for data processing. By avoiding this we aim at improving usability, robustness, and detection delay. \u0000<italic>Methods:</i>\u0000 We present a new technical solution, that runs detection and cueing algorithms directly on the sensing and cueing devices, bypassing the smartphone. This solution relies on edge computing on the devices' hardware. The wearable system consists of a single inertial sensor to control a stimulator and enables machine-learning-based FoG detection by classifying foot motion phases as either normal or FoG-affected. We demonstrate the system's functionality and safety during on-demand gait-synchronous electrical cueing in two patients, performing freezing of gait assessments. As references, motion phases and FoG episodes have been video-annotated. \u0000<italic>Results:</i>\u0000 The analysis confirms adequate gait phase and FoG detection performance. The mobility assistant detected foot motions with a rate above 94 % and classified them with an accuracy of 84 % into normal or FoG-affected. The FoG detection delay is mainly defined by the foot-motion duration, which is below the delay in existing sliding-window approaches. \u0000<italic>Conclusions:</i>\u0000 Direct computing on the sensor and cueing devices ensures robust detection of FoG-affected motions for on demand cueing synchronized with the gait. The proposed solution can be easily adopted to other sensor and cueing modalities.","PeriodicalId":33825,"journal":{"name":"IEEE Open Journal of Engineering in Medicine and Biology","volume":"5 ","pages":"306-315"},"PeriodicalIF":5.8,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10504963","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140625436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BeatProfiler: Multimodal In Vitro Analysis of Cardiac Function Enables Machine Learning Classification of Diseases and Drugs","authors":"Youngbin Kim;Kunlun Wang;Roberta I. Lock;Trevor R. Nash;Sharon Fleischer;Bryan Z. Wang;Barry M. Fine;Gordana Vunjak-Novakovic","doi":"10.1109/OJEMB.2024.3377461","DOIUrl":"https://doi.org/10.1109/OJEMB.2024.3377461","url":null,"abstract":"<italic>Goal:</i>\u0000 Contractile response and calcium handling are central to understanding cardiac function and physiology, yet existing methods of analysis to quantify these metrics are often time-consuming, prone to mistakes, or require specialized equipment/license. We developed BeatProfiler, a suite of cardiac analysis tools designed to quantify contractile function, calcium handling, and force generation for multiple in vitro cardiac models and apply downstream machine learning methods for deep phenotyping and classification. \u0000<italic>Methods:</i>\u0000 We first validate BeatProfiler's accuracy, robustness, and speed by benchmarking against existing tools with a fixed dataset. We further confirm its ability to robustly characterize disease and dose-dependent drug response. We then demonstrate that the data acquired by our automatic acquisition pipeline can be further harnessed for machine learning (ML) analysis to phenotype a disease model of restrictive cardiomyopathy and profile cardioactive drug functional response. To accurately classify between these biological signals, we apply feature-based ML and deep learning models (temporal convolutional-bidirectional long short-term memory model or TCN-BiLSTM). \u0000<italic>Results:</i>\u0000 Benchmarking against existing tools revealed that BeatProfiler detected and analyzed contraction and calcium signals better than existing tools through improved sensitivity in low signal data, reduction in false positives, and analysis speed increase by 7 to 50-fold. Of signals accurately detected by published methods (PMs), BeatProfiler's extracted features showed high correlations to PMs, confirming that it is reliable and consistent with PMs. The features extracted by BeatProfiler classified restrictive cardiomyopathy cardiomyocytes from isogenic healthy controls with 98% accuracy and identified relax90 as a top distinguishing feature in congruence with previous findings. We also show that our TCN-BiLSTM model was able to classify drug-free control and 4 cardiac drugs with different mechanisms of action at 96% accuracy. We further apply Grad-CAM on our convolution-based models to identify signature regions of perturbations by these drugs in calcium signals. \u0000<italic>Conclusions:</i>\u0000 We anticipate that the capabilities of BeatProfiler will help advance in vitro studies in cardiac biology through rapid phenotyping, revealing mechanisms underlying cardiac health and disease, and enabling objective classification of cardiac disease and responses to drugs.","PeriodicalId":33825,"journal":{"name":"IEEE Open Journal of Engineering in Medicine and Biology","volume":"5 ","pages":"238-249"},"PeriodicalIF":5.8,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10490213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140351488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}