Ocular Biomechanical Responses to Long-Duration Spaceflight

IF 2.7 Q3 ENGINEERING, BIOMEDICAL

IEEE Open Journal of Engineering in Medicine and Biology Pub Date : 2024-09-05 DOI:10.1109/OJEMB.2024.3453049

Marissé Masís Solano;Remy Dumas;Mark R Lesk;Santiago Costantino

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引用次数: 0

Abstract

Objective: To assess the impact of microgravity exposure on ocular rigidity (OR), intraocular pressure (IOP), and ocular pulse amplitude (OPA) following long-term space missions. OR was evaluated using optical coherence tomography (OCT) and deep learning-based choroid segmentation. IOP and OPA were measured with the PASCAL Dynamic Contour Tonometer (DCT). Results: The study included 26 eyes from 13 crew members who spent 157 to 186 days on the International Space Station. Post-mission results showed a 25% decrease in OPA (p < 0.005), an 11% decrease in IOP from 16.0 mmHg to 14.2 mmHg (p = 0.04), and a 33% reduction in OR (p = 0.04). No significant differences were observed between novice and experienced astronauts. Conclusions: These findings reveal previously unknown effects of microgravity on the eye's mechanical properties, contributing to a deeper understanding of Spaceflight-Associated Neuro-ocular Syndrome (SANS). Long-term space missions significantly alter ocular biomechanics and have the potential to become biomarkers of disease progression.

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长时间太空飞行的眼部生物力学反应

目的评估长期太空任务后微重力暴露对眼球僵硬度（OR）、眼压（IOP）和眼脉搏振幅（OPA）的影响。使用光学相干断层扫描（OCT）和基于深度学习的脉络膜分割对眼球僵硬度（OR）进行评估。眼压和眼脉搏振幅是通过 PASCAL 动态轮廓仪（DCT）测量的。研究结果研究包括 13 名在国际空间站度过 157 至 186 天的乘员的 26 只眼睛。任务结束后的结果显示，OPA 降低了 25%（p < 0.005），眼压降低了 11%，从 16.0 mmHg 降至 14.2 mmHg（p = 0.04），OR 降低了 33%（p = 0.04）。新手和经验丰富的宇航员之间没有明显差异。结论：这些发现揭示了以前未知的微重力对眼球机械特性的影响，有助于加深对太空飞行相关神经眼综合征（SANS）的理解。长期太空任务极大地改变了眼部生物力学，有可能成为疾病进展的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Open Journal of Engineering in Medicine and Biology ENGINEERING, BIOMEDICAL-

CiteScore

9.50

自引率

3.40%

发文量

审稿时长

10 weeks

期刊介绍： The IEEE Open Journal of Engineering in Medicine and Biology (IEEE OJEMB) is dedicated to serving the community of innovators in medicine, technology, and the sciences, with the core goal of advancing the highest-quality interdisciplinary research between these disciplines. The journal firmly believes that the future of medicine depends on close collaboration between biology and technology, and that fostering interaction between these fields is an important way to advance key discoveries that can improve clinical care.IEEE OJEMB is a gold open access journal in which the authors retain the copyright to their papers and readers have free access to the full text and PDFs on the IEEE Xplore® Digital Library. However, authors are required to pay an article processing fee at the time their paper is accepted for publication, using to cover the cost of publication.