Clinical Parkinsonism Related Disorders最新文献

{"title":"Hospital utilization and telemedicine preferences in patients with late-stage Parkinson’s disease and caregivers","authors":"Seo Hyun Hong ,&nbsp;Seoyeon Kim ,&nbsp;Seungmin Lee ,&nbsp;Bora Jin ,&nbsp;Jung Hwan Shin ,&nbsp;Kyung Ah Woo ,&nbsp;Han-Joon Kim","doi":"10.1016/j.prdoa.2024.100296","DOIUrl":"10.1016/j.prdoa.2024.100296","url":null,"abstract":"<div><h3>Background</h3><div>There remains a significant gap in systematic research on healthcare utilization behaviors and the influencing factors for patients with Parkinson’s disease (PD), particularly those in late stages.</div></div><div><h3>Methods</h3><div>PD patients in late stage (Hoehn and Yahr (HY) stages 4 and 5) and their caregivers from Seoul National University Hospital Movement Disorders Clinic participated. A total of 103 respondents completed a questionnaire covering medical utilization behaviors, perceptions of face-to-face and telemedicine consultations, and additional medical service needs. Descriptive analysis was conducted based on HY stage, age, and travel time to the hospital.</div></div><div><h3>Results</h3><div>82.1% of patients in HY4 make more than 50% of in-person visits by themselves or with caregivers, compared with only 38.9% of patients in HY5. Despite proxy visits by caregivers were common, audiovisual or written materials about the patient’s condition were underused (63% answered ‘never’). Over three-quarters of patients did not receive rehabilitation therapy, mainly due to mobility issues and the lack of nearby facilities. One third of respondents were open to telemedicine, with differing preferences between age groups. 22% of HY5 patients or their caregivers were willing to pay more for telemedicine than in-person visit.</div></div><div><h3>Conclusion</h3><div>This study seeks to understand hospital use patterns and needs in late-stage PD patients and their caregivers. Current treatment framework for PD has areas that, if improved, could significantly enhance the quality of care. Telemedicine offers an opportunity to enhance PD education and assessment, introducing new methods for remotely measuring symptoms.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"12 ","pages":"Article 100296"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a blended learning program designed to improve clinical practice skills in novice healthcare professionals caring for patients with Parkinson’s disease","authors":"Koichi Nagaki ,&nbsp;Wataru Matsushita ,&nbsp;Makio Takahashi","doi":"10.1016/j.prdoa.2025.100367","DOIUrl":"10.1016/j.prdoa.2025.100367","url":null,"abstract":"<div><h3>Introduction</h3><div>Specialized healthcare facilities for Parkinson’s disease (PD) patients require professionals with comprehensive knowledge of disease management and palliative care. This intervention study evaluated a blended learning program for healthcare professionals (n = 117) at five newly established PD care facilities in Japan.</div></div><div><h3>Methods</h3><div>The program integrated theoretical education, active learning, and role-playing exercises. Outcomes were evaluated by scores on self-rated knowledge and confidence in palliative care for PD patients, End-of-Life Professional Caregiver Survey (EPCS), and Team STEPPS Teamwork Attitudes Questionnaire.</div></div><div><h3>Results</h3><div>The scores for self-rated knowledge of palliative care increased from 3.36 to 5.28, and confidence improved from 3.79 to 5.05 (<em>p</em> &lt; 0.001). Although overall teamwork attitudes remained stable, situation-monitoring skills improved (<em>p</em> = 0.045). The EPCS total score increased from 2.36 to 2.55 (<em>p</em> &lt; 0.001), with improvements in all subscales. Multiple regression analysis revealed that pre-intervention knowledge (β = 0.586, <em>p</em> &lt; 0.001) and professional role were associated with improvement of post-intervention knowledge scores. Notably, professional physiotherapists showed higher improvements than care management workers (β = 1.995, <em>p</em> = 0.002).</div></div><div><h3>Conclusion</h3><div>The blended learning program, combining theoretical education, active learning, and role-playing exercises, effectively enhanced the palliative care competencies of healthcare professionals in PD care facilities. Future studies should examine the long-term retention of these competencies and their impact on patient care outcomes.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"13 ","pages":"Article 100367"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A four-year trajectory of Alexithymia in Parkinson’s disease patients","authors":"Lea Krey,&nbsp;Annika Heike Ritzrau,&nbsp;Theresa Schnur,&nbsp;Stephan Greten,&nbsp;Florian Wegner,&nbsp;Martin Klietz","doi":"10.1016/j.prdoa.2025.100298","DOIUrl":"10.1016/j.prdoa.2025.100298","url":null,"abstract":"<div><div>The aim of this study was to assess the presence of Alexithymia in Parkinson’s disease (PD) patients compared to their caregivers (CG) and to investigate whether Alexithymia progressed over a 4-year observational period. Alexithymia in PD is a cognitive affective disturbance resulting in difficulty to identify, distinguish and describe feelings and it is known to be strongly associated with health-related quality of life and other cognitive/ neuropsychiatric symptoms. So far, there have been no longitudinal investigations of Alexithymia in PD. We recruited 34 moderately progressed PD patients (mean disease duration of 8.9 ± 5.3 years) and their caregivers in our neurological department and did a baseline and follow-up assessment using the validated Toronto Alexithymia Scale-26 (TAS-26). Our data show that Alexithymia is more abundant in the PD cohort compared to their caregivers (p = 0.007, PD 21 %, CG 6 % at follow-up). In the 4-year observational period, Alexithymia did not increase significantly in PD patients or caregivers. However, there was a high variance in Alexithymia scores in both groups. It remains unclear when Alexithymia appears during the disease course and whether there is a dynamic in Alexithymia scores later in PD progression. This should be the objective for future studies of Alexithymia in advanced PD patients.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"12 ","pages":"Article 100298"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Assessment of Parkinson’s Motor Symptoms and Dopaminergic Dysfunction Patterns Using DaTSCAN","authors":"Amir Hossein Najmi ,&nbsp;Armin Ariaei ,&nbsp;Mahboobeh Khezri ,&nbsp;Masoud Noroozi ,&nbsp;Melika Arab Bafrani ,&nbsp;Avesta Gheysari ,&nbsp;Farideh Sabetghadam ,&nbsp;Mehdi Ahmadi ,&nbsp;Mohammad Sadeghi ,&nbsp;Mahsa Mayeli ,&nbsp;The Parkinson’s Progression Markers Initiative","doi":"10.1016/j.prdoa.2025.100331","DOIUrl":"10.1016/j.prdoa.2025.100331","url":null,"abstract":"<div><h3>Introduction</h3><div>Determining Parkinson’s disease (PD) stage and severity are among the factors affecting treatment strategy. Dopamine transporter scan (DaTSCAN) has high efficiency in the diagnosis of PD, while its role in predicting motor function, dyskinesia, and symptoms severity trajectory remains controversial. This study aimed to evaluate the associations between motor symptoms patterns in PD with DaTscan findings.</div></div><div><h3>Methods</h3><div>A total of 196 patients were included and grouped based on tremor score, postural instability and gait difficulty score, and the presentation of dyskinesia. Multivariate and ordinal logistic regression models were used to investigate the association between two-year follow-up of the PD patients’ motor symptoms assessment scores and DaTSCAN finding patterns.</div></div><div><h3>Results</h3><div>Patients with dyskinesia exhibited significantly lower DaTSCAN uptake across all measured regions, with the most pronounced reductions observed in the right caudate and left putamen (p &lt; 0.001). Additionally, DaTSCAN values were strongly associated with overall disease severity (p &lt; 0.001). A notable positive correlation was found between DaTSCAN uptake and Schwab and England Activities of Daily Living (ADL) scores, whereas significant negative correlations were observed between DaTSCAN measures (including the caudate, putamen, and anterior putamen) and clinical motor scores, such as MDS-UPDRS III, MDS-UPDRS II, and PIGD. In contrast, DaTSCAN parameters did not significantly predict tremor-dominant (TD) scores.</div></div><div><h3>Conclusion</h3><div>Beyond its diagnostic utility, DaTSCAN provides meaningful insights into disease severity and motor dysfunction in PD, with particular relevance to postural instability and gait disturbance.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"12 ","pages":"Article 100331"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of Frégoli syndrome following 24-hour levodopa-carbidopa intestinal gel infusion in a patient with Parkinson’s disease undergoing STN-DBS","authors":"Shunsuke Ogata ,&nbsp;Katsuo Kimura ,&nbsp;Katsuya Abe ,&nbsp;Yumeko Urago ,&nbsp;Noriko Hayashi ,&nbsp;Misako Kunii ,&nbsp;Naohisa Ueda ,&nbsp;Fumiaki Tanaka","doi":"10.1016/j.prdoa.2025.100364","DOIUrl":"10.1016/j.prdoa.2025.100364","url":null,"abstract":"","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"13 ","pages":"Article 100364"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of dance/music and meditation on the progression of Parkinson’s disease with mild/ moderate severity: a single-blinded randomized controlled pilot study","authors":"Paresh K. Doshi ,&nbsp;Bhagyashree Mehrotra ,&nbsp;Neha Rai ,&nbsp;M.R. Rajani ,&nbsp;Aparna Budhakar ,&nbsp;Ritika Aggarwal ,&nbsp;Mona Thomas ,&nbsp;Sampada Patole ,&nbsp;Raj V. Agarbattiwala","doi":"10.1016/j.prdoa.2025.100366","DOIUrl":"10.1016/j.prdoa.2025.100366","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson’s disease (PD) significantly impairs motor and cognitive functions, reducing quality of life. Non-pharmacological interventions, such as dance/music therapy combined with meditation, may offer potential benefits in managing symptoms of PD.</div></div><div><h3>Methods</h3><div>A parallel, single-blinded, randomized, controlled pilot study was conducted from March to August 2023 with a six-month follow-up. Thirty patients with mild to moderate PD under 80 years and capable of participating were included. Exclusion criteria were deep brain stimulation and high fall risk. The intervention group received dance/music therapy with meditation sessions, while the control group continued regular activities. Medications remained unchanged in both groups. Primary outcomes were changes in UPDRS I-III and PDQ-39 scores. Secondary outcomes included a mini-mental state examination, Beck’s Depression Inventory, Parkinson’s Anxiety Scale, Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale, Berg Balance Test, Time Up and Go Test, and Parkinson’s disease Questionnaire-Carer (PDQ-Carer), Zarit-Caregiver Burden Interview (ZBI).</div></div><div><h3>Results</h3><div>Twenty-eight participants were analyzed, with 15 in the intervention group and 13 in the control group. Significant improvement {difference of 8 points, <em>P</em> = <em>0.013</em>} was noted in UPDRS I-III scores in the intervention group (n = 15). PDQ-39 scores improved in the intervention group {6.82 points reduction, P = 0.0057}. Caregivers in the intervention group showed a significant decrease in PDQ-Carer (1.5 points, P = 0.008) and ZBI scores (1.0 points, P = 0.005). There were no significant changes in other secondary outcome measures.</div></div><div><h3>Conclusions</h3><div>The study’s findings showed potential benefits from these non-pharmacological interventions, warranting a more extensive study.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"13 ","pages":"Article 100366"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrinogen is the key factor associated with tremor relief and recurrence after magnetic resonance-guided focused ultrasound thalamotomy","authors":"Jiaji Lin ,&nbsp;Haoxuan Lu ,&nbsp;Xianbing Bian ,&nbsp;Jianxing Hu ,&nbsp;Longsheng Pan ,&nbsp;Xin Lou","doi":"10.1016/j.prdoa.2025.100376","DOIUrl":"10.1016/j.prdoa.2025.100376","url":null,"abstract":"<div><h3>Introduction</h3><div>Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is safe and effective for tremor disorders such as essential tremor (ET), but whether preoperative serum profiles mediate tremor recurrence after treatment requires further investigation.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed the data of 59 ET patients who underwent unilateral MRgFUS thalamotomy during 2018–2020. Tremor severity was assessed off-medication using the Clinical Rating Scale for Tremor (CRST), with contralateral hand tremor measured via a derived CRST subscale. Short-term tremor relief was defined as ≥ 50 % reduction at 1-month postoperatively, and tremor recurrence was defined as a worsening by 25 % and at least 8 points within 12 months. Multivariate logistic regression analyses were performed to identify predictors of tremor relief and recurrence, and variables with <em>P</em> &lt; 0.05 were used to construct nomograms for tremor relief and recurrence. Receiver operating characteristic curves, calibration analysis, and the Hosmer-Lemeshow test were conducted to evaluate the nomograms.</div></div><div><h3>Results</h3><div>At 1-month after MRgFUS thalamotomy, hand tremor scores were decreased by &gt; 50 % relative to the preoperative score in all patients and by &gt; 75 % in 39 (66.10 %) patients. However, 9 (15.25 %) patients developed tremor recurrence within 12 months. Multivariate analysis showed that fibrinogen was independently linked to short-term tremor relief (odds ratio [OR]: 0.18) and long-term tremor recurrence (OR: 1.620). The nomograms for tremor relief and recurrence showed high performance (areas under the curve: 0.82 and 0.83, respectively); the Hosmer-Lemeshow test yielded <em>P</em> values of 0.54 and 0.498, respectively. The calibration curves exhibited high consistency.</div></div><div><h3>Conclusion</h3><div>Serum fibrinogen is a key factor for tremor relief and recurrence in ET patients undergoing unilateral MRgFUS thalamotomy.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"13 ","pages":"Article 100376"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term efficacy of deep brain stimulation in PLA2G6-related Parkinson’s disease: A case report with literature review","authors":"Takashi Tsuboi ,&nbsp;Takashi Uematsu ,&nbsp;Yoshiki Ito ,&nbsp;Tomotaka Ishizaki ,&nbsp;Satoshi Maesawa ,&nbsp;Ryuta Saito ,&nbsp;Hiroyo Yoshino ,&nbsp;Nobutaka Hattori ,&nbsp;Adolfo Ramirez-Zamora ,&nbsp;Michael S. Okun ,&nbsp;Masahisa Katsuno","doi":"10.1016/j.prdoa.2025.100377","DOIUrl":"10.1016/j.prdoa.2025.100377","url":null,"abstract":"<div><div>A patient with early-onset PARK14 and novel <em>PLA2G6</em> variants underwent globus pallidus internus deep brain stimulation, achieving sustained three-year motor and quality-of-life improvements. Although a literature review supports motor benefits, our case’s cognitive decline highlights the need for comprehensive assessment of non-motor symptoms and quality-of-life in this rare disorder.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"13 ","pages":"Article 100377"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144748596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SNP rs7549881, near SGIP1 at 1p31.3, is significantly associated with digestive disorders and Parkinsonism in women","authors":"Steven Lehrer ,&nbsp;Peter Rheinstein","doi":"10.1016/j.prdoa.2025.100391","DOIUrl":"10.1016/j.prdoa.2025.100391","url":null,"abstract":"<div><h3>Background</h3><div>SGIP1 (SH3GL Interacting Endocytic Adaptor 1) at 1p31.3 has been implicated in early-onset Parkinsonism in a rare familial case. We investigated the nearby intronic SNP rs7549881 (A &gt; G, MAF 0.43) for association with Parkinson’s disease (PD) and other traits in the UK Biobank.</div></div><div><h3>Methods</h3><div>A total of 385,629 UK Biobank participants with ≥7 years of education were included. Logistic regression adjusted for age, sex, smoking, and constipation evaluated the association between rs7549881 and PD. PheWAS was performed using PheWeb to identify additional phenotypic associations.</div></div><div><h3>Results</h3><div>Among females, 26.0 % of rs7549881 GG homozygotes had PD, compared to 22.2 % without PD (p = 0.004). No significant genotype-PD association was observed in males. Logistic regression showed that age (OR 1.14), male sex (OR 1.83), and constipation (OR 4.73) increased PD risk, while smoking was protective (OR 0.75). GG genotype conferred increased PD risk versus AA (OR 1.21, p = 0.015). PheWAS identified significant associations with gastrointestinal phenotypes, including functional digestive disorders and noninfectious gastroenteritis.</div></div><div><h3>Conclusion</h3><div>SNP rs7549881 is associated with PD in females and with gastrointestinal disorders across both sexes. These findings reinforce the role of SGIP1 in synaptic endocytosis and suggest its contribution to gut-brain axis dysfunction in PD.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"13 ","pages":"Article 100391"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144987987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Memantine-induced delayed sleep phase in Huntington’s disease: A case report","authors":"Youshi Fujita ,&nbsp;Toshio Hamada ,&nbsp;Satoshi Kubota ,&nbsp;Tomomi Sakoh-Goshima ,&nbsp;Hirotaka Shirasaki","doi":"10.1016/j.prdoa.2025.100306","DOIUrl":"10.1016/j.prdoa.2025.100306","url":null,"abstract":"<div><div>Circadian rhythm sleep disorders may occur after memantine administration. We describe a 49-year-old woman with Huntington’s disease, who complained of sleep onset insomnia following the administration of memantine. Memantine reduced hyperkinetic movements but led to delayed sleep phases, that were dose-dependent and reversible, confirmed by sleep logs and actigraphy.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"12 ","pages":"Article 100306"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}