Clinical Parkinsonism Related Disorders最新文献

{"title":"Botulinum toxin therapy in Parkinson disease-related lower limb dystonia. An 8 year retrospective review","authors":"Antonia Schonwald ,&nbsp;Katherine Amodeo ,&nbsp;Victoria Levy ,&nbsp;Fabio Danisi","doi":"10.1016/j.prdoa.2024.100260","DOIUrl":"https://doi.org/10.1016/j.prdoa.2024.100260","url":null,"abstract":"<div><h3>Background</h3><p>Lower extremity dystonia (LED) is a frequent complication of Parkinson disease (PD). Treatment with botulinum neurotoxinA (BoNTA) over 8 years was retrospectively reviewed.</p><p>Cases</p><p>14 patients with LED received an average of 3.86 injections (1–8). Mean interval was 40 weeks (median of 25). Average dose was 182 units. Injections were well-tolerated. Using a 6 point scale, there was an average of 3.37 point improvement in disability after each session, with average duration of 28.56 weeks (median 11 weeks). After mean follow-up of 101 weeks, disabling dystonia was not present in 11 of 14 patients.</p></div><div><h3>Conclusions</h3><p>Botulinum toxin is safe and effective in PD related LED. Good response to the first two injection sessions was significantly associated with greater likelihood of long-term response. Assertive BoNTA dosing may lead to sustained remission of symptoms. As natural history of LED in PD has not been reported, prospective placebo-controlled studies are needed.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"11 ","pages":"Article 100260"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590112524000318/pdfft?md5=6048d78b1cb0a01adf92551e36356c7e&pid=1-s2.0-S2590112524000318-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141313064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring bradyphrenia in Huntington’s disease using the computerized test of information processing (CTiP)","authors":"Georgia M. Parkin ,&nbsp;Braden Culbert ,&nbsp;Emma Churchill ,&nbsp;Paul E. Gilbert ,&nbsp;Jody Corey-Bloom","doi":"10.1016/j.prdoa.2024.100243","DOIUrl":"https://doi.org/10.1016/j.prdoa.2024.100243","url":null,"abstract":"<div><h3>Background</h3><p>Bradyphrenia, best thought of as the mental equivalent of bradykinesia, has been described in several disorders of the brain including Parkinson’s disease and schizophrenia; however, little is known about this phenomenon in Huntington’s Disease (HD).</p></div><div><h3>Objective</h3><p>The aim of this study was to investigate the presence of bradyphrenia in HD using the Computerized Test of Information Processing (CTiP), an easy to administer and objective task that assesses cognitive processing speed with increasing task complexity.</p></div><div><h3>Methods</h3><p>This study included 211 participants: Huntington’s Disease Integrated Staging System (HD-ISS) Stage 0 [n = 28], Stage 1 [n = 30], Stage 2 [n = 48] and Stage 3 [n = 48], and healthy controls (HC) [n = 57]. The CTiP incorporates three subtests: Simple Reaction Time (SRT), which assesses baseline motor function; Choice Reaction Time (CRT), with an added decisional component; and Semantic Search Reaction Time (SSRT), with an added conceptual component. SRT scores were subtracted from CRT and SSRT scores to establish a motor-corrected measure of central conduction time, which was used to operationalize bradyphrenia.</p></div><div><h3>Results</h3><p>HD-ISS and HC within-group reaction times differed significantly when comparing motor-corrected CRT vs SSRT (all <em>p</em>s &lt; 0.0001). Furthermore, the magnitude of these differences increased with HD disease stage (p &lt; 0.0001). An ROC analysis determined that motor-corrected within-subject differences significantly distinguished Stage 2 + 3 from Stage 0 + 1 (AUC = 0.72, p &lt; 0.0001).</p></div><div><h3>Conclusions</h3><p>We report evidence of bradyphrenia in HD that increases with disease progression. This processing deficit, which can be quantified using the CTiP, has the potential to greatly impact HD daily life and warrants additional research.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"10 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590112524000124/pdfft?md5=84939ed7d20e689dd9ec03f5693e9f13&pid=1-s2.0-S2590112524000124-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139935537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc gluconate for Wilson disease","authors":"Mark S. LeDoux","doi":"10.1016/j.prdoa.2024.100272","DOIUrl":"10.1016/j.prdoa.2024.100272","url":null,"abstract":"<div><div>Due to financial constraints, a patient with Wilson disease required transitioning his maintenance pharmacotherapy from zinc acetate to zinc gluconate. Herein, we report the clinical and laboratory outcomes of this switch and review the relevant literature on the treatment of Wilson disease with zinc. Zinc gluconate can be a viable treatment option for patients with Wilson disease and may be associated with fewer gastrointestinal side effects than zinc acetate and, accordingly, improved long-term compliance and improved clinical outcomes.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"11 ","pages":"Article 100272"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of care partner burden in atypical Parkinsonian syndromes: A retrospective, multi-center analysis","authors":"Jessica Shurer ,&nbsp;Margaret Ivancic ,&nbsp;Vanessa Nesspor ,&nbsp;Maria Schmidt ,&nbsp;Mingyuan Li ,&nbsp;Yi-Ting Lin ,&nbsp;Grant Schumock ,&nbsp;Richard Xu ,&nbsp;Miriam Sklerov ,&nbsp;Alexander Pantelyat","doi":"10.1016/j.prdoa.2024.100266","DOIUrl":"10.1016/j.prdoa.2024.100266","url":null,"abstract":"<div><h3>Introduction</h3><p>Progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA) are rare neurodegenerative diseases associated with rapid decline and require complex symptom management. Caregiving responsibilities significantly increase with progression of these atypical Parkinsonian syndromes, yet care burden in these syndromes has not been researched extensively to date.</p></div><div><h3>Methods</h3><p>The Zarit Burden Interview (ZBI) was used to assess burden in care partners of patients clinically diagnosed with PSP, CBS, or MSA seen in specialty interdisciplinary clinics at two academic movement disorders centers. Univariable and multivariable regression analyses were performed to evaluate cross-sectional demographic and clinical determinants of care partner burden.</p></div><div><h3>Results</h3><p>A total of 139 care partners completed the ZBI (59.0% PSP, 28.1% MSA, 12.9% CBS). Cohorts at both medical centers were similar across all variables. Female gender of both patients and care partners was independently associated with higher ZBI scores. Additionally, MSA-Parkinsonian type was significantly associated with lower total care partner burden compared to PSP and CBS.</p></div><div><h3>Conclusion</h3><p>Several determinants of higher care partner burden in atypical Parkinsonian syndromes were identified, particularly female gender and diagnosis. Healthcare professionals can consider this information when assessing individualized needs of patients and care partners and referring to disease-specific resources. Additionally, this study’s methods and results highlight the potential to further explore interdisciplinary care as a means of comprehensive evaluation and support for those with atypical Parkinsonism.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"11 ","pages":"Article 100266"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590112524000379/pdfft?md5=b631fffe9201d99e6cffb5c3cbd272b5&pid=1-s2.0-S2590112524000379-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of tactile cueing on dual task performance in Parkinson’s disease. A systematic review and meta-analysis","authors":"Viktoria Azoidou ,&nbsp;Alastair J Noyce ,&nbsp;Cristina Simonet","doi":"10.1016/j.prdoa.2024.100284","DOIUrl":"10.1016/j.prdoa.2024.100284","url":null,"abstract":"<div><h3>Background</h3><div>Dual-task (DT) performance is impaired in Parkinson’s disease (PD), contributing to bradykinesia, postural instability, freezing of gait, and falls. Tactile cueing, including vibrotactile stimulation, has been suggested to improve DT performance in PD.</div></div><div><h3>Research Question</h3><div>Does tactile cueing affect DT performance in PD, specifically measured by dual-task cost (DTC)?</div></div><div><h3>Methods</h3><div>A systematic review was conducted in PubMed and EMBASE up to October 30, 2023, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Eligible studies were those in English that examined the effects of tactile cueing and/or closed-loop vibrotactile stimulation on DT performance in adults over 18 with idiopathic PD. The primary outcome, DTC, was calculated as the percentage change in performance from DT to single-task using the formula: [(single-task − dual-task)/single-task]* 100. A <em>meta</em>-analysis using a random-effects model pooled standardized mean differences (SMD) of DTC. Statistical significance was set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>From 130 initially identified studies, eight were included in the review. Four studies with 374 participants were included in <em>meta</em>-analyses focusing on walking speed and step length. Three of the four studies indicated that tactile cueing improved DTC for these parameters. However, the SMD for walking speed (−109.69; 95 % CI −454.89 to 235.51, p = 0.39) and step length (−14.21; 95 %CI −53.25 to 24.83, p = 0.33) showed weak evidence of improvement.</div></div><div><h3>Conclusion</h3><div>The <em>meta</em>-analysis provides weak evidence that tactile cueing may enhance walking speed and step length in DT conditions in PD. Rigorous objective studies are still lacking in this field of research.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"11 ","pages":"Article 100284"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VCP mutations and parkinsonism: An emerging link","authors":"Jumana T. Alshaikh ,&nbsp;Ashley Paul ,&nbsp;Emile Moukheiber ,&nbsp;Sonja W. Scholz ,&nbsp;Alexander Pantelyat","doi":"10.1016/j.prdoa.2023.100230","DOIUrl":"https://doi.org/10.1016/j.prdoa.2023.100230","url":null,"abstract":"","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"10 ","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590112523000488/pdfft?md5=9d12452b952fae0070fe54f040583bde&pid=1-s2.0-S2590112523000488-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138484889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plantar Grasp sign as a screening tool for Orthostatic Tremor (OT)","authors":"Rebecca Thompson ,&nbsp;Danish Bhatti ,&nbsp;Kalyan Malgireddy ,&nbsp;Venkata Sunil Bendi ,&nbsp;John M. Bertoni ,&nbsp;Vekash Raja ,&nbsp;Diego Torres-Russotto","doi":"10.1016/j.prdoa.2023.100196","DOIUrl":"10.1016/j.prdoa.2023.100196","url":null,"abstract":"<div><h3>Introduction</h3><p>Orthostatic tremor (OT) is a rare neurological disorder characterized by a sensation of instability while standing. Very few clinical signs have been described for OT to date. Finding other symptoms and signs could prove valuable for this hard-to-recognized disease.</p></div><div><h3>Methods</h3><p>This protocol is part of the University of Nebraska Medical Center Orthostatic Tremor longitudinal study. It was noted that OT patients flex their toes and sometimes the foot arch while standing (Plantar Grasp). They reported doing this to “grab” the floor and improve stability. This paper analyses the diagnostic test characteristics of the patient-self-reported Plantar Grasp, a new sign in OT.</p></div><div><h3>Results</h3><p>There were 34 OT patients (88% females), and 20 controls (65% females). Eighty-eight percent of patients with OT reported the plantar grasp sign and none of the controls. The Plantar Grasp Sign was found to be very sensitive (88%), and extremely specific (100%) in our cohort. Non-weighted Negative Likelihood Ratio (NLR) was 0.12. And the 3% prevalence-weighted NLR was so low that the negative post-test probability was close to zero.</p></div><div><h3>Conclusion</h3><p>Due to its high sensitivity, specificity, and ideal likelihood ratio, we propose that the Plantar Grasp sign could be considered to screen patients with possible OT. Further studies are needed to determine the specificity of this sign in OT versus other balance disorders.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"8 ","pages":"Article 100196"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/bf/main.PMC10126904.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9363744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updated Parkinson's disease motor subtypes classification and correlation to cerebrospinal homovanillic acid and 5-hydroxyindoleacetic acid levels","authors":"Christopher Adams ,&nbsp;Jessika Suescun ,&nbsp;Anam Haque ,&nbsp;Kelly Block ,&nbsp;Shivika Chandra ,&nbsp;Timothy M. Ellmore ,&nbsp;Mya C. Schiess","doi":"10.1016/j.prdoa.2023.100187","DOIUrl":"10.1016/j.prdoa.2023.100187","url":null,"abstract":"<div><h3>Introduction</h3><p>Motor classifications of Parkinson's Disease (PD) have been widely used. This paper aims to update a subtype classification using the MDS-UPDRS-III and determine if cerebrospinal neurotransmitter profiles (HVA and 5-HIAA) differ between these subtypes in a cohort from the Parkinson's Progression Marker Initiative (PPMI).</p></div><div><h3>Methods</h3><p>UPDRS and MDS-UPDRS scores were collected for 20 PD patients. Akinetic-rigid (AR), Tremor-dominant (TD), and Mixed (MX) subtypes were calculated using a formula derived from UPDRS, and a new ratio was developed for subtyping patients with the MDS-UPDRS. This new formula was subsequently applied to 95 PD patients from the PPMI dataset, and subtyping was correlated to neurotransmitter levels.<!--> <!-->Data were analyzed using receiver operating characteristic models and ANOVA.</p></div><div><h3>Results</h3><p>Compared to previous UPDRS classifications, the new MDS-UPDRS TD/AR ratios produced significant areas under the curve (AUC) for each subtype. The optimal sensitivity and specificity cutoff scores were ≥0.82 for TD, ≤0.71 for AR, and &gt;0.71 and &lt;0.82 for Mixed. Analysis of variance showed that the AR group had significantly lower HVA and 5-HIAA levels than the TD and HC groups. A logistic model using neurotransmitter levels and MDS-UPDRS-III could predict the subtype classification.</p></div><div><h3>Conclusions</h3><p>This MDS-UPDRS motor classification system provides a method to transition from the original UPDRS to the new MDS-UPDRS. It is a reliable and quantifiable subtyping tool for monitoring disease progression. The TD subtype is associated with lower motor scores and higher HVA levels, while the AR subtype is associated with higher motor scores and lower 5-HIAA levels.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"8 ","pages":"Article 100187"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1c/57/main.PMC9922918.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10739629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity of depressive and motor symptoms impacts quality of life in Parkinson’s disease patients at an academic movement clinic: A cross-sectional study","authors":"Brianne Lacy,&nbsp;Hien J. Piotrowski,&nbsp;Richard B. Dewey Jr.,&nbsp;Mustafa M. Husain","doi":"10.1016/j.prdoa.2022.100180","DOIUrl":"10.1016/j.prdoa.2022.100180","url":null,"abstract":"<div><h3>Introduction</h3><p>Parkinson’s disease (PD) is a neurodegenerative disease with motor and non-motor manifestations that have been previously reported to affect patient quality of life (QoL). Our objective is to investigate the factors that contribute to QoL in a cohort of PD patients receiving care at a major academic institution.</p></div><div><h3>Methods</h3><p>In this cross-sectional study of 124 participants (71.77% male, mean age 65.20, mean UPDRS-III score 11.25), we analyzed if certain clinical features such as UPDRS-III, QIDS-C, and total disease duration contributed to QoL as measured by two different metrics (PDQ-39 and EQ-5D) in PD patients at a university Movement Disorders Clinic.</p></div><div><h3>Results</h3><p>Motor symptoms of PD, with the exception of tremor, as well as depression and specific depressive symptoms were significantly and positively correlated with lower QoL metrics for patients with Parkinson’s, with total depressive symptom severity (QIDS-C₁₆ Total score) contributing most to QoL scores. Of the specific depressive and motor symptoms, anhedonia and rigidity contributed the most to QoL. Disease duration was significantly correlated with lower QoL for participants with Parkinson’s according to the QoL metric PDQ-39 but not ED-5D. Parkinson’s patients with access to high-quality healthcare are at risk for having diminished QoL due to both depressive and motor symptoms.</p></div><div><h3>Conclusion</h3><p>While severity of motor symptoms certainly impacted QoL in our cohort, our findings suggest that depressive symptoms contribute more to impaired QoL than severe motor symptoms do. This phenomenon suggests that concomitant depression in PD as well as one’s psychological adjustment to disability may have a greater impact on QoL than severe motor symptoms.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"8 ","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fc/0a/main.PMC9795528.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10472149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pallidal stimulation-induced psychosis and suicidality in Parkinson’s disease","authors":"Sebastian Hanna ,&nbsp;Vala Palmadottir ,&nbsp;Paul L. Penar ,&nbsp;James T. Boyd","doi":"10.1016/j.prdoa.2022.100175","DOIUrl":"10.1016/j.prdoa.2022.100175","url":null,"abstract":"<div><p>Neuropsychiatric adverse events have been previously reported following deep brain stimulation (DBS) for Parkinson’s disease (PD). Most cases described have involved DBS of the subthalamic nucleus (STN). We report a unique case of acute-onset and reversible psychosis, suicidality, and depressive symptoms following DBS of the globus pallidus internus (GPi) and review the relevant literature.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"8 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fd/73/main.PMC9803938.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10477056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}