Clinical Parkinsonism Related Disorders最新文献

{"title":"Comparing smell identification ability among different motor subtypes of Parkinson’s disease using the Vietnamese Smell Identification Test and the Brief Smell Identification Test","authors":"Thuong Huyen Thi Dang ,&nbsp;Daniel Truong ,&nbsp;Khang Vinh Nguyen ,&nbsp;Uyen Le Ngoc Ha ,&nbsp;Khang Chung Ngoc Vo ,&nbsp;Thanh Vinh Nguyen ,&nbsp;Hien Thi Le ,&nbsp;Tai Ngoc Tran","doi":"10.1016/j.prdoa.2024.100270","DOIUrl":"10.1016/j.prdoa.2024.100270","url":null,"abstract":"<div><h3>Introduction</h3><p>Olfactory dysfunction is one of the most common non-motor symptoms of Parkinson’s disease (PD). The association between smell identification ability and motor subtypes of PD is not uniform in previous studies. This study aimed to compare the odor identification ability among different motor subtypes of PD in Vietnamese participants.</p></div><div><h3>Methods</h3><p>Patients who were diagnosed with PD according to the International Parkinson’s Disease and Movement Disorder Society 2015 Diagnostic Criteria and had normal cognitive function were recruited. Participants were divided into akinetic-rigid (AR), tremor-dominant (TD), and mixed (MX) motor subgroups using the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) score. Olfactory identification ability was evaluated using the Vietnamese Smell Identification Test (VSIT) and the Brief Smell Identification Test (BSIT). Cognitive status was assessed using the Mini-Mental State Examination (MMSE). Age, age at PD onset, disease duration, smell identification ability, and cognitive function were compared among the three PD motor subtypes.</p></div><div><h3>Results</h3><p>The AR subgroup was the most common motor subtype (n = 164, 75.2 %), followed by TD (n = 39, 17.9 %), and MX (n = 15, 6.9 %) subtypes. Age, age at PD onset, sex, disease duration, and MMSE score were not significantly different between the three motor subgroups (all p &gt; 0.05). The median (IQR) VSIT scores of AR, TD, and MX subgroups were 5.00 [4.00;7.00], 5.00 [3.50;7.00], and 5.00 [3.00;6.00], respectively. The median (IQR) BSIT scores of AR, TD, and MX subgroups were 6.00 [4.00;7.00], 5.00 [4.00;7.00], and 5.00 [4.50;7.00], respectively. The VSIT and the BSIT scores were not significantly different among the three motor subtypes (all p &gt; 0.05).</p></div><div><h3>Conclusion</h3><p>Smell identification ability assessed in both the VSIT and BSIT did not differ across the three motor subtypes of PD.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"11 ","pages":"Article 100270"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590112524000410/pdfft?md5=0e0ac9e42873dd16bdcafb91d0e2b732&pid=1-s2.0-S2590112524000410-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthostatic tremor as possible presenting sign of progressive supranuclear palsy","authors":"Emke Maréchal ,&nbsp;Sven Dekeyzer ,&nbsp;David Crosiers","doi":"10.1016/j.prdoa.2024.100275","DOIUrl":"10.1016/j.prdoa.2024.100275","url":null,"abstract":"","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"11 ","pages":"Article 100275"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-center experience of utilization and clinical efficacy of segmented leads for subthalamic deep brain stimulation in Parkinson’s disease","authors":"Ana Luísa de Almeida Marcelino ,&nbsp;Viktor Heinz ,&nbsp;Melanie Astalosch ,&nbsp;Bassam Al-Fatly ,&nbsp;Gerd-Helge Schneider ,&nbsp;Patricia Krause ,&nbsp;Dorothee Kübler-Weller ,&nbsp;Andrea A. Kühn","doi":"10.1016/j.prdoa.2024.100273","DOIUrl":"10.1016/j.prdoa.2024.100273","url":null,"abstract":"<div><h3>Background</h3><div>Segmented electrodes for deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson’s disease (PD) enable directional current steering leading to expanded programming options.</div></div><div><h3>Objective</h3><div>This retrospective study covering a longitudinal period of up to 7 years compares the efficacy of segmented and non-segmented leads in motor symptom alleviation and reduction of dopaminergic medication in PD patients treated in a specialized center and assesses the long-term use of directional steering in clinical routine.</div></div><div><h3>Methods</h3><div>Demographic data and clinical scores before surgery and at 12-month follow-up (12MFU) as well as stimulation parameters at 12MFU and last follow-up (LFU) were assessed in all patients implanted with segmented leads between 01/2016 and 12/2019 and non-segmented leads in a corresponding time-period. Patients were classified as very good (&gt;60 %), good (30–60 %) and poor (&lt;30 %) responders according to DBS-induced motor improvement.</div></div><div><h3>Results</h3><div>Clinical data at 12MFU was available for 61/96 patients with segmented (SEG) and 42/53 with non-segmented leads (N-SEG). Mean DBS-induced motor improvement and reduction of medication at 12MFU did not differ significantly between SEG and N-SEG groups or in a subgroup analysis of steering modes. There was a lower proportion of poor responders in the SEG compared with the N-SEG group (23% vs. 31%), though not statistically significant. At LFU, the percentage of patients set at directional steering increased from 54% to 70%.</div></div><div><h3>Conclusion</h3><div>Efficacy in reduction of motor symptoms and medication does not differ between electrode types for STN-DBS at 12 months follow-up. The use of directional steering increases over time and may account for a lower proportion of poor responders.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"11 ","pages":"Article 100273"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of alpha-synuclein seed amplification assay in Parkinson’s disease clinical trials: A case of misdiagnosis","authors":"Emily Tharp,&nbsp;Juan D. Martinez-Lemus,&nbsp;Mya C. Schiess,&nbsp;Timothy M. Ellmore,&nbsp;Jessika Suescun,&nbsp;Mohammad Shahnawaz","doi":"10.1016/j.prdoa.2024.100274","DOIUrl":"10.1016/j.prdoa.2024.100274","url":null,"abstract":"","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"11 ","pages":"Article 100274"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial variability and directional shifts in postural control in Parkinson’s disease","authors":"Damian G. Kelty-Stephen ,&nbsp;Ken Kiyono ,&nbsp;Nick Stergiou ,&nbsp;Madhur Mangalam","doi":"10.1016/j.prdoa.2024.100249","DOIUrl":"10.1016/j.prdoa.2024.100249","url":null,"abstract":"<div><p>Individuals with Parkinson’s disease exhibit tremors, rigidity, and bradykinesia, disrupting normal movement variability and resulting in postural instability. This comprehensive study aimed to investigate the link between the temporal structure of postural sway variability and Parkinsonism by analyzing multiple datasets from young and older adults, including individuals with Parkinson’s disease, across various task conditions. We used the Oriented Fractal Scaling Component Analysis (OFSCA), which identifies minimal and maximal long-range correlations within the center of pressure time series, allowing for detecting directional changes in postural sway variability. The objective was to uncover the primary directions along which individuals exerted control during the posture. The results, as anticipated, revealed that healthy adults predominantly exerted control along two orthogonal directions, closely aligned with the anteroposterior (AP) and mediolateral (ML) axes. In stark contrast, older adults and individuals with Parkinson’s disease exhibited control along suborthogonal directions that notably diverged from the AP and ML axes. While older adults and those with Parkinson’s disease demonstrated a similar reduction in the angle between these two control directions compared to healthy older adults, their reliance on this suborthogonal angle concerning endogenous fractal correlations exhibited significant differences from the healthy aging cohort. Importantly, individuals with Parkinson’s disease did not manifest the sensitivity to destabilizing task settings observed in their healthy counterparts, affirming the distinction between Parkinson’s disease and healthy aging.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"10 ","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590112524000185/pdfft?md5=86428f45d52443538a5d7d94e8dbbb36&pid=1-s2.0-S2590112524000185-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The electrophysiological findings of Marcus-Gunn jaw winking syndrome","authors":"Yih-Chih Jacinta Kuo,&nbsp;Ru-Jen Lin,&nbsp;Yan-Siu Dong,&nbsp;Kai-Hsiang Stanley Chen","doi":"10.1016/j.prdoa.2024.100259","DOIUrl":"10.1016/j.prdoa.2024.100259","url":null,"abstract":"","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"10 ","pages":"Article 100259"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590112524000306/pdfft?md5=36aa3aed0b45f1b11f58fcab7548d25e&pid=1-s2.0-S2590112524000306-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141136132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of Baduanjin on fine motor skills in mild and moderate Parkinson’s disease: A randomized controlled trial","authors":"Ke-Fan Li ,&nbsp;Jun Li ,&nbsp;A-Long Xia ,&nbsp;Xiao-Wei Wang ,&nbsp;Ai-Ling Wang ,&nbsp;Ying Shi ,&nbsp;Huai-Zhen Chen","doi":"10.1016/j.prdoa.2024.100276","DOIUrl":"10.1016/j.prdoa.2024.100276","url":null,"abstract":"<div><h3>Background</h3><div>Fine motor impairment is common in Parkinson’s disease (PD), which reduces patients’ quality of life. There are few suitable targeted treatments. We conducted a clinical trial to determine whether Baduanjin Qigong exercise would increase fine motor skills in PD patients.</div></div><div><h3>Methods</h3><div>Sixty PD patients (Hoehn-Yahr stage 1–4) with hand fine motor impairment were randomly assigned to the Baduanjin group and the physical activity group. Baduanjin group practiced Baduanjin exercise five times weekly for 40 min (warm-up 5 min, Baduanjin 30 min, cool-down 5 min). The usual physical activity groups maintained their habit of usual physical activities. The participants underwent assessments in the “ON” medication state at baseline and 4-week follow-up time points. The Purdue Pegboard Test (PPT) was used as the primary outcome to assess manual dexterity. The secondary outcomes included the Movement Disorders Society-Unified Parkinson’s Disease Rating Scale, part III (MDS-UPDRS III), and the Parkinson’s disease questionnaire (PDQ-39).</div></div><div><h3>Results</h3><div>The results of PPT revealed the Baduanjin group showed statistically significant improvement in the “non-dominant hand” and “assembly” scores compared to the usual physical activity group (P &lt; 0.05), but with no significant difference in “dominant hand” and “both hands” (P &gt; 0.05). Additionally, the Baduanjin group showed better performance in the PDQ-39 (P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Our study concludes that a 4-week Baduanjin exercise is effective in improving fine motor function and quality of life in patients with mild and moderate PD. The results suggest a promising intervention to be implemented in community or home settings for managing fine motor impairment in PD.</div></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"11 ","pages":"Article 100276"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two distinct degenerative types of nigrostriatal dopaminergic neuron in the early stage of parkinsonian disorders","authors":"Tomoya Kawazoe ,&nbsp;Keizo Sugaya ,&nbsp;Yasuhiro Nakata ,&nbsp;Masato Okitsu ,&nbsp;Kazushi Takahashi","doi":"10.1016/j.prdoa.2024.100242","DOIUrl":"https://doi.org/10.1016/j.prdoa.2024.100242","url":null,"abstract":"<div><h3>Introduction</h3><p>The present study characterized the degeneration of nigrostriatal dopaminergic neurons in the early stages of parkinsonian disorders using integrative neuroimaging analysis with neuromelanin-sensitive MRI and ¹²³I-FP-CIT dopamine transporter (DAT) SPECT.</p></div><div><h3>Methods</h3><p>Thirty-one, 30, and 29 patients with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS) with abnormal specific binding ratio (SBR) in either hemisphere (mean ± 2SD), and parkinsonism-predominant multiple system atrophy (MSA-P), respectively, were enrolled. Neuromelanin-related contrast (NRC) in the substantia nigra (NRC_SN) and locus coeruleus (NRC_LC) and the SBR of DAT SPECT were measured. All the patients underwent both examinations simultaneously within five years after symptom onset. After adjusting for interhemispheric asymmetry on neuromelanin-related MRI contrast using the Z-score, linear regression analysis of the NRC_SN and SBR was performed for the most- and least-affected hemispheres, as defined by the interhemispheric differences per variable (SBR, NRC_SN, standardized [SBR + NRC_SN]) in each patient.</p></div><div><h3>Results</h3><p>Although the variables did not differ significantly between PSP and CBS, a significant correlation was found for CBS in the most-affected hemisphere for all the definitions, including the clinically defined, most-affected hemisphere. No significant correlation was found between the NRC_SN and SBR for any of the definitions in either PSP or MSA-P.</p></div><div><h3>Conclusion</h3><p>Together with the findings of our previous study of dementia with Lewy bodies (DLB) and Parkinson’s disease (PD), the present findings indicated that neural degeneration in the disorders examined may be categorized by the significance of the NRC_SN-SBR correlation in PD and CBS and its non-significance in DLB, PSP, and MSA-P.</p></div>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"10 ","pages":"Article 100242"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590112524000112/pdfft?md5=d89ae4696309caa5d2726c1b349f3aa3&pid=1-s2.0-S2590112524000112-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139748811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in neurologists’ treatment preferences for Parkinson’s disease in the Netherlands","authors":"Constant V.M. Verschuur,&nbsp;Sven R. Suwijn,&nbsp;Rob M.A. de Bie","doi":"10.1016/j.prdoa.2024.100241","DOIUrl":"https://doi.org/10.1016/j.prdoa.2024.100241","url":null,"abstract":"","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"10 ","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590112524000100/pdfft?md5=1b7f827fc6a5844274e78dcd78055bf4&pid=1-s2.0-S2590112524000100-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139748812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micrographia after midbrain infarction alleviated by Japanese calligraphy-style writing: A case report","authors":"Kazutaka Sakamoto ,&nbsp;Kyungshil Kim ,&nbsp;Ryota Kobayashi ,&nbsp;Kayoko Yokoi ,&nbsp;Daichi Morioka ,&nbsp;Shinobu Kawakatsu ,&nbsp;Akihito Suzuki ,&nbsp;Kazumi Hirayama","doi":"10.1016/j.prdoa.2024.100257","DOIUrl":"https://doi.org/10.1016/j.prdoa.2024.100257","url":null,"abstract":"","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"10 ","pages":"Article 100257"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590112524000288/pdfft?md5=295faf277feba7e29dad4c9fbbd2e268&pid=1-s2.0-S2590112524000288-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140914062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}