Fujita Medical Journal最新文献_第6页

Agaritine derived from Agaricus blazei Murrill induces apoptosis via mitochondrial membrane depolarization in hematological tumor cell lines. 姬松茸碱通过线粒体膜去极化诱导血液学肿瘤细胞凋亡。

Fujita Medical Journal Pub Date : 2023-05-01 DOI: 10.20407/fmj.2022-021

Atsushi Ogasawara, Hiroki Doi, Taei Matsui, Etsuko Tokunaga, Masao Amakawa, Hidehiko Akiyama

{"title":"Agaritine derived from Agaricus blazei Murrill induces apoptosis via mitochondrial membrane depolarization in hematological tumor cell lines.","authors":"Atsushi Ogasawara, Hiroki Doi, Taei Matsui, Etsuko Tokunaga, Masao Amakawa, Hidehiko Akiyama","doi":"10.20407/fmj.2022-021","DOIUrl":"https://doi.org/10.20407/fmj.2022-021","url":null,"abstract":"Objectives: Agaritine (AGT) is a hydrazine-containing compound derived from the mushroom Agaricus blazei Murill. We previously reported the antitumor effect of AGT on hematological tumor cell lines and suggested that AGT induces apoptosis in U937 cells via caspase activation. However, the antitumor mechanism of AGT has not been fully understood.Methods: Four hematological tumor cell lines (K562, HL60, THP-1, H929) were used in this study. The cells were incubated in the presence of 50 μM AGT for 24 h and analyzed for cell viability, annexin V positivity, caspase-3/7 activity, mitochondrial membrane depolarization, cell cycle, DNA fragmentation, and the expression of mitochondrial membrane-associated proteins (Bax and cytochrome c).Results: In HL60, K562, and H929 cells, AGT reduced cell viability and increased annexin V- and dead cell-positive rates; however, it did not affect THP-1 cells. In K562 and HL60 cells, caspase-3/7 activity, mitochondrial membrane depolarization, and expression of mitochondrial membrane proteins, Bax and cytochrome c, were all increased by AGT. Cell cycle analysis showed that only K562 exhibited an increase in the proportion of cells in G2/M phase after the addition of AGT. DNA fragmentation was also observed after the addition of AGT.Conclusions: These results indicate that AGT induces apoptosis in K562 and HL60 cells, like U937 reported previously, but showed no effect on THP-1 cells. It was suggested that AGT-induced apoptosis involves the expression of Bax and cytochrome c via mitochondrial membrane depolarization.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"147-153"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9897496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of chronic gastric anisakiasis coexisting with early gastric cancer. 慢性胃异根菌病并发早期胃癌1例。

Fujita Medical Journal Pub Date : 2023-05-01 DOI: 10.20407/fmj.2022-010

Eiko Sakurai, Masaaki Okubo, Yutaka Tsutsumi, Tomoyuki Shibata, Tomomitsu Tahara, Yuka Kiriyama, Ayano Michiba, Naoki Ohmiya, Tetsuya Tsukamoto

{"title":"A case of chronic gastric anisakiasis coexisting with early gastric cancer.","authors":"Eiko Sakurai, Masaaki Okubo, Yutaka Tsutsumi, Tomoyuki Shibata, Tomomitsu Tahara, Yuka Kiriyama, Ayano Michiba, Naoki Ohmiya, Tetsuya Tsukamoto","doi":"10.20407/fmj.2022-010","DOIUrl":"https://doi.org/10.20407/fmj.2022-010","url":null,"abstract":"Background: Anisakiasis is a parasitic disease caused by the consumption of raw or undercooked fish that is infected with Anisakis third-stage larvae. In countries, such as Japan, Italy, and Spain, where people have a custom of eating raw or marinated fish, anisakiasis is a common infection. Although anisakiasis has been reported in the gastrointestinal tract in several countries, reports of anisakiasis accompanied by cancer are rare.Case presentation: We present the rare case of a 40-year-old male patient with anisakiasis coexisting with mucosal gastric cancer. Submucosal gastric cancer was suspected on gastric endoscopy and endoscopic ultrasonography. After laparoscopic distal gastrectomy, granulomatous inflammation with Anisakis larvae in the submucosa was pathologically revealed beneath mucosal tubular adenocarcinoma. Histological and immunohistochemical investigation showed cancer cells as intestinal absorptive-type cells that did not produce mucin.Conclusion: Anisakis larvae could have invaded the cancer cells selectively because of the lack of mucin in the cancerous epithelium. Anisakiasis coexisting with cancer is considered reasonable rather than coincidental. In cancer with anisakiasis, preoperative diagnosis may be difficult because anisakiasis leads to morphological changes in the cancer.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"163-169"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9897495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Laboratory analysis of glucose, fructose, and sucrose contents in Japanese common beverages for the exact assessment of beverage-derived sugar intake. 对日本普通饮料中葡萄糖、果糖和蔗糖含量的实验室分析，以准确评估饮料中糖的摄入量。

Fujita Medical Journal Pub Date : 2023-05-01 DOI: 10.20407/fmj.2022-009

Yoshitaka Ando, Yoshiji Ohta, Eiji Munetsuna, Hiroya Yamada, Yuki Nouchi, Itsuki Kageyama, Genki Mizuno, Mirai Yamazaki, Ryosuke Fujii, Hiroaki Ishikawa, Koji Suzuki, Shuji Hashimoto, Koji Ohashi

{"title":"Laboratory analysis of glucose, fructose, and sucrose contents in Japanese common beverages for the exact assessment of beverage-derived sugar intake.","authors":"Yoshitaka Ando, Yoshiji Ohta, Eiji Munetsuna, Hiroya Yamada, Yuki Nouchi, Itsuki Kageyama, Genki Mizuno, Mirai Yamazaki, Ryosuke Fujii, Hiroaki Ishikawa, Koji Suzuki, Shuji Hashimoto, Koji Ohashi","doi":"10.20407/fmj.2022-009","DOIUrl":"https://doi.org/10.20407/fmj.2022-009","url":null,"abstract":"Objectives: The adverse health effects of consuming sugar-sweetened beverages have been studied worldwide. However, no recent report on the actual sugar contents of Japanese sugar-sweetened beverages is available. Therefore, we analyzed the glucose, fructose, and sucrose contents of common Japanese beverages.Methods: The glucose, fructose, and sucrose contents of 49 beverages (8 energy drinks, 11 sodas, 4 fruit juices, 7 probiotic drinks, 4 sports drinks, 5 coffee drinks, 6 green tea drinks, and 4 black tea drinks) were determined using enzymatic methods.Results: Three zero calorie drinks, 2 sugarless coffee drinks, and 6 green tea drinks contained no sugar. Three coffee drinks contained only sucrose. The orders of median glucose, fructose, and sucrose contents in the categories of beverages containing sugars were as follows: for glucose, fruit juice > energy drink ≥ soda ≫ probiotic drink > black tea drink > sports drink; for fructose, probiotic drink ≥ energy drink > fruit juice > soda ≫ sports drink > black tea drink; and for sucrose, black tea drink > energy drink ≥ probiotic drink > fruit juice > soda > coffee drink ≫ sports drink. The total fructose as a percentage of the total sugar content in the 38 sugar-containing beverages was between 40% and 60%. The total sugar content analyzed was not always equivalent to the carbohydrate content indicated on the nutrition label.Conclusions: These results indicate that information on the actual sugar content of common Japanese beverages is necessary for the exact assessment of beverage-derived sugar intake.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"126-133"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9527524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dry loop-mediated isothermal amplification assay for detection of SARS-CoV-2 from clinical specimens. 干环介导等温扩增法检测临床标本中SARS-CoV-2。

Fujita Medical Journal Pub Date : 2023-05-01 DOI: 10.20407/fmj.2022-003

Yuki Higashimoto, Masaru Ihira, Yoshiki Kawamura, Masato Inaba, Kazuya Shirato, Tadaki Suzuki, Hideki Hasegawa, Tsutomu Kageyama, Yohei Doi, Tadayoshi Hata, Tetsushi Yoshikawa

{"title":"Dry loop-mediated isothermal amplification assay for detection of SARS-CoV-2 from clinical specimens.","authors":"Yuki Higashimoto, Masaru Ihira, Yoshiki Kawamura, Masato Inaba, Kazuya Shirato, Tadaki Suzuki, Hideki Hasegawa, Tsutomu Kageyama, Yohei Doi, Tadayoshi Hata, Tetsushi Yoshikawa","doi":"10.20407/fmj.2022-003","DOIUrl":"https://doi.org/10.20407/fmj.2022-003","url":null,"abstract":"Objectives: To establish a point-of-care test for coronavirus disease 2019 (COVID-19), we developed a dry loop-mediated isothermal amplification (LAMP) method to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA.Methods: We carried out reverse transcription (RT)-LAMP using the Loopamp SARS-CoV-2 Detection kit (Eiken Chemical, Tokyo, Japan). The entire mixture, except for the primers, is dried and immobilized inside the tube lid.Results: To determine the specificity of the kit, 22 viruses associated with respiratory infections, including SARS-CoV-2, were tested. The sensitivity of this assay, determined by either a real-time turbidity assay or colorimetric change of the reaction mixture, as evaluated by the naked eye or under illumination with ultraviolet light, was 10 copies/reaction. No LAMP product was detected in reactions performed with RNA from any pathogens other than SARS-CoV-2. After completing an initial validation analysis, we analyzed 24 nasopharyngeal swab specimens collected from patients suspected to have COVID-19. Of the 24 samples, 19 (79.2%) were determined by real-time RT-PCR analysis as being positive for SARS-CoV-2 RNA. Using the Loopamp SARS-CoV-2 Detection kit, we detected SARS-CoV-2 RNA in 15 (62.5%) of the 24 samples. Thus, the sensitivity, specificity, positive predictive value, and negative predictive values of the Loopamp 2019-CoV-2 detection reagent kit were 78.9%, 100%, 100%, and 55.6%, respectively.Conclusions: The dry LAMP method for detecting SARS-CoV-2 RNA is fast and easy to use, and its reagents can be stored at 4°C, solving the cold chain problem; thus, it represents a promising tool for COVID-19 diagnosis in developing countries.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"84-89"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9579739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Association of circulating histone H3 and high mobility group box 1 levels with postoperative prognostic indicators in intensive care unit patients: a single-center observational study. 重症监护病房患者循环组蛋白H3和高迁移率组盒1水平与术后预后指标的关系:一项单中心观察性研究

Fujita Medical Journal Pub Date : 2023-05-01 DOI: 10.20407/fmj.2022-008

Ken Sawada, Yasuyo Shimomura, Daisuke Hasegawa, Tatsuhiko Harada, Tomoyuki Nakamura, Naohide Kuriyama, Yoshitaka Hara, Hidefumi Komura, Osamu Nishida

{"title":"Association of circulating histone H3 and high mobility group box 1 levels with postoperative prognostic indicators in intensive care unit patients: a single-center observational study.","authors":"Ken Sawada, Yasuyo Shimomura, Daisuke Hasegawa, Tatsuhiko Harada, Tomoyuki Nakamura, Naohide Kuriyama, Yoshitaka Hara, Hidefumi Komura, Osamu Nishida","doi":"10.20407/fmj.2022-008","DOIUrl":"https://doi.org/10.20407/fmj.2022-008","url":null,"abstract":"Objectives: Damage associated molecular patterns (DAMPs) levels are associated with sepsis severity and prognosis. Histone and high mobility group box 1 (HMGB1) levels are also potential indicators of prognosis. We investigated the relationship between serum histone H3 and HMGB1 levels and the illness severity score and prognosis in postoperative patients.Methods: Postoperative serum histone H3 and HMGB1 levels in 39 intensive care unit (ICU) patients treated at our institution were measured. The correlation between peak histone H3 and HMGB1 levels in each patient and clinical data (age, sex, surgical time, length of ICU stay, and survival after ICU discharge), which also included the patients' illness severity score, was examined.Results: Histone H3 but not HMGB1 levels were positively correlated with surgical time, the Sequential Organ Failure Assessment score, the Japanese Association for Acute Medicine acute phase disseminated intravascular coagulation diagnosis score, and the length of ICU stay. Both histone H3 and HMGB1 levels were negatively correlated with age. However, survival post-ICU discharge was not correlated with histone H3 or HMGB1 levels.Conclusions: Histone H3 levels are correlated with severity scores and the length of ICU stay. Serum histone H3 and HMGB1 levels are elevated postoperatively. These DAMPs, however, are not prognostic indicators in postoperative ICU patients.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"95-100"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9881551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Objective assessment of nasal obstruction. 鼻塞的客观评价。

Fujita Medical Journal Pub Date : 2023-05-01 DOI: 10.20407/fmj.2021-029

Kensei Naito, Seiji Horibe, Yosuke Tanabe, Hisayuki Kato, Satoshi Yoshioka, Ichiro Tateya

{"title":"Objective assessment of nasal obstruction.","authors":"Kensei Naito, Seiji Horibe, Yosuke Tanabe, Hisayuki Kato, Satoshi Yoshioka, Ichiro Tateya","doi":"10.20407/fmj.2021-029","DOIUrl":"https://doi.org/10.20407/fmj.2021-029","url":null,"abstract":"There are many methods and types of equipment for measuring the nasal airway, but there is no consensus regarding the results of various clinical studies on nasal obstruction. In this review, we discuss the two major methods of objectively assessing the nasal airway: rhinomanometry and acoustic rhinometry. The Japanese standard of rhinomanometry in Japanese adults and children was established by the Japanese Standardization Committee on Rhinomanometry in 2001 and 2018, respectively. However, the International Standardization Committee has proposed different standards because of differences in race, equipment, and social health insurance systems. The standardization of acoustic rhinometry in Japanese adults is making progress in several Japanese institutes, but the international standardization of acoustic rhinometry has not yet begun. Rhinomanometry is the physiological expression of nasal airway breathing, whereas acoustic rhinometry is the anatomic expression. In this review, we introduce the history and methods of the objective assessment of nasal patency and the physiological and pathological issues regarding nasal obstruction.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"53-64"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9881552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective immunohistochemical analysis of human cytomegalovirus infection in the placenta and its association with fetal growth restriction. 胎盘中人巨细胞病毒感染及其与胎儿生长受限的关系的回顾性免疫组织化学分析。

Fujita Medical Journal Pub Date : 2023-05-01 DOI: 10.20407/fmj.2022-001

Yusuke Funato, Yuki Higashimoto, Yoshiki Kawamura, Yoshiko Sakabe, Minori Iwakura, Masaru Ihira, Kazuya Shiogama, Masafumi Miyata, Haruki Nishizawa, Takao Sekiya, Takuma Fujii, Isao Kosugi, Tetsushi Yoshikawa

{"title":"Retrospective immunohistochemical analysis of human cytomegalovirus infection in the placenta and its association with fetal growth restriction.","authors":"Yusuke Funato, Yuki Higashimoto, Yoshiki Kawamura, Yoshiko Sakabe, Minori Iwakura, Masaru Ihira, Kazuya Shiogama, Masafumi Miyata, Haruki Nishizawa, Takao Sekiya, Takuma Fujii, Isao Kosugi, Tetsushi Yoshikawa","doi":"10.20407/fmj.2022-001","DOIUrl":"https://doi.org/10.20407/fmj.2022-001","url":null,"abstract":"Objectives: Fetal human cytomegalovirus (HCMV) infection might be involved in fetal growth restriction (FGR). Maternal serostatus and the prevalence of congenital HCMV infection are affected by various factors, such as socioeconomic status and ethnicity. Therefore, the prevalence of congenital HCMV-related FGR should be examined in each region.Methods: Seventy-eight cases of FGR with delivery between January 2012 and January 2017 at Fujita Health University Hospital were studied. Twenty-one non-FGR cases were also included as a control group. Placental sections obtained from the FGR and control cases were immunostained with two primary antibodies for detecting immediate early antigens.Results: Nineteen placental samples from FGR cases with another etiology were excluded. Finally, 59 placental samples from FGR cases of unknown etiology were included in the pathological analysis. Four of 59 (6.8%) placental samples were positive for HCMV antigen. All four positive cases were stained with the M0854 antibody, and there were no positive case with the MAB810R antibody. Neither maternal nor infantile clinical features were different between the HCMV-positive and -negative FGR cases. A pathological examination showed a hematoma in three of four cases and infarction in two of four cases.Conclusions: HCMV antigen was detected in 6.8% of placental samples obtained from FGR cases without an obvious etiology. No remarkable maternal or neonatal clinical features discriminated HCMV-related FGR from FGR due to other causes. Vasculitis and inflammation might play important roles in the pathogenesis of HCMV-related FGR.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"90-94"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9897497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of in-hospital mortality in elderly patients with heart failure treated with tolvaptan. 托伐普坦治疗老年心力衰竭患者住院死亡率的预测因素

Fujita Medical Journal Pub Date : 2023-05-01 DOI: 10.20407/fmj.2021-027

Masakazu Kobayashi, Mutsuharu Hayashi, Ryo Yamada, Tomoya Ishiguro, Wakaya Fujiwara, Hideki Ishii, Hiroyuki Naruse, Eiichi Watanabe, Yukio Ozaki, Hideo Izawa

{"title":"Predictors of in-hospital mortality in elderly patients with heart failure treated with tolvaptan.","authors":"Masakazu Kobayashi, Mutsuharu Hayashi, Ryo Yamada, Tomoya Ishiguro, Wakaya Fujiwara, Hideki Ishii, Hiroyuki Naruse, Eiichi Watanabe, Yukio Ozaki, Hideo Izawa","doi":"10.20407/fmj.2021-027","DOIUrl":"https://doi.org/10.20407/fmj.2021-027","url":null,"abstract":"Objectives: We conducted an analysis of first-time tolvaptan users (≥80 years old) to determine the factors associated with the prognosis of elderly patients with heart failure.Methods: We retrospectively analyzed 66 consecutive patients with worsening heart failure (aged ≥80 years) who were admitted to Fujita Health University Bantane Hospital from 2011 to 2016 and treated with tolvaptan. Differences between the in-hospital death and survival groups were evaluated. Multivariate logistic regression analysis was also performed to identify the risk factors for mortality.Results: Sixty-six patients were included, and 26 patients died during the index hospitalization. The patients who died had a significantly higher prevalence of ischemic heart disease; a higher heart rate; higher levels of plasma C-reactive protein, blood urea nitrogen (BUN), and creatinine; a lower serum albumin level; and a lower estimated glomerular filtration rate than surviving patients. The proportion of patients requiring early initiation of tolvaptan treatment (within 3 days of admission) was significantly higher in surviving patients. On the basis of multivariate logistic regression analysis, although a high heart rate and high BUN levels were independent factors for in-hospital prognosis, they were not significantly associated with the early use of tolvaptan (≤3 days vs. ≥4 days; odds ratio=0.39; 95% confidence interval=0.07-2.21; p=0.29).Conclusions: This study revealed that a higher heart rate and higher BUN levels were independent factors for in-hospital prognosis in elderly patients who received tolvaptan and that early tolvaptan use may not always be effective in elderly patients.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"80-83"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9897498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of brain natriuretic peptide and urinary albumin as a predictor of cardiovascular-renal events in outpatients with chronic kidney disease. 脑利钠肽和尿白蛋白联合作为慢性肾病门诊患者心血管-肾脏事件的预测因子

Fujita Medical Journal Pub Date : 2023-05-01 DOI: 10.20407/fmj.2022-004

Shoya Oyama, Hiroshi Takahashi, Hiroki Hayashi, Shigehisa Koide, Shigeru Nakai, Kazuo Takahashi, Daijo Inaguma, Midori Hasegawa, Junichi Ishii, Yukio Yuzawa, Naotake Tsuboi

{"title":"Combination of brain natriuretic peptide and urinary albumin as a predictor of cardiovascular-renal events in outpatients with chronic kidney disease.","authors":"Shoya Oyama, Hiroshi Takahashi, Hiroki Hayashi, Shigehisa Koide, Shigeru Nakai, Kazuo Takahashi, Daijo Inaguma, Midori Hasegawa, Junichi Ishii, Yukio Yuzawa, Naotake Tsuboi","doi":"10.20407/fmj.2022-004","DOIUrl":"https://doi.org/10.20407/fmj.2022-004","url":null,"abstract":"Objectives: Cardiovascular and renal diseases are closely related. Brain natriuretic peptide (BNP) and urinary albumin are established predictors for cardiac and renal morbidities, respectively. To date, no reports have investigated the combined predictive value of BNP and urinary albumin for long-term cardiovascular-renal events in patients with chronic kidney disease (CKD). The aim of this study was to investigate this theme.Methods: Four hundred eighty-three patients with CKD were enrolled into this study and followed-up for 10 years. The endpoint was cardiovascular-renal events.Results: During the median follow-up period of 109 months, 221 patients developed cardiovascular-renal events. Log-transformed BNP and urinary albumin were identified as independent predictors for cardiovascular-renal events, with a hazard ratio of 2.59 (95% confidence interval [CI], 1.81-3.72) and 2.27 (95% CI, 1.82-2.84) for BNP and urinary albumin, respectively. For the combined variables, the group with high BNP and urinary albumin had a markedly higher risk (12.41-times; 95% CI 5.23-29.42) of cardiovascular-renal events compared with that of the group with low BNP and urinary albumin. Adding both variables to a predictive model with basic risk factors improved the C-index (0.767, 0.728 to 0.814, p=0.009), net reclassification improvement (0.497, p<0.0001), and integrated discrimination improvement (0.071, p<0.0001) more than each of them alone.Conclusions: This is the first report to demonstrate that the combination of BNP and urinary albumin can stratify and improve the predictability of long-term cardiovascular-renal events in CKD patients.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"105-112"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9897502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of folate and vitamin B12 deficiency in patients with normocytic anemia. 叶酸和维生素B12缺乏症与正常细胞性贫血的关系。

Fujita Medical Journal Pub Date : 2023-05-01 DOI: 10.20407/fmj.2022-016

Tatsuya Bando, Masutaka Tokuda, Itsuro Katsuda, Nobuhiko Emi, Akihiro Tomita

{"title":"Involvement of folate and vitamin B12 deficiency in patients with normocytic anemia.","authors":"Tatsuya Bando, Masutaka Tokuda, Itsuro Katsuda, Nobuhiko Emi, Akihiro Tomita","doi":"10.20407/fmj.2022-016","DOIUrl":"https://doi.org/10.20407/fmj.2022-016","url":null,"abstract":"Objectives: Deficiencies in folate (FA) and vitamin B12 (VB12) are causes of macrocytic anemia. However, in clinical practice, FA and/or VB12 deficiency can occur in patients with normocytic anemia. This study aimed to determine the prevalence of FA/VB12 deficiency in patients with normocytic anemia and the importance of vitamin replacement therapy in these patients.Methods: We retrospectively reviewed electronic medical record information of patients whose hemoglobin and serum FA/VB12 concentrations were measured at the Department of Hematology (N=1,388) and other departments (N=1,421) of Fujita Health University Hospital.Results: In the Hematology Department, 530 (38%) patients showed normocytic anemia. Of these, 49 (9.2%) had FA/VB12 deficiency. Twenty of 49 (41%) patients had some hematological malignancies and 27 (55%) had benign hematological disorders. Of the nine patients who received vitamin replacement therapy, one showed a partial improvement in the hemoglobin concentration of ≥1 g/dL.Conclusions: In the clinical setting, the measurement of FA/VB12 concentrations in patients with normocytic anemia may be useful. Replacement therapy may be a treatment option to consider in patients with low FA/VB12 concentrations. However, physicians need to pay attention to the presence of background diseases, and the mechanisms of this situation require further investigation.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"134-141"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9527527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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