Fujita Medical Journal最新文献

{"title":"Oral appliance therapy for obstructive sleep apnea: a retrospective study in a psychiatric sleep clinic.","authors":"Kota Funahashi,&nbsp;Marina Hirose,&nbsp;Suguru Kondo,&nbsp;Yoshimi Sano,&nbsp;Shiho Fujita,&nbsp;Nakao Iwata,&nbsp;Tsuyoshi Kitajima","doi":"10.20407/fmj.2022-023","DOIUrl":"https://doi.org/10.20407/fmj.2022-023","url":null,"abstract":"<p><strong>Objectives: </strong>We evaluated the continuity and effectiveness of oral appliances (OAs) for treating obstructive sleep apnea (OSA) in a psychiatric sleep clinic, specifically focusing on mild cases and those with psychiatric comorbidity.</p><p><strong>Methods: </strong>We retrospectively examined the medical records of 106 OSA patients treated with OA. Survival analysis was performed to assess the discontinuation of OA use. Clinical Global Impression-Improvement (CGI-I) scale were obtained from medical records. The apnea-hypopnea index (AHI), measured by polysomnography (PSG), and Epworth Sleepiness Scale (ESS) were compared between diagnosis and after post-OA treatment if a second PSG for efficacy assessment was conducted.</p><p><strong>Results: </strong>Among all 106 patients, Kaplan-Meier analysis estimated a discontinuation rate of 16.8% at 1 year. This tended to be higher for OSA patients with psychiatric comorbidity (22.7%) than those without (11.6%), though it was not statistically significant (<i>P</i>=0.08). The overall rate of improvement in CGI-I scale was 37.7% and was significantly lower in OSA patients with psychiatric comorbidity (25.0%) than those without (48.3%). Among the 74 patients who underwent a second PSG, AHI and ESS were significantly lower after OA treatment for the entire group and subgroups of OSA severity at diagnosis and psychiatric comorbidity, except for ESS in the moderate OSA severity subgroup.</p><p><strong>Conclusion: </strong>OA continuation was relatively good, and sleepiness was relieved by OA use, even in mild OSA patients and those with psychiatric comorbidity. However, the continuation and subjective improvement of symptoms were slightly lower in OSA patients with psychiatric comorbidity.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 3","pages":"218-224"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9956773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreas transplantation improves the quality of life of Japanese type 1 diabetes patients with diabetic kidney disease.","authors":"Chika Fujisawa-Tanaka,&nbsp;Izumi Hiratsuka,&nbsp;Megumi Shibata,&nbsp;Kei Kurihara,&nbsp;Naohiro Aida,&nbsp;Takeshi Takayanagi,&nbsp;Yusuke Seino,&nbsp;Taihei Ito,&nbsp;Takashi Kenmochi,&nbsp;Atsushi Suzuki","doi":"10.20407/fmj.2022-019","DOIUrl":"https://doi.org/10.20407/fmj.2022-019","url":null,"abstract":"<p><strong>Objectives: </strong>Type 1 diabetes mellitus (T1DM) patients with diabetic kidney disease-induced kidney failure have a significantly impaired quality of life (QOL), resulting in a high level of physical, mental, and social anxiety. In this study, we evaluated the QOL of T1DM patients on the list for pancreas transplantation (PTx) at their registration, and determined whether PTx improved their QOL.</p><p><strong>Methods: </strong>There were 58 patients (men/women, 22/36; mean age, 42.8±8.0 years) with T1DM and who were registered on the waiting list for PTx. Quantitative QOL assessment was performed using the Medical Health Survey Short Form (SF-36) version 2. Changes in the QOL before and after PTx were also examined in 24 of these patients.</p><p><strong>Results: </strong>The mean value of each endpoint and the summary score of the SF-36 physical (PCS), mental (MCS), and role (RCS) components were all below the national normal level at PTx registration. No significant difference in QOL scores was observed in the intergroup comparison of 35 patients on dialysis, 13 patients without dialysis, and ten patients after kidney transplantation. The 24 patients who underwent PTx showed improvement in PCS, MCS, and most SF-36 scores.</p><p><strong>Conclusion: </strong>T1DM patients waiting for PTx had a decreased QOL, regardless of dialysis, and PTx improved their QOL.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 3","pages":"194-199"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9963118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological findings affect quantitative values of single photon emission computed tomography in patients with antiresorptive agent-related osteonecrosis of the jaws.","authors":"Taro Okui,&nbsp;Yoshikazu Kobayashi,&nbsp;Madoka Isomura,&nbsp;Masakazu Tsujimoto,&nbsp;Koji Satoh,&nbsp;Hiroshi Toyama","doi":"10.20407/fmj.2022-025","DOIUrl":"https://doi.org/10.20407/fmj.2022-025","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the relationships between quantitative values calculated from bone single photon emission computed tomography/computed tomography (SPECT/CT) images and histopathological findings observed in surgical specimens from patients with antiresorptive agent-related osteonecrosis of the jaw (ARONJ); it sought to clarify histopathological factors that cause accumulation in bone SPECT/CT images of patients with ARONJ.</p><p><strong>Methods: </strong>This study included 81 pathological specimens of 21 lesions obtained from 18 patients with ARONJ who underwent SPECT/CT and jaw resection. The maximum standardized uptake value (SUV_max) of each volume of interest of the specimens was calculated using RAVAT^® software. The ratio of the SUV_max to the mean value of SUV_max in temporal bone was termed rSUV_max. The rSUV_max and pathological findings (sequestration, degree of fibrosis, degree of trabecular bone destruction, degree of inflammatory cell infiltration, and vascularity) were compared using the Mann-Whitney U test and the Kruskal-Wallis test.</p><p><strong>Results: </strong>In univariate analysis with rSUV_max as the dependent variable, the pathological findings of sequestration (P=0.058), degree of fibrosis (P=0.810), degree of trabecular bone destruction (P=0.237), degree of inflammatory cell infiltration (P=0.120), and vascularity (P=0.111) showed no significant difference among the groups for each variable.</p><p><strong>Conclusions: </strong>We found no association between quantitative values in bone SPECT/CT and histological changes in ARONJ, probably because bone SPECT/CT has limited spatial resolution. Limitations of this study may include the imaging findings of a decrease in tracer accumulation because of an involucrum of necrosed bone, various histopathological findings in ARONJ, and failure to consider the effect of preoperative anti-inflammatory treatment.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 3","pages":"186-193"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9963123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased levels of nectin-4 as a serological marker for pre-eclampsia.","authors":"Hikari Yoshizawa,&nbsp;Haruki Nishizawa,&nbsp;Mayuko Ito,&nbsp;Akiko Ohwaki,&nbsp;Yoshiko Sakabe,&nbsp;Takao Sekiya,&nbsp;Takuma Fujii,&nbsp;Hiroki Kurahashi","doi":"10.20407/fmj.2022-027","DOIUrl":"https://doi.org/10.20407/fmj.2022-027","url":null,"abstract":"<p><strong>Objectives: </strong>Nectin-4 is a cell adhesion molecule with vital functions at adherens and tight junctions. Cumulative evidence now indicates that the <i>NECTIN4</i> gene is overexpressed in a variety of cancers, and that the nectin-4 protein is both a disease marker and therapeutic target in a subset of these cancers. We previously demonstrated that <i>NECTIN4</i> is overexpressed in placenta during pre-eclamptic pregnancy, which is one of the most serious obstetric disorders.</p><p><strong>Methods: </strong>Nectin-4 protein levels were measured in maternal sera from pregnant women with pre-eclampsia and its related disorder, unexplained fetal growth retardation.</p><p><strong>Results: </strong>Maternal serum concentrations of nectin-4 were significantly elevated in pre-eclamptic women compared with those with an uncomplicated normotensive pregnancy. However, no increase was observed in pregnancies with unexplained fetal growth retardation. Serum nectin-4 levels were higher in cases with early-onset pre-eclampsia that generally showed more severe clinical symptoms, but levels were not correlated to other clinical indicators of disease severity.</p><p><strong>Conclusions: </strong>Nectin-4 is a potential new diagnostic and predictive biomarker for severe pre-eclampsia.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 3","pages":"200-205"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9968634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity of locomotive syndrome in surgical cervical spondylotic myelopathy patients: a cross-sectional study.","authors":"Kurenai Hachiya,&nbsp;Soya Kawabata,&nbsp;Takehiro Michikawa,&nbsp;Sota Nagai,&nbsp;Hiroki Takeda,&nbsp;Daiki Ikeda,&nbsp;Shinjiro Kaneko,&nbsp;Nobuyuki Fujita","doi":"10.20407/fmj.2022-035","DOIUrl":"https://doi.org/10.20407/fmj.2022-035","url":null,"abstract":"<p><strong>Objectives: </strong>Although cervical spondylotic myelopathy (CSM) has a marked impact on locomotive function, few studies have evaluated this relationship in terms of locomotive syndrome. Thus, we assessed (i) the stages of locomotive syndrome in preoperative CSM patients using the 25-question geriatric locomotive function scale (GLFS-25), (ii) the correlation between GLFS-25 scores and the Japanese orthopaedic association (JOA) scores or the JOA cervical myelopathy evaluation questionnaire (JOACMEQ) scores, and (iii) the factors associated with stage 3 locomotive syndrome in preoperative CSM patients.</p><p><strong>Methods: </strong>We used clinical data from 107 patients scheduled for cervical spinal surgery for CSM. Data were collected prior to surgery, and included age, gender, body mass index, medical history, JOA score, and JOACMEQ and GLFS-25 scores.</p><p><strong>Results: </strong>Of the included CSM patients, 93.5% were diagnosed with locomotive syndrome, of whom 77.6% were stage 3 according to GLFS-25 evaluation. For the correlation between GLFS-25 and JOA or JOACMEQ, the upper and lower extremity function scores of JOACMEQ and the JOA were strongly inversely correlated with the GLFS-25 score. Finally, multivariate analysis suggested that severe lower extremity status in the JOACMEQ was significantly associated with stage 3 locomotive syndrome in preoperative CSM patients.</p><p><strong>Conclusions: </strong>Using the GLFS-25, we found that lower extremity status had the strongest association with stage 3 locomotive syndrome in preoperative CSM patients. These findings are useful for preventing CSM patients from requiring future nursing care.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 3","pages":"246-252"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9956766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promotion of a venous thromboembolism prevention protocol at a perioperative management center.","authors":"Himuro Fujiwara,&nbsp;Chizuru Yamashita,&nbsp;Takahiro Kawaji,&nbsp;Tomoyuki Nakamura,&nbsp;Naohide Kuriyama,&nbsp;Yoshitaka Hara,&nbsp;Satoshi Komatsu,&nbsp;Minako Fukushima,&nbsp;Shinya Suzuki,&nbsp;Takaaki Tsutsumi,&nbsp;Osamu Nishida","doi":"10.20407/fmj.2022-024","DOIUrl":"https://doi.org/10.20407/fmj.2022-024","url":null,"abstract":"<p><strong>Objectives: </strong>Perioperative venous thromboembolism (VTE) is a potentially fatal complication, making preoperative VTE diagnosis and secondary thromboprophylaxis important. This study was performed to investigate the impact of promotion of a preoperative VTE protocol at a perioperative management center (PMC) on detecting the preoperative VTE rate and subsequent treatment.</p><p><strong>Methods: </strong>This retrospective study involved patients aged ≥20 years who underwent elective anesthesia. The patients were divided into two groups: the pre-PMC group (January to October 2014, before the opening of the PMC) and the post-PMC group (January to December 2019, after the opening of the PMC). The rates of preoperative lower-limb compression ultrasonography (CUS), VTE detection, anticoagulation therapy, and new postoperative pulmonary embolism (PE) were compared between the two groups.</p><p><strong>Results: </strong>The pre-PMC and post-PMC groups comprised 3737 and 5388 patients, respectively. The preoperative CUS and VTE detection rates were significantly higher in the post-PMC than pre-PMC group (7.2% and 1.43% vs. 25.6% and 3.93%, respectively; P<0.001). There was no significant difference in the rate of anticoagulation therapy in patients with preoperative VTE (88.9% vs. 84.7%, P=0.43). Heparin and direct oral anticoagulants were primarily used in the pre-PMC and post-PMC groups, respectively. The efficacy and safety were comparable between the two groups. No new postoperative PE was detected in either group.</p><p><strong>Conclusions: </strong>Promotion of the preoperative VTE protocol led by the PMC increased the rates of preoperative CUS and preoperative VTE detection. This may aid in secondary thromboprophylaxis in the preoperative period and prevention of postoperative PE.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 3","pages":"179-185"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9963116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of fat emulsion administration on blood coagulation in terminal lung cancer patients.","authors":"Takaki Kanie,&nbsp;Akihiko Futamura,&nbsp;Tomohiro Mizuno,&nbsp;Shigeki Yamada,&nbsp;Masanobu Usui","doi":"10.20407/fmj.2021-012","DOIUrl":"https://doi.org/10.20407/fmj.2021-012","url":null,"abstract":"<p><strong>Objectives: </strong>Patients with cancer, especially those with lung cancer, are at high risk of developing thrombosis. Intralipos^® infusion 20% is contraindicated for thrombosis, and there is no consensus on whether it can be safely used in cases of advanced cancer. We conducted a retrospective observational study to elucidate the impact of fat emulsion administration on blood coagulation in patients with terminal lung cancer.</p><p><strong>Methods: </strong>The subjects were patients with terminal lung cancer in the Department of Surgery and Palliative Medicine, Fujita Health University Nanakuri Memorial Hospital between January 2016 and December 2019. We compared changes in their blood coagulation profile before hospitalization and one month later.</p><p><strong>Results: </strong>There were a total of 213 patients with lung cancer-139 who were administered fat emulsion and 74 who were not-with no significant differences in baseline characteristics. In the fat emulsion administration group (n=27), the prothrombin time-international normalized ratio (PT-INR) and activated partial thromboplastin time (APTT), respectively, were 1.17±0.26 (mean±standard deviation) and 30.5±5.0 s at hospitalization and 1.16±0.12 and 31.2±4.2 s one month later with no significant differences. In the non-administration group (n=6), the PT-INR and APTT, respectively, were 1.44±0.43 and 30.6±5.2 s before hospitalization and 1.28±0.18 and 33.0±7.5 s one month later with no significant differences.</p><p><strong>Conclusions: </strong>We did not identify any changes in PT-INR and APTT after fat emulsion administration in patients with terminal lung cancer. There were also no new cases of thrombosis, suggesting that fat emulsions were administered safely in patients with terminal lung cancer.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"73-79"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9527526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agaritine derived from <i>Agaricus blazei</i> Murrill induces apoptosis via mitochondrial membrane depolarization in hematological tumor cell lines.","authors":"Atsushi Ogasawara,&nbsp;Hiroki Doi,&nbsp;Taei Matsui,&nbsp;Etsuko Tokunaga,&nbsp;Masao Amakawa,&nbsp;Hidehiko Akiyama","doi":"10.20407/fmj.2022-021","DOIUrl":"https://doi.org/10.20407/fmj.2022-021","url":null,"abstract":"<p><strong>Objectives: </strong>Agaritine (AGT) is a hydrazine-containing compound derived from the mushroom <i>Agaricus blazei</i> Murill. We previously reported the antitumor effect of AGT on hematological tumor cell lines and suggested that AGT induces apoptosis in U937 cells via caspase activation. However, the antitumor mechanism of AGT has not been fully understood.</p><p><strong>Methods: </strong>Four hematological tumor cell lines (K562, HL60, THP-1, H929) were used in this study. The cells were incubated in the presence of 50 μM AGT for 24 h and analyzed for cell viability, annexin V positivity, caspase-3/7 activity, mitochondrial membrane depolarization, cell cycle, DNA fragmentation, and the expression of mitochondrial membrane-associated proteins (Bax and cytochrome c).</p><p><strong>Results: </strong>In HL60, K562, and H929 cells, AGT reduced cell viability and increased annexin V- and dead cell-positive rates; however, it did not affect THP-1 cells. In K562 and HL60 cells, caspase-3/7 activity, mitochondrial membrane depolarization, and expression of mitochondrial membrane proteins, Bax and cytochrome c, were all increased by AGT. Cell cycle analysis showed that only K562 exhibited an increase in the proportion of cells in G₂/M phase after the addition of AGT. DNA fragmentation was also observed after the addition of AGT.</p><p><strong>Conclusions: </strong>These results indicate that AGT induces apoptosis in K562 and HL60 cells, like U937 reported previously, but showed no effect on THP-1 cells. It was suggested that AGT-induced apoptosis involves the expression of Bax and cytochrome c via mitochondrial membrane depolarization.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"147-153"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9897496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of chronic gastric anisakiasis coexisting with early gastric cancer.","authors":"Eiko Sakurai,&nbsp;Masaaki Okubo,&nbsp;Yutaka Tsutsumi,&nbsp;Tomoyuki Shibata,&nbsp;Tomomitsu Tahara,&nbsp;Yuka Kiriyama,&nbsp;Ayano Michiba,&nbsp;Naoki Ohmiya,&nbsp;Tetsuya Tsukamoto","doi":"10.20407/fmj.2022-010","DOIUrl":"https://doi.org/10.20407/fmj.2022-010","url":null,"abstract":"<p><strong>Background: </strong>Anisakiasis is a parasitic disease caused by the consumption of raw or undercooked fish that is infected with <i>Anisakis</i> third-stage larvae. In countries, such as Japan, Italy, and Spain, where people have a custom of eating raw or marinated fish, anisakiasis is a common infection. Although anisakiasis has been reported in the gastrointestinal tract in several countries, reports of anisakiasis accompanied by cancer are rare.</p><p><strong>Case presentation: </strong>We present the rare case of a 40-year-old male patient with anisakiasis coexisting with mucosal gastric cancer. Submucosal gastric cancer was suspected on gastric endoscopy and endoscopic ultrasonography. After laparoscopic distal gastrectomy, granulomatous inflammation with <i>Anisakis</i> larvae in the submucosa was pathologically revealed beneath mucosal tubular adenocarcinoma. Histological and immunohistochemical investigation showed cancer cells as intestinal absorptive-type cells that did not produce mucin.</p><p><strong>Conclusion: </strong><i>Anisakis</i> larvae could have invaded the cancer cells selectively because of the lack of mucin in the cancerous epithelium. Anisakiasis coexisting with cancer is considered reasonable rather than coincidental. In cancer with anisakiasis, preoperative diagnosis may be difficult because anisakiasis leads to morphological changes in the cancer.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"163-169"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9897495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory analysis of glucose, fructose, and sucrose contents in Japanese common beverages for the exact assessment of beverage-derived sugar intake.","authors":"Yoshitaka Ando,&nbsp;Yoshiji Ohta,&nbsp;Eiji Munetsuna,&nbsp;Hiroya Yamada,&nbsp;Yuki Nouchi,&nbsp;Itsuki Kageyama,&nbsp;Genki Mizuno,&nbsp;Mirai Yamazaki,&nbsp;Ryosuke Fujii,&nbsp;Hiroaki Ishikawa,&nbsp;Koji Suzuki,&nbsp;Shuji Hashimoto,&nbsp;Koji Ohashi","doi":"10.20407/fmj.2022-009","DOIUrl":"https://doi.org/10.20407/fmj.2022-009","url":null,"abstract":"<p><strong>Objectives: </strong>The adverse health effects of consuming sugar-sweetened beverages have been studied worldwide. However, no recent report on the actual sugar contents of Japanese sugar-sweetened beverages is available. Therefore, we analyzed the glucose, fructose, and sucrose contents of common Japanese beverages.</p><p><strong>Methods: </strong>The glucose, fructose, and sucrose contents of 49 beverages (8 energy drinks, 11 sodas, 4 fruit juices, 7 probiotic drinks, 4 sports drinks, 5 coffee drinks, 6 green tea drinks, and 4 black tea drinks) were determined using enzymatic methods.</p><p><strong>Results: </strong>Three zero calorie drinks, 2 sugarless coffee drinks, and 6 green tea drinks contained no sugar. Three coffee drinks contained only sucrose. The orders of median glucose, fructose, and sucrose contents in the categories of beverages containing sugars were as follows: for glucose, fruit juice > energy drink ≥ soda ≫ probiotic drink > black tea drink > sports drink; for fructose, probiotic drink ≥ energy drink > fruit juice > soda ≫ sports drink > black tea drink; and for sucrose, black tea drink > energy drink ≥ probiotic drink > fruit juice > soda > coffee drink ≫ sports drink. The total fructose as a percentage of the total sugar content in the 38 sugar-containing beverages was between 40% and 60%. The total sugar content analyzed was not always equivalent to the carbohydrate content indicated on the nutrition label.</p><p><strong>Conclusions: </strong>These results indicate that information on the actual sugar content of common Japanese beverages is necessary for the exact assessment of beverage-derived sugar intake.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 2","pages":"126-133"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9527524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}