Clocks & Sleep最新文献_第7页

Deletion of Clock Gene Period1 (Per1) in Neurons but Not in Astrocytes Shortens Clock Period and Diminishes Light-Mediated Rapid Phase Advances in Mice. 在小鼠神经元中删除时钟基因周期1 (Per1)，而在星形胶质细胞中不删除，可缩短时钟周期并减少光介导的快速相位推进。

IF 3.2

Clocks & Sleep Pub Date : 2026-02-23 DOI: 10.3390/clockssleep8010009

Dan-Adrian Epuran, Urs Albrecht

{"title":"Deletion of Clock Gene Period1 (Per1) in Neurons but Not in Astrocytes Shortens Clock Period and Diminishes Light-Mediated Rapid Phase Advances in Mice.","authors":"Dan-Adrian Epuran, Urs Albrecht","doi":"10.3390/clockssleep8010009","DOIUrl":"10.3390/clockssleep8010009","url":null,"abstract":"The circadian clock enables organisms to anticipate daily recurring events and synchronize their internal rhythms with environmental cues, such as light, aligning with the day/night cycle. Central to the molecular mechanisms of the circadian clock and light sensing are the Period (Per) 1 and 2 genes. While the roles of Per2 in astrocytes and neurons have been characterized, the specific contributions of Per1 remain less understood. Previous research has shown that Per2 in neurons, but not astrocytes, influences phase shifts, whereas the regulation of the circadian period involves Per2 in both cell types. In this study, we investigated the role of Per1 in neurons and astrocytes in modulating the circadian period and phase shifts. Using an Aschoff Type I protocol (constant darkness) combined with 15 min light pulses at circadian times (CT) 10, 14, and 22, we found that the absence of Per1 in neurons-but not in astrocytes-significantly affected both the circadian period and phase advance shifts in response to light at CT22.","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"8 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13025491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147532905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of Research Protocols Assessing Sleep and Circadian Rhythms in Challenging Real-Life Settings: A Critical Appraisal of a Study Protocol, Including Researchers' Reflections and Participants' Perspectives. 在具有挑战性的现实环境中评估睡眠和昼夜节律的研究方案的实施：对一项研究方案的批判性评估，包括研究人员的反思和参与者的观点。

IF 3.2

Clocks & Sleep Pub Date : 2026-02-09 DOI: 10.3390/clockssleep8010007

Carina Fernandes, Ema Leite, Joana E Coelho, Cátia Reis

{"title":"Implementation of Research Protocols Assessing Sleep and Circadian Rhythms in Challenging Real-Life Settings: A Critical Appraisal of a Study Protocol, Including Researchers' Reflections and Participants' Perspectives.","authors":"Carina Fernandes, Ema Leite, Joana E Coelho, Cátia Reis","doi":"10.3390/clockssleep8010007","DOIUrl":"10.3390/clockssleep8010007","url":null,"abstract":"Sleep and circadian research in real-life environments is challenging but essential. This study presents the design and implementation of a data-collection protocol in a highly challenging real-life setting over 56 days, examining both researchers' and participants' perspectives on its strengths, limitations, and key challenges, and highlighting the lessons learned relevant to future studies in similar contexts. Thirty military submariners completed a questionnaire after the 56-day pre-mission, mission, and post-mission data collection to assess their views on the study and each task. Compliance with measurements (questionnaires, diaries, actigraphy, and blood collections) was quantified and correlated with participants' answers. Mean global satisfaction was 3.57 ± 0.77 (0-5 scale) and declined across study phases, with a significant change only in the post-mission phase (p < 0.001). Higher work satisfaction correlated with better global study satisfaction (ρ = 0.396; p = 0.030). Diaries were rated the most burdensome task, while blood collections generated the most polarized responses. Compliance with continuous measurements was high, but these also decreased in the third phase of the study, significantly for actigraphy (p < 0.001), although without clear predictors, including satisfaction. In this extreme setting, satisfaction and compliance declined significantly in the final phase of the study, without clear predictive factors. Having different engagement strategies for different work shifts is also an important consideration for future studies.","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"8 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12922145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Effects of Melanopic-Enhanced Classroom Lighting on Sleep, Mood, and Cognition in Male Korean Adolescents: A Field-Based Pilot Study. 黑视增强教室照明对韩国男性青少年睡眠、情绪和认知的实际影响：一项基于实地的试点研究。

IF 3.2

Clocks & Sleep Pub Date : 2026-01-30 DOI: 10.3390/clockssleep8010006

Sumin Bae, Eunji Hwang, Ki-Young Jung

{"title":"Real-World Effects of Melanopic-Enhanced Classroom Lighting on Sleep, Mood, and Cognition in Male Korean Adolescents: A Field-Based Pilot Study.","authors":"Sumin Bae, Eunji Hwang, Ki-Young Jung","doi":"10.3390/clockssleep8010006","DOIUrl":"10.3390/clockssleep8010006","url":null,"abstract":"Light exposure profoundly influences human emotions and physiology. Yet, adolescents spend considerable time under artificial indoor lighting. Reduced daytime light exposure delays the circadian clock, negatively affecting sleep, cognition, and mood. This pilot study examined whether 470-490 nm enhanced LED lighting modulates mood, sleep quality, and attention among 65 male Korean high school students (mean age = 15.4 years) who participated in a two-week intervention. Both groups were exposed to natural daylight, but the experimental group additionally used LED lighting enriched in the 470-490 nm wavelength range, whereas the control group used LED lighting without modified spectral characteristics. Students were exposed to the assigned lighting from 08:00 to 17:00 during regular school hours for two consecutive weeks. To evaluate the effects of the two-week intervention, pre- and post-assessments included the Beck Depression Inventory (BDI-II), the Richards-Campbell Sleep Questionnaire (RCSQ), the Epworth Sleepiness Scale (ESS), the Perceived Stress Scale (PSS), and the Frankfurter Attention Inventory (FAIR), administered twice at each assessment point. The linear mixed-effect model showed a significant time × group interaction for line errors in the first FAIR trial (F (1, 52) = 5.21, p = 0.027, η2 partial = 0.09), suggesting a greater relative reduction in attentional errors in the experimental group compared with the control group. No significant effects were observed for sleep- or mood-related outcomes. These results indicate the potential relevance of wavelength-optimized lighting in educational settings where sustained attention is critical. Future studies with larger samples and longer interventions are required to confirm and extend these findings.","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"8 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12922084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep Complaints in the Psychiatric Hospital: A Qualitative Study of Nurses and Psychiatrists' Approaches to Sleep Management in a Swiss Psychiatric Hospital. 精神病院的睡眠投诉：瑞士一家精神病院护士和精神科医生睡眠管理方法的定性研究。

IF 3.2

Clocks & Sleep Pub Date : 2026-01-20 DOI: 10.3390/clockssleep8010005

Maria Dalmau I Ribas, Geoffroy Solelhac, José Haba-Rubio, Julien Elowe, Véronique Griffith

{"title":"Sleep Complaints in the Psychiatric Hospital: A Qualitative Study of Nurses and Psychiatrists' Approaches to Sleep Management in a Swiss Psychiatric Hospital.","authors":"Maria Dalmau I Ribas, Geoffroy Solelhac, José Haba-Rubio, Julien Elowe, Véronique Griffith","doi":"10.3390/clockssleep8010005","DOIUrl":"10.3390/clockssleep8010005","url":null,"abstract":"Insomnia symptoms are very common among psychiatric inpatients and can increase the risk of suicide in this population. However, little is known about how psychiatrists and nurses manage insomnia symptoms in psychiatric inpatients. This study aimed to investigate the views, opinions, and experiences of psychiatrists and nurses regarding inpatients' sleep complaints in a Swiss psychiatric hospital. This qualitative study used individual semi-structured interviews with a purposive sample of psychiatrists and nurses working in a Swiss psychiatric hospital. Interviews were audio-recorded, transcribed verbatim, and analysed manually using inductive thematic analysis. Ten participants (six psychiatrists and four nurses) were interviewed. Three overarching themes were identified: identifying and classifying sleep complaints, the decision-making process, and the actions taken to respond to the complaint. Insomnia symptoms were approached by psychiatrists and nurses in a highly heterogeneous, non-evidence-based manner, with a lack of adaptation of CBT-I leading to overmedication. This heterogeneity may be explained by the diversity of underlying problems associated with insomnia symptoms, the lack of hospital-specific guidelines, and the fact that current guidelines focus mainly on chronic insomnia and do not fully account for the complexity of psychiatric inpatients.","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"8 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Obstructive Sleep Apnea and Adherence to CPAP for TAXI Drivers. 出租车司机阻塞性睡眠呼吸暂停的患病率和CPAP的依从性。

IF 2.1

Clocks & Sleep Pub Date : 2026-01-07 DOI: 10.3390/clockssleep8010004

Yik Hin Chan, Anastasya Maria Kosasih, Venetia Kok, Yi-Hui Ou, Yun Jing Crystal Chng, Joshua J Gooley, Chi-Hang Lee

{"title":"Prevalence of Obstructive Sleep Apnea and Adherence to CPAP for TAXI Drivers.","authors":"Yik Hin Chan, Anastasya Maria Kosasih, Venetia Kok, Yi-Hui Ou, Yun Jing Crystal Chng, Joshua J Gooley, Chi-Hang Lee","doi":"10.3390/clockssleep8010004","DOIUrl":"10.3390/clockssleep8010004","url":null,"abstract":"We investigated the effects of Continuous Positive Airway Pressure (CPAP) on blood pressure (BP) and vigilance in taxi drivers with obstructive sleep apnea (OSA). This pilot study recruited taxi drivers aged ≥60 years to undergo polysomnography. Those diagnosed with OSA underwent 6 months of CPAP therapy. Baseline and follow-up assessments included 24 h ambulatory blood pressure monitoring (ABPM) and the psychomotor vigilance test (PVT). Among the 32 participants, 22 (68.8%) were diagnosed with OSA (median age 63.0 [62.0-65.0] years; 21 males). The average CPAP adherence was 3.1 ± 2.3 h per night, with 23.5% using CPAP for more than 4 h per night. There were no significant changes in 24 h mean systolic ABPM (125.9 [116.8-134.9] mmHg to 126.0 [118.3-133.7] mmHg; p = 0.93) or reaction times measured by PVT (2.0 [0.0-3.0] lapses to 2.0 [1.0-3.0] lapses; p = 0.82) after CPAP therapy. A high prevalence of OSA was observed among taxi drivers. CPAP adherence was suboptimal and did not result in significant improvements in BP or vigilance.","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

People Living in Places with Limited Illuminance Declare Better Health and Higher Quality of Life in Environmental and Physical Domains. 生活在照明有限的地方的人们在环境和物理领域声称更健康和更高的生活质量。

IF 2.1

Clocks & Sleep Pub Date : 2026-01-05 DOI: 10.3390/clockssleep8010003

Jolanta Malinowska-Borowska, Anna Czupryna, Marta Buczkowska, Aleksandra Kulik

{"title":"People Living in Places with Limited Illuminance Declare Better Health and Higher Quality of Life in Environmental and Physical Domains.","authors":"Jolanta Malinowska-Borowska, Anna Czupryna, Marta Buczkowska, Aleksandra Kulik","doi":"10.3390/clockssleep8010003","DOIUrl":"10.3390/clockssleep8010003","url":null,"abstract":"Background: Exposure to artificial light at night can lead to circadian disruption and health risks. It can cause mood swings, confusion, and depression. The aim of this cross-sectional study was to assess the relationship between the illuminance of urban lighting and the health of residents.Methods: This study was carried out among residents of two similar towns, one with typical street lighting and a Dark Sky Park characterized by reduced lighting. A total of 272 respondents participated in this study. A self-administered questionnaire and the WHOQOL-BREF were used among the respondents.Results: People living in the Dark Sky Park were more likely to be satisfied with their sleep (p < 0.001). In fact, 58.7% of Dark Sky Park residents reported no sleep problems. In the control town, only 49.25% did (p = 0.04). The sleep duration was similar in the two towns, but Dark Sky Park residents were statistically less likely to use sleeping pills and window blinds. People exposed to typical street lighting at night reported suffering from eye diseases, cardiovascular diseases, and mood changes more often than those living in the Dark Sky Park. The environmental and physical quality of life, as measured by the WHOQOL-BREF, were significantly higher in the Dark Sky Park residents than in the control town (p < 0.05).Conclusions: People living in places with limited illuminance declare better health and a higher quality of life in the physical and environmental domains.","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thirty-Sixth Annual Meeting of the Society for Light, Rhythms, and Circadian Health (SLRCH), 14-16 June, Boston, MA, USA. 第36届光、节奏和昼夜健康学会年会（SLRCH）， 6月14-16日，美国马萨诸塞州波士顿。

IF 2.1

Clocks & Sleep Pub Date : 2025-12-31 DOI: 10.3390/clockssleep8010002

Corrado Garbazza

引用次数: 0

Late-Night Feeding, Sleep Disturbance, and Nocturnal Congestion Mediated by Hyperglycemia, Renal Sodium Retention, and Cortisol: A Narrative Review. 深夜进食、睡眠障碍和夜间充血由高血糖、肾钠潴留和皮质醇介导：叙述性综述。

IF 2.1

Clocks & Sleep Pub Date : 2025-12-24 DOI: 10.3390/clockssleep8010001

Ronald B Brown

{"title":"Late-Night Feeding, Sleep Disturbance, and Nocturnal Congestion Mediated by Hyperglycemia, Renal Sodium Retention, and Cortisol: A Narrative Review.","authors":"Ronald B Brown","doi":"10.3390/clockssleep8010001","DOIUrl":"10.3390/clockssleep8010001","url":null,"abstract":"Late-night feeding, defined in the present review as feeding after 8:00 pm when evening insulin secretion and sensitivity are low, is increasingly prevalent in Western society and is recognized as a disruptor of metabolic homeostasis. Yet health problems related to late-night feeding are largely ignored in time-restricted feeding studies that generally do not extend past an 8:00 pm feeding window. This paper proposes a novel cascade linking late-night hyperglycemia with sleep disturbances and nasal congestion mediated by renal sodium retention, increased plasma osmolarity, and stress hormone release by hypothalamic-pituitary-adrenal axis activation. The narrative describes the circadian decline in insulin sensitivity, which amplifies postprandial glucose surges following late-night feeding. Elevated glucose levels drive renal glucose reabsorption via sodium-glucose cotransporters, promoting sodium retention independent of insulin. Increased sodium retention raises extracellular osmolarity, activating hypothalamic osmoreceptors and stimulating the hypothalamic-pituitary-adrenal axis. Cortisol release promotes alertness, while fluid retention and mucosal edema contribute to nasal congestion and early waking. Supine fluid redistribution during sleep further exacerbates airway narrowing, increasing the risk of sleep fragmentation and obstructive sleep apnea. The present paper fills a gap in current time-restricted feeding literature by integrating renal, osmotic, and neuroendocrine pathways that may be overlooked as underlying mechanisms of dysregulated glucose control and hormone dysfunction. Reviewed evidence suggests that symptoms such as nocturnal congestion and sleep disruption are not merely incidental to late-night feeding but frame late night feeding as a risk factor with underlying physiological stressors that could contribute to cardiometabolic risk.","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"8 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Digital Cognitive Behavioral Therapy for Insomnia on Self-Reported Sleep Parameters: Systematic Review and Meta-Analysis. 数字认知行为疗法对失眠症患者自我报告睡眠参数的影响：系统回顾和meta分析。

IF 3.2

Clocks & Sleep Pub Date : 2025-12-08 DOI: 10.3390/clockssleep7040069

Ingrid Porto Araújo Leite, Viviane Akemi Kakazu, Lucca Andrade Teixeira de Carvalho, Sergio Tufik, Gabriel Natan Pires

{"title":"Effects of Digital Cognitive Behavioral Therapy for Insomnia on Self-Reported Sleep Parameters: Systematic Review and Meta-Analysis.","authors":"Ingrid Porto Araújo Leite, Viviane Akemi Kakazu, Lucca Andrade Teixeira de Carvalho, Sergio Tufik, Gabriel Natan Pires","doi":"10.3390/clockssleep7040069","DOIUrl":"10.3390/clockssleep7040069","url":null,"abstract":"Digital Cognitive Behavioral Therapy for Insomnia (dCBT-I) is an effective alternative to therapist-delivered CBT-I. However, there is a lack of meta-analyses assessing its effects on other sleep-related outcomes. We aimed to conduct a meta-analysis of randomized controlled trials (RCTs) evaluating dCBT-I in adults with insomnia through polysomnography (PSG) and sleep diary. Systematic searches were performed in PubMed and Web of Science. The outcomes considered were total sleep time (TST), sleep onset latency (SOL), sleep efficiency (SE), wake after sleep onset (WASO), and number of awakenings (NWAK). Meta-analyses were performed using random-effects models to compare dCBT-I with active (in-person or telehealth CBT-I) or inactive (waiting list, no treatment, or minimal intervention) control groups. Of the fourteen RCTs included, only three employed an active control. As no trials used PSG, the analyses relied solely on sleep diary data. DCBT-I showed no statistically significant differences from active controls, indicating comparable effects with therapist-delivered CBT-I. In contrast, it demonstrated statistically significant effects against inactive controls; TST increased by 0.20 h, SOL decreased by 15.53 min, SE improved by 7.91%, WASO reduced by 15.61 min, and NWAK decreased by 0.53. Future research should prioritize comparisons with therapist-delivered CBT-I and incorporate PSG for measuring these parameters.","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"7 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12731755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing Infant Mattresses Tailored to Developmental Sleep Characteristics: A Comprehensive Review. 设计适合发育性睡眠特征的婴儿床垫：一项综合综述。

IF 2.1

Clocks & Sleep Pub Date : 2025-12-08 DOI: 10.3390/clockssleep7040070

Yasunori Oka, Akiko Tange, Yuki Maeda

引用次数: 0