Infection Prevention in Practice最新文献

{"title":"Pharmacist-led antimicrobial stewardship program in the treatment of Staphylococcus aureus bacteraemia in paediatric patients: a multivariate analysis","authors":"Stella Caroline Schenidt Bispo da Silva ,&nbsp;Mariana Millan Fachi ,&nbsp;Marinei Campos Ricieri ,&nbsp;Fábio de Araújo Motta","doi":"10.1016/j.infpip.2024.100419","DOIUrl":"10.1016/j.infpip.2024.100419","url":null,"abstract":"<div><h3>Background</h3><div>Care bundles are a recognised strategy to improve treatment. When managed through an Antimicrobial Stewardship Program (ASP) based on the pharmacist-led program model, care bundles can be an effective tool to guide decision making in clinical practice and to improve patient outcomes. This study aimed to evaluate the results of a pharmacist-led ASP which included a care bundle based on clinical outcomes of <em>Staphylococcus aureus</em> bacteraemia (SAB) in a paediatric hospital.</div></div><div><h3>Methods</h3><div>A retrospective cohort study with multivariate analysis was conducted in a paediatric hospital in Brazil. The study comprised 120 paediatric patients with a positive blood culture for <em>S. aureus</em> with occurred between 2014 and 2021 and clinical and laboratory results consistent with infection. The study was classified into two periods: pre-intervention (n=44) and intervention (n=76). A pharmacist-led ASP program with a care bundle was established during the intervention period 2017–2021. The primary outcome assessed was the impact on clinical outcomes, including infection-related mortality and 90-day reinfection rate, both being considered therapeutic failure.</div></div><div><h3>Results</h3><div>The multivariate analysis demonstrated that the following variables had an impact on primary outcome: infant patients [Odds ratio (OR) 12.998, <em>P</em>=0.044]; use of more than three antimicrobial treatment regimens [OR 0.006, <em>P</em>=0.017]; intervention period [OR 0.060, <em>P</em>=0.034]; bundle item 1 – follow-up blood culture [OR 18.953, <em>P</em>=0.049]; bundle item 2 – early source control [OR 0.002, <em>P</em>=0.018]; bundle item 4 – de-escalation to oxacillin for methicillin-sensitive <em>S. aureus</em> [OR 0.041, <em>P</em>=0.046].</div></div><div><h3>Conclusions</h3><div>The pharmacist-led ASP model showed an increase in adherence to the care bundle between the two study periods, with reduced probability of a negative outcome. Furthermore, risk factors for <em>S. aureus</em> bacteraemia were identified that may inform management and contribute to better patient outcomes in the paediatric population.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 4","pages":"Article 100419"},"PeriodicalIF":1.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142707064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of hand disinfection in paediatric advanced life support (PALS): A simulation study","authors":"Michael Bentele ,&nbsp;Stefanie Bentele ,&nbsp;Nicolas Reinoso-Schiller ,&nbsp;Simone Scheithauer ,&nbsp;Stefan Bushuven","doi":"10.1016/j.infpip.2024.100418","DOIUrl":"10.1016/j.infpip.2024.100418","url":null,"abstract":"<div><h3>Background</h3><div>Hand disinfection is often omitted during emergencies because it may delay life-saving treatments. As healthcare-associated infections significantly worsen patient outcomes, the categorical omission of hand disinfection in emergencies should be re-evaluated. Real-world observations on this subject tentatively indicate compliance rates of &lt;10%. In an adult simulation study, we have previously shown that proper hand disinfection without delaying patient care is feasible in &gt;50% of scenarios. However, no comparable data have been published regarding emergencies in infants or children.</div></div><div><h3>Aim</h3><div>This observational study aimed to assess the feasibility of hand disinfection in simulated paediatric patients requiring advanced life support (PALS).</div></div><div><h3>Methods</h3><div>We observed 32 simulations of life-threatening conditions. Two observers counted all possible moments for administering hand hygiene, according to the World Health Organization protocol, and assessed them for time-neutral feasibility.</div></div><div><h3>Results</h3><div>In the 32 scenarios, the feasibility of hand disinfection for all WHO moments ranged from 78.3 to 100%. Of all 573 hand disinfection moments, 552 (96.3%) were deemed feasible.</div><div>Altogether 208 (36.3%) occurred before aseptic tasks. Of these, 187 (89.9%) were considered feasible. Hand disinfection for WHO-2 moments feasibility showed to be at least 50% in the cases. A total of 189 (90.9%) of all WHO-2 hand disinfections were applied by the role of the “iv-manager”. Scenarios with shockable rhythms and peri-arrest showed higher feasibility ratios than those without.</div></div><div><h3>Conclusions</h3><div>The categorical omission of hand disinfection in PALS seems to be no longer acceptable or appropriate. The feasibility of hand hygiene should be re-evaluated in real-world scenarios.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"7 1","pages":"Article 100418"},"PeriodicalIF":1.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessing the need for scheduled replacement of short term central venous catheters: A narrative comprehensive review","authors":"Regev Cohen","doi":"10.1016/j.infpip.2024.100420","DOIUrl":"10.1016/j.infpip.2024.100420","url":null,"abstract":"<div><div>Central venous catheters (CVCs) are essential in modern healthcare but are associated with significant risks, particularly catheter-related bloodstream infections (CRBSIs). Current guidelines do not recommend routine replacement of CVCs based on time alone. However, recent evidence challenges this recommendation. A comprehensive literature review was conducted, focusing on studies exploring the risk-factors of short-term, non-hemodialysis CVCs, that were published in the last two decades while including seminal older works for context. The guidelines regarding scheduled CVC-replacement are not based on sufficiently convincing data. Current literature establishes the significance of CVC-duration as a major risk-factor for CRBSI occurrence, especially after 9–14 days of catheter-dwelling. The daily CRBSI risk is probably not constant, and the cumulative risk may reach high rates after 9–14 days, especially for femoral and jugular insertions compared to the subclavian site, suggesting potential benefits of scheduled CVC replacement, especially for non-subclavian catheters.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 4","pages":"Article 100420"},"PeriodicalIF":1.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142707114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid implementation of a clinical decision-support workflow during the national blood culture bottle shortage","authors":"Saira Butt ,&nbsp;Amy B. Kressel ,&nbsp;Brian L. Haines ,&nbsp;Katherine Merrill ,&nbsp;Amber M. Ryan ,&nbsp;Kenneth C. Gavina ,&nbsp;Bree Weaver ,&nbsp;Michael Kays ,&nbsp;Molly Tieman ,&nbsp;Margaret Muciarelli ,&nbsp;Phillip Clapham","doi":"10.1016/j.infpip.2024.100417","DOIUrl":"10.1016/j.infpip.2024.100417","url":null,"abstract":"<div><h3>Background</h3><div>The United States Food and Drug Administration recently announced a national blood culture (BC) bottle shortage; the exact date of restoration is still being determined.</div></div><div><h3>Aim</h3><div>Implement a workflow to mitigate the BC bottle shortage at our hospital.</div></div><div><h3>Methods</h3><div>We created the following clinical decision support workflow in electronic medical record to help mitigate BC bottle use: (a) limit to two BC in 24 hours, (b) only repeat BC if 72 hours have passed from the prior sets, (c) do not repeat BC for coagulase-negative <em>Staphylococcus</em> bacteremia when considered a contaminant (i.e., no implanted vascular device), (d) do not repeat BC for <em>Streptococcus</em> bacteremia, (e) do not repeat cultures for Gram-negative rod bacteremia unless an unknown source, immunosuppression, or clinical worsening.</div></div><div><h3>Findings</h3><div>Post implementation, our weekly average BC bottle use decreased to 29.5%.</div></div><div><h3>Conclusion</h3><div>Within three weeks of the BC bottle shortage announcement, we successfully deployed evidence-based BC restrictions in the electronic medical record (EMR), reducing our BC orders by 29.5%. We encourage others to consider and potentially replicate our workflow to contribute to diagnostic stewardship.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 4","pages":"Article 100417"},"PeriodicalIF":1.8,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status of infection prevention and control in Cameroon healthcare facilities: lessons learned from the WHO COVID-19 scorecard tool under the hierarchy of control model","authors":"Boris Arnaud Kouomogne Nteungue ,&nbsp;Erick Tandi ,&nbsp;Chanceline Bilounga Ndongo ,&nbsp;Tania Bissouma-Ledjou ,&nbsp;Alphonse Acho ,&nbsp;Jeffrey Campbell ,&nbsp;Dieudonnée Reine Ndougou ,&nbsp;Reverien Habimana ,&nbsp;Ambomo Sylvie Myriam ,&nbsp;Bertolt Brecht Kouam Nteungue ,&nbsp;Oyono Yannick ,&nbsp;Louis Joss Bitang ,&nbsp;Georges Alain Etoundi Mballa ,&nbsp;Yap Boum","doi":"10.1016/j.infpip.2024.100407","DOIUrl":"10.1016/j.infpip.2024.100407","url":null,"abstract":"<div><h3>Background</h3><div>Infection prevention and control (IPC) helps prevent disease transmission in healthcare facilities. There is a dearth of information on the implementation of IPC during the COVID-19 outbreak in Cameroon using the recommended WHO COVID-19 IPC scorecard tool. The present study assessed healthcare facilities' compliance to IPC by continuous assessments, with an evaluation of the tool using the hierarchy of control theory.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted in the 10 administrative regions of Cameroon by evaluating healthcare facilities prioritized by the Ministry of Public Health as high-risk facilities between March 2020 and November 2023. Comparisons were made regarding the facilities' ownership, level and status.</div></div><div><h3>Results</h3><div>2,188 assessments from 1,358 healthcare facilities were collected. The median IPC scores at each evaluation were between the intermediate and advanced level, with a bias linked with decreasing selection of facilities. However, only 172 (13%) healthcare facilities achieved advanced IPC score (≥75%). Higher IPC scores were found in hospitals (p&lt;0.001) and in private facilities (p=0.02). Predictors of good IPC compliance were hospital (OR=3.7, CI: 1.4–9.8) and private facility (OR=2.3, CI: 1.6–3.3). The tool met the five domains of the hierarchy of control model.</div></div><div><h3>Conclusion</h3><div>Repeated IPC assessments using recommended tools contribute to a better compliance of IPC by healthcare facilities in resources constrained settings.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 4","pages":"Article 100407"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low prevalence of borderline oxacillin resistant Staphylococcus aureus (BORSA) in a tertiary care hospital in South Carolina","authors":"Connor Horne ,&nbsp;Gabrielle DiMattia ,&nbsp;Nicholas Perkins ,&nbsp;Prerana Roth","doi":"10.1016/j.infpip.2024.100414","DOIUrl":"10.1016/j.infpip.2024.100414","url":null,"abstract":"<div><div>Prompt treatment for <em>Staphylococcus aureus</em> bloodstream infections is often dependent on known diagnostic testing modalities to differentiate between methicillin-susceptible <em>S. aureus</em> (MSSA) and methicillin-resistant <em>S. aureus</em> (MRSA). Borderline-oxacillin resistant S. aureus (BORSA), a rare, non-mecA mediated phenotype, has unclear resistance mechanisms but potentially significant consequences as it is frequently misidentified as MSSA but behaves more like MRSA. A retrospective analysis was performed of MSSA bloodstream infections to determine the prevalence of BORSA. Our institution found BORSA prevalence of 0.1%, consistent with literature. Though prevalence is low, due to unclear mechanisms and unreliable detection methods, BORSA may pose a therapeutic and epidemiological threat.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 4","pages":"Article 100414"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of ICD-9-CM coding for identifying antibiotic prescriptions during hospitalization: a Delphi consensus model","authors":"Agnese Comelli ,&nbsp;Camilla Genovese ,&nbsp;Giulia Renisi ,&nbsp;Luigia Scudeller ,&nbsp;Martina Zanforlini ,&nbsp;Giulia Macaluso ,&nbsp;Arianna Mazzone ,&nbsp;Antonio Muscatello ,&nbsp;Giorgio Bozzi ,&nbsp;Alessia Zoncada ,&nbsp;Angelo Pan ,&nbsp;Marianna Rossi ,&nbsp;Paolo Bonfanti ,&nbsp;Stefania Chiappetta ,&nbsp;Salvatore Casari ,&nbsp;Marco Ripa ,&nbsp;Antonella Castagna ,&nbsp;Liana Signorini ,&nbsp;Francesco Castelli ,&nbsp;Margherita Chiamenti ,&nbsp;Alessandra Bandera","doi":"10.1016/j.infpip.2024.100416","DOIUrl":"10.1016/j.infpip.2024.100416","url":null,"abstract":"<div><div>A Delphi consensus-seeking procedure was conducted to validate a list of ICD-9-CM codes that could help identify hospital admissions in which antimicrobials are more likely to be prescribed. The panel agreed to include 2967 codes out of 16229 (18.28%). Such codes could support AMS strategies by large-scale monitoring of drug consumption.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 4","pages":"Article 100416"},"PeriodicalIF":1.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the implementation of infection prevention measures by an infection prevention link physician in trauma and orthopaedic surgery on hygiene-relevant processes and nosocomial infections","authors":"Meike M. Neuwirth ,&nbsp;Benedikt Marche ,&nbsp;Jerome Defosse ,&nbsp;Frauke Mattner ,&nbsp;Robin Otchwemah","doi":"10.1016/j.infpip.2024.100415","DOIUrl":"10.1016/j.infpip.2024.100415","url":null,"abstract":"<div><h3>Background</h3><div>The German Infection Protection Act and KRINKO recommend nominating one authorized medical specialist in every medical department as an infection prevention link physician (PLP). Detailed evidence on the contribution of PLPs to reducing infection rates is not available in Germany.</div></div><div><h3>Aim</h3><div>The \"HygArzt\"-study investigated whether, and to what extent, a PLP in orthopaedics/trauma surgery is able to improve hand hygiene adherence (HHA), process steps of dressing change, nosocomial infection (NI) and surgical site infection (SSI) rates by implementing an infection prevention bundle (IPB).</div></div><div><h3>Methods</h3><div>In consideration of a literature review on infection prevention measures in orthopaedics/trauma surgery and existing departmental hygiene standards, supported by the responsible infection control specialist, an IPB was developed by an interdisciplinary team and implemented by a PLP. The effects of IPB on NI, SSI, and HHA were determined in a pre-post study design on three trauma surgery/orthopaedic wards of a university hospital.</div></div><div><h3>Findings</h3><div>In pre-post comparison HHA was significantly increased, and NI rates were reduced significantly. The greatest increase in adherence occurred in the pre-indications \"Before touching a patient\" (pre: 37.3%; post: 73.0%), \"Before clean/aseptic procedure\" (pre: 34.2%; post: 75.5%) and \"Before surgery\" (pre: 9.7%; post: 57.0%). The analysis of NI and SSI rates (NI: <em>p</em>=0.03; SSI: <em>p</em>=0.01; relative risk (RR) of 0.53 in each case) revealed rate reductions.</div></div><div><h3>Conclusion</h3><div>The implementation of an IPB by a PLP led to an optimisation of processes and to a reduction of SSIs and NIs. PLPs seem to have the potential for targeted, group-specific implementation of complex IPBs.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 4","pages":"Article 100415"},"PeriodicalIF":1.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there an association between colonisation of vancomycin resistant Enterococci, methicillin resistant Staphylococcus Aureus, or Clostridiodes Difficile and mortality in sepsis?","authors":"Matthew JG. Sigakis ,&nbsp;Joseph Posluszny ,&nbsp;Michael D. Maile ,&nbsp;Elizabeth S. Jewell ,&nbsp;Milo Engoren","doi":"10.1016/j.infpip.2024.100413","DOIUrl":"10.1016/j.infpip.2024.100413","url":null,"abstract":"<div><h3>Background</h3><div>To determine if colonisation with drug resistant organisms is associated with worse outcomes in patients who subsequently develop sepsis.</div></div><div><h3>Methods</h3><div>Retrospective study of patients with sepsis employing logistic regression and linear regression to determine the independent association of colonisation with adverse outcomes.</div></div><div><h3>Results</h3><div>Mortality was higher in patients colonized with VRE [501 of 1937 (26%) v. 1052 of 5624 (19%) non-VRE colonised patients, difference 7% (95% confidence interval (5,9%), p&lt;0.001] and MRSA [168 of 708 (24%) v 1342 of 6804 (20%) non-MRSA colonised patients, difference 4% (1,7%), p = 0.014]. CDiff colonisation was not associated with increased mortality [153 of 757 (21%) v 762 of 7432 (18%), difference 3% (0,6%), p=0.052]. After multivariable logistic regression, VRE colonisation remained associated with increased hospital mortality [odds ratio = 1.273, 95% confidence interval (1.099, 1.475), p = 0.001]. VRE colonisation was also associated with subsequent receipt of mechanical ventilation [odds ratio = 1.179, 95% confidence interval (1.043, 1.334), p = 0.009] and with receipt of renal replacement therapy (RRT) [OR = 1.36 (1.11, 1.66), p = 0.003].</div></div><div><h3>Conclusions</h3><div>We found that VRE colonisation, but not MRSA or C. diff colonisation, was associated with increased hospital mortality in septic patients.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 4","pages":"Article 100413"},"PeriodicalIF":1.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methicillin and vancomycin-resistant Staphylococcus aureus and associated risk factors among patients with wound infection in East Wallaga Zone, Western Ethiopia","authors":"Milkias Abebe ,&nbsp;Getachew Alemkere ,&nbsp;Gizachew Ayele","doi":"10.1016/j.infpip.2024.100409","DOIUrl":"10.1016/j.infpip.2024.100409","url":null,"abstract":"<div><h3>Background</h3><div>Methicillin and vancomycin-resistant <em>S. aureus</em> have become increasingly problematic in recent years. This may be explained by the indiscriminate use of this antibiotic. The aim of this study was to determine the prevalence of methicillin-resistant and vancomycin-resistant <em>Staphylococcus aureus</em> (VRSA) and associated risk factors in patients with wound infections in the East Wallaga Zone, Western Ethiopia.</div></div><div><h3>Methods</h3><div>A hospital-based cross-sectional prospective study was conducted on 384 patients with wound infections including surgical wound who sought healthcare at Nekemte Specialized Hospital. Wound samples were collected using aseptic techniques and cultured on blood agar and mannitol salt agar. Vancomycin E-test and cefoxitin (30 μg) antibiotic disc diffusion were used to detect MRSA and VRSA, respectively. Data were analyzed using SPSS version 23, and a <em>P</em>-value of less than 0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>Of the 384 wound samples collected, 109 (28.4%) were identified as <em>Staphylococcus aureus</em>. Of these, 40.4% (44/109) were identified as MRSA, and 7.3% (8/109) were VRSA. Thirty-two (72.7%) MRSA isolates were showed multidrug resistance. The depth of the wound, patient setting, history of wound infection, and history of antibiotic use became significantly associated with the prevalence of MRSA wound infection.</div></div><div><h3>Conclusions</h3><div>This study found significant levels of <em>S. aureus</em>, MRSA, and VRSA in patients with wound infection. Therefore, it is crucial to implement effective infection prevention and control measures to prevent the spread of antimicrobial resistance.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 4","pages":"Article 100409"},"PeriodicalIF":1.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}