Craig Hogg , Caoimhe McKerr , Noel Craine , Dafydd Williams , Malorie Perry , Simon Cottrell
{"title":"在威尔士一家急性医院COVID-19爆发期间,疫苗接种和获得医疗保健在呼吸衰竭中的作用","authors":"Craig Hogg , Caoimhe McKerr , Noel Craine , Dafydd Williams , Malorie Perry , Simon Cottrell","doi":"10.1016/j.infpip.2025.100474","DOIUrl":null,"url":null,"abstract":"<div><div>This study provides descriptive analysis of a COVID-19 outbreak of 323 cases in a Welsh hospital in early 2021, with a focus on respiratory failure (RF) as a severe outcome. Multivariate analysis demonstrated decreased odds of RF in healthcare acquired cases (aOR 0.40 (95%CI 0.24–0.65), <em>p</em><0.001) and individuals with at least one dose of vaccine 14 days before first positive test (aOR 0.45 (95%CI 0.28–0.75), <em>p</em>=0.002). In healthcare acquired cases, vaccination significantly reduced the odds of RF (OR 0.47 (95%CI 0.22-0.00), <em>p</em>=0.037). This analysis highlights the importance of vaccination as a protective factor against severe respiratory outcomes.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"7 3","pages":"Article 100474"},"PeriodicalIF":1.9000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of vaccination and healthcare acquisition in respiratory failure during a COVID-19 outbreak in an acute hospital in Wales\",\"authors\":\"Craig Hogg , Caoimhe McKerr , Noel Craine , Dafydd Williams , Malorie Perry , Simon Cottrell\",\"doi\":\"10.1016/j.infpip.2025.100474\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This study provides descriptive analysis of a COVID-19 outbreak of 323 cases in a Welsh hospital in early 2021, with a focus on respiratory failure (RF) as a severe outcome. Multivariate analysis demonstrated decreased odds of RF in healthcare acquired cases (aOR 0.40 (95%CI 0.24–0.65), <em>p</em><0.001) and individuals with at least one dose of vaccine 14 days before first positive test (aOR 0.45 (95%CI 0.28–0.75), <em>p</em>=0.002). In healthcare acquired cases, vaccination significantly reduced the odds of RF (OR 0.47 (95%CI 0.22-0.00), <em>p</em>=0.037). This analysis highlights the importance of vaccination as a protective factor against severe respiratory outcomes.</div></div>\",\"PeriodicalId\":33492,\"journal\":{\"name\":\"Infection Prevention in Practice\",\"volume\":\"7 3\",\"pages\":\"Article 100474\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infection Prevention in Practice\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590088925000381\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection Prevention in Practice","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590088925000381","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
The role of vaccination and healthcare acquisition in respiratory failure during a COVID-19 outbreak in an acute hospital in Wales
This study provides descriptive analysis of a COVID-19 outbreak of 323 cases in a Welsh hospital in early 2021, with a focus on respiratory failure (RF) as a severe outcome. Multivariate analysis demonstrated decreased odds of RF in healthcare acquired cases (aOR 0.40 (95%CI 0.24–0.65), p<0.001) and individuals with at least one dose of vaccine 14 days before first positive test (aOR 0.45 (95%CI 0.28–0.75), p=0.002). In healthcare acquired cases, vaccination significantly reduced the odds of RF (OR 0.47 (95%CI 0.22-0.00), p=0.037). This analysis highlights the importance of vaccination as a protective factor against severe respiratory outcomes.