{"title":"The impact of meropenem shortage and post-prescription review and feedback on broad-spectrum antimicrobial use: An interrupted time-series analysis","authors":"Kohei Maruyama , Kiyoshi Sekiya , Noriyuki Yanagida , Shuhei Yasuda , Daisuke Fukumoto , Satoshi Hosoya , Hiromitsu Moriya , Motoko Kawabe , Tatsuya Mori","doi":"10.1016/j.infpip.2024.100380","DOIUrl":"https://doi.org/10.1016/j.infpip.2024.100380","url":null,"abstract":"<div><h3>Background</h3><p>Meropenem (MEPM) holds significance in treating severe infections and drug-resistant bacteria. There are concerns that antimicrobial shortages may lead to the use of alternative antimicrobials that are less effective and safer. We have responded to the MEPM shortage with post-prescription monitoring and feedback (PPRF) with no restrictions on MEPM initiation. We aimed to assess the impact of the MEPM shortage and the PPRF on broad-spectrum antimicrobial use and mortality.</p></div><div><h3>Methods</h3><p>This retrospective study was conducted in a single hospital in Japan. The period from October 2021 to August 2022 was defined as the period before the MEPM shortage, and the period from September 2022 to March 2023 was defined as the period during the MEPM shortage. To support the appropriate use of antimicrobials during MEPM shortages, the antimicrobial stewardship team (AST) developed a list of alternatives to MEPM. An interrupted time series analysis was used to assess changes in use and mortality among patients receiving broad-spectrum antimicrobials over the study period.</p></div><div><h3>Discussion</h3><p>The shortage of MEPM and PPRF temporarily increased the use of alternative cefepime; however, the subsequent change in days of therapy and days of coverage of broad-spectrum antimicrobials suggests a decrease in the use of these antimicrobials. Despite these shifts, the mortality rates remained stable, suggesting that the response to the shortage did not adversely affect treatment outcomes.</p></div><div><h3>Conclusion</h3><p>In the context of antimicrobial shortages, AST support plays an important role in enabling physicians to make optimal use of antimicrobials.</p></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 3","pages":"Article 100380"},"PeriodicalIF":1.8,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590088924000441/pdfft?md5=6d24510e9e8b8625422d85dc2ec1996a&pid=1-s2.0-S2590088924000441-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141487144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trine Herskind Hasløv , Cecilie Fuglsbjerg , Anne Kirstine Nielsen , Anne Brun Hesselvig , Blaine Gabriel Fritz , Lene Bay , Tom Møller , Thomas Bjarnsholt , Anders Odgaard
{"title":"Hair removal with a clipper and microbial colonisation prior to knee arthroplasty: a randomised controlled trial","authors":"Trine Herskind Hasløv , Cecilie Fuglsbjerg , Anne Kirstine Nielsen , Anne Brun Hesselvig , Blaine Gabriel Fritz , Lene Bay , Tom Møller , Thomas Bjarnsholt , Anders Odgaard","doi":"10.1016/j.infpip.2024.100377","DOIUrl":"10.1016/j.infpip.2024.100377","url":null,"abstract":"<div><h3>Background</h3><p>Despite the widely reported success of knee arthroplasty, studies show that 1.6–3 % of patients undergo revision within the first postoperative year predominantly due to infection. Preoperative skin preparation may potentially decrease the bacterial load and consequently, the risk of periprosthetic joint infections. The effects of hair removal on prosthetic joint infection are inconsistent. Our primary aim was to investigate if hair removal with a clipper influenced skin colonisation and bacterial composition.</p></div><div><h3>Methods</h3><p>Forty Caucasian male participants who were planned to undergo knee arthroplasty, (mean age 63.8 years), were included. Patients were randomised to hair removal in a within-person study design. As a control, the opposite leg of the patient was used. Swabs were collected prior to hair removal (baseline), immediately after hair removal (Day 0), and with follow-up after one and seven days.</p></div><div><h3>Results</h3><p>The intervention showed significant decrease in mean log colony-forming units per. cm<sup>2</sup> from baseline 2.97 to 2.67 (<em>P</em><0.01) immediately after hair removal and sustained at Day 1 (<em>P</em>=0.01). At Day 7, the mean was non-significant compared to baseline. The control group did not show any decrease of skin microbiota at follow-up on Day 0, 1 or 7.</p><p>No significant differences within the bacterial composition were found between the intervention and control leg at baseline among the six most prevalent detected bacterial species: <em>Staphylococcus epidermidis, Micrococcus luteus, S</em>. <em>hominis, S</em>. <em>capitis, S</em>. <em>haemolyticus and S</em>. <em>aureus.</em> The study did not find any changes in the bacterial composition over time.</p></div><div><h3>Conclusion</h3><p>Hair removal with a clipper within 24 hours prior to surgery causes a significant non-selective reduction in skin colonisation.</p></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 3","pages":"Article 100377"},"PeriodicalIF":1.8,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590088924000416/pdfft?md5=9b309d3013575d9996c87595086c470c&pid=1-s2.0-S2590088924000416-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141402764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Infection prevention and control: knowledge, practices and associated factors among cleaners at a National Referral Hospital in Uganda","authors":"Edwin Kigozi , Livingstone Kamoga , Nelson Ssewante , Patrick Banadda , Faith Atai , Lydia Kabiri , Scovia Nalugo Mbalinda","doi":"10.1016/j.infpip.2024.100376","DOIUrl":"10.1016/j.infpip.2024.100376","url":null,"abstract":"<div><h3>Background</h3><p>While most infection prevention and control (IPC) studies focus on healthcare professionals, IPC is everyone's responsibility in any healthcare facility. There is little known about the IPC knowledge among the cleaners who are responsible for housekeeping, environmental cleaning, and waste management within hospitals. This study sought to evaluate the knowledge and practice of IPC among cleaners at Mulago National Referral Hospital (MNRH) to establish a foundation for empowering a strategic workforce that will improve IPC practices within the hospital.</p></div><div><h3>Methods</h3><p>A cross-sectional study was conducted among the cleaners in a national referral hospital in Uganda. The participants were purposively sampled, and data was collected using a web-based, interviewer-administered, questionnaire about IPC knowledge and practices.</p></div><div><h3>Results</h3><p>Of the 120 cleaners recruited, 52.5% were female. Good IPC knowledge was demonstrated in 58.3%, and 30.8% reported good IPC practices. Participants with at least 5 years' work experience had higher knowledge levels (aOR: 10.3, <em>P</em>=0.006, 95% CI: 2–54). Those closely supervised had lower IPC knowledge compared with those with less supervision. Participants with fixed work schedules (aOR: 0.2, <em>P</em>=0.028, 95%CI: 0–0.8), were less likely to exhibit good IPC practices. In addition, 63.1% were knowledgeable about waste segregation, recognising bin colours and the correct disposal of sharps and needles. Despite good compliance with personal protective equipment, poor hand-washing practices were reported. A positive correlation between knowledge and practice scores was established.</p></div><div><h3>Conclusion</h3><p>Hospital cleaners in a national referral hospital in Uganda IPC reported poor infection prevention practices despite good knowledge. For IPC knowledge and practice to correlate positively, ongoing practical training is vital to maintain knowledge and good practice to establish a successful IPC program.</p></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 3","pages":"Article 100376"},"PeriodicalIF":1.8,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590088924000404/pdfft?md5=cbf6574d12b9410643dd12f901007cfe&pid=1-s2.0-S2590088924000404-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141396715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marisa Almuzara , Roxana Cittadini , Germán Traglia , María Sol Haim , Denise De Belder , Carla Alvarez , Zandra de Lourdes Reynal O'Connor , Cecilia Vera Ocampo , Claudia Barberis , Mónica Prieto , Josefina Campos , Carlos Vay
{"title":"Phytobacter spp: the emergence of a new genus of healthcare-associated Enterobacterales encoding carbapenemases in Argentina: a case series","authors":"Marisa Almuzara , Roxana Cittadini , Germán Traglia , María Sol Haim , Denise De Belder , Carla Alvarez , Zandra de Lourdes Reynal O'Connor , Cecilia Vera Ocampo , Claudia Barberis , Mónica Prieto , Josefina Campos , Carlos Vay","doi":"10.1016/j.infpip.2024.100379","DOIUrl":"10.1016/j.infpip.2024.100379","url":null,"abstract":"<div><p>Members of the genus <em>Phytobacter</em> (order <em>Enterobacterales</em>) are isolated from the natural environment and clinical settings. Identification of <em>Phytobacter</em> strains based on biochemical characteristics is complicated due to taxonomic confusion, and they are often misidentified by automated identification systems in laboratories.</p><p>In this study we describe the first three clinical cases associated with <em>Phytobacter</em> spp. reported in Argentina. We describe the identification, the molecular analysis using whole genome sequencing and the potential clinical relevance.</p></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 3","pages":"Article 100379"},"PeriodicalIF":1.8,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259008892400043X/pdfft?md5=9220c17852ef2c830645d9cae3a3040a&pid=1-s2.0-S259008892400043X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141403476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leonie A.J. Derickx , Diana Willemse-Erix , Anne van Piggelen , Paul Steegh , A. Caroline Heijckmann , Mirjam H.A. Hermans , Thijn F. de Vocht , Peter C. Wever
{"title":"An outbreak of Pseudomonas aeruginosa urinary tract infections following cystoscopy traceable to a malfunctioning drying cabinet","authors":"Leonie A.J. Derickx , Diana Willemse-Erix , Anne van Piggelen , Paul Steegh , A. Caroline Heijckmann , Mirjam H.A. Hermans , Thijn F. de Vocht , Peter C. Wever","doi":"10.1016/j.infpip.2024.100378","DOIUrl":"10.1016/j.infpip.2024.100378","url":null,"abstract":"<div><h3>Background</h3><p><em>Pseudomonas aeruginosa</em> is an important bacterial pathogen, particularly as a cause of nosocomial infections in hospitalized patients. Only few reports exist in which cystoscopes were implicated as an outbreak source. We describe an investigation into the cause of a sudden increase in the number of urinary tract infections (UTI) with <em>P</em>. <em>aeruginosa</em> in patients after cystoscopy. In addition, we share the lessons learned and measures taken to reduce the risk of similar infections in the future.</p></div><div><h3>Presentation of Case</h3><p>Over a period of two weeks the urology outpatient department noticed a UTI in four patients following cystoscopy. An investigation was started for a common source of the outbreak in the urological treatment room. Additional screening of patients revealed a total of eleven males with <em>P. aeruginosa</em> UTI following cystoscopy. The infections were found to be due to a defective drying cabinet, which lacked an alarm signaling in case of loss of airflow. Amplified fragment length polymorphism (AFLP) analysis revealed that <em>P. aeruginosa</em> isolates from three patients and six isolates from environmental cultures (including cystoscopes from the drying cabinet) genotypically belonged to one strain.</p></div><div><h3>Discussion</h3><p>The AFLP results suggest that contaminated cystoscopes caused <em>P. aeruginosa</em> UTI in 11 patients, with the drying cabinet as site of transfer of the infective strain. To our knowledge, this is the first report describing a malfunctioning drying cabinet as source of an outbreak following cystoscopy.</p></div><div><h3>Conclusion</h3><p>In case of concomitant <em>P. aeruginosa</em> infections, cystoscopes and drying cabinets should be suspected as a potential source. Molecular techniques are helpful in investigating the epidemiology of an outbreak.</p></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 3","pages":"Article 100378"},"PeriodicalIF":1.8,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590088924000428/pdfft?md5=75187789065eb04702fa41f45dea7cb0&pid=1-s2.0-S2590088924000428-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141407045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diabetes and MRSA Infections: A comparative analysis in an Indian tertiary healthcare setting","authors":"M. Sagiraju , R. Prasad , A. Gopi","doi":"10.1016/j.infpip.2024.100372","DOIUrl":"10.1016/j.infpip.2024.100372","url":null,"abstract":"","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 3","pages":"Article 100372"},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590088924000362/pdfft?md5=1ac03f80876b955eb6b47205a38d028f&pid=1-s2.0-S2590088924000362-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141139455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the detection of diarrhoea-associated RNA viruses in immunocompromised children in Iran","authors":"Shokouh Yasaie , Seyed Dawood Mousavi Nasab , Saeed Shams , Atousa Ferdousi , Hooman Kaghazian","doi":"10.1016/j.infpip.2024.100370","DOIUrl":"10.1016/j.infpip.2024.100370","url":null,"abstract":"<div><h3>Background</h3><p>Gastroenteritis accounts for about 10% of the deaths among children, especially in immunocompromised children. Few studies on the prevalence of gastrointestinal infections caused by RNA viruses have been done in Iran. The aim of the study was to evaluate the detection of RNA viruses causing diarrhoea using a multiplex PCR.</p></div><div><h3>Methods</h3><p>Stool samples were collected from 130 paediatric patients with diarrhoea who had acute lymphocytic leukaemia, non-Hodgkin lymphoma, and retinoblastoma. After RNA extraction and synthesis of cDNA, multiplex PCR was done to evaluate the presence of rotavirus, norovirus, astrovirus, and enterovirus.</p></div><div><h3>Results</h3><p>There were 9 (6.9%), 7 (5.4%), 3 (2.3%), and 6 (4.6%) cases of rotavirus, norovirus, astrovirus, and enterovirus detected, respectively. One case of co-infection with astrovirus and norovirus was observed.</p></div><div><h3>Conclusions</h3><p>This is the first report from Iran which identified the presence of common RNA viruses causing diarrhoea in immunocompromised children. Increased awareness of these viruses will enable healthcare professionals to improve strategies and policies to control spread and infection caused by these viruses.</p></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 3","pages":"Article 100370"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590088924000349/pdfft?md5=a5fc657e22a643e0f4fbd5f5b391dcf5&pid=1-s2.0-S2590088924000349-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141040501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Misailovski , D. Koller , S. Blaschke , M. Berens , A.M. Köster , R. Strobl , R. Berner , P. Boor , M. Eisenmann , S. von Stillfried , D. Krefting , M. Krone , J. Liese , P. Meybohm , G. Ulrich- Merzenich , S. Zenker , S. Scheithauer , E. Grill
{"title":"Refining the hospitalization rate: A mixed methods approach to differentiate primary COVID-19 from incidental cases","authors":"M. Misailovski , D. Koller , S. Blaschke , M. Berens , A.M. Köster , R. Strobl , R. Berner , P. Boor , M. Eisenmann , S. von Stillfried , D. Krefting , M. Krone , J. Liese , P. Meybohm , G. Ulrich- Merzenich , S. Zenker , S. Scheithauer , E. Grill","doi":"10.1016/j.infpip.2024.100371","DOIUrl":"10.1016/j.infpip.2024.100371","url":null,"abstract":"<div><h3>Purpose</h3><p>Until now, the Hospitalization Rate (HR) served as an indicator (among others) for the COVID-19 associated healthcare burden. To ensure that the HR accomplishes its full potential, hospitalizations caused by COVID-19 (primary cases) and hospitalizations of patients with incidental positive SARS-CoV-2 test results (incidental cases) must be differentiated. The aim of this study was to synthesize the existing evidence on differentiation criteria between hospitalizations of primary cases and incidental cases.</p></div><div><h3>Methods</h3><p>An online survey of the members of the German Network University Medicine (NUM) was conducted. Additionally, senior clinicians with expertise in COVID-19 care were invited for qualitative, semi-structured interviews. Furthermore, a rapid literature review was undertaken on publications between 03/2020 and 12/2022.</p></div><div><h3>Results</h3><p>In the online survey (n=30, response rate 56%), pneumonia and acute upper respiratory tract infections were the most indicative diagnoses for a primary case. In contrast, malignant neoplasms and acute myocardial infarctions were most likely to be associated with incidental cases. According to the experts (n=6), the diagnosis, ward, and type of admission (emergency or elective), low oxygen saturation, need for supplemental oxygen, and initiation of COVID-19 therapy point to a primary case. The literature review found that respiratory syndromes and symptoms, oxygen support, and elevated levels of inflammatory markers were associated with primary cases.</p></div><div><h3>Conclusion</h3><p>There are parameters for the differentiation of primary from incidental cases to improve the objective of the HR. Ultimately, an updated HR has the potential to serve as a more accurate indicator of the COVID-19 associated healthcare burden.</p></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 3","pages":"Article 100371"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590088924000350/pdfft?md5=d05b8ce62a69d3ddf2824c3d118a7cec&pid=1-s2.0-S2590088924000350-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141048005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taryn B. Amos , Cameron Griffin , Joshua K. Schaffzin , Andrea Ankrum , Felicia Scaggs Huang
{"title":"Adherence to Personal Protective Equipment practices during the COVID-19 pandemic: A pilot study","authors":"Taryn B. Amos , Cameron Griffin , Joshua K. Schaffzin , Andrea Ankrum , Felicia Scaggs Huang","doi":"10.1016/j.infpip.2024.100369","DOIUrl":"10.1016/j.infpip.2024.100369","url":null,"abstract":"<div><p>A direct observational pilot project of healthcare personnel (HCP) was conducted to validate a tool that measures personal protective equipment (PPE) adherence at a large pediatric institution. Overall unit PPE adherence for all moments ranged from 50–61%. Masking was the most adhered to PPE moment (100%); hand hygiene prior to donning PPE had the lowest adherence (13%). Using data from this standardized tool, researchers can evolve PPE standards to maximize their adherence, effectiveness, and ease of utilization.</p></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 2","pages":"Article 100369"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590088924000337/pdfft?md5=47a983ac4595bd9f3b177071acb21fe9&pid=1-s2.0-S2590088924000337-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141030637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akaninyene Otu , Zoe Wellbelove , Anda Samson , Andrew Blackmore
{"title":"Use of low-dose, high-frequency in situ simulation for preventing healthcare-associated infections – the STOP-HCAI pilot project","authors":"Akaninyene Otu , Zoe Wellbelove , Anda Samson , Andrew Blackmore","doi":"10.1016/j.infpip.2024.100368","DOIUrl":"10.1016/j.infpip.2024.100368","url":null,"abstract":"","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 2","pages":"Article 100368"},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590088924000325/pdfft?md5=ca4f5d084c85450d2fbb86de6d2f8da4&pid=1-s2.0-S2590088924000325-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141048865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}