Infection Prevention in Practice最新文献

{"title":"Genomic evaluation of phenotypic antibiotic susceptibility patterns as a surrogate for MRSA relatedness and putative transmission during outbreak investigations","authors":"Francesc Coll ,&nbsp;Michelle S. Toleman ,&nbsp;Ewan M. Harrison ,&nbsp;Beth Blane ,&nbsp;Dorota Jamrozy ,&nbsp;Nicholas M. Brown ,&nbsp;Julian Parkhill ,&nbsp;Sharon J. Peacock","doi":"10.1016/j.infpip.2024.100435","DOIUrl":"10.1016/j.infpip.2024.100435","url":null,"abstract":"<div><div>Antibiograms have been used during outbreak investigations for decades as a surrogate for genetic relatedness of Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA). In this study, we evaluate the accuracy of antibiograms in detecting transmission, using genomic epidemiology as the reference standard. We analysed epidemiological and genomic data from 1,465 patients and 1,465 MRSA isolates collected at a single clinical microbiology laboratory in the United Kingdom over a one-year period. A total of 132 unique antibiograms (AB) were identified based on VITEK 2 susceptibility testing, with two profiles (AB1 and AB2) accounting for 698 isolates (48%). We identified MRSA-positive patients with a known hospital or community contact and evaluated the prediction of MRSA transmission based on identical antibiograms. The sensitivity and specificity of identical antibiograms to infer genetically related MRSA isolates (≤25 SNPs) within hospital contacts (presumed transmission events) was 66.4% and 85.5% respectively and 73.8% and 85.7% within community contacts. Reanalysis, where any single drug mismatch in susceptibility results was allowed, increased sensitivity but reduced specificity: 95.2% and 58.8%, respectively, for hospital contacts; and 91.7% and 62.6% for community contacts. Overall, the sensitivity and specificity of identical antibiograms for inferring genetically related MRSA isolates (≤25 SNPs), regardless of epidemiological links, were 49.1% and 87.5%, respectively. We conclude that using an antibiogram with one mismatch can detect most transmission events; however, its poor specificity may lead to an increased workload through the evaluation of numerous pseudo-outbreaks. This study further supports the integration of genomic epidemiology into routine practice for the detection and control of MRSA transmission.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"7 1","pages":"Article 100435"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of hand disinfection in paediatric advanced life support (PALS): A simulation study","authors":"Michael Bentele ,&nbsp;Stefanie Bentele ,&nbsp;Nicolas Reinoso-Schiller ,&nbsp;Simone Scheithauer ,&nbsp;Stefan Bushuven","doi":"10.1016/j.infpip.2024.100418","DOIUrl":"10.1016/j.infpip.2024.100418","url":null,"abstract":"<div><h3>Background</h3><div>Hand disinfection is often omitted during emergencies because it may delay life-saving treatments. As healthcare-associated infections significantly worsen patient outcomes, the categorical omission of hand disinfection in emergencies should be re-evaluated. Real-world observations on this subject tentatively indicate compliance rates of &lt;10%. In an adult simulation study, we have previously shown that proper hand disinfection without delaying patient care is feasible in &gt;50% of scenarios. However, no comparable data have been published regarding emergencies in infants or children.</div></div><div><h3>Aim</h3><div>This observational study aimed to assess the feasibility of hand disinfection in simulated paediatric patients requiring advanced life support (PALS).</div></div><div><h3>Methods</h3><div>We observed 32 simulations of life-threatening conditions. Two observers counted all possible moments for administering hand hygiene, according to the World Health Organization protocol, and assessed them for time-neutral feasibility.</div></div><div><h3>Results</h3><div>In the 32 scenarios, the feasibility of hand disinfection for all WHO moments ranged from 78.3 to 100%. Of all 573 hand disinfection moments, 552 (96.3%) were deemed feasible.</div><div>Altogether 208 (36.3%) occurred before aseptic tasks. Of these, 187 (89.9%) were considered feasible. Hand disinfection for WHO-2 moments feasibility showed to be at least 50% in the cases. A total of 189 (90.9%) of all WHO-2 hand disinfections were applied by the role of the “iv-manager”. Scenarios with shockable rhythms and peri-arrest showed higher feasibility ratios than those without.</div></div><div><h3>Conclusions</h3><div>The categorical omission of hand disinfection in PALS seems to be no longer acceptable or appropriate. The feasibility of hand hygiene should be re-evaluated in real-world scenarios.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"7 1","pages":"Article 100418"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 4-year outbreak of MRSA ST72-MRSA-IV spa type t1597 in a surgical high dependency unit in Ireland linked to repeated healthcare worker recolonisation","authors":"Deirdre Brady ,&nbsp;Grainne Brennan ,&nbsp;Brian O'Connell ,&nbsp;Ruth Buckley ,&nbsp;Marie Brennan ,&nbsp;Maria Lenehan ,&nbsp;Jincy Jerry ,&nbsp;Lars Nolke ,&nbsp;Seyed Hossein Javadpour ,&nbsp;Margaret M. Hannan ,&nbsp;Breda Lynch ,&nbsp;Maureen Lynch","doi":"10.1016/j.infpip.2024.100421","DOIUrl":"10.1016/j.infpip.2024.100421","url":null,"abstract":"<div><h3>Background</h3><div>Patients undergoing cardiac surgery are identified as high risk for <em>Staphylococcus aureus</em> infection, including MRSA. An outbreak of MRSA was identified when two patients experienced MRSA infection concurrently in a cardiothoracic high dependency unit with uncommon detection of MRSA previously and an established screening programme.</div></div><div><h3>Methods</h3><div>An outbreak control team was convened and interventions applied including refresher training in hand and environmental hygiene, review of practice with regard to aseptic access of medical devices and consideration of antibiotic use in the unit. MRSA isolates were referred to the Irish National MRSA Reference Laboratory where <em>spa</em> typing assigned all isolates to t1597 and whole genome sequencing assigned them to multilocus sequence type ST72-MRSA-IV. Recovery of this strain from only this unit in Ireland and infrequent reporting in Europe prompted staff MRSA screening with two staff members found to harbour the outbreak strain. Despite successful decolonisation, recolonisation and further transmission to patients occurred.</div></div><div><h3>Conclusions</h3><div>In the clinical unit in which this outbreak occurred, the usual control measures to prevent spread of MRSA were in place. Recent Joint Healthcare Infection Society and Infection Prevention Society Guidance does not recommend routine staff screening for MRSA but does support its consideration in an outbreak of an unusual strain. In total, 9 patients and 2 staff were affected by this outbreak. There were 4 infections and 3 deaths. Sustained outbreak closure was necessary to protect certain national clinical programmes and was achievable only when colonised staff were no longer working in the unit.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"7 1","pages":"Article 100421"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An outbreak of carbapenemase producing Enterobacterales – importance of thorough decontamination of beds","authors":"Richard Puleston ,&nbsp;Kirsty Morgan ,&nbsp;Iresha Asanthi ,&nbsp;Helen Bucior ,&nbsp;Kerry Rawlin ,&nbsp;Jeorge Orendi ,&nbsp;Jonathan Snape ,&nbsp;Steven Bourne ,&nbsp;Ann-Marie Riley ,&nbsp;Lorraine Whitehead ,&nbsp;Tom O'Leary ,&nbsp;Emyr Phillips ,&nbsp;Catherine Alves ,&nbsp;Matthew Knock","doi":"10.1016/j.infpip.2024.100422","DOIUrl":"10.1016/j.infpip.2024.100422","url":null,"abstract":"","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"7 1","pages":"Article 100422"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143091937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of non-compliance with hand hygiene using a covert direct observation methodology","authors":"Majid M. Alshamrani ,&nbsp;Aiman El-Saed ,&nbsp;Fatmah Othman ,&nbsp;Mohammed Al Zunitan ,&nbsp;Seema Noushad ,&nbsp;Ayham Albadawi ,&nbsp;Eman Alghamdi ,&nbsp;Saad Almohrij","doi":"10.1016/j.infpip.2025.100442","DOIUrl":"10.1016/j.infpip.2025.100442","url":null,"abstract":"<div><h3>Background</h3><div>The Hawthorne effect may result in an overestimation of hand hygiene (HH) compliance during routine observations, which may weaken the significance of factors associated with non-compliance. The aim of this study was to examine professional and healthcare determinants of HH non-compliance using covert observation.</div></div><div><h3>Methods</h3><div>A cross-sectional study design was conducted among healthcare workers (HCWs) at a tertiary care hospital in Saudi Arabia. HH observations were conducted discreetly by trained observers, followed by a questionnaire and an audit to identify possible determinants of HH non-compliance. HH non-compliance was assessed according to the World Health Organisation's (WHO) five-moments for HH, while inappropriate compliance was evaluated by additionally considering incorrect HH technique.</div></div><div><h3>Results</h3><div>A total of 6580 HH opportunities were observed by 502 HCWs. The overall non-compliance rate was 54.1% with inappropriate compliance at 71.1%. Significant factors associated (<em>P</em>&lt;0.05) with non-compliance included lack of HH education/training, lack of job promotion, working in the emergency department, lack of HH auditing, absence of pocket-sized alcohol-based handrub (ABHR) bottles, inconveniently placed hand washing sinks and ABHR wall dispensers, infrequent replacement of empty ABHR wall dispensers, and lack of nearby promoting posters. With few exceptions, the determinants of HH inappropriate compliance were similar to those of HH non-compliance, when objectively audited by the researcher.</div></div><div><h3>Conclusions</h3><div>The findings underscore the importance of HH training and supportive healthcare infrastructures. These insights may assist decision-makers in identifying specific work environment factors that could improve HH compliance through appropriate interventions. Further research is required to evaluate the impact of these suggested modifications on HH compliance.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"7 1","pages":"Article 100442"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and economic impact of ventilator-associated pneumonia in intensive care units in Japan","authors":"Taikan Nanao ,&nbsp;Koichi Benjamin Ishikawa ,&nbsp;Shunya Ikeda ,&nbsp;Tsutomu Yamazaki","doi":"10.1016/j.infpip.2025.100440","DOIUrl":"10.1016/j.infpip.2025.100440","url":null,"abstract":"<div><div>Ventilator-associated pneumonia (VAP) has a considerable impact on both clinical outcomes and healthcare costs. This study compared 40 patients having VAP with 40 matched controls from a Japanese ICU dataset. Patients with VAP experienced significantly longer ICU and hospital stays, fewer ventilator-free days, and a higher incidence of tracheostomies. VAP cases also required more broad-spectrum antimicrobials, leading to an additional cost of approximately USD 24,410 per case. These results highlight the importance of implementing effective infection control strategies to mitigate VAP's clinical and economic consequences.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"7 1","pages":"Article 100440"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrahospital dissemination of multidrug-resistant Acinetobacter baumannii at a teaching hospital in Northeast of Mexico","authors":"Samantha Villarreal-Cruz ,&nbsp;Adrián Camacho-Ortiz ,&nbsp;Samantha Flores-Treviño ,&nbsp;Licet Villarreal-Treviño ,&nbsp;Paola Bocanegra-Ibarias","doi":"10.1016/j.infpip.2025.100443","DOIUrl":"10.1016/j.infpip.2025.100443","url":null,"abstract":"<div><h3>Background</h3><div><em>Acinetobacter baumannii</em> is an opportunistic drug-resistant Gram-negative coccobacillus associated with nosocomial infections, representing a worldwide public health problem.</div></div><div><h3>Aim</h3><div>The aim of this study was to analyse the dissemination of <em>A. baumannii</em> in two hospital buildings in Mexico through phenotypic and genotypic characterization of clinical isolates obtained for three years.</div></div><div><h3>Methods</h3><div>Clinical strains were collected from two buildings in a tertiary-care hospital in Monterrey, Mexico. After species identification by MALDI-TOF MS and PCR, antimicrobial susceptibility was determined by disk diffusion and microdilution methods, carbapenemase-encoding genes (OXA-23, -24, -51, and -58) were searched, and clonal diversity was analysed by PFGE and MLST.</div></div><div><h3>Findings</h3><div>Among 204 specimens, 87.3% and 50.5% of the isolates were classified as multidrug-resistant (MDR) and difficult-to-treat-resistant (DTR), respectively. The OXA-24 gene was detected in 95% of the isolates. Most isolates (n=181) were grouped into 15 clones, four which predominated and disseminated after five months. Among ST detected (ST1694, ST758, ST124, and ST490), ST124, which belongs to the high-risk CC636 clonal complex, is reported for the first time in Mexico.</div></div><div><h3>Conclusions</h3><div>Long-term persistence and dissemination of <em>A. baumannii</em> clones were observed in specific hospital wards from two buildings in a tertiary-care hospital in Mexico. High antimicrobial resistance, such as MDR and DTR, were observed in this hospital. DTR surveillance and early recognition of MDR <em>A. baumannii</em> clones should be performed routinely to prevent their dissemination.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"7 1","pages":"Article 100443"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The financial burden of healthcare-associated infections: a propensity score analysis in an Italian healthcare setting","authors":"S. Orlando ,&nbsp;M. Cicala ,&nbsp;C. De Santo ,&nbsp;C. Mosconi ,&nbsp;F. Ciccacci ,&nbsp;L. Guarente ,&nbsp;M. Carestia ,&nbsp;G. Liotta ,&nbsp;D. Di Giovanni ,&nbsp;E. Buonomo ,&nbsp;F. Riccardi ,&nbsp;L. Palombi ,&nbsp;L. Emberti Gialloreti","doi":"10.1016/j.infpip.2024.100406","DOIUrl":"10.1016/j.infpip.2024.100406","url":null,"abstract":"<div><h3>Introduction</h3><div>Hospital-acquired infections (HAIs) present a global public health challenge, impacting patient safety and incurring substantial economic costs across healthcare settings. This study aims to accurately measure the financial burden of HAIs by analyzing real costs associated with various infections, providing insights for targeted prevention and management strategies.</div></div><div><h3>Methods</h3><div>This retrospective cohort study at a university hospital in Rome, Italy, analysed Hospital Discharge Records (HDR) from January to December 2018, focusing on patients with and without HAIs. The study employed ICD-9-CM codes, microbiology databases, and stratified analyses by infection site and microorganism. Cost increments were calculated using DRG reimbursement data. Propensity score matching compared infected patients with matched non-infected counterparts, simulating a randomized trial through two models: one adjusting for length of stay and mortality (less conservative), and one not using these factors as confounders (more conservative).</div></div><div><h3>Results</h3><div>In the study of 12,033 patients at Policlinico Universitario Tor Vergata, 10.07% developed an HAI, significantly raising mean DRG by 53.4% (€3,744 to €5,744). Propensity score analysis showed HAIs elevated costs by €4,695 (60.45%) in one model, and by €3,335 (31.15%) in another. Specific microbes and infection sites further influenced the cost impact, highlighting the need for targeted HAI prevention strategies.</div></div><div><h3>Conclusion</h3><div>Our study reveals the significant economic impact of hospital-acquired infections (HAIs), with a substantial increase in costs linked to specific microorganisms and infection sites. These findings highlight the need for effective HAI prevention strategies to enhance patient safety and reduce healthcare expenditures.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"7 1","pages":"Article 100406"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methicillin and vancomycin-resistant Staphylococcus aureus and associated risk factors among patients with wound infection in East Wallaga Zone, Western Ethiopia","authors":"Milkias Abebe ,&nbsp;Getachew Alemkere ,&nbsp;Gizachew Ayele","doi":"10.1016/j.infpip.2024.100409","DOIUrl":"10.1016/j.infpip.2024.100409","url":null,"abstract":"<div><h3>Background</h3><div>Methicillin and vancomycin-resistant <em>S. aureus</em> have become increasingly problematic in recent years. This may be explained by the indiscriminate use of this antibiotic. The aim of this study was to determine the prevalence of methicillin-resistant and vancomycin-resistant <em>Staphylococcus aureus</em> (VRSA) and associated risk factors in patients with wound infections in the East Wallaga Zone, Western Ethiopia.</div></div><div><h3>Methods</h3><div>A hospital-based cross-sectional prospective study was conducted on 384 patients with wound infections including surgical wound who sought healthcare at Nekemte Specialized Hospital. Wound samples were collected using aseptic techniques and cultured on blood agar and mannitol salt agar. Vancomycin E-test and cefoxitin (30 μg) antibiotic disc diffusion were used to detect MRSA and VRSA, respectively. Data were analyzed using SPSS version 23, and a <em>P</em>-value of less than 0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>Of the 384 wound samples collected, 109 (28.4%) were identified as <em>Staphylococcus aureus</em>. Of these, 40.4% (44/109) were identified as MRSA, and 7.3% (8/109) were VRSA. Thirty-two (72.7%) MRSA isolates were showed multidrug resistance. The depth of the wound, patient setting, history of wound infection, and history of antibiotic use became significantly associated with the prevalence of MRSA wound infection.</div></div><div><h3>Conclusions</h3><div>This study found significant levels of <em>S. aureus</em>, MRSA, and VRSA in patients with wound infection. Therefore, it is crucial to implement effective infection prevention and control measures to prevent the spread of antimicrobial resistance.</div></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 4","pages":"Article 100409"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Device associated healthcare associated infection (DA-HAI): a detailed analysis of risk factors and outcomes in a university hospital in Rome, Italy","authors":"Luca Guarente ,&nbsp;Claudia Mosconi ,&nbsp;Mariagrazia Cicala ,&nbsp;Carolina De Santo ,&nbsp;Fausto Ciccacci ,&nbsp;Mariachiara Carestia ,&nbsp;Leonardo Emberti Gialloreti ,&nbsp;Leonardo Palombi ,&nbsp;Giuseppe Quintavalle ,&nbsp;Daniele Di Giovanni ,&nbsp;Ersilia Buonomo ,&nbsp;Stefania Moramarco ,&nbsp;Fabio Riccardi ,&nbsp;Stefano Orlando","doi":"10.1016/j.infpip.2024.100391","DOIUrl":"10.1016/j.infpip.2024.100391","url":null,"abstract":"<div><h3>Introduction</h3><p>This study investigates the impact of invasive procedures on healthcare-associated infections (HAI) at Policlinico Universitario Tor Vergata in Rome, Italy, aiming to understand their role in device-associated HAI and to inform prevention strategies.</p></div><div><h3>Methods</h3><p>A retrospective cohort analysis was conducted, examining mandatory discharge records and microbiology data from 2018 across all departments. The study focused on adult patients, analysing the correlation between invasive procedures and HAI through univariate and multivariate logistic regression.</p></div><div><h3>Results</h3><p>Of the 12,066 patients reviewed, 1,214 (10.1%) experienced HAI. Univariate analysis indicated an association between invasive procedures and HAI (OR = 1.81, <em>P</em> &lt; 0.001), which was not observed in multivariable analysis. Specific procedures significantly raised HAI risks: temporary tracheostomy (AOR = 22.69, <em>P</em> &lt;0.001), central venous pressure monitoring (AOR = 6.74, <em>P</em> &lt;0.001) prolonged invasive mechanical ventilation (AOR = 4.44, <em>P</em> &lt;0.001), and venous catheterisation (AOR = 1.58, <em>P</em> &lt;0.05). Aggregated high-risk procedures had an increased likelihood of HAI in multivariable analysis (OR = 2.51, <em>P</em> &lt; 0.001). High-risk departments were also notably associated with HAI (OR = 6.13, <em>P</em> &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>This study suggests that specific invasive procedures, such as temporary tracheostomy, significantly increase HAI risks. The results highlighting the need for targeted infection prevention and control procedures and supports the need for innovative methods such as record-linkage in policymaking to address HAI. These findings inform clinical practice and healthcare policy to improve patient safety and care quality.</p></div>","PeriodicalId":33492,"journal":{"name":"Infection Prevention in Practice","volume":"6 4","pages":"Article 100391"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590088924000556/pdfft?md5=43d7c06fec6ad516bbc45fda70374095&pid=1-s2.0-S2590088924000556-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}