The role of vaccination and healthcare acquisition in respiratory failure during a COVID-19 outbreak in an acute hospital in Wales

IF 1.9 Q3 INFECTIOUS DISEASES

Infection Prevention in Practice Pub Date : 2025-07-09 DOI:10.1016/j.infpip.2025.100474

Craig Hogg , Caoimhe McKerr , Noel Craine , Dafydd Williams , Malorie Perry , Simon Cottrell

引用次数: 0

Abstract

This study provides descriptive analysis of a COVID-19 outbreak of 323 cases in a Welsh hospital in early 2021, with a focus on respiratory failure (RF) as a severe outcome. Multivariate analysis demonstrated decreased odds of RF in healthcare acquired cases (aOR 0.40 (95%CI 0.24–0.65), p<0.001) and individuals with at least one dose of vaccine 14 days before first positive test (aOR 0.45 (95%CI 0.28–0.75), p=0.002). In healthcare acquired cases, vaccination significantly reduced the odds of RF (OR 0.47 (95%CI 0.22-0.00), p=0.037). This analysis highlights the importance of vaccination as a protective factor against severe respiratory outcomes.

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在威尔士一家急性医院COVID-19爆发期间，疫苗接种和获得医疗保健在呼吸衰竭中的作用

本研究对2021年初威尔士一家医院爆发的323例COVID-19病例进行了描述性分析，重点关注呼吸衰竭（RF）这一严重后果。多因素分析显示，医疗保健获得性病例（aOR 0.40 (95%CI 0.24-0.65), p<0.001）和在首次阳性检测前14天至少接种过一剂疫苗的个体（aOR 0.45 (95%CI 0.28-0.75), p=0.002）发生RF的几率降低。在医疗保健获得性病例中，接种疫苗显著降低了RF的几率（OR 0.47 (95%CI 0.22-0.00), p=0.037）。这一分析强调了疫苗接种作为预防严重呼吸道后果的保护因素的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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