Therapeutic Advances in Vaccines and Immunotherapy最新文献

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Exploring COVID-19 vaccine adverse events among pregnant women: a cross-sectional study, 2022. 探索 COVID-19 疫苗在孕妇中的不良事件:一项横断面研究,2022 年。
Therapeutic Advances in Vaccines and Immunotherapy Pub Date : 2024-10-05 eCollection Date: 2024-01-01 DOI: 10.1177/25151355241285594
Ahmed A Amer, Samar A Amer, Amerah Badokhon, Sherif M Hammad, Mohamed A Wasfy, Misha Khan, Tahani Ateyah Al-Harbi, Sadah Qamous Alobaid, Georgette Eskander, Amro Abdel-Azeem, Abdulmajeed Alshowair, Mohamed Sh Ramadan
{"title":"Exploring COVID-19 vaccine adverse events among pregnant women: a cross-sectional study, 2022.","authors":"Ahmed A Amer, Samar A Amer, Amerah Badokhon, Sherif M Hammad, Mohamed A Wasfy, Misha Khan, Tahani Ateyah Al-Harbi, Sadah Qamous Alobaid, Georgette Eskander, Amro Abdel-Azeem, Abdulmajeed Alshowair, Mohamed Sh Ramadan","doi":"10.1177/25151355241285594","DOIUrl":"https://doi.org/10.1177/25151355241285594","url":null,"abstract":"<p><strong>Background: </strong>Clear and trustworthy information is crucial to improving public acceptance of COVID-19 vaccinations, especially among pregnant women. Given the increased risk of severe viral pneumonia in pregnant women, it is critical to foster confidence in the vaccine's safety and understand any potential adverse events (AEs). So, we did this study in Jeddah, Saudi Arabia (SA), from March to May 2022 to compare women who did not get any doses of the COVID-19 vaccine during pregnancy (Group A) to women who did get at least one dose during pregnancy (Group B) regarding (1) the frequency, types, AEs, and management of its AEs of the COVID-19 vaccination; and (2) exploring pregnancy, delivery, and fetus-related complications (e.g., miscarriage, birth defects, and preterm labor).</p><p><strong>Methods: </strong>A cross-sectional study targeted 438 women who gave birth or were pregnant within the previous 8 weeks. Data was collected through face-to-face interviews with skilled nurses in 13 randomly selected primary healthcare facilities, using a validated, well-structured questionnaire that included the Centers for Disease Control (CDC) COVID-19 vaccination-related AEs. We analyzed the collected data using SPSS version 27.</p><p><strong>Results: </strong>Most participants were aged 25 to less than 35 (58.8%), and 287 (61.3%) were university graduates. There was no statistically significant difference among the studied groups regarding demographics. However, women in Group B had a significantly higher rate of abortions, oligohydramnios (24.4%), abnormal placentas (size and location), 103 (42.7%) abnormal fetal growth, 122 (53.7%) problems breastfeeding, blood pressure problems, and more cases of malaise, headaches, chest pain, breathing problems, and sleep problems than women in Group A. After the second and third doses, the confirmed post-vaccination COVID-19 rates in Group B were lower than those in Group A.</p><p><strong>Conclusion: </strong>The COVID-19 vaccine significantly reduces post-vaccination COVID-19. Although COVID-19 vaccine-related AES are prevalent, analgesics and antipyretics effectively treat most of them.</p>","PeriodicalId":33285,"journal":{"name":"Therapeutic Advances in Vaccines and Immunotherapy","volume":"12 ","pages":"25151355241285594"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relative effectiveness of COVID-19 vaccine booster doses in people aged 65 and older-a retrospective cohort study in Türkiye. 65 岁及以上人群接种 COVID-19 疫苗加强剂量的相对有效性--土耳其回顾性队列研究。
Therapeutic Advances in Vaccines and Immunotherapy Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.1177/25151355241285375
Mehmet Akif Sezerol, Alican Sarisaltik
{"title":"Relative effectiveness of COVID-19 vaccine booster doses in people aged 65 and older-a retrospective cohort study in Türkiye.","authors":"Mehmet Akif Sezerol, Alican Sarisaltik","doi":"10.1177/25151355241285375","DOIUrl":"10.1177/25151355241285375","url":null,"abstract":"<p><strong>Background: </strong>Immunization in the elderly population is critical due to the high frequency of health outcomes related to COVID-19.</p><p><strong>Objectives: </strong>This study aimed to compare the effectiveness levels of COVID-19 vaccine schedules in preventing SARS-CoV-2 infection in the older adult group who received at least one booster dose.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Methods: </strong>This study evaluated 8969 adults aged 65 and over in the Sultanbeyli district of İstanbul. COVID-19 vaccination and SARS-CoV-2 polymerase chain reaction testing data between January 14, 2021 and December 2, 2022 were obtained from the National Public Health Management System.</p><p><strong>Results: </strong>The median age of participants was 71 years. The vaccines were mostly administered as CoronaVac for the first and second doses (81.4% and 82.2%, respectively) and BNT162b2 for the third and fourth doses (61.8% and 73.1%, respectively). Turkovac was administered only in booster doses (third dose 0.6%, fourth dose 4.8%). The adjusted relative vaccine effectiveness (rVE) was found to be 61.8% (95% confidence interval (CI) 51.5-69.9) in two doses of inactivated vaccine and one dose of mRNA vaccine schedule compared to the homolog booster of CoronaVac primary vaccine schedule. In two booster doses receipts, the adjusted rVE was found to be 45.4% (95% CI 13.8-65.4) in three doses of inactivated and one dose mRNA vaccine schedule and 43.0% (95% CI 20.5-59.2) in two doses of inactivated and two doses of mRNA vaccines schedule compared to the two homolog boosters with CoronaVac primary vaccine schedule.</p><p><strong>Conclusion: </strong>In this study, the effectiveness of the mRNA vaccine as a booster dose was higher than that of the homologous boosters in participants receiving the CoronaVac primary series for those aged 65 and over.</p>","PeriodicalId":33285,"journal":{"name":"Therapeutic Advances in Vaccines and Immunotherapy","volume":"12 ","pages":"25151355241285375"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 vaccine coverage effectiveness among elderly with geographical information system mapping: what about Indonesia? COVID-19 疫苗在老年人中的覆盖效果与地理信息系统绘图:印度尼西亚的情况如何?
Therapeutic Advances in Vaccines and Immunotherapy Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.1177/25151355241285379
Widya Ratna Wulan, Evina Widianawati, Anis Tri Wahyuni
{"title":"COVID-19 vaccine coverage effectiveness among elderly with geographical information system mapping: what about Indonesia?","authors":"Widya Ratna Wulan, Evina Widianawati, Anis Tri Wahyuni","doi":"10.1177/25151355241285379","DOIUrl":"10.1177/25151355241285379","url":null,"abstract":"<p><strong>Background: </strong>The elderly are the next priority after health workers and public service workers get the COVID-19 vaccine to control morbidity and even mortality in the elderly who have a risk factor that is up to 60 times more severe than children.</p><p><strong>Objectives: </strong>This study aimed to spatially analyze the effectiveness of COVID-19 vaccine coverage among the elderly in Indonesia with geographic information system (GIS) mapping and to analyze the relationship between COVID-19 vaccine coverage in the elderly with the COVID-19 cure rate.</p><p><strong>Design: </strong>This quantitative study used secondary data on COVID-19 vaccination coverage in the elderly group of Central Java Province, Indonesia in 2021.</p><p><strong>Methods: </strong>Data were analyzed using a simple linear correlation test to test the relationship between variables with a 1,774,396 elderly sample size, then distributed using mapping of COVID-19 vaccination coverage using a GIS.</p><p><strong>Results: </strong>The relationship between COVID-19 vaccine dose-2 elderly coverage cure rate showed a strong relationship (<i>r</i> = 0.677) and a positive pattern. The coefficient value with a determination of 0.459 means that the regression line equation obtained can explain 45.90% of the variation in the COVID-19 cure rate. There was a significant relationship between COVID-19 vaccine elderly coverage and the COVID-19 cure rate (<i>p</i>-value = 0.005).</p><p><strong>Conclusion: </strong>Clinicians and public health workers should continue to encourage elderly vaccination at all recommended doses for eligible individuals.</p>","PeriodicalId":33285,"journal":{"name":"Therapeutic Advances in Vaccines and Immunotherapy","volume":"12 ","pages":"25151355241285379"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, attitude, and acceptance of COVID-19 vaccine in pregnant women. 孕妇对 COVID-19 疫苗的了解、态度和接受程度。
Therapeutic Advances in Vaccines and Immunotherapy Pub Date : 2024-09-21 eCollection Date: 2024-01-01 DOI: 10.1177/25151355241278832
Arissara Kuptarak, Vorapong Phupong
{"title":"Knowledge, attitude, and acceptance of COVID-19 vaccine in pregnant women.","authors":"Arissara Kuptarak, Vorapong Phupong","doi":"10.1177/25151355241278832","DOIUrl":"https://doi.org/10.1177/25151355241278832","url":null,"abstract":"<p><strong>Background: </strong>Due to the COVID-19 situation, vaccination is a key factor in reducing the severity and transmission of the disease, especially in the vulnerable population, which includes pregnant women. Currently, various policies are in place to promote the vaccination of pregnant women against COVID-19; however, some pregnant women decline vaccination.</p><p><strong>Objectives: </strong>To study pregnant women's knowledge, attitude, and acceptance regarding the COVID-19 vaccine.</p><p><strong>Design: </strong>A cross-sectional study was conducted among pregnant women who received antenatal care at King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.</p><p><strong>Methods: </strong>Pregnant women who received antenatal care at King Chulalongkorn Memorial Hospital, Chulalongkorn University from November 2021 to April 2022 were included. The participants answered an online questionnaire through their electronic devices. Univariate and multivariate logistic regression analyses were performed to analyze the data.</p><p><strong>Results: </strong>A total of 500 pregnant women participated in this study. Among them, 67.4% and 81.4% had great knowledge and a positive attitude toward the COVID-19 vaccine, respectively, with scores of 80% or higher in each section. Of the 500 participants, 468 (93.6%) accepted to receive the COVID-19 vaccine. After adjusting for certain variables through multivariate analysis, the factor associated with the decision to receive the COVID-19 vaccine was having great knowledge about the vaccine (adjusted odds ratio (OR) 13.25, 95% confidence interval (CI) 2.45-71.61). However, the most significant factor associated with the decision to reject the COVID-19 vaccine was the recent COVID-19 infection (adjusted OR 0.11, 95% CI 0.02-0.62).</p><p><strong>Conclusion: </strong>The COVID-19 pandemic presents severe and life-threatening conditions for both pregnant women and their fetuses. The majority of the pregnant women in this study had great knowledge and acceptance of the vaccine and a positive attitude toward it. The pregnant women who had prior knowledge of the vaccine tended to accept to receive it during pregnancy, whereas those who recently contracted COVID-19 were hesitant to receive the vaccine.</p>","PeriodicalId":33285,"journal":{"name":"Therapeutic Advances in Vaccines and Immunotherapy","volume":"12 ","pages":"25151355241278832"},"PeriodicalIF":0.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11428176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative 60-day effectiveness of bivalent versus monovalent mRNA vaccines in Shelby County: a population-level analysis. 谢尔比县二价与单价 mRNA 疫苗的 60 天效果比较:人群水平分析。
Therapeutic Advances in Vaccines and Immunotherapy Pub Date : 2024-09-19 eCollection Date: 2024-01-01 DOI: 10.1177/25151355241278852
Allison P Plaxco, Jennifer Kmet, Matthew P Smeltzer, Yu Jiang, Michelle Taylor, Vikki G Nolan
{"title":"Comparative 60-day effectiveness of bivalent versus monovalent mRNA vaccines in Shelby County: a population-level analysis.","authors":"Allison P Plaxco, Jennifer Kmet, Matthew P Smeltzer, Yu Jiang, Michelle Taylor, Vikki G Nolan","doi":"10.1177/25151355241278852","DOIUrl":"10.1177/25151355241278852","url":null,"abstract":"<p><strong>Background: </strong>Two monovalent mRNA vaccines, available in December 2020, were demonstrated to have high efficacy against both the original SARS-CoV-2 strain and variants circulating through the summer and into the fall of 2021. In the context of the Omicron/BA.1 variant, which was predominant from late fall 2021 into winter of 2022 in the United States, and subsequent Omicron subvariants that have been predominant thereafter, vaccine effectiveness of the monovalent mRNA vaccine option is attenuated.</p><p><strong>Objectives: </strong>We aim to investigate the relative effectiveness of the bivalent booster compared to the monovalent booster against SARS-CoV-2 infection in the 60 days following administration in Shelby County, TN.</p><p><strong>Design: </strong>This observational population-based cohort study utilizes COVID-19 surveillance data to identify adults who were vaccinated with a monovalent booster dose between August 1, 2022 and August 30, 2022 or a bivalent booster dose between September 1, 2022 and September 30, 2022. Both groups were followed for COVID-19 status for 60 days from their administration date.</p><p><strong>Methods: </strong>We calculated incidence rates with 95% confidence intervals and propensity-adjusted hazard ratios with 95% confidence intervals of COVID-19 diagnosis in the 60 days following administration of the booster dose between the bivalent group and the monovalent group. Stratified analysis was conducted by age group (18-34, 35-64, and 65+ years old).</p><p><strong>Results: </strong>The incidence of reported SARS-CoV-2 infection was substantially higher for those who received the monovalent booster, across age groups. Overall, we observed a 51% lower hazard of infection during the study period among those who received the bivalent booster, compared to the monovalent booster.</p><p><strong>Conclusion: </strong>These results support and extend prior findings that the bivalent booster dose may be more effective in preventing infection against the Omicron sub-variants of SARS-CoV-2.</p>","PeriodicalId":33285,"journal":{"name":"Therapeutic Advances in Vaccines and Immunotherapy","volume":"12 ","pages":"25151355241278852"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11418355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccination practices and knowledge among adults with hemoglobinopathies in Greece: a nationwide survey. 希腊成年血红蛋白病患者的疫苗接种习惯和知识:一项全国性调查。
Therapeutic Advances in Vaccines and Immunotherapy Pub Date : 2024-09-17 eCollection Date: 2024-01-01 DOI: 10.1177/25151355241278869
Sophia Delicou, Konstantinos Manganas, Aikaterini Xydaki, Loukia Evliati, Ioanna Myrilla, Leonidas Rubatis, Stavroula Kostaridou
{"title":"Vaccination practices and knowledge among adults with hemoglobinopathies in Greece: a nationwide survey.","authors":"Sophia Delicou, Konstantinos Manganas, Aikaterini Xydaki, Loukia Evliati, Ioanna Myrilla, Leonidas Rubatis, Stavroula Kostaridou","doi":"10.1177/25151355241278869","DOIUrl":"10.1177/25151355241278869","url":null,"abstract":"<p><strong>Background: </strong>Hemoglobinopathies, such as sickle cell disease and thalassemia, are genetic disorders that affect hemoglobin structure or production, leading to various health complications, including an increased risk of infections. Vaccinations play a crucial role in managing these conditions by providing essential protection against preventable diseases. Ensuring timely and appropriate immunizations is vital for reducing infection-related morbidity and improving the overall health and quality of life for affected individuals.</p><p><strong>Objectives: </strong>Our objective was to assess vaccination coverage, as well as knowledge, attitudes, and practices toward vaccination in Greek patients with hemoglobinopathies.</p><p><strong>Design and methods: </strong>A nationwide survey of hemoglobinopathy patients in Greece using a 37-item questionnaire was conducted anonymously via Google Forms. It covered demographics, previous vaccinations, vaccine-preventable infections, beliefs about vaccines, and antibiotic prophylaxis post-splenectomy. The survey was distributed through Thalassemia and Sickle Cell Units and organizations.</p><p><strong>Results: </strong>Participants were predominantly university-educated married women aged 30-50 years with transfusion-depended thalassemia (<i>n</i> = 149, 60.5%) or sickle cell anemia (<i>n</i> = 52, 21.1%). Reported childhood vaccination rates aligned with Greece's national immunization program. However, adult coverage was suboptimal across all age groups for measles (10%), varicella (27%), zoster (2% for over 50 years old individuals), hepatitis A (13.9% of those with chronic liver disease) and hepatitis B (41%), pneumococcal (81.3%), meningococcal (37%), tetanus (20.3%), and influenza (67.1%) vaccines compared to guidelines. Participants relied predominantly on healthcare providers for vaccine information but perceived limited engagement. Those over age 50 demonstrated lower adult vaccination rates and higher misconceptions compared to younger cohorts.</p><p><strong>Conclusion: </strong>Addressing educational and access gaps could help protect this vulnerable population. Our findings highlight the need for coordinated efforts to optimize adult immunization for those with hemoglobinopathies.</p>","PeriodicalId":33285,"journal":{"name":"Therapeutic Advances in Vaccines and Immunotherapy","volume":"12 ","pages":"25151355241278869"},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11418312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Media literacy: exploring the key to social media influences for wise parental decision-making on vaccines. 媒体素养:探索社交媒体影响的关键,让家长明智地做出疫苗决策。
Therapeutic Advances in Vaccines and Immunotherapy Pub Date : 2024-09-12 eCollection Date: 2024-01-01 DOI: 10.1177/25151355241277780
Dalmacito A Cordero
{"title":"Media literacy: exploring the key to social media influences for wise parental decision-making on vaccines.","authors":"Dalmacito A Cordero","doi":"10.1177/25151355241277780","DOIUrl":"https://doi.org/10.1177/25151355241277780","url":null,"abstract":"","PeriodicalId":33285,"journal":{"name":"Therapeutic Advances in Vaccines and Immunotherapy","volume":"12 ","pages":"25151355241277780"},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11402060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoclonal IgY antibodies: advancements and limitations for immunodiagnosis and immunotherapy applications. 单克隆 IgY 抗体:免疫诊断和免疫疗法应用的进步与局限。
Therapeutic Advances in Vaccines and Immunotherapy Pub Date : 2024-07-25 eCollection Date: 2024-01-01 DOI: 10.1177/25151355241264520
Ashraf A Tabll, Yasser E Shahein, Mohamed M Omran, Nahla A Hussein, Asmaa El-Shershaby, Ana Petrovic, Marija Glasnovic, Robert Smolic, Martina Smolic
{"title":"Monoclonal IgY antibodies: advancements and limitations for immunodiagnosis and immunotherapy applications.","authors":"Ashraf A Tabll, Yasser E Shahein, Mohamed M Omran, Nahla A Hussein, Asmaa El-Shershaby, Ana Petrovic, Marija Glasnovic, Robert Smolic, Martina Smolic","doi":"10.1177/25151355241264520","DOIUrl":"10.1177/25151355241264520","url":null,"abstract":"<p><p>Due to their high specificity and scalability, Monoclonal IgY antibodies have emerged as a valuable alternative to traditional polyclonal IgY antibodies. This abstract provides an overview of the production and purification methods of monoclonal IgY antibodies, highlights their advantages over polyclonal IgY antibodies, and discusses their recent applications. Monoclonal recombinant IgY antibodies, in contrast to polyclonal IgY antibodies, offer several benefits. such as derived from a single B-cell clone, monoclonal antibodies exhibit superior specificity, ensuring consistent and reliable results. Furthermore, it explores the suitability of monoclonal IgY antibodies for low- and middle-income countries, considering their cost-effectiveness and accessibility. We also discussed future directions and challenges in using polyclonal IgY and monoclonal IgY antibodies. In conclusion, monoclonal IgY antibodies offer substantial advantages over polyclonal IgY antibodies regarding specificity, scalability, and consistent performance. Their recent applications in diagnostics, therapeutics, and research highlight their versatility.</p>","PeriodicalId":33285,"journal":{"name":"Therapeutic Advances in Vaccines and Immunotherapy","volume":"12 ","pages":"25151355241264520"},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing and validating a scale to measure the perceptions of safety, usability and acceptability of microarray patches for vaccination: a study protocol. 开发并验证用于测量疫苗接种微阵列贴片的安全性、可用性和可接受性的量表:研究方案。
Therapeutic Advances in Vaccines and Immunotherapy Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1177/25151355241263560
Matthew N Berger, Cristyn Davies, Erin Mathieu, Ramon Z Shaban, Shopna Bag, S Rachel Skinner
{"title":"Developing and validating a scale to measure the perceptions of safety, usability and acceptability of microarray patches for vaccination: a study protocol.","authors":"Matthew N Berger, Cristyn Davies, Erin Mathieu, Ramon Z Shaban, Shopna Bag, S Rachel Skinner","doi":"10.1177/25151355241263560","DOIUrl":"10.1177/25151355241263560","url":null,"abstract":"<p><strong>Background: </strong>Vaccination is a fundamental tenet of public and population health. Several barriers to vaccine uptake exist, exacerbated post-COVID-19, including misconceptions about vaccine efficacy and safety, vaccine hesitancy, vaccine inequity, costs, religious beliefs, and insufficient education and guidance for healthcare professionals. Vaccine uptake may be aided using microarray patches (MAPs) due to reduced pain, no hypodermic needle, enhanced thermostability, and potential for self and lay administration.</p><p><strong>Objectives: </strong>This protocol outlines the development of a scale that aims to accurately measure the perceived safety, usability, and acceptability of MAPs for vaccination among laypeople, MAP recipients, clinicians, and parents or guardians of children.</p><p><strong>Methods and analysis: </strong>This study will follow three phases of scale development and validation, including (1) item development, (2) scale development, and (3) scale evaluation. Inductive (interviews) and deductive methods (literature searches) will be used to develop scale items, which experts from target populations will assess through an online survey. Cognitive interviews will be conducted to observe their processes of answering the draft survey. Thematic analysis will be conducted to analyse qualitative data. Lastly, four surveys will be administered online to our target populations over two time points to determine their repeatability. Exploratory and confirmatory factor analyses, Cronbach's alpha, and construct validity will be performed.</p><p><strong>Ethics: </strong>This study was approved by Metro South Health (HREC/2021/QMS/81653) and Western Sydney Local Health District (2023/ETH00705) Human Research Ethics Committees.</p><p><strong>Discussion: </strong>The scale will support a standardised approach to assessing the social and behavioural aspects of MAP vaccines, enabling comparison of outcomes across studies. Once validated, this scale will assist vaccination programmes in developing effective strategies for integrating MAPs and overcoming barriers to vaccination. This includes improving vaccine equity and accessibility, especially in lower- and middle-income countries and rural or remote locations.</p>","PeriodicalId":33285,"journal":{"name":"Therapeutic Advances in Vaccines and Immunotherapy","volume":"12 ","pages":"25151355241263560"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11265248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Routine immunization for children in the Philippines: challenges and interventions. 菲律宾儿童常规免疫接种:挑战与干预措施。
Therapeutic Advances in Vaccines and Immunotherapy Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1177/25151355241264528
Dalmacito A Cordero
{"title":"Routine immunization for children in the Philippines: challenges and interventions.","authors":"Dalmacito A Cordero","doi":"10.1177/25151355241264528","DOIUrl":"https://doi.org/10.1177/25151355241264528","url":null,"abstract":"","PeriodicalId":33285,"journal":{"name":"Therapeutic Advances in Vaccines and Immunotherapy","volume":"12 ","pages":"25151355241264528"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11265232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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