EAS Journal of Pharmacy and Pharmacology最新文献

{"title":"Determination of Antioxidant and α–Amylase Inhibition Properties of Alligator Pepper (Aframomum Melegueta): A Potential Therapeutic Against Diabetes Mellitus","authors":"Abdullahi J. Muhammad, M. Muhammad, A. Yunusa, Tasiu A. Mikail, M. Dalhatu, I. Habib, Shahida I. Sarki, Mariah S. Gwarzo, N. Muhammad, Rabitu Kabir Mustapha","doi":"10.36349/easjpp.2022.v04i03.001","DOIUrl":"https://doi.org/10.36349/easjpp.2022.v04i03.001","url":null,"abstract":"Diabetes is a chronic metabolic disease characterized by raised levels of blood glucose, which over time leads to serious damage to the heart, blood vessels, eyes, kidneys, and nerves. α-amylase Plays a major role in the digestion of starch and glycogen. Thus, inhibitors of this enzyme delay the breakdown of carbohydrates in the small intestine, thereby diminishing postprandial blood glucose in the diabetic patient. In this study, a DPPH radical scavenging activity and computational approaches were employed to uncover the potential of Aframomum Melegueta phytochemicals against type two diabetes mellitus mainly by molecular docking, molecular dynamic simulation, MMPBSA and ADMET analysis. The results show that it has high antioxidant properties. Molecular docking indicates that laurifolin, genkwanin and gulunalactone have good binding scores of -9.9 kcal/mol, -8.9 kcal/mol and -8.2 kcal/mol, respectively. And have interacted with at least two of the catalytic triads of α-amylase; Asp 300, Glu 233 and Asp 197. Molecular dynamic simulation results show that all the compounds are stable at the active site of the enzyme. Furthermore, MMPBSA analysis revealed they bind strongly with the binding energy of -21.77± 1.03 Kcal/mol, -17.82 ± 0.84 Kcal/mol and 15.07± 0.26 Kcal/mol for laurifolin, genkwanin and galanolactone. ADMET analysis indicated that all the ligands are water-soluble, drug-like and safe. This study shows that A. Melegueta extract has antioxidant properties and possess phytochemicals that can be exploited for further anti-diabetic drug development.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125412627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Sturge – Weber Syndrome: A Case Report and Review of Literature”","authors":"D. S, D. T, Dr. Anbumani Dr. Anbumani, Dr. Prabakaran M","doi":"10.36349/easjrit.2022.v04i03.002","DOIUrl":"https://doi.org/10.36349/easjrit.2022.v04i03.002","url":null,"abstract":"Sturge-Weber syndrome is a rare, sporadically occurring neurocutaneous syndrome characterized by port wine stain (facial nevus flammeus), congenital glaucoma, and anomalous leptomeningeal angiomatous malformation. Port wine stain is usually the first component of the syndrome. Seizures of the side contralateral to the port wine stain occur early in infancy and worsen with age. Radiological investigations, like computed tomography and magnetic resonance imaging are most useful, playing a pivotal role in demonstrating the cerebral changes. We report the case of a three year old child presenting with port wine stain over left half of the body, weakness of right upper and lower limb with an episode of seizure. The child was known to have seizures from 6 months of age and was on irregular anticonvulsant treatment. This case highlights the various neurological manifestations of Sturge-Weber syndrome and how imaging helps to characterize each.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131815507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Mediastinal Pseudocyst: A Case Report and Review of Literature”","authors":"Dr. Anbumani Dr. Anbumani, Dr. Aravind Dr. Aravind, D. T, Dr. Prabakaran M","doi":"10.36349/easjrit.2022.v04i03.003","DOIUrl":"https://doi.org/10.36349/easjrit.2022.v04i03.003","url":null,"abstract":"A mediastinal pseudocyst is the extension of pancreatic pseudocyst into the posterior mediastinum through esophageal or aortic hiatus or rarely through the foramen of Morgagni. It is a rare complication of acute or chronic pancreatitis. We report a rare case of mediastinal pseudocyst of a 35-year-old male alcoholic who was presented with dyspnea, hemoptysis.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128700532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyke-Davidoff-Masson Syndrome: A Case Report and Review of Literature","authors":"D. T, Dr. Anbumani Dr. Anbumani, Dr. Aravind Dr. Aravind, Dr. Prabakaran M","doi":"10.36349/easjrit.2022.v04i03.001","DOIUrl":"https://doi.org/10.36349/easjrit.2022.v04i03.001","url":null,"abstract":"Dyke-Davidoff-Masson syndrome (DDMS) is a rare neurological disorder caused by brain injury in intrauterine or early years of life. Characteristic findings are prominent cortical sulci, dilated lateral ventricles, cerebral hemiatrophy, hyperpneumatization of the frontal sinus and compensatory hypertrophy of the skull. Hereby describing a male patient who presented with generalized tonic-clonic seizure and left-sided body weakness with neuroimaging findings of cerebral hemiatrophy, right lateral ventricle dilatation, hyperpneumatization of right frontal sinus, and asymmetric calvarial thickening. The above mentioned imaging features enables timely and accurate diagnosis, allowing appropriate management.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134581800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does food have anything to do with Memory and Intelligence? A Review on Alzheimer's disease Fighting","authors":"H. Abushwereb","doi":"10.36349/easjpp.2022.v04i02.003","DOIUrl":"https://doi.org/10.36349/easjpp.2022.v04i02.003","url":null,"abstract":"Alzheimer's disease is a neurological disorder that causes the brain to gradually and irreversibly shrink, atrophy, and die. There is no successful treatment for Alzheimer's disease to this day that makes it necessary to reduce its occurrence rather than treat the disease after it has occurred. Therefore, it became necessary and priority to focus on preventing it and knowing the causes that lead to the deterioration of the brain after it was fully active and strong. Back in the early stages of brain development in which food plays an important role. The focus comes on the important elements and materials that increase intelligence, skills, brilliance of thinking and memory, which continue with the person throughout his life after feeding him with important functional elements and vitamins. It is noted that with the development and increase of processed and refined food items that have recently entered the human body, there has been a significant increase and acceleration in the incidence of Alzheimer's disease at alarming and frightening rates. It has become worth reconsidering what we eat and focusing on the right food and its goal as one of the factors affecting the health of brain cells. Therefore nutritional awareness has become essential and nutritional supplementation is essential for a certain age as a fighter and as a preventer before contracting the disease.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126076059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Choosing Wisely Initiative and Esomeprazole Over-Prescription","authors":"H. A. Awashi, Hussain A. Darbashi, L. Khan","doi":"10.36349/easjpp.2022.v04i02.002","DOIUrl":"https://doi.org/10.36349/easjpp.2022.v04i02.002","url":null,"abstract":"The choosing wisely initiative of the Adaa program, in collaboration with the Ministry of Health (MoH), Kingdom of Saudi Arabia, aimed to improve physician-patient interaction to plan their care while avoiding the unnecessary and inappropriate tests, treatments, and procedures that increase the cost while adding no benefit in the health-related outcome of the patient. Of the many avoidable treatment medications, the one noted and selected is the over and misuse of esomeprazole, a proton pump inhibitor (PPI), used for gastroesophageal reflux disease (GERD), gastric ulcers, etc. The drug is commonly prescribed in clinical practice in general and over-the-counter in specific. As the published literature reports major adverse events associated with the drug, there is a need for a controlled prescription in selected cases to avoid its overprescription. In compliance with the choosing wisely initiative of Adaa health, we surveyed a regional secondary care facility (Baish General Hospital) after a twelve-week rigorous health education program for physicians and patients and concluded a substantial reduction in the prescription of esomeprazole. The survey findings; indicate the beneficial effects of teaching programs on avoidable treatment options to opt for suitable alternatives which will be both productive and cost-effective.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132218565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Phytochemical Screening and HPTLC Fingerprinting of Leaf Methanolic Extract of Spermacoce hispida","authors":"Shikha Sharma, J. Malik, D. Chandra","doi":"10.36349/easjpp.2022.v04i01.003","DOIUrl":"https://doi.org/10.36349/easjpp.2022.v04i01.003","url":null,"abstract":"The main objective of the present work to established the fingerprint profile of S.hispida using high performance thin layer chromatography (HPTLC) technique. Preliminary phytochemical screening was done and HPTLC studies were carried out. The scanning was performed using 'CAMAG' densitometer scanner 3V equipped with CATS3 software, at a wavelength of 400 and 254 nm using deuterium lamp.Preliminary phytochemical screening of the methanolic extract S.hispida showed the presence of alkaloids, carbohydrates, phenols, tannins, flavanoids, gums and mucilage. HPTLC finger printing of S.hispida methanolic extract showed best results in Toluene: Ethyl Acetate: Formic acid: 5:4:1 solvent system. After scanning and visualizing the plates in absorbance mode at 254nm, 366 nm and visible light range (400-600nm after spraying with anisaldehyde sulphuric acid reagent) best results were shown at 400nm. The Rf values ranged from 0.06 to 0.99. The result showed that out of 15 components, the component with Rf values 0.95, 0.82 were found to be more predominant as the percentage area is more with 28.85% and 12.91% respectively.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128267449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Ethanol Extract of Camellia Sinensis on Salmonella Typhi Infection in Adult Male Rats","authors":"M. Haider, Z. F. Dewan, Md. Moniruzzaman Khan, M. E. Kabir, M. Shahabuddin, M. Aktar, J. Roy, F. Akter","doi":"10.36349/easjpp.2022.v04i01.002","DOIUrl":"https://doi.org/10.36349/easjpp.2022.v04i01.002","url":null,"abstract":"Background: Typhoid fever, a potentially fatal multisystem illness which is due to infection by Salmonella typhi, is an important health problem in many developing countries including Bangladesh. Investigators from the US Centers for Disease Control and Prevention estimate that there are 21.6 million typhoid cases annually, with the annual incidence varying from 100 to 1000 cases per 100 000 population. Objective: To evaluate the effect of ethanol extract of camellia sinensis on salmonella typhi infection in adult male rats. Materials and Methods: Type of study: This was an experimental study. Duration of study: September 2014-February 2016. Place of study: Department of Pharmacology, BSMMU, Shahbag, Dhaka, Department of Microbiology, BSMMU, Shahbag, Dhaka, Department of Clinical Pathology, BSMMU, Shahbag, Dhaka, Department of Chemistry, Dhaka University, Dhaka, Bangladesh. Materials: Animals: 84 adult male Long Evan’s Norwegian rats were obtained from the animal house of BSMMU. Sample Size Estimation: So, we took six groups and 10 rats in each group. The groups were: Control group (I), Rat infected with S. typhi (II), Rat infected with S. typhi then treated with ethanolic leaf extracts of CAS (III), Rat given ethanolic extracts of CAS only (IV), Rat infected with S. typhi then treated with ciprofloxacin (V), Rat infected with S. typhi then treated with both ciprofloxacin and ethanolic extracts of CAS (VI). Adult male rats were taken for this experiment. The number of rat for each group were 10 (n=10). Methodology: Preparation of ethanol extract of C. sinensis Linn: Home processing Black and Green tea (C. sinensis) was published by the college of Tropical Agriculture and Human resources (2007) which was supported in part by the USDA, agricultural Research Service’s pacific Basin, Agricultural Research center and the Department of Research and Development, County of Hawai’I, Japan. i) Collection of C. sinensis leaves: Harvest 10 kg of fresh tea shoots from ..........","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129756116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minocycline Modulates Anxiety-Like Manifestations in Sleep Deprived Mice","authors":"A. Eduviere, L. Otomewo, Hearty E. Ophori","doi":"10.36349/easjpp.2022.v04i01.001","DOIUrl":"https://doi.org/10.36349/easjpp.2022.v04i01.001","url":null,"abstract":"Primarily, sleep allows the brain to recover and regenerate. In view of this, central nervous system disorders are the most common effects that result from sleep loss or prolonged periods of wakefulness since the system most benefits from sleep. Therefore, this increases the risk of schizoaffective disorders such as mania and bipolar disorder. This research was therefore designed to investigate the possible anti-manic and anxiolytic effect of minocycline in mice exposed to sleep deprivation. Twenty-four mice were grouped into four of six animals each (n=6) and orally treated with 10 mL/kg distilled water, 25 or 50 mg/kg minocycline. Treatment was scheduled for 7 days and three out of the four groups were subjected to the sleep deprivation protocol which lasted for 3 days. Afterwards, all groups were subjected to behavioural tests to evaluate anxiety-like behaviour. Subsequently, histology of selected brain regions was carried out. Experimental data were analysed using one-way ANOVA with statistical significance of p<0.05. The results obtained suggested that minocycline ameliorated the manic-like behaviour in mice caused by sleep deprivation. This study therefore concluded that minocycline can be classified as an anxiolytic and anti-manic agent in mice exposed to sleep-deprivation.","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126332811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Screening and Antimicrobial Activities of Rwandan traditional medicinal plant, Urtica massaica Mildbr (Urticaceae)","authors":" Maniriho O, Nkurunziza Jp, Ayodele Ae, Benimana F, Murhula Hp, Farhan Hfa, Nimbeshaho F, Cyiza F","doi":"10.36349/easjpp.2021.v03i02.004","DOIUrl":"https://doi.org/10.36349/easjpp.2021.v03i02.004","url":null,"abstract":"1 Department of Pharmacognosy, Medicinal Plants Research and Drug Development Programme, Pan African University/University of Ibadan, Ibadan, Nigeria 2 Department of Chemistry, School of Sciences, College of Science and Technology, University of Rwanda, Rwanda 3 Department of Botany, Faculty of Science, University of Ibadan, Ibadan, Nigeria 4 Department of Food and Biotechnology, Faculty of Medical Biology, South Ural State University, Chelyabinsk, Russia 5 Department of chemistry, University of Bandung, Indonesia","PeriodicalId":328128,"journal":{"name":"EAS Journal of Pharmacy and Pharmacology","volume":"32 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133784292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}