Forensic Chemistry最新文献_第2页

Detection of synthetic cathinones in seized drugs using surface-enhanced Raman spectroscopy (SERS) 利用表面增强拉曼光谱（SERS）检测缉获药物中的合成卡西酮类化合物

IF 2.6 3区医学

Forensic Chemistry Pub Date : 2024-10-28 DOI: 10.1016/j.forc.2024.100613

Mario O. Vendrell-Dones, Emily Hernandez, Sevde Dogruer Erkok, Bruce McCord

{"title":"Detection of synthetic cathinones in seized drugs using surface-enhanced Raman spectroscopy (SERS)","authors":"Mario O. Vendrell-Dones, Emily Hernandez, Sevde Dogruer Erkok, Bruce McCord","doi":"10.1016/j.forc.2024.100613","DOIUrl":"10.1016/j.forc.2024.100613","url":null,"abstract":"<div><div>There is need for a screening method to assist authorities in detecting cathinone analogs in a rapid, reliable, and sensitive fashion. This work describes the development of Ag colloidal systems for use as SERS-enhancing substrates to detect six synthetic cathinone analogs. Furthermore, specific interactions between the analyte and metal surface were probed by determining the effect of functional groups attached to the core synthetic cathinone. Initial work involved Density Functional Theory (DFT) calculations at B3LYP/6-311G** level to predict Raman frequencies of the studied compounds. Normal Raman measurements on dried solid residues of synthetic cathinone standards were next examined, and the resulting scaled spectra were used to ensure concordance of the DFT-predicted frequencies with experimental values. Subsequent work focused on the development of a SERS protocol, which included the selection ofnanoparticles in solution, followed by the addition of aggregating agents such as MgCl<sub>2</sub> and KBr to produce high-density hot-spots on the nanometallic surface. Sample treatment conditions necessary to detect the selected synthetic cathinone analogs were also optimized. Once completed, the characterization and identification of the main peaks that make up the synthetic cathinone core structure were assigned and unique functional groups for each of the analogs were identified. Overall, the analytical process takes less than a minute, making the procedure useful for field screening. Ultimately, this procedure can aid law enforcement and first responders by providing a more specific method for rapid and sensitive on-site analysis of seized drugs.</div></div>","PeriodicalId":324,"journal":{"name":"Forensic Chemistry","volume":"41 ","pages":"Article 100613"},"PeriodicalIF":2.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142587227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of a forensic workflow for the complete profiling of illicit drugs and excipients 开发和验证用于非法药物和辅料完整特征分析的法医工作流程

IF 2.6 3区医学

Forensic Chemistry Pub Date : 2024-10-18 DOI: 10.1016/j.forc.2024.100612

Mikaela J. Radke, Alan White, Wendy A. Loughlin, Sarah L. Cresswell

{"title":"Development and validation of a forensic workflow for the complete profiling of illicit drugs and excipients","authors":"Mikaela J. Radke, Alan White, Wendy A. Loughlin, Sarah L. Cresswell","doi":"10.1016/j.forc.2024.100612","DOIUrl":"10.1016/j.forc.2024.100612","url":null,"abstract":"<div><div>The development of a complete understanding of the societal harms of illicit drug mixtures requires a greater emphasis on the complete identification of illicit and excipient compounds. To increase the feasibility of this in practice, common and emerging analytical techniques were examined in the context of developing a non-targeted forensic workflow. The purpose of this workflow was to increase the identification of excipient compounds without compromising the quality of illicit drug identification as required for admissibility of evidence in court. This incorporated the testing of simulated compound mixtures to develop the principal avenues of analysis. These pathways were then validated through the testing of unknown compound mixtures. The techniques of focus included GCMS, FTIR, LC-HRMS for identification, and LC-HRMS for quantitation. These techniques were organised into their respective categories of techniques, according to the SWGDRUG guidelines, to produce a workflow that would ensure the admissibility of evidence no matter the pathway taken. HRMS was examined as an emerging technique not currently used in illicit drug analysis facilitating non-targeted analysis pathways. From this, and in combination with GCMS, all organic components were identifiable in simulated and unknown mixtures. Partial identification was also achieved for insoluble compounds using FTIR analysis. Identification by HRMS was facilitated by comparison to reference standards and MS/MS spectra matching to the high-resolution database MzCloud. This demonstrated the applicability of HRMS, specifically the Exploris 120 Orbitrap, to the identification and quantitation of both illicit and organic excipient compounds within Forensic Chemistry.</div></div>","PeriodicalId":324,"journal":{"name":"Forensic Chemistry","volume":"41 ","pages":"Article 100612"},"PeriodicalIF":2.6,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recovery and detection of ignitable liquid residues from the substrates by solid phase microextraction – direct analysis in real time mass spectrometry 通过固相微萃取--实时质谱直接分析--回收和检测底物中的可燃液体残留物

IF 2.6 3区医学

Forensic Chemistry Pub Date : 2024-10-18 DOI: 10.1016/j.forc.2024.100611

Shruthi Perna , Ngee Sing Chong , Mengliang Zhang

{"title":"Recovery and detection of ignitable liquid residues from the substrates by solid phase microextraction – direct analysis in real time mass spectrometry","authors":"Shruthi Perna , Ngee Sing Chong , Mengliang Zhang","doi":"10.1016/j.forc.2024.100611","DOIUrl":"10.1016/j.forc.2024.100611","url":null,"abstract":"<div><div>In this study, direct analysis in real time mass spectrometry (DART-MS) was coupled to the solid phase microextraction (SPME) to extract and analyze the ignitable liquid residues (ILR) present in the sample matrices. The SPME extraction parameters, such as extraction temperature and extraction time, were optimized using a two-factor central composite design. The SPME-DART-MS setup was utilized to analyze the substrates and fire debris matrices spiked with gasoline. The results indicate that the less volatile marker compounds from gasoline were recovered from the substrates and fire debris, and their profiles matched well with the gasoline liquid samples analyzed directly by DART-MS. As expected, the effective extraction of marker compounds in gasoline required a relatively high temperature, i.e., 150 ℃. In the presence of a matrix, a higher extraction temperature and longer extraction time could benefit the extraction efficiency. The desorption of ILR on SPME fiber was performed by inserting the fiber into the DART-MS helium gas stream at 300 ℃ for 1 min with no carry-over residues being observed between successive samples. The chemical information attained with this method is typically not observed in the current GC/MS-based practice. The SPME-DART-MS was also extended to reanalyze less volatile components of ILR on substrates after the ASTM E1412 activated charcoal method, which indicates its possible application subsequent to the traditional GC/MS ILR analysis. The SPME-DART-MS has shown promise in ILR detection as an important complementary tool.</div></div>","PeriodicalId":324,"journal":{"name":"Forensic Chemistry","volume":"41 ","pages":"Article 100611"},"PeriodicalIF":2.6,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-throughput LC-PDA method for determination of Δ9-THC and related cannabinoids in Cannabis sativa 测定大麻中 Δ9-THC 和相关大麻素的高通量 LC-PDA 方法

IF 2.6 3区医学

Forensic Chemistry Pub Date : 2024-10-09 DOI: 10.1016/j.forc.2024.100610

Walter B. Wilson, Aaron A. Urbas, Haley Jensen, Lane C. Sander

{"title":"High-throughput LC-PDA method for determination of Δ9-THC and related cannabinoids in Cannabis sativa","authors":"Walter B. Wilson, Aaron A. Urbas, Haley Jensen, Lane C. Sander","doi":"10.1016/j.forc.2024.100610","DOIUrl":"10.1016/j.forc.2024.100610","url":null,"abstract":"<div><div>Before the passage of the <em>Agriculture Improvement Act of 2018</em>, more commonly referred to as the 2018 Farm Bill, forensic laboratories were only required to perform qualitative measurements to confirm the identity of seized plant samples as <em>Cannabis sativa</em> (hemp or marijuana). The new law defines hemp at a federal level as <em>Cannabis sativa</em> containing 0.3 % or less Δ<sup>9</sup>-THC. Because forensic laboratories were not adequately equipped with the proper methods or training to meet these requirements, significant backlogs in casework resulted. The National Institute of Standards and Technology (NIST) responded by providing analytical tools to the forensic community. An accurate and precise method was previously developed to determine Δ<sup>9</sup>-THC, Δ<sup>9</sup>-THCA, and total Δ<sup>9</sup>-THC in botanical samples based on liquid chromatography with photodiode array detection (LC-PDA). <em>Cannabis</em> plant samples were ground and extracted with methanol using routine laboratory equipment. The original sample preparation procedure was time-consuming, taking over 70 min. The method described here has been optimized with the time required for sample preparation and LC-PDA analysis has been reduced to less than 30 min.</div></div>","PeriodicalId":324,"journal":{"name":"Forensic Chemistry","volume":"41 ","pages":"Article 100610"},"PeriodicalIF":2.6,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of a rapid GC–MS method for forensic seized drug screening applications 验证用于法医缉获药物筛查的快速气相色谱-质谱法

IF 2.6 3区医学

Forensic Chemistry Pub Date : 2024-09-13 DOI: 10.1016/j.forc.2024.100609

Briana A. Capistran , Edward Sisco

{"title":"Validation of a rapid GC–MS method for forensic seized drug screening applications","authors":"Briana A. Capistran , Edward Sisco","doi":"10.1016/j.forc.2024.100609","DOIUrl":"10.1016/j.forc.2024.100609","url":null,"abstract":"<div><p>With the lack of standardized validation protocols across the forensic chemistry community, validation of instrumentation can be a challenging and time-consuming task. However, this process is crucial to understanding the associated capabilities and limitations, especially for nascent technologies. Rapid GC–MS is one such emerging analytical technique being increasingly implemented in forensic laboratories due to its fast and informative screening capabilities. However, a full validation for forensic samples has yet to be published since its debut. This work presents the results of a comprehensive validation of a rapid GC–MS system for seized drug screening through the assessment of nine components: selectivity, matrix effects, precision, accuracy, range, carryover/contamination, robustness, ruggedness, and stability. Single- and/or multi-compound test solutions of commonly encountered seized drug compounds were used to assess method and system performance. Results met the designated acceptance criteria for a majority of components. For example, retention time and mass spectral search score % RSDs were ≤10 % for precision and robustness studies. Limitations were identified for components that did not meet the acceptance criteria (<em>e.g.</em>, inability to differentiate some isomers). The study design is part of a larger validation package developed for rapid GC–MS that includes a validation plan and automated workbook. The template, available for adoption by laboratories, ultimately aims to reduce the barrier of implementation for rapid GC–MS technology.</p></div>","PeriodicalId":324,"journal":{"name":"Forensic Chemistry","volume":"41 ","pages":"Article 100609"},"PeriodicalIF":2.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural characterization of nitazene analogs using electron ionization-mass spectrometry (EI-MS) 利用电子电离质谱法（EI-MS）确定硝氮类似物的结构特征

IF 2.6 3区医学

Forensic Chemistry Pub Date : 2024-09-01 DOI: 10.1016/j.forc.2024.100605

Emma K. Hardwick, J. Tyler Davidson

{"title":"Structural characterization of nitazene analogs using electron ionization-mass spectrometry (EI-MS)","authors":"Emma K. Hardwick, J. Tyler Davidson","doi":"10.1016/j.forc.2024.100605","DOIUrl":"10.1016/j.forc.2024.100605","url":null,"abstract":"<div><p>Nitazene analogs are among the most recent and potent additions to the novel synthetic opioid (NSO) market, and new analogs continue to emerge. Seized drug analysis commonly utilizes gas chromatography-electron ionization-mass spectrometry (GC-EI-MS), so it is therefore imperative to understand how nitazene analogs behave under EI-MS conditions, and how substitution at various sites on the molecule may impact the resulting EI mass spectra. This study characterizes the EI fragmentation behavior of 20 representative nitazene analogs that contain differing substitutions and proposes rational mechanisms to explain the observed behavior.</p><p>A general EI fragmentation pathway for nitazene analogs was proposed, with the most common nitazene fragment ions being observed at <em>m</em>/<em>z</em> 86, <em>m</em>/<em>z</em> 107, <em>m</em>/<em>z</em> 58, and <em>m</em>/<em>z</em> 77. Characteristic ions were determined for different substitution groups, enabling the identification of diethyl, desethyl, pyrrolidine, and piperidine substitutions at the amine moiety, and different alkoxy chain lengths at the aromatic ring of the benzyl group. Mechanisms for the formation of these characteristic ions were proposed with the aid of isotopically labeled standards and high-resolution mass spectrometry measurements. To help with the interpretation of EI mass spectra for nitazene analogs, decision trees were developed that encompass the characteristic fragment ions observed for substitutions to the amine moiety and benzyl group, with additional criteria provided for substitutions to the benzimidazole moiety. This study summarizes the fragmentation patterns and characteristic fragment ions in the EI mass spectra of 20 representative nitazene analogs, which will aid the seized drug community in identifying novel nitazene analogs.</p></div>","PeriodicalId":324,"journal":{"name":"Forensic Chemistry","volume":"40 ","pages":"Article 100605"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-mixed small engine fuels (SEFs): Ignitable liquid analysis, canine detection, and a discussion of formulation changes 预混合小型发动机燃料 (SEF)：可燃液体分析、警犬检测以及配方变化讨论

IF 2.6 3区医学

Forensic Chemistry Pub Date : 2024-09-01 DOI: 10.1016/j.forc.2024.100604

Lisa Schwenk

{"title":"Pre-mixed small engine fuels (SEFs): Ignitable liquid analysis, canine detection, and a discussion of formulation changes","authors":"Lisa Schwenk","doi":"10.1016/j.forc.2024.100604","DOIUrl":"10.1016/j.forc.2024.100604","url":null,"abstract":"<div><p>A variety of types and brands of pre-mixed small engine fuels (SEFs) were analyzed by gas chromatography-mass spectrometry (GC–MS) to determine their ignitable liquid composition. Additionally, many of these brands and fuel mixes were tested six years apart, first in 2018 and again in 2024, to determine if any formulation changes had occurred. All tested products were comprised of a range of isoparaffinic content, and most also contained at least one aromatic compound. One product marketed as a fuel treatment to fix ethanol-related issues contained 2-butoxyethanol. To determine Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) ignitable liquid detection canine (ILDC) response to the specific combination of ignitable liquids in these products, ILDC teams searched representative samples of the SEFs with no detection difficulty shown for the vast majority of these products. Reporting the ignitable liquid classification of SEFs would be dependent upon individual forensic science service provider (FSSP) protocols and the appearance of the ignitable liquid in casework data. The classification possibilities for these mixtures are discussed, including a case example of data resembling an SEF.</p></div>","PeriodicalId":324,"journal":{"name":"Forensic Chemistry","volume":"40 ","pages":"Article 100604"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of high-resolution mass spectrometry for identification and structural elucidation of scopolamine metabolomic biomarkers in a confirmed case of Brugmansia intoxication. Specially application in drug-facilitated crimes 高分辨质谱法在一例确诊的布鲁曼西亚中毒事件中鉴定和阐明东莨菪碱代谢组生物标志物结构的潜力。在毒品犯罪中的特殊应用

IF 2.6 3区医学

Forensic Chemistry Pub Date : 2024-09-01 DOI: 10.1016/j.forc.2024.100602

Luis Manuel Menéndez-Quintanal , Jose Manuel Matey , M.D. Perretti , Cristian Martínez-Ramírez , Francisco J. Hernández-Dı́az

{"title":"Potential of high-resolution mass spectrometry for identification and structural elucidation of scopolamine metabolomic biomarkers in a confirmed case of Brugmansia intoxication. Specially application in drug-facilitated crimes","authors":"Luis Manuel Menéndez-Quintanal , Jose Manuel Matey , M.D. Perretti , Cristian Martínez-Ramírez , Francisco J. Hernández-Dı́az","doi":"10.1016/j.forc.2024.100602","DOIUrl":"10.1016/j.forc.2024.100602","url":null,"abstract":"<div><p>In forensic toxicology, scopolamine remains as one of the most challenging alkaloid in terms of analytical detection. Given its rapid elimination, the detection window in common matrices is short. Taking advantage of a real case of <em>Brugmansia</em> intoxication, a metabolic study was carried out. We report the real case of a 16-year-old boy admitted to an Emergency Unit after consumption at high school of a beverage made of <em>Brugmansia</em> dried flowers. The medical staff noticed agitation, mydriasis and tachycardia. Scopolamine and atropine were positively detected in biological fluids using liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS/MS). To better characterize the intake and identify metabolic biomarkers, we developed a data mining workflow specific to tropane alkaloids and applied it to the urine sample. This metabolic profile may be useful in providing analytical methods with a wider detection window particularly in drug-facilitated crimes (DFC). Scopolamine and atropine metabolites were predicted <em>in silico</em> with GLORYx freeware to assist in metabolite identification. The previously published metabolic pathways for scopolamine and atropine in mammals were studied as well. A total of fifteen phase I and II metabolites were tentatively identified for scopolamine, while one metabolite was detected for atropine. In addition, we identified some tropane alkaloids from the plant that were also metabolized. These metabolites can be used as biomarkers of exposure to Solanaceae plants and may also be useful to distinguish between natural product use and clinical therapy.</p></div>","PeriodicalId":324,"journal":{"name":"Forensic Chemistry","volume":"40 ","pages":"Article 100602"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct and selective alkylation of indazole-3-carboxylic acid for the preparation of synthetic cannabinoids and metabolites 直接和选择性烷基化吲唑-3-羧酸以制备合成大麻素和代谢物

IF 2.6 3区医学

Forensic Chemistry Pub Date : 2024-08-23 DOI: 10.1016/j.forc.2024.100603

Tobias Rautio , Matthew J. Connolly , Huiling Liu , Peter Konradsson , Henrik Gréen , Johan Dahlén , Xiongyu Wu

{"title":"Direct and selective alkylation of indazole-3-carboxylic acid for the preparation of synthetic cannabinoids and metabolites","authors":"Tobias Rautio , Matthew J. Connolly , Huiling Liu , Peter Konradsson , Henrik Gréen , Johan Dahlén , Xiongyu Wu","doi":"10.1016/j.forc.2024.100603","DOIUrl":"10.1016/j.forc.2024.100603","url":null,"abstract":"<div><p>The most common method for the synthesis of synthetic cannabinoids with an indazole core utilizes methyl indazole-3-carboxylate as a starting material. However, this method commonly suffers from poor selectivity and low yield. In the current work, a method using indazole-3-carboxylic acid as the starting material was developed and successfully applied in the synthesis of nine synthetic cannabinoids and six of their metabolites. The method provided selective alkylation at the <em>N</em>1-position and resulted in overall yields in the range of 51–96 %. Five of the synthetic cannabinoids have not been reported in the literature and were synthesized in a proactive attempt to predict future SCs. All of the synthesized metabolites have previously been encountered in either in vitro studies or authentic urine samples. Hence, the method proved to be useful for production of SC metabolites, which are relevant for forensic toxicology. All synthesized compounds were characterized with NMR and LC-QTOF-HRMS.</p></div>","PeriodicalId":324,"journal":{"name":"Forensic Chemistry","volume":"40 ","pages":"Article 100603"},"PeriodicalIF":2.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-frequency Raman spectrum of methamphetamine hydrochloride and its alterations induced by impurities 盐酸甲基苯丙胺的低频拉曼光谱及其由杂质引起的变化

IF 2.6 3区医学

Forensic Chemistry Pub Date : 2024-08-03 DOI: 10.1016/j.forc.2024.100601

Hiroki Segawa, Yuko T. Iwata, Yuki Okada, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori

{"title":"Low-frequency Raman spectrum of methamphetamine hydrochloride and its alterations induced by impurities","authors":"Hiroki Segawa, Yuko T. Iwata, Yuki Okada, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori","doi":"10.1016/j.forc.2024.100601","DOIUrl":"10.1016/j.forc.2024.100601","url":null,"abstract":"<div><p>Methamphetamine is one of the most abused drugs worldwide. Forensic laboratories have developed various methods to analyze methamphetamine for identifying and comparing seizures. These methods basically focus on the physicochemical properties of the methamphetamine molecule. Because methamphetamine is commonly distributed in its hydrochloride salt form, information on the crystalline state of methamphetamine could give new insight for forensic drug analysis. To grasp this information, we applied low-frequency Raman spectroscopy to methamphetamine hydrochloride. A laboratory-built low-frequency Raman microspectrometer was used for measuring low-frequency Raman spectra of optically pure and racemic methamphetamine hydrochloride. A mixture of methamphetamine hydrochloride with dimethyl sulfone, which is frequently added as a diluent to illicit methamphetamines, was also measured. An ab initio calculation was performed to assign peaks in the low-frequency spectra. The phonon modes of methamphetamine hydrochloride, and their changes induced by impurities are discussed. To the best of our knowledge, this is the first reported application of low-frequency Raman spectroscopy technique to methamphetamine hydrochloride.</p></div>","PeriodicalId":324,"journal":{"name":"Forensic Chemistry","volume":"40 ","pages":"Article 100601"},"PeriodicalIF":2.6,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141945167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0