Kartika Jurnal Ilmiah Farmasi最新文献

{"title":"Isolation of alkaloids compound of ethanol extract of mangrove perepat (S. alba) root and its antibacterial activity","authors":"M. Latief, M. Muhaimin, H. Amanda, I. L. Tarigan, S. Aisyah","doi":"10.20885/jif.vol17.iss1.art2","DOIUrl":"https://doi.org/10.20885/jif.vol17.iss1.art2","url":null,"abstract":"Background: Exploration of the chemical contents and bioactivities of mangrove plants is important to discover new therapeutic agents for society and to develop its medicinal values. Objective: This study aims to isolate alkaloid compounds from the ethanol extract of Sonneratia alba root which is likely to have an antibacterial activity. Methods: Isolation was carried out using fractionation and chromatography, while antibacterial activity test was performed using the disc diffusion methods. Results: Our phytochemical screening shows that the ethanol extract has a high concentration of alkaloid compounds. The alkaloid which contain in isolate (F4) is further confirmed through UV-Vis Spectra and FT-IR spectra. The ethanol extract exhibits the antibacterial activity against S. aureus and E. coli with the inhibition zone of 1.5 mm and 2.5 mm, respectively. Conclusion: Alkaloid compound has been isolated from Sonneratia alba and has potential as antibacterial agent. Keywords: mangrove perepat (Sonneratia alba), alkaloid, antibacterial agent","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79475497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment pattern and direct medical costs of pediatric outpatients with actuate respiratory infection at X hospital in Jambi","authors":"Hendri Pranata, Rasmaladewi Rasmaladewi, M. Sanuddin","doi":"10.20885/jif.vol16.iss2.art10","DOIUrl":"https://doi.org/10.20885/jif.vol16.iss2.art10","url":null,"abstract":"Introduction: Acute respiratory infection is common among the general public. Such disease and its associated symptoms encourage higher consumption of medicine. Varied medications for ARI patients incur different costs of each patient, which eventually lead to higher healthcare costs. Objectives: To identify the treatment patterns and direct medical costs among ARI pediatric patients at X Hospital in Jambi. Methods: This research was an observational study with retrospective data collection. The samples were collected in 2018. Results: The results showed that the most-frequently administered antibiotic for ARI pediatric patients was cefixime (29.17%), while the most-commonly used supportive therapy for ARI pediatric patients was the combination of antihistamines, antipyretics-analgesics, decongestant, and corticosteroid (16.67%). The total direct medical cost to ARI pediatric patients was IDR 191,097. Conclusion: The mean direct medical cost for ARI therapy was IDR 191,097. More administered therapy resulted in higher medical costs. Keywords: ARI, child, antibiotics, direct medical costs","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86153803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization parameters for cocoa pods (Theobroma cacao L.)","authors":"Nida Isti Azah, Resmi Muchtarichie, Y. Iskandar","doi":"10.20885/jif.vol16.iss2.art9","DOIUrl":"https://doi.org/10.20885/jif.vol16.iss2.art9","url":null,"abstract":"Background: Cocoa (Theobroma cacao L.) pods are a waste from chocolate production which has medicinal benefits. Cocoa pods have scientifically proved to have pharmacological activities. Objective: Standardization of plants to be used as medicine is required to control the quality and ensure the safety, efficacy, and quality. Methods: Data on the standardization parameters of cocoa pods were collected from journals published during the period 2010-2020 by searching in Google, Google Scholar, and Research Gate. Results: Standardization parameters of cocoa pods consisted of macroscopic and microscopic examinations, ash content, solute concentration in solvents, phytochemical screening, and thin layer chromatography. Conclusion: Macroscopic examination showed that the skin of cacao fruit has a brownish-yellow color and purplish red, a specific odor, and a bitter taste with four forms, namely amelonado, angoleta, cundeamor, and calabacil. Microscopic examination showed a collection of stone cells and hair covering. The moisture content of cocoa pods fulfills the requirement which is below 10%. The total ash content is 5.80 - 7.41, and the acid-insoluble ash content is 0.45 - 0.64. The concentration of solute in water is higher than in ethanol with 22.69 and 5.21, respectively. The phytochemical screening showed that cocoa pods have flavonoids, saponins, quinones, tannins, steroids, triterpenoids, monoterpenes, and sesquiterpenes. The thin-layer chromatography indicated the presence of phenolic compounds, catechol tannins, flavonoids, and terpenoids. Keywords: Cocoa pods, standardization, Theobroma cacao","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82908583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JPH203 as a potential L-Type Amino Acid Transporter 1 (LAT 1) inhibitor in the development of cancer theragnostic compounds","authors":"Y. Pertiwi, D. Rahayu, M. E. Sriyani, Raden Bayu Indradi, H. A. Holik","doi":"10.20885/JIF.VOL16.ISS2.ART8","DOIUrl":"https://doi.org/10.20885/JIF.VOL16.ISS2.ART8","url":null,"abstract":"Background: Cancer has become a major cause of global health problems. Latest research currently focuses on an approach to cancer therapy that involves specific target molecules and theragnostic (therapy and diagnostic) agents. Among the specific target molecules in cancer therapy is LAT1, which is over expressed in cancer cells but under expressed in normal cells. Therefore, LAT1 inhibition can become an alternative to cancer therapy. A number of studies have shown that JPH203 specifically inhibits LAT1, thus reducing amino acid absorption into cancer cells and inhibiting cancer cell growth. Objective: The main objective of this literature study was to determine the potential of JPH203 as a LAT1 inhibitor to be developed into a novel theragnostic agent for cancer. Methods: Various studies were summarized to outline the development of JPH203 as a therapy targeting LAT1 and potential candidate of theragnostic compounds. Results: The results of the literature study showed that JPH203 as a selective LAT1 inhibitor was able to efficiently suppress the growth of cancer cells with a low IC50 value. Conclusion: The activity of LAT1 as an amino acid transporter of cancer cells could be selectively inhibited by JPH203, thereby allowing JPH203 to be reconsidered as a potential therapy in the development of theragnostic compounds against cancer. Keywords: JPH203, theragnostic, LAT1 inhibitor","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80725374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium species in vegetables: benefits and toxicity for the body","authors":"Alya Luthfiyani Heryadi, Ayu Shalihat, Rimadani Pratiwi, M. Mutakin","doi":"10.20885/jif.vol16.iss2.art7","DOIUrl":"https://doi.org/10.20885/jif.vol16.iss2.art7","url":null,"abstract":"Background: Selenium is one of the essential trace elements in various biological body functions. The main source of Selenium in the body is food, one of which is vegetables. Vegetables collect Selenium from the soil which is then converted into various chemical species of Selenium. Such species should be recognized since each has different biological activities. Objective: The aim of this review was to identify chemical species of Selenium in vegetables as well as the benefits and toxicity for the body. Methods: Reference searches were done in Pubmed and Google Scholar databases with the keywords Selenium speciation in plants, selenite, selenate, selenomethionine, selenocystine, and se-methylselenocysteine Results: The results of speciation in several types of vegetables showed that the chemical species of Selenium abundantly found in vegetables were selenomethionine (SeMet), selenocystine (SeCys2) and se-methylselenocysteine (Se-MeSeCys), gamma-glutamyl-Se-methyl-selenocysteine, and inorganic species. Both Selenium-enriched vegetables and the species contained therein have a variety of benefits for the body. However, excessive consumption can also cause toxic effects. Conclusion: The chemical species of Selenium in vegetables can be either organic or inorganic. Both types of species have different benefits and toxic effects. Keywords: benefits, chemical species, Selenium, toxicity, vegetable","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89830889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability studies of mefenamic acid Self-Nanoemulsifying Drug Delivery System (SNEEDS) preparation with oleic acid as the oil phase","authors":"Y. Syukri, Septiani Eka Cahyani, B. Nugroho","doi":"10.20885/jif.vol16.iss2.art5","DOIUrl":"https://doi.org/10.20885/jif.vol16.iss2.art5","url":null,"abstract":"Background: Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with low solubility in water. Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) play a role to improve the solubility and bioavailability of mefenamic acid. Objective: This study aimed to determine the stability of mefenamic acid in SNEDDS formulation through various stability studies. Methods: The stability studies conducted consisted of centrifugation test, heating-cooling cycle test, freezethaw cycle test, robustness to dilution, accelerated storage test, and determination of drug content. Results: The centrifugation test, heating-cooling cycle test, and freeze-thaw cycle test showed no phase separation in the samples. The robustness to dilution and accelerated storage test resulted in 2 formulas of mefenamic acid loaded SNEDDS having good stability with 10% oleic acid, 80% tween 80, 10% PEG 400 and 10% oleic acid, 70% tween 80, 20% PEG 400. The determination of drug content in both of these formulations showed 98.20 ± 0.04% and 90.98 ± 0.06%. Conclusion: The SNEDDS formulation of mefenamic acid in this study had good stability. Keywords: SNEDDS, mefenamic acid, stability study, oleic acid","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83981571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confusion, difficulty concentrating, and slow response induced by ropinirole therapy in an elderly patient with secondary Parkinsonism: a case report","authors":"Emilia Sidharta, Ivon Sindu Wijaya, H. Cahyadi","doi":"10.20885/jif.vol16.iss2.art3","DOIUrl":"https://doi.org/10.20885/jif.vol16.iss2.art3","url":null,"abstract":"Background: Ropinirole is a therapy that is widely used in patients with Parkinson's disease or Restless Leg Syndrome (RLS). Some research journals show that the long-term use of ropinirole can cause side effects. But unfortunately, there are no published studies from Indonesia that show the side effects of ropinirole.. Objective: To report a case of several side effects induced by ropinirole therapy Method : Assessment methods used were time series data collection followed by causality analysis using Naranjo Scale. Results: This case reports several side effects such as confusion, difficulty concentrating, and slow response experienced by a 75-year-old elderly patient who consumed ropinirole 2 mg as a therapy for Secondary Parkinsonism. Before using ropinirole, the patient had used levodopa-benserazide, trihexyphenidyl, and pramipexole to overcome Parkinson's for more than 3 years. During the period no side effects occurred. Side effects occurred after ropinirole therapy was given to patients. The analysis using Naranjo Scale shows a score of 6 which means Probable. Conclusion: The aim of this study is to raise awareness for health workers, especially pharmacists in order to increase alertness in patients using long-term medications such as those with Parkinson's. Keywords: side effect, secondary parkinsonism, ropinirole, elderly","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86697456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of physicochemical properties and comparison of the dissolution profile of amoxicillin caplets","authors":"Een Widiyasari, T. N. Sulaiman","doi":"10.20885/jif.vol16.iss2.art4","DOIUrl":"https://doi.org/10.20885/jif.vol16.iss2.art4","url":null,"abstract":"Background: Marketed drugs must meet the required standards to guarantee product quality. Amoxicillin is a generic compound marketed under various trademarks as copy drugs. Amoxicillin caplets are an immediate release dosage form of BCS class I. An essential aspect of evaluating copy drugs is to assess the equivalence for their treatment to the innovator drugs to ensure the safety and effectiveness of the circulating copy drugs. Objective: The study aims to evaluate the physicochemical properties and compare the dissolution profile of amoxicillin caplets available in the market. Methods: Five amoxicillin caplet products, four test products, and one reference product were tested for their physicochemical properties and dissolution. The dissolution test was carried out with a type II device at a speed of 75 rpm in 900 mL of media buffered at pH 1.2, 4.5, and 6.8 and at a temperature of 37 +/- 0.5degrees celcius. The dissolution profile was analyzed by comparing it with the similarity factor (f2) parameters. Results: Two of the four amoxicillin caplet products had a similar dissolution profile to the reference products, namely products A and B. Products C and D were dissimilar because f2 was lower than 50 at pH 4.5. The caplets tested had almost the same dimensions, and all caplets met the requirements for uniformity of content, hardness, disintegration time, and dissolution. Conclusion: Not all of the amoxicillin caplets in the market have a similar dissolution profile to the reference products. Keywords: caplets, amoxicillin, dissolution, similarity factor","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87764347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic evaluation of Artocarpus odoratissimus (Moraceae) fruit","authors":"Kay Ann S. Jonatas, Joseph Mari B. Querequincia, Shiela Dv Miranda, U. Obatavwe, M. Corpuz, R. D. Vasquez","doi":"10.20885/jif.vol16.iss1.art1","DOIUrl":"https://doi.org/10.20885/jif.vol16.iss1.art1","url":null,"abstract":"Background: Diabetes mellitus causes 4.2 million of deaths worldwide and 79% adults with diabetes are living in low- and middle-income countries. This research providing an alternative therapy through the prevention of postprandial hyperglycemia may help diabetic patients and provide a new utilization model of fruit peel.  Artocarpus odoratissimus , commonly known as marang, is an edible fruit found in the southern part of the Philippines. Most of the weight of the fruit is discarded and treated as waste. Objectives: This study aimed to utilize the by-products of marang fruit as a promising pharmaceutical agent by determining the phytochemicals present and in vitro  antidiabetic activity of the different parts of the fruit. Methods: Phytochemical screening of phenolics and flavonoids was done through thin layer chromatography. Ten concentrations (2-1000 µg/mL) of the extracts from the peel, pulp, and seeds were evaluated for the in vitro  antidiabetic assay using alpha-glucosidase enzyme. Mean percent inhibition was calculated, and data was analyzed using ANOVA. The IC 50  estimates were calculated using the program GraphPad Prism version 8. Results: Extracts from the fruit parts of A. odoratissimus contained phenols and flavonoids and were active inhibitors of alpha-glucosidase enzyme. The fruit peel extract of marang was the most potent (IC 50  = 48.19 µg/mL) compared to the seed extract, pulp extract, and the standard drug acarbose (p value = 0.035). Conclusion: The fruit waste, the peel and seeds, has an intense activity against alpha-glucosidase enzyme because of their phenols and flavonoid contents. Keywords: alpha-glucosidase, Artocarpus, diabetes, phenolics, fruit peel","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91273668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the level of knowledge of mothers about self-medication to children in Cangkringan District, Yogyakarta","authors":"Yosi Febrianti, Dessy Melanita, Bondan Ardiningtyas","doi":"10.20885/jif.vol16.iss1.art8","DOIUrl":"https://doi.org/10.20885/jif.vol16.iss1.art8","url":null,"abstract":"Abstract Background : Self-medication refers to an endeavor that is mostly frequently done by society in coping with any symptoms of disease prior to have an aid from medical practitioner. In this case, knowledge about medication and any disease complaints will bring about the impact on the medication use. Insufficiency of mother in understanding about drug and the way of using it in self-medication is potential to be a factor of medication error both for the mothers themselves and for their family. Knowledge required to properly do self-medication is by identifying the active substances, indication, contraindication, dosage and side effect of the medication. Objective : This research is designed to observed the description of the implementation of self-medication, the description of knowledge level of mothers about self-medication and factors determining the knowledge level of mothers.  Method: In addition, this research used questionnaires written in accordance with the Guidelines of Free Medicine Use and Limited Free Medicine. Categorization of the knowledge level of mothers is based on the final score of the questionnaires. Results : The result then showed that the knowledge level of the mothers about the general knowledge of medicine was at 61% for those categorized into good knowledge and 39% for those categorized into medium-level knowledge. Meanwhile, in terms of knowledge level of mother about complaint and diseases treatable using self-medication was at 90% for those categorized into good knowledge and 10% for those categorized at medium-level knowledge. Conclusion : The factors determining the knowledge level of mothers included age, educational level and income. On the other hand, the factor that mostly determined the knowledge level of mother was educational level. Keywords : self-medication, knowledge level, Yogyakarta Intisari Latar belakang : Swamedikasi adalah upaya yang paling banyak dilakukan masyarakat untuk mengatasi gejala penyakit sebelum mencari pertolongan dari tenaga kesehatan Pengetahuan tentang obat dan keluhan penyakit berdampak pada penggunaan obat. Keterbatasan pengetahuan para ibu akan obat dan cara penggunaannya dalam swamedikasi dapat menjadi sumber terjadinya kesalahan pengobatan (medication error) pada diri sendiri dan anggota keluarganya. Pengetahuan yang dibutuhkan untuk melakukan swamedikasi dengan benar adalah mengetahui bahan aktif, indikasi, kontraindikasi, dosis, dan efek samping pengobatan.  Tujuan : Tujuan penelitian untuk mengetahui gambaran pelaksanaan swamedikasi,mengetahui gambaran tingkat pengetahuan para ibu tentang swamedikasi dan mengetahui faktor- faktor yang mempengaruhi tingkat pengetahuan para ibu.  Metode : Penelitian menggunakan kuesioner yang disusun berdasarakan Pedoman Penggunaan Obat Bebas dan Obat Bebas Tebatas. Pembagian golongan tingkat pengetahuan para ibu berdasarkan skor akhir kuesioner.  Hasil : Tingkat pengetahuan para ibu tentang informasi umum obat, sebanyak 61% ibu tergolon","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74660226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}