Kartika Jurnal Ilmiah Farmasi最新文献

{"title":"The design of bioactive marine peptides as a HIV-1 protease inhibitor","authors":"T. M. Fakih, Mentari Luthfika Dewi","doi":"10.20885/jif.vol17.iss2.art6","DOIUrl":"https://doi.org/10.20885/jif.vol17.iss2.art6","url":null,"abstract":"Background: Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV or AIDS) is a disease related to the human immune system. Given its important role in viral replication, HIV1 protease (HIV1 PR) becomes the major therapeutic target in the treatment of AIDS. In this case, we need a dynamic aspect of molecular interactions that can demonstrate the important role of conformational variability in the design of HIV1 PR inhibitors. There are several inhibitor candidates from marine organisms, such as the LLEYSL and LLEYSI bioactive peptides produced by oysters (Crassostrea gigas). Objective: Proteinpeptide docking method was used in silico to identify, evaluate, and explore the molecular interactions between bioactive peptide molecules and HIV-1 protease macromolecules. Methods: The sequencing of bioactive peptide molecules was modeled into 3D conformation using the PEPFOLD software. The best conformation was chosen for the study of molecular interactions against HIV1 protease macromolecules using the PatchDock software. The molecular interactions formed were further observed using the BIOVIA Discovery Studio 2020 software. Results: The results of this study indicated that the LLEYSL bioactive peptide had the best affinity with an ACE score of minus 1284.70 kJ per mol. Conclusion: Bioactive peptide molecule is predicted to be a candidate for HIV1 protease inhibitor. Keywords: AIDS, HIV1 protease, bioactive peptides, protein-peptide docking, in silico","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90761176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development innovation of silver nanoparticles used leaves of banana (Musa sapientum) as eco-friendly bioreductor","authors":"B. Nugroho, Rika Artikawati, S. Suparmi","doi":"10.20885/jif.vol17.iss1.art7","DOIUrl":"https://doi.org/10.20885/jif.vol17.iss1.art7","url":null,"abstract":"Background: Silver nanoparticle could be developed by natural reducing agent like Epigallocatechin Gallate (EGCG) of banana leaves (Musa sapientum) as bioreductor in biosynthesis. Objective: This study aimed to examine the formulation and characterization of silver nanoparticles using the combination of banana leaf (M. sapientum) extract containing epigallocatechin gallate (EGCG) for biosynthesis. The biosynthesis of silver nanoparticles is eco-friendly and low energy process. Method: Each formula was added with 500microlitre AgNO3. Identification of nanoparticles was characterized by duration of its discoloration, its absorbance using UV/Vis spectrophotometer and FTIR, its particle size using PSA, and its morphology under TEM. Result: The silver nanoparticle formation need less than 15 minutes. The measurement of its absorbance showed the wavelength of this silver nanoparticles are in the range of 410-480nm. Characterization using FTIR showed a decrease in absorption of the functional -OH group spectrum. This particle has the smallest particle size in value of 57.16 ± 0.40 nm in spherical shape. Conclusion: Nanosilver could be prepared using banana leaf extract using low energy biosynthesis process. Keywords: characterization, nanosilver, banana leaf (M. sapientum)","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74077362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluasi penyimpanan obat di Puskesmas \"X\" Kabupaten Sleman","authors":"Novi Dwi Rugiarti, Atika Nurul Hidayati, Dian Medisa, Diesty Anita Nugraheni","doi":"10.20885/jif.vol17.iss1.art8","DOIUrl":"https://doi.org/10.20885/jif.vol17.iss1.art8","url":null,"abstract":"Background: Evaluation of drug storage in a primary health care is an important process in drug management. Evaluation use with indicators. Some of indicators are Percentage of expired date drugs, percentage of stockout and Turn Over Ratio (TOR). Objective: This study aimed to know the efficiency of drug storage in Mlati II primary health care Methods: This observation research use retrospective data. Results: Percentage of expired date drugs was 2.45% and percentage stockout was 2.45% and Turn Over Ratio was 5.2 times Conclusion: Drug storage has not efficient yet. Keywords: Evaluation, drug storage, primary health care","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90593626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and activity of active compound of bamboo leaves (Bambusa vulgaris Schrad ex.J.C) ethanolic extract against diabetic ulcers gram-negative bacteria from diabetic ulcer’s patient","authors":"P. Apridamayanti","doi":"10.20885/jif.vol17.iss1.art10","DOIUrl":"https://doi.org/10.20885/jif.vol17.iss1.art10","url":null,"abstract":"Background: Bamboo leaves (Bambusa vulgaris Schrad ex.J.C) are plants that are known to have pharmacological activity, one of which is to have antibacterial activity. Diabetic Foot Ulcers (DFU) is one chronic complication of diabetes mellitus. DFU is open sores on the surface of the skin that can be accompanied by local tissue death. Infection that is not appropriately treated in patients can cause amputation. Improper use of antibiotics can cause resistance events. A resistance that occurs in Proteus mirabilis, Pseudomonas aeruginosa, and Escherichia coli in isolates from DFU patients encourages researchers to look for alternative antibiotics from natural resources. Objective: Determine the profile of secondary metabolites by thin-layer chromatography, foam index, total phenols, total flavonoids and the antibacterial activity of bamboo (B. vulgaris) through the antibacterial with clear zone value of bamboo leaf ethanol extract against bacteria E. coli, P. aeruginosa, and P. mirabilis. Method: Phenol, flavonoid, and triterpenoid test using TLC method. Saponin tests were carried out using foam index, fish index, and hemolytic index test methods. Total flavonoid testing using Chang method and total phenol method using the Follin Ciocalteau reagent then proceed using a spectrophotometer. Test the antibacterial activity using the agar diffusion method. Results: Chromatographic profile, phenol, flavonoid, and triterpenoid compounds were obtained; saponin index obtained foam index of 333; fish index of 200; and the hemolytic index of 1,111. The total phenol test was 16.052 ± 3.12 % and the total flavonoid was 2.42 ± 0.44 %. Antibacterial activity test obtained MIC values of 60 mg/ml for E. coli bacteria; 100 mg/ml for the bacterium P. aeruginosa; and 30 mg/ml of P. mirabilis. Conclusion: The content of secondary metabolites found in the ethanol extract of bamboo leaves were flavonoid, phenol, saponin and triterpenoids. Ethanol extract of bamboo leaves has a the potential to produce antibacterial activity against gram-negative pathogenic bacteria isolated from diabetic wound patients Keywords: Bambusa vulgaris Schrad ex.J.C, total phenol, total flavonoid, MIC","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"s3-22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90813356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kajian potensi antioksidan dari tanaman herbal dan pengaruhnya terhadap penyakit Parkinson","authors":"I. Pratiwi, W. Aligita, Marita Kaniawati","doi":"10.20885/jif.vol17.iss1.art9","DOIUrl":"https://doi.org/10.20885/jif.vol17.iss1.art9","url":null,"abstract":"Background: Parkinson's disease is the most common neurodegenerative disorder affecting more than 10 million people worldwide. This disease is characterized by progressive dopaminergic neuron damage in the substantia nigra. This damage can be triggered by aging and the presence of oxidative stress because of free radicals. Antioxidants can inhibit the formation of free radicals and reduce oxidative stress, so they can be used as an alternative treatment for Parkinson's disease. Objective: This review article aimed to provide information about the antioxidant effects of selected herbal plants on Parkinson's disease. Method: This study used literature study methods sourced from national and international scientific journals published in the last 5 years (2016-2020). Literature search were carried out using databases such as Google Scholar, PubMed®, ScienceDirect, and Garuda Portal. Results: The high content of antioxidants in plants could protect nerve cells from oxidative damage and reduce symptoms such as tremors, muscle stiffness, impaired coordination and motor balance in test animals. Conclusion: Natural antioxidants from herbal plants proved to be able to prevent oxidative stress caused by free radicals and reduce symptoms of Parkinson's disease. Keywords: Parkinson's disease, antioxidants, oxidative stress, herbal plants","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86113670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The immunostimulant activity of Tibb an-Nabawi natural products: a literature review","authors":"Sani Ega Priani","doi":"10.20885/jif.vol17.iss1.art5","DOIUrl":"https://doi.org/10.20885/jif.vol17.iss1.art5","url":null,"abstract":"Background: Enhancing the immune system is very important during the Covid-19 pandemic to prevent infections and reduce the risk of disease severity. Therefore, it is necessary to use natural products with an immunostimulant effect. In Islam, there is a system of treatment or disease prevention based on Al-Quran and Hadith, which is called Tibb an-Nabawi or prophetic medicine. Objective: This research aims to conduct a literature study of Tibb an-Nabawi, which has proved to be able to increase the immune system, based on Islamic and scientific approaches. Method: The research was based on a systematic literature review using research articles from the last ten years. The inclusion criteria were articles discussing the immunostimulatory activity of Tibb an-Nabawi, while the exclusion criteria were immune system enhancing herbs that were not Tibb an-Nabawi. Results: Based on the literature studies, it is known that at least six natural products based on Tibb an-Nabawi have scientifically proved to increase the immune system, namely black cumin, honey, dates, ginger, garlic, and pumpkin. The mechanism of immune system enhancement is different in each substance, but in general, they can increase humoral or cellular immunity. The active compounds contained in each of these ingredients contribute to the resulting immunostimulant activity. Conclusion: Black cumin, honey, dates, ginger, garlic, and pumpkin are natural products based on Al-Quran and Hadith, which have scientifically proved to enhance the immune system. Keywords: Tibb an-Nabawi, Thibbun Nabawi, immune system, immunostimulant, pandemic","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75295503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between monotherapy and combination therapy among inpatients with community-acquired pneumonia","authors":"Rike Syahniar, Audia Nizhma Nabila, Dayu Swasti Kharisma, Muhammad Afif Akbar","doi":"10.20885/jif.vol17.iss1.art6","DOIUrl":"https://doi.org/10.20885/jif.vol17.iss1.art6","url":null,"abstract":"Background: Pneumonia causes high mortality, hospitalization costs and health services. There is some growing debate regarding the efficacy of different treatment management approaches. The use of certain antibiotic regimens combination and monotherapy have been associated with improved outcomes. Objective: This study aims to determine the effectiveness of monotherapy and combination therapy on length of stay. Method: This retrospective study included patients with Community Acquired Pneumonia (CAP) who received empirical therapy between January - December 2017 at Jakarta Islamic Hospital of Cempaka Putih. Two hundred and ninety four subjects were included in this study. Results: Subjects who received monotherapy and combination therapy were 73.8% and 26.2%. Mean length of stay was 5 days. The most widely used antibiotic in this study was ceftriaxone with levofloxacin (35%) for combination therapy and levofloxacin (38,2%) for monotherapy. There is a relationship between comorbidities and long-term hospitalization (p=0.008). Conclusion: There was no significant difference between combination therapy and monotherapy with length of stay (p=0.277). Keywords: Pneumonia, monotherapy, combination therapy, Jakarta Islamic Hospital of Cempaka Putih","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"7 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72627282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inventarytation of medicinal plants as a self-medication by the Tolaki, Puundoho village, North Kolaka regency, Southeast Sulawesi","authors":"H. Alang, H. Hastuti, M. S. Yusal","doi":"10.20885/jif.vol17.iss1.art3","DOIUrl":"https://doi.org/10.20885/jif.vol17.iss1.art3","url":null,"abstract":"Background: Traditional medicine knowledge is one of the local wisdoms and is passed down from generation to generation. Traditional medicine needs to be preserved in order to maintain the continuity of this knowledge; besides that, it requires a balance between modern medicine and herbal medicine. Herbal medicine is easy to obtain in the surrounding environment, at affordable prices and guarantees the safety of medicinal chemicals that are harmful to the body. The use of drugs for a long period of time is a habit that is harmful to the body organs because they contain certain chemical compounds that are not safe for human vital organs, so it is necessary to make an inventory effort by digging up information from traditional healers. This research is expected to make a significant contribution so that the role of herbal plants can be maintained and developed in the future. Objective: to inventory the plant species which useful as traditional medicines used by traditional healers of the Tolaki tribe in Puundoho village. Method: The method used in this research is a qualitative exploration, through an emic approach or a community and ethical perspective supported by scientific literature. The use of qualitative methods in this study is intended to describe people's knowledge Results: The interview results with three traditional healers (mbu'wai) in Puundoho village about plants that can be used as traditional medicines. It can be found on the side of the road, garden and yard. The part of the plant used is the whole plant or part of the plant such as roots, stems, or leaves. The method to blend it is boiled or mashed. The use of traditional medicines is applied orally or topically. Conclusion: The types of traditional medicinal plants used by the Tolaki tribe in Puundoho village can be obtained from yards, gardens, and roadsides including sidaguri, ciplukan, jeringan, bangle, purslane, bandotan, boborongan, turi, meniran, ­­­­banjar berrywit, mesoyi, ketepeng, guava, ginger, kencur, blechnum nails and ketepeng Keywords: Herbal medicine, inventarytation, medicinal plants, traditional medicine","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83158128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross sectional survey of side effects of antiretroviral (ARV) in outpatients HIV by Naranjo Algorithm","authors":"O. Putra","doi":"10.20885/jif.vol17.iss1.art4","DOIUrl":"https://doi.org/10.20885/jif.vol17.iss1.art4","url":null,"abstract":"Background: The main modality in HIV patients is the administration of long-treatment antiretroviral therapy (ARV). One of the problems from the use of ARV therapy is the side effects that can reduce patient compliance in taking medication, which has the potential to cause treatment failure. Objective: This study aims to examine the side effects and their causality in the use of ARVs in outpatient HIV patients at the VCT Clinic, Bhayangkara H.S. Hospital. Samsoeri Mertojoso Surabaya. Methods: This research was a prospective observational study with a cross-sectional design. Side effect data were taken from HIV patients by interview using the Naranjo algorithm. HIV patients who met the inclusion criteria were included in the study sample using consecutive sampling. This research was conducted from January to March 2020. Results: There were 72 outpatient HIV patients who met the inclusion criteria. The most opportunistic infections found in HIV patients are tuberculosis and Pneumocystis pneumonia. The results showed that the most common side effects experienced by patients were dizziness (43%), nausea and vomiting (31%), and rash (11%) with the highest Naranjo score being in the probable category of 86%. The Naranjo score in HIV patients with opportunistic infections and with comorbidities was significantly smaller than those in HIV patients without opportunistic infections or without comorbidities with independent t-test (P <0.05). Conclusion: The side effects in HIV patients while undergoing treatment with antiretroviral therapy are classified as a minor side effect and the cause of the side effects that occur is thought to be due to the probable category of ARV therapy. Keywords: HIV Patients, Antiretroviral, Side Effects, Naranjo's Algorithm.","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75302341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARISON OF ANTIOXIDANT ACTIVITIES OF TESPONG HERBAL (OENANTHE JAVANICA DC.) EXTRACT AND NANOEXTRACT USING DPPH METHOD","authors":"In Rahmi Fatria Fajar, D. Fitri, Nisa Fitriyani, Michael Chuanvin","doi":"10.20885/jif.vol17.iss1.art1","DOIUrl":"https://doi.org/10.20885/jif.vol17.iss1.art1","url":null,"abstract":"Background: Tespong herbs (O. Javanica DC.) contain numerous chemical compounds considered beneficial for medications, including flavonoids, phenols, and tannins, which can function as antioxidants. Nanoparticles are materials with a size range of 1-1000 nanometers which can increase the bioavailability of drugs, thus accelerating the drug delivery system in the body. Objective: The aim of this study is to identify the characteristics of herbal extract and nanoextract of Tespong and to compare their antioxidant activity. Methods: Extraction of tespong herbs was done using maceration for three days, nanoextract was formulated using the ionic gelation method with herbal extract of tespong, chitosan, and Na-TPP. Antioxidant activity testing was carried out using the DPPH method. Results: The water content of tespong herbal extract was 1.78%, and the total ash content was 4.95%. The tespong herbal nanoextract was 148.1nm in diameter with a polydispersity index of 0.362 and a zeta potential value of -39.16 mV. The IC50 values of tespong herbal extract and nanoextract were 65.424 ppm and 97.106 ppm, respectively, which fell into the strong category. Conclusion: Tespong herbal extract had a higher antioxidant activity compared to its nanoextract. Keywords: Tespong herb, nanoextract, chitosan, Na-TPP","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76058600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}