Comparison between monotherapy and combination therapy among inpatients with community-acquired pneumonia

Abstract

Background: Pneumonia causes high mortality, hospitalization costs and health services. There is some growing debate regarding the efficacy of different treatment management approaches. The use of certain antibiotic regimens combination and monotherapy have been associated with improved outcomes. Objective: This study aims to determine the effectiveness of monotherapy and combination therapy on length of stay. Method: This retrospective study included patients with Community Acquired Pneumonia (CAP) who received empirical therapy between January - December 2017 at Jakarta Islamic Hospital of Cempaka Putih. Two hundred and ninety four subjects were included in this study. Results: Subjects who received monotherapy and combination therapy were 73.8% and 26.2%. Mean length of stay was 5 days. The most widely used antibiotic in this study was ceftriaxone with levofloxacin (35%) for combination therapy and levofloxacin (38,2%) for monotherapy. There is a relationship between comorbidities and long-term hospitalization (p=0.008). Conclusion: There was no significant difference between combination therapy and monotherapy with length of stay (p=0.277). Keywords: Pneumonia, monotherapy, combination therapy, Jakarta Islamic Hospital of Cempaka Putih