COMPARISON OF ANTIOXIDANT ACTIVITIES OF TESPONG HERBAL (OENANTHE JAVANICA DC.) EXTRACT AND NANOEXTRACT USING DPPH METHOD

Kartika Jurnal Ilmiah Farmasi Pub Date : 2021-03-17 DOI:10.20885/jif.vol17.iss1.art1

In Rahmi Fatria Fajar, D. Fitri, Nisa Fitriyani, Michael Chuanvin

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Abstract

Background: Tespong herbs (O. Javanica DC.) contain numerous chemical compounds considered beneficial for medications, including flavonoids, phenols, and tannins, which can function as antioxidants. Nanoparticles are materials with a size range of 1-1000 nanometers which can increase the bioavailability of drugs, thus accelerating the drug delivery system in the body. Objective: The aim of this study is to identify the characteristics of herbal extract and nanoextract of Tespong and to compare their antioxidant activity. Methods: Extraction of tespong herbs was done using maceration for three days, nanoextract was formulated using the ionic gelation method with herbal extract of tespong, chitosan, and Na-TPP. Antioxidant activity testing was carried out using the DPPH method. Results: The water content of tespong herbal extract was 1.78%, and the total ash content was 4.95%. The tespong herbal nanoextract was 148.1nm in diameter with a polydispersity index of 0.362 and a zeta potential value of -39.16 mV. The IC50 values of tespong herbal extract and nanoextract were 65.424 ppm and 97.106 ppm, respectively, which fell into the strong category. Conclusion: Tespong herbal extract had a higher antioxidant activity compared to its nanoextract. Keywords: Tespong herb, nanoextract, chitosan, Na-TPP

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黄芪的抗氧化活性比较采用DPPH法提取和纳米提取

背景:Tespong herbs (O. Javanica DC.)含有许多被认为对药物有益的化合物，包括类黄酮、酚类和单宁，它们可以作为抗氧化剂。纳米颗粒是一种尺寸范围在1-1000纳米之间的材料，它可以提高药物的生物利用度，从而加速药物在体内的传递系统。目的:研究丹参草药提取物和纳米提取物的特性，并比较其抗氧化活性。方法:采用浸渍法提取海绵药材3 d，以海绵提取物、壳聚糖、Na-TPP为原料，采用离子凝胶法制备纳米提取物。采用DPPH法进行抗氧化活性测试。结果:海绵药材提取物含水量为1.78%，总灰分含量为4.95%。该药材纳米提取物直径为148.1nm，多分散指数为0.362,zeta电位值为-39.16 mV。海绵草药提取物和纳米提取物的IC50值分别为65.424 ppm和97.106 ppm，属于强类。结论:丹参提取物具有较强的抗氧化活性。关键词:海绵草，纳米提取物，壳聚糖，Na-TPP

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Kartika Jurnal Ilmiah Farmasi

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16 weeks