香树果的抗糖尿病作用评价

Kay Ann S. Jonatas, Joseph Mari B. Querequincia, Shiela Dv Miranda, U. Obatavwe, M. Corpuz, R. D. Vasquez
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引用次数: 3

摘要

背景:全世界有420万人死于糖尿病,79%的成年糖尿病患者生活在低收入和中等收入国家。本研究通过预防餐后高血糖提供了一种替代疗法,为糖尿病患者提供了一种新的果皮利用模式。Artocarpus odoratissimus,俗称marang,是菲律宾南部发现的一种可食用水果。水果的大部分重量被丢弃并作为废物处理。目的:通过测定芒萁不同部位的植物化学成分及体外抗糖尿病活性,将芒萁副产物作为一种有前景的药物开发利用。方法:采用薄层色谱法对黄酮类化合物进行筛选。采用α -葡萄糖苷酶对果皮、果肉和种子提取物的10种浓度(2-1000µg/mL)进行体外抗糖尿病测定。计算平均抑制率,并用方差分析对数据进行分析。IC 50的估计是使用GraphPad Prism版本8程序计算的。结果:香松果部提取物中含有酚类物质和黄酮类物质,是α -葡萄糖苷酶活性抑制剂。与马兰果籽提取物、果肉提取物和标准药物阿卡波糖相比,马兰果皮提取物的抗氧化活性最强(ic50 = 48.19µg/mL) (p值= 0.035)。结论:果皮和果籽具有较强的抗α -葡萄糖苷酶活性,其主要成分为酚类和类黄酮。关键词:α -葡萄糖苷酶,熊果,糖尿病,酚类物质,果皮
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antidiabetic evaluation of Artocarpus odoratissimus (Moraceae) fruit
Background: Diabetes mellitus causes 4.2 million of deaths worldwide and 79% adults with diabetes are living in low- and middle-income countries. This research providing an alternative therapy through the prevention of postprandial hyperglycemia may help diabetic patients and provide a new utilization model of fruit peel.  Artocarpus odoratissimus , commonly known as marang, is an edible fruit found in the southern part of the Philippines. Most of the weight of the fruit is discarded and treated as waste. Objectives: This study aimed to utilize the by-products of marang fruit as a promising pharmaceutical agent by determining the phytochemicals present and in vitro  antidiabetic activity of the different parts of the fruit. Methods: Phytochemical screening of phenolics and flavonoids was done through thin layer chromatography. Ten concentrations (2-1000 µg/mL) of the extracts from the peel, pulp, and seeds were evaluated for the in vitro  antidiabetic assay using alpha-glucosidase enzyme. Mean percent inhibition was calculated, and data was analyzed using ANOVA. The IC 50  estimates were calculated using the program GraphPad Prism version 8. Results: Extracts from the fruit parts of A. odoratissimus contained phenols and flavonoids and were active inhibitors of alpha-glucosidase enzyme. The fruit peel extract of marang was the most potent (IC 50  = 48.19 µg/mL) compared to the seed extract, pulp extract, and the standard drug acarbose (p value = 0.035). Conclusion: The fruit waste, the peel and seeds, has an intense activity against alpha-glucosidase enzyme because of their phenols and flavonoid contents. Keywords: alpha-glucosidase, Artocarpus, diabetes, phenolics, fruit peel
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