SPIE Micro + Nano Materials, Devices, and Applications最新文献_第10页

Spark plasma sintering of silver nanopowder 银纳米粉的放电等离子烧结

SPIE Micro + Nano Materials, Devices, and Applications Pub Date : 2007-12-27 DOI: 10.1117/12.759383

H. B. Ng, C. Shearwood, T. White, Lai Gui Yu, K. Khor

引用次数: 3

Characterization of flows in micro contractions using micro PIV and CFD to study the protein aggregation process 利用微型PIV和CFD研究蛋白质聚集过程的微收缩流动表征

SPIE Micro + Nano Materials, Devices, and Applications Pub Date : 2007-12-27 DOI: 10.1117/12.759388

F. Tovar-Lopez, A. Mitchell, G. Rosengarten

{"title":"Characterization of flows in micro contractions using micro PIV and CFD to study the protein aggregation process","authors":"F. Tovar-Lopez, A. Mitchell, G. Rosengarten","doi":"10.1117/12.759388","DOIUrl":"https://doi.org/10.1117/12.759388","url":null,"abstract":"Protein aggregation is arguably the most common and troubling manifestation of protein instability, encountered in almost all stages of protein drug development. The production process in the pharmaceutical industry can induce flows with shear and extensional components and high strain rates which can affect the stability of proteins. We use a microfluidic platform to produce accurately controlled strain regions in order to systematically study the main parameters of the flow involved in the protein aggregation. This work presents a characterization of the pressure driven flow encountered in arrays of micro channels. The micro channels were fabricated in polydimethyl siloxane (PDMS) using standard soft-lithography techniques with a photolithographically patterned KMPR mold. We present a relationship of the main geometrical variables of the micro channels and its impact on the extensional strain rate along the center line, for different cross sectional shapes and over a range of strain rates typically encountered in protein processing. Computational Fluid Dynamics (CFD) simulations have been carried out to gain more detailed local flow information, and the results have been validated with experiments. We show good agreement between the CFD and experiments and demonstrate the use of microfluidics in the production of a large range of controllable shear and extensional rates that can mimic large scale processing conditions.","PeriodicalId":320411,"journal":{"name":"SPIE Micro + Nano Materials, Devices, and Applications","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126697566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Surface acoustic wave device based wireless passive microvalve for microfluidic applications 基于表面声波装置的微流控无线无源微阀

SPIE Micro + Nano Materials, Devices, and Applications Pub Date : 2007-12-27 DOI: 10.1117/12.765011

D. Dissanayake, S. Al-Sarawi, D. Abbott

引用次数: 5

Effects of spacer growth temperature on the optical properties of quantum dot laser structures 间隔层生长温度对量子点激光结构光学性质的影响

SPIE Micro + Nano Materials, Devices, and Applications Pub Date : 2007-12-21 DOI: 10.1117/12.759663

N. F. Hasbullah, J. S. Ng, H. Liu, M. Hopkinson, J. David, T. Badcock, D. Mowbray, A. Sanchez, R. Beanland

{"title":"Effects of spacer growth temperature on the optical properties of quantum dot laser structures","authors":"N. F. Hasbullah, J. S. Ng, H. Liu, M. Hopkinson, J. David, T. Badcock, D. Mowbray, A. Sanchez, R. Beanland","doi":"10.1117/12.759663","DOIUrl":"https://doi.org/10.1117/12.759663","url":null,"abstract":"Electroluminescence (EL) and its temperature dependence of InAs quantum dots embedded in In0.15Ga0.85As quantum well [dots in a well (DWELL)] have been investigated as functions of the growth temperature of the GaAs spacer layer. The EL intensity at room temperature increases as the spacer growth temperature increases. The integrated EL intensity as a function of injection current at room temperature for all samples shows that at low currents, the gradients are superlinear but this superlinearity decreases as the spacer growth temperature is increased. From a simple analysis of the generation-recombination rate equations, it can be shown that the superlinearity stems from the nonradiative recombination being the dominant recombination process. As the spacer growth temperature is increased, this nonradiative recombination become less dominant. An Arrhenius plot of the temperature dependence of the EL intensity gives an activation energy of ~300 ± 15 meV at high temperature. The dominant loss mechanism is therefore concluded to be the electron escape from the quantum dot ground state to the GaAs barrier.","PeriodicalId":320411,"journal":{"name":"SPIE Micro + Nano Materials, Devices, and Applications","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114985328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Superhydrophobic and superhydrophilic surfaces with MoOx sub micron structures 具有MoOx亚微米结构的超疏水和超亲水表面

SPIE Micro + Nano Materials, Devices, and Applications Pub Date : 2007-12-21 DOI: 10.1117/12.759867

J. Campbell, M. Breedon, W. Wlodarski, K. Kalantar-zadeh

{"title":"Superhydrophobic and superhydrophilic surfaces with MoOx sub micron structures","authors":"J. Campbell, M. Breedon, W. Wlodarski, K. Kalantar-zadeh","doi":"10.1117/12.759867","DOIUrl":"https://doi.org/10.1117/12.759867","url":null,"abstract":"Presented is an investigation of surface morphology of arrayed MoOx structures with increasing aspect ratios, and their resultant superhydrophillic, and their modified superhydrophobic properties. Molybdenum oxide (MoOx) submicron structures were grown on lithium niobate (LiNbO3) substrates via the thermal evaporation of MoO3 nanopowder at 750°C in a horizontal tube furnace. A mixture of 90% argon and 10% oxygen was introduced into the thermal evaporation tube at flow rate of 1L/min. This resulted in the formation of a white film which consisted of submicron tabular structures. Scanning electron micrographs revealed that the tabular molybdenum oxide grew in arrays 80-100° with respect to the plane of the substrate, with tabular structures with a thickness of approx 0.5 - 1.5μm. Initial testing of MoOx structures revealed that they were extremely super hydrophilic. Such MoOx arrays were coated with fluoropolymer Teflon, deposited using the RF sputtering technique. The addition of a semi-conformal Teflon layer effectively converts the superhydrophilic MoOx layer into a superhydrophobic surface. These superhydrophobic surfaces exhibit contact angles with aqueous media in excess of 150°. Such surfaces can be utilized for the selective adsorption and desorption of protein or pharmacokinetic molecules, with applications in drug delivery and biomedical systems.","PeriodicalId":320411,"journal":{"name":"SPIE Micro + Nano Materials, Devices, and Applications","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115272271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SOI waveguide fabrication process development using star coupler scattering loss measurements 利用星形耦合器测量散射损耗的SOI波导制造工艺开发

SPIE Micro + Nano Materials, Devices, and Applications Pub Date : 2007-12-21 DOI: 10.1117/12.758968

K. P. Yap, J. Lapointe, B. Lamontagne, A. Delâge, A. Bogdanov, S. Janz, B. Syrett

{"title":"SOI waveguide fabrication process development using star coupler scattering loss measurements","authors":"K. P. Yap, J. Lapointe, B. Lamontagne, A. Delâge, A. Bogdanov, S. Janz, B. Syrett","doi":"10.1117/12.758968","DOIUrl":"https://doi.org/10.1117/12.758968","url":null,"abstract":"We show that integrated optical star couplers can be useful characterization devices to measure the sidewall roughness-induced scattering losses of planar waveguides. We describe the detailed fabrication processes of these star couplers on the silicon-on-insulator (SOI) platform and the process improvements implemented to reduce the waveguide sidewall roughness and scattering loss. We report the main process challenges, particularly to assure a clear gap between any adjacent waveguides of the dense and closely spaced output waveguide array. These challenges are addressed by optimizing the exposure dose of the resist and adding an oxygen ashing treatment to eliminate waveguide footings. We demonstrate further improvement on the waveguide profile and sidewall roughness through the use of a thin Cr hardmask for the dry plasma etching. This optimized fabrication process is capable of producing approximately a 3 nm root-mean-square sidewall roughness, measured using both scanning electron microscopy (SEM) and atomic force microscopy (AFM). Using the fabricated star couplers, we manage to measure the relative scattering losses of various waveguides with the width varying from 0.2 to 2.0 μm in a single measurement, and show that the measured losses agree with the measured sidewall roughness.","PeriodicalId":320411,"journal":{"name":"SPIE Micro + Nano Materials, Devices, and Applications","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115657238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Stability constraints on structural and functional neuronal network connectivity 结构和功能神经网络连通性的稳定性约束

SPIE Micro + Nano Materials, Devices, and Applications Pub Date : 2007-12-21 DOI: 10.1117/12.778619

P. Robinson, R. Gray, C. K. C. Fung

引用次数: 1

DNA-conjugated metal nanoparticle for bioanalytics, nanophotonics, and nanoelectronics 用于生物分析、纳米光子学和纳米电子学的dna共轭金属纳米粒子

SPIE Micro + Nano Materials, Devices, and Applications Pub Date : 2007-12-21 DOI: 10.1117/12.758621

W. Fritzsche, A. Csáki, R. Möller, A. Steinbrück, G. Festag, A. Wolff, T. Schüler

{"title":"DNA-conjugated metal nanoparticle for bioanalytics, nanophotonics, and nanoelectronics","authors":"W. Fritzsche, A. Csáki, R. Möller, A. Steinbrück, G. Festag, A. Wolff, T. Schüler","doi":"10.1117/12.758621","DOIUrl":"https://doi.org/10.1117/12.758621","url":null,"abstract":"Metal (especially gold) nanoparticles exhibit unique electronic, optical, and catalytic properties. In order to utilize these properties, an integration of the particles into technical setups such as a chip surface is helpful. We develop techniques to use (bio) molecular tools in order to address and control the positioning of particles on microstructured chips. These techniques are utilized for novel DNA detection schemes using optical or electrical principles. Plasmonic properties of the particles and the combination of nano-apertures with particles are promising fields for further bioanalytical developments. On the other hand, methods for defined positioning of single molecules or molecular constructs in parallel approaches are under development, in order to provide needed defined nanostructures for applications in nanoelectronics. Connecting DNA with nanoparticles, metallization of DNA or positioning of individual DNA-structures over microstructured electrode gap including subsequent metal particle binding are important steps in this direction. The utilization of (bio) molecular tools and principles based on highly specific binding and self-assembly represent a promising development in order to realize novel nanoparticle-based devices for bioanalytics, nano-optics and - electronics.","PeriodicalId":320411,"journal":{"name":"SPIE Micro + Nano Materials, Devices, and Applications","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116783805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding complex matter from simple packing models 从简单的包装模型理解复杂的物质

SPIE Micro + Nano Materials, Devices, and Applications Pub Date : 2007-12-21 DOI: 10.1117/12.759030

T. Aste, G. Delaney, T. Di Matteo

引用次数: 0

Improved protein-adsorption resistance of digital microfluidic device via surface coating and structure modification 通过表面涂层和结构修饰提高数字微流控装置的蛋白质吸附阻力

SPIE Micro + Nano Materials, Devices, and Applications Pub Date : 2007-12-21 DOI: 10.1117/12.755340

Shun-Yuan Chen, Heng-Cang Hu, Chih-Sheng Yu, Yi-Chiuen Hu

引用次数: 0