Malang Neurology Journal最新文献_第5页

PARKINSON AND STEM CELL THERAPY 帕金森和干细胞治疗

Malang Neurology Journal Pub Date : 2017-01-01 DOI: 10.21776/UB.MNJ.2017.003.01.7

Gerry Gunawan, M. Dalhar, S. Kurniawan

引用次数: 6

BETA AMYLOID POLYCLONAL ANTIBODY IMMUNOGENICITY AS EARLY DEVELOPMENT STUDY OF EARLY DIAGNOSIS FOR ALZHEIMER’S DISEASE β淀粉样蛋白多克隆抗体免疫原性作为阿尔茨海默病早期诊断的早期发展研究

Malang Neurology Journal Pub Date : 2017-01-01 DOI: 10.21776/UB.MNJ.2017.003.01.1

M. R. Indra, Eko Arisetijono Marhaendraputro, Rudi Rakhmad Hidayat

{"title":"BETA AMYLOID POLYCLONAL ANTIBODY IMMUNOGENICITY AS EARLY DEVELOPMENT STUDY OF EARLY DIAGNOSIS FOR ALZHEIMER’S DISEASE","authors":"M. R. Indra, Eko Arisetijono Marhaendraputro, Rudi Rakhmad Hidayat","doi":"10.21776/UB.MNJ.2017.003.01.1","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2017.003.01.1","url":null,"abstract":"Background. Alzheimer's disease is a progressive neurologic disease of the brain that triggers irreversible neuronal cell loss, which can interfere with social and occupational functioning. The theory of ACH (Amyloid Cascade Hypothesis) states there are deposits and misfolding of beta amyloid protein thus lead to the formation of plaques and tangles in neurons cells. Objective. To identify the immunogenicity of beta amyloid polyclonal antibodies that can be developed as a first step early diagnosis of Alzheimer's disease. Methods. Rrandomized group post test only design conducted on rabbits. Blood samples were taken from rabbits that had been injected antigen once a week for 5 weeks. Variables were found in this study is the formation of beta amyloid polyclonal antibody with detection levels using dot blot and ELISA methods. Results. It has been reproduced specific polyclonal antibody beta amyloid which has been evidenced by the bond between the antigen with the antibody in a dot blot. Conclusion. The beta amyloid antibodies can be produced through production techniques with a polyclonal antibody against beta amyloid antigen induced rabbit.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"3 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

GRAPE’S LEATHER AND SEED EXTRACT (VITIS VINIFERA) IMPROVING THE FUNCTION OF WISTAR RATS’ MOTOR (RATTUS NORVEGICUS) ISCHEMIC STROKE MODEL 葡萄皮及葡萄籽提取物对褐家鼠缺血性脑卒中模型的改善作用

Malang Neurology Journal Pub Date : 2017-01-01 DOI: 10.21776/UB.MNJ.2017.003.01.2

M. R. Indra, Zanella Yolanda Lie

{"title":"GRAPE’S LEATHER AND SEED EXTRACT (VITIS VINIFERA) IMPROVING THE FUNCTION OF WISTAR RATS’ MOTOR (RATTUS NORVEGICUS) ISCHEMIC STROKE MODEL","authors":"M. R. Indra, Zanella Yolanda Lie","doi":"10.21776/UB.MNJ.2017.003.01.2","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2017.003.01.2","url":null,"abstract":"Background. Grape peel and seed extract (Vitis vinifera), that has resveratrol, is one of many antioxidants that can pass through blood brain barrier and can induce release neurotrophic factor that contribute in ERK 1/2 pathway mechanism in post stroke. Objective . To prove that grape peel and seed extract can regenerate neuron in brain functional. Methods. True experimental design with five groups in this research. The five groups are negative control, positive control, grape peel and seed extract 50mg/KgBW, 100mg/KgBW, and 200mg/KgBW. rats are given grape peel and seed extract in variable dose to know how extract’s effect in neuron repairment. The repairment is monitored from ladder rung walking test score. Results. Range average score ladder rung walking test post stroke dan post treatment group N, K, Ra, Rb, dan Rc, were 0 ± 0, 0.001028933 ± 0.011664445, 0.123214286 ± 0.019834983, 0.064744427 ± 0.024296721, 0.03781401 ± 0.006888803. Statistical test used Annova significantly p;0,001.Dose 50mg/KgBW is effective in repairing neuron. Conclusion . Grape’s leather and Seed extract 50 mg/kgBW can improve neuron regeneration on animal model.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"3 1","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE DIFFERENCE LEVEL OF NUTRITIONAL STATUS WITH CLINICAL OUTCOME IN PATIENT WITH ACUTE PHASE ISCHEMIC STROKE 急性期缺血性脑卒中患者营养状况与临床预后的差异

Malang Neurology Journal Pub Date : 2017-01-01 DOI: 10.21776/UB.MNJ.2017.003.01.4

Edwina Narulita Sari Agustin Junaidi, S. Winarsih, Tina Handayani Nasution

{"title":"THE DIFFERENCE LEVEL OF NUTRITIONAL STATUS WITH CLINICAL OUTCOME IN PATIENT WITH ACUTE PHASE ISCHEMIC STROKE","authors":"Edwina Narulita Sari Agustin Junaidi, S. Winarsih, Tina Handayani Nasution","doi":"10.21776/UB.MNJ.2017.003.01.4","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2017.003.01.4","url":null,"abstract":"Background. Nutritional status is predictor that can affects on clinical outcome in patient with acute phase ischemic stroke. Objective. To investigate the difference of nutritional status level with clinical outcome in patient with acute phase ischemic stroke. Methods. Cohort retrospective design used medical record of all registered acute ischemic stroke patient in hospital Dr. Saiful Anwar Malang. 60 sample that inquired inclusion criteria and classified into three groups (the group of patient with acute phase ischemic stroke with normal nutrition status, undernutrition status, and overnutrition status). Nutritional status measured with body mass index parameter and clinical outcome measured with of NIHSS score admission and NIHSS score discharge. Results . There were 60 had good clinical outcome with undernutrition status (n=20) amount 65%, normal nutrition status (n=20) amount 70% and overnutrition status (n=20) amount 60%. The difference of nutritional status level with clininical outcome in patient with acute phase ischemic stroke showed that no significantly difference (chi square, p-value=0,803). Conclusion. There is no difference of nutritional status level with clinical outcome in patient with acute phase ischemic stroke.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"3 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DIAGNOSIS AND MANAGEMENT OF NONCONVULSIVE STATUS EPILEPTICUS (NCSE) 非惊厥性癫痫持续状态(ncse)的诊断与处理

Malang Neurology Journal Pub Date : 2017-01-01 DOI: 10.21776/UB.MNJ.2017.003.01.6

Fathia Annis Pramesti, M. Husna, S. Kurniawan, Masruroh Rahayu

引用次数: 1

EFFECT OF ALPHA LIPOIC ACID ON MDA LEVELS AND HISTOLOGY OF BRAIN IN TYPE 1 DM α-硫辛酸对1型糖尿病大鼠脑组织MDA含量及组织学的影响

Malang Neurology Journal Pub Date : 2017-01-01 DOI: 10.21776/UB.MNJ.2017.003.01.5

Rania Arif Mahfud, D. Lyrawati, Imam Sarwono

{"title":"EFFECT OF ALPHA LIPOIC ACID ON MDA LEVELS AND HISTOLOGY OF BRAIN IN TYPE 1 DM","authors":"Rania Arif Mahfud, D. Lyrawati, Imam Sarwono","doi":"10.21776/UB.MNJ.2017.003.01.5","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2017.003.01.5","url":null,"abstract":"Background. Diabetic neuropaty is a condition that can affect pyramidal cells and neuronal cells in the hippocampus. Alpha lipoic acid is effective in pathological conditions where ROS (Reactive Oxygen Species) have been implicated, include in brain. Objective. To investigate effects of ALA on oxidative stress in diabetic brain of male Wistar rats. Methods. True experimental design and Posttest Only Control Group are used in this study. Thirty male rats were randomly divided into 5 groups: normal rats without ALA (NTA), diabetic rats without ALA (DTA), diabetic rats with ALA 80 mg, ALA dose 200 mg, and ALA dose 500 mg/kg/day. ALA therapy in mice conducted orally once a day. Diabetes was induced in rats by single intraperitonial injection of streptozotocin (STZ) at 60 mg/kg body weight. The content of malondialdehyde (MDA) in the brain was measured by spectrophotometeric assays. Brain structure (pyramidal cell in hippocampus) was assessed by staining with hematoxylin and eosin. Results. MDA levels in the DTA, DA80 and DA200 is greater than the levels of MDA in the NTA group, but not statistically significant at the MDA values (p = 0,260). Test-Product Moment Pearson correlation showed a weak positive relationship and not significant (r = 0,327) between the groups of NTA, DA80 and DA200 with MDA. No differences pyramidal cell structure between NTA and DTA. Conclusion. The treatment for 4 weeks with ALA had not reduced oxidative stress in diabetic brain.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"3 1","pages":"23-29"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

THE EFFECT OF INFECTION OF MYCOBACTERIUM TUBERCULOSIS STRAIN H37RV TOWARDS THE EXPRESSION OF TNF- α IN THE BRAIN 结核分枝杆菌H37RV感染对脑组织TNF-α表达的影响

Malang Neurology Journal Pub Date : 2017-01-01 DOI: 10.21776/UB.MNJ.2017.003.01.3

G. Santoso, H. Sujuti, D. Hidayati

引用次数: 1

NUTRITIONAL STATUS RELATION TOWARD DEVELOPMENT OF NEURODEVELOPMENTAL TO INFANTS AGED 0-6 MONTHS WHO RECEIVED BREAST MILK EXCLUSIVELY AND NONEXCLUSIVELY (IN PUSKESMAS KEDUNGKANDANG MALANG) 纯母乳和非纯母乳喂养0-6个月婴儿的营养状况与神经发育的关系

Malang Neurology Journal Pub Date : 2016-09-27 DOI: 10.21776/UB.MNJ.2016.002.02.5

Brigitta Ida, F. Nugroho, Inke Triana Arysanthi

{"title":"NUTRITIONAL STATUS RELATION TOWARD DEVELOPMENT OF NEURODEVELOPMENTAL TO INFANTS AGED 0-6 MONTHS WHO RECEIVED BREAST MILK EXCLUSIVELY AND NONEXCLUSIVELY (IN PUSKESMAS KEDUNGKANDANG MALANG)","authors":"Brigitta Ida, F. Nugroho, Inke Triana Arysanthi","doi":"10.21776/UB.MNJ.2016.002.02.5","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2016.002.02.5","url":null,"abstract":"Background. Breastfeeding is an important activity to maintain and prepare the next generation in the future. The low of exclusive breastfeeding at the family is one of the triggers for low of nutritional status and it associated with neurodevelopmental delays of infants. Objective. To identify and analyze the correlation of nutritional status on neurodevelopmental development in infants aged 0-6 months who are exclusive and non-exclusive breastfeeding in Kedungkandang Health Center Malang. Methods. An observational analytic using a cross-sectional approach . The samples were taken by Consecutive Sampling technique. Data were analyzed by Spearman Rank correlation test. Results. There is a significant correlation between nutritional status with neurodevelopmental development in infants aged 0-6 months with significance value p = 0.000 ( 0.000 < 0.05 ) and the strength of correlation (r=0,552) is medium. Conclusion. There is a positive correlation between nutritional status with neurodevelopmental progress of infants aged 0-6 months who are exclusively breastfed . Exclusive breastfeeding affects the nutritional status better, then a good nutritional status affected neurodevelopmental development also better.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"2 1","pages":"71-78"},"PeriodicalIF":0.0,"publicationDate":"2016-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

THE INFECTION EFFECT OF STRAIN H37Rv MYCOBACTERIUM TUBERCULOSIS ON APOPTOSIS OF MICE’S NEURON CELL BRAIN (MUS MUSCULUS) H37Rv结核分枝杆菌感染小鼠脑神经细胞凋亡的研究

Malang Neurology Journal Pub Date : 2016-06-27 DOI: 10.21776/UB.MNJ.2016.002.02.2

Rima Nor Kaspia, D. Hidayati, Aris Widayati

{"title":"THE INFECTION EFFECT OF STRAIN H37Rv MYCOBACTERIUM TUBERCULOSIS ON APOPTOSIS OF MICE’S NEURON CELL BRAIN (MUS MUSCULUS)","authors":"Rima Nor Kaspia, D. Hidayati, Aris Widayati","doi":"10.21776/UB.MNJ.2016.002.02.2","DOIUrl":"https://doi.org/10.21776/UB.MNJ.2016.002.02.2","url":null,"abstract":"Background. Ischemia on the cells and the lack of supply of glucose, will trigger a Ca2 + influx into the cell and increased expression of glutamate. Result in mitochondrial Ca2 + Influx be \"overloaded\". Glucose metabolism then switched to the anaerobic process that makes ATP increasingly depleted and there acidosis. This situation makes the neuron cell apoptosis triggered to occur. Apoptosis is programmed cell death. Neuron cell apoptosis is thought to have a strong connection to the tuberculosis infection in the brain. Objective. To determine the number of cells undergoing apoptosis neurons in brain tissue of mice. Methods. This study is a semiquantitative by comparing the number of cells undergoing apoptosis neurons in the three groups of samples. Observations apoptosis of neuronal cells in the brain tissue of mice was conducted using TUNEL staining technique (terminal deoxynucleotidyl transferase dUTP nick end labeling) are seen in a microscope with a magnification of 1000x. Results. The results showed that neuronal cells undergo apoptosis in brain tissue infected with M.tb for 8 and 16 weeks were marked with brown color in the cell nucleus. Neuron cell apoptosis were observed at M.tb-infected brain tissue for 16 weeks. Conclusion. The longer the M.tb infection can affect the increase in the number of neuronal cell apoptosis.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"2 1","pages":"52-59"},"PeriodicalIF":0.0,"publicationDate":"2016-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68323977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BIOMOLECULAR ASPECTS AND UPDATE ON TREATMENT OF CEREBRAL MALARIA 脑型疟疾治疗的生物分子方面和最新进展

Malang Neurology Journal Pub Date : 2016-06-27 DOI: 10.21776/UB.MNJ.2016.002.02.6

M. Husna, Bowo Hery Prasetyo

引用次数: 0