GRAPE’S LEATHER AND SEED EXTRACT (VITIS VINIFERA) IMPROVING THE FUNCTION OF WISTAR RATS’ MOTOR (RATTUS NORVEGICUS) ISCHEMIC STROKE MODEL

Malang Neurology Journal Pub Date : 2017-01-01 DOI:10.21776/UB.MNJ.2017.003.01.2

M. R. Indra, Zanella Yolanda Lie

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Abstract

Background. Grape peel and seed extract (Vitis vinifera), that has resveratrol, is one of many antioxidants that can pass through blood brain barrier and can induce release neurotrophic factor that contribute in ERK 1/2 pathway mechanism in post stroke. Objective . To prove that grape peel and seed extract can regenerate neuron in brain functional. Methods. True experimental design with five groups in this research. The five groups are negative control, positive control, grape peel and seed extract 50mg/KgBW, 100mg/KgBW, and 200mg/KgBW. rats are given grape peel and seed extract in variable dose to know how extract’s effect in neuron repairment. The repairment is monitored from ladder rung walking test score. Results. Range average score ladder rung walking test post stroke dan post treatment group N, K, Ra, Rb, dan Rc, were 0 ± 0, 0.001028933 ± 0.011664445, 0.123214286 ± 0.019834983, 0.064744427 ± 0.024296721, 0.03781401 ± 0.006888803. Statistical test used Annova significantly p;0,001.Dose 50mg/KgBW is effective in repairing neuron. Conclusion . Grape’s leather and Seed extract 50 mg/kgBW can improve neuron regeneration on animal model.

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葡萄皮及葡萄籽提取物对褐家鼠缺血性脑卒中模型的改善作用

背景。葡萄皮和葡萄籽提取物(Vitis vinifera)含有白藜芦醇，是多种抗氧化剂之一，可通过血脑屏障，诱导释放神经营养因子，参与脑卒中后ERK 1/2通路机制。目标。证明葡萄皮及葡萄籽提取物可使脑内神经元再生。方法。本研究采用五组实验设计。5组分别为阴性对照组、阳性对照组、葡萄皮及籽提取物50mg/KgBW、100mg/KgBW、200mg/KgBW。用不同剂量的葡萄皮和葡萄籽提取物对大鼠神经细胞的修复作用进行研究。从梯子梯级行走测试分数监测修复情况。结果。范围平均评分阶梯阶梯行走试验后卒中后治疗组N、K、Ra、Rb、Rc分别为0±0、0.001028933±0.011664445、0.123214286±0.019834983、0.064744427±0.024296721、0.03781401±0.006888803。统计学检验采用方差分析，p < 0.001。剂量50mg/KgBW对神经元修复有效。结论。葡萄皮和葡萄籽提取物50 mg/kgBW对动物模型神经元再生有促进作用。

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来源期刊

Malang Neurology Journal

自引率

0.00%

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审稿时长

48 weeks