N. Raisa, Sri Budhi Rianawati, Shahdevi Nandar Kurniawan, Fahimma F, Mulika Ade Fitria Nikmahtustsani
{"title":"HEMICHOREA-HEMIBALLISM IN VARIOUS CONDITIONS: SERIAL CASE REPORTS","authors":"N. Raisa, Sri Budhi Rianawati, Shahdevi Nandar Kurniawan, Fahimma F, Mulika Ade Fitria Nikmahtustsani","doi":"10.21776/ub.mnj.2021.007.01.15","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.15","url":null,"abstract":"Introduction: Hemichorea-hemiballism (HCHB) is an uncommon movement disorder involved unilateral extremities characterized by irregular, poorly patterned, a continual hyperkinetic involuntary movement disorder in the proximal or distal parts of the body. The acute development of HCHB depends on focal lesions on the contralateral basal ganglia and subthalamic nuclei. Various conditions such as cerebrovascular, neurodegenerative, neoplastic, immunologic, infectious, and metabolic diseases are known as secondary causes of HCHB. This paper aims to compare and discuss the HCHB in various etiologies. Case Reports: Here, we reported 5 cases of HCHB induced by non-ketotic hyperosmolar hyperglycemia (NKKH), thrombotic stroke, and toxoplasmosis cerebral. We compare the admission data, clinical course, imaging, treatment, and outcome of every case. Conclusion: Various hypotheses have been proposed to explain the pathophysiology of HCHB due to these conditions. Principally, the main management for these cases is to determine the etiology and correct the underlying disorder","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"50 1","pages":"74-79"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68325063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Widyadharma, Agung B S Satyarsa, F. Sanjaya, Ni Made Gitari, I. Niryana, T. E. Purwata, I. M. Jawi, Dewa Ngurah Suprapta, A. Sudewi
{"title":"POTENTIAL OF ANTHOCYANIN BASED POLY (METHYL METHACRYLATE) NANOPARTICLES SPECIFIC ACTIVATED MICROGLIA IN MANAGEMENT INFLAMMATORY PAIN ON HERNIATED NUCLEUS PULPOSUS: A LITERATURE REVIEW","authors":"I. Widyadharma, Agung B S Satyarsa, F. Sanjaya, Ni Made Gitari, I. Niryana, T. E. Purwata, I. M. Jawi, Dewa Ngurah Suprapta, A. Sudewi","doi":"10.21776/ub.mnj.2021.007.01.9","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.9","url":null,"abstract":"Pain is an unpleasant sensory and emotional experience that can affect the quality of life and leads to decreased productivity in patients. Low back pain (LBP) is one of the significant causes of disability worldwide with lifelong incidence. The purpose of this literature review describes the potential of anthocyanin-based Poly (Methyl Methacrylate) (PMMA) nanoparticles as the management of inflammatory pain in the Hernia Nucleus Pulposus (HNP ). The method used is a literature study by entering the keyword. Of the 77 journals reviewed, 47 journals were found by the topic and used as a reference for this work. The anthocyanin-based PMMA nanoparticles act as anti-nociceptors by inhibiting microglia that produce inflammatory mediators in HNP. Poly (Methyl Methacrylate) nanoparticles have specific targets in microglia. Anthocyanins have the effect of inhibiting inflammatory pain through many destinations. Anthocyanin inhibits the synthesis of nitric oxide (NO ) and prostaglandin E2 (PGE 2) and inhibits the activation of p38 MAPK and NF-kB pathways that express TNF-α and IL-1β genes as anti-nociceptive. The anthocyanin-based PMMA nanoparticles have potential as a novel therapy for inflammatory pain in HNP. There has been no research between these modalities. Therefore, further research is needed to find out the exact potential of anthocyanin-based PMMA nanoparticles.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68325338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chandra Calista Wardoyo, U. Gamayani, A. Ong, A. Rizal, Yusuf Wibisono, L. Amalia, R. Panigoro
{"title":"COGNITIVE IMPAIRMENT DETECTION IN ADULT THALASSEMIA PATIENT USING MOCA-INA","authors":"Chandra Calista Wardoyo, U. Gamayani, A. Ong, A. Rizal, Yusuf Wibisono, L. Amalia, R. Panigoro","doi":"10.21776/ub.mnj.2021.007.01.6","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.6","url":null,"abstract":"Background: Cognitive impairment in thalassemia patients are prevalent, therefore early detection of cognitive impairment in adult thalassemia patients is crucial for prevention. Montreal Cognitive Assessment (MoCA) is a public domain cognition screening tools that covers all cognitive domains in detecting mild cognitive impairments. Objective: To compare cognitive function between adult thalassemia patients and healty control by using Indonesia version of MoCA test (MoCA-Ina) Methods: This prospective observational analytic with case control study, compared the total scores and scores of each domain of cognition between adult thalassemia patients and healthy subjects at the Medical Hematology Oncology Clinic of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia using MoCA-Ina from August to October 2018. Results: A total of 32 thalassemia subjects and 50 healthy subjects were conducted. A total of 16(50%) subjects in the case group had a value of MoCA-Ina <26, while only 1(2%) healthy control had a value of MoCA-Ina <26. The median total MoCA-Ina score in case and control groups were 25.5 and 27.50 (p <0.001). The median score of memory domains, executive functions and visuospatial of the case and control groups were 3 versus 4 (p <0.001), 3 versus 3.5 (p <0.001) and 3.53 ± 0.671 versus 3.88 ± 0.385 (p <0.003), respectively. Conclusion: Adults thalassemia patients have lower score in total MoCA-Ina, domains of memory, executive function and visuospatial score compared to healthy control.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"137 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68325480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE CIDR1α-PfEMP1 SEQUENCE FROM INDONESIAN PLASMODIUM FALCIPARUM AND ITS POTENTIAL ASSOCIATION WITH THE CEREBRAL OUTCOME","authors":"E. Sulistyaningsih, Yunita Armiyanti, R. Dewi","doi":"10.21776/ub.mnj.2021.007.01.8","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.8","url":null,"abstract":"Background: Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is an important protein responsible for the pathogenesis of severe malaria, including cerebral malaria. The protein is highly diverse. The CIDR1α-PfEMP1 binds endothelial protein receptor (EPCR) and may associated with the brain swelling in childhood malaria. Objective: To analyze the CIDR1α-PfEMP1 from Indonesian isolate and determine its association with cerebral malaria outcome. Methods: Fifteen blood samples of clinically mild to severe malaria-patient were collected for DNA extraction. Malaria diagnosis was conducted microscopically by Giemsa-stained thin blood smear. The CIDR1α domain was amplified by PCR using specific primer and PCR product was sequenced. The nucleotide sequences were analyzed by NCBI blast, DNASIS MAX 3 and translated into amino acid sequences using Expasy Translation Tool. Results: One out of fifteen samples was severe malaria case and infected with P. falciparum, the rest were clinically mild to moderate malaria and infected with pure P. falciparum or mixed infection of P. falciparum and P. vivax. Amplification for CIDR1α domain resulted a single band of + 550 bp from a severe sample only. Sequencing of PCR product on both strands read 524 nucleotides and BLAST analysis confirmed as CIDR1α sequence. Multiple alignment showed 74-78% nucleotide sequence similarity with reference sequences, but amino acid sequences presented 23.5% homologous. Conclusion: An identified CIDR1α domain only from severe case implicating the potential association with the severe outcome including cerebral malaria, but the highly diverse of the domain needs further studies on the interaction with the pathological-causing receptor in the host.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"7 1","pages":"34-39"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68325650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sajeesh Parameswaran, T. V. A. Kumar, Ajith Mohan, John Thomas, Nikhil Sajeev, K. Swarnam, A. M. Pillai
{"title":"COMPARISON OF VARIOUS EEG ELECTRODE PLACEMENT SYSTEMS TO DETECT EPILEPTIFORM ABNORMALITIES IN INFANTS","authors":"Sajeesh Parameswaran, T. V. A. Kumar, Ajith Mohan, John Thomas, Nikhil Sajeev, K. Swarnam, A. M. Pillai","doi":"10.21776/ub.mnj.2021.007.01.7","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.7","url":null,"abstract":"Background: Technical difficulties in placement of whole 10-20 electrode system is not uncommon in neonates and infants. Apart from the full channel many centers uses the modified and amplitude integrated EEG montages to identify seizures. Objective: Efficacy of standard, modified and amplitude integrated EEG electrode placement in infants to detect epileptiform abnormalities. Methods: All routine EEGs from June 2015 to April 2018 were taken. Age ≤ 2years at the time of recoding was the inclusion criteria. Digital EEG was performed according to standard 10-20 electrode placement system in all patients. Abnormal EEGs were reanalyzed in different montages like A) 21 electrodes- full channel, B) 10 electrodes- modified long distance and C)4 electrodes- (centro/parietal) respectively. Inter ictal epileptiform discharges (IEDs), seizures, periodic complexes and non-specific dysfunctions were tabulated in all patients. Full channel montages are considered bench mark for the analysis Results: A total 129 EEGs analyzed. A) Full channel standard 21 electrodes montages could identify IEDs in 35, non-specific electrophysiological dysfunction in 9 and burst-suppression pattern in 2 EEGs. B) Modified electrode placement consists of 10 electrodes could identify IEDs only in 26 EEGs and non-specific electro physiological dysfunction in 6 EEGs. A total of 28 nonconvulsive seizures (NCS) recorded in 6 patients; 20 numbers of NCS (71.4%) seen in modified electrode placement (B) and only 16 (57.1%) seen in centro/parietal electrode placement (C).. Conclusion: Standard EEG electrode placement has higher yield in detecting epileptiform abnormalities.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68325600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nabilah Hasna Imami, Yudha Haryono, A. Sensusiati, M. Hamdan, H. Hidayati
{"title":"DEMENTIA IN DR. SOETOMO GENERAL HOSPITAL SURABAYA: A SYNTHETIC REVIEW OF ITS CHARACTERISTICS","authors":"Nabilah Hasna Imami, Yudha Haryono, A. Sensusiati, M. Hamdan, H. Hidayati","doi":"10.21776//ub.mnj.2021.007.01.3","DOIUrl":"https://doi.org/10.21776//ub.mnj.2021.007.01.3","url":null,"abstract":"Background: Dementia is a clinical syndrome characterized by progressive loss of cognitive function in elderly people interferes the ability to function independently. The number of elderly patients increased so fast in worldwide. The prevalence of dementia rapidly increases due to increasing of population. Aging demographic transition is proceeding rapidly especially in China, India, and Latin America, where dementia is rapidly becoming the major public health problem. Demographic data of elderly patients of dementia in Indonesia is still a little. Dementia’s research data in Indonesia were only obtained from Bali and Yogyakarta, while data from Surabaya were not obtained. Our research data is taken from Dr. General Hospital Soetomo Surabaya, East Java, Indonesia. This study is important for dementia epidemiological data and baseline data for further treatment of dementia patients in Surabaya. Objective: The purpose of this study to determine the characteristics profile of elderly patients with dementia in Dr. Soetomo General Hospital Surabaya, East Java, Indonesia. Methods: Sampling was done with purposive sampling by observing the medical records of patients in the period of January 2017 to December 2017 based on inclusion and exclusion criterias that have been set. The data was taken from the patient's medical record which had been written and examined by neurologists from the neurology department in the neurobehaviour sub-department of Dr. Soetomo Surabaya. Results: The majority of dementia patients are men (51,7%); the age group which is most at risk for dementia is between age of 75-79 years; most of the patients are jobless; more than half of patients are high school graduates; and Vascular Dementia (VaD) is the type of dementia that most people suferred Conclusion: This characteristic’s data of dementia can be used for providing information about dementia to make public health care provides a better facillities and treatment for elderly patients to prevent dementia burden.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"7 1","pages":"12-16"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68305894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RELATIONSHIP BETWEEN LEVEL OF EDUCATION AND POST-STROKE COGNITIVE STATUS IN HOSPITAL-BASED ISCHEMIC STROKE SURVIVORS","authors":"Herpan Syafii Harahap, Y. Indrayana, S. A. Putri","doi":"10.21776/ub.mnj.2021.007.01.1","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.1","url":null,"abstract":"Background: Post-ischemic stroke cognitive decline is significantly affecting the quality of life of its survivors. Its prevalence was about 7.5-72% which was mostly determined by the existing of vascular risk factors and cognitive reserve of the subjects. Level of education is one of determinants of cognitive reserve, a factor that affect the susceptibility of subjects to cognitive decline after experiencing ischemic stroke-related neuronal damage. Since level of education is protective for cognitive function, the intervention on it can reduce the occurrence of cognitive decline. Objective: To investigate the relationship between level of education and cognitive status among hospital-based ischemic stroke survivors. Methods: This cross-sectional study involved post-ischemic stroke outpatients in two hospitals. The data collected in this study were demographic data, including level of education, and clinical data as well. The level of education was categorized into ≥12 years and <12 years groups. Cognitive status was assessed using Montreal Cognitive Assessment in Indonesia version (MoCA-Ina) and subjects with score of 26-30 were normal. The relationship between level of education as well as clinical data and cognitive status were analyzed using chi-square test. Results: There were 166 subjects eligible for this study (n=166). The mean age of subjects was 58 years and 68.67% of them were male. Cognitive decline were found 80.12% of subjects (n=133). The level of education was significantly associated with cognitive status of the subjects and hypertension as well. Conclusion: The level of education had significant relationship with cognitive decline in the hospital-based population of ischemic stroke survivors.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"7 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SEIZURES IN CHILDREN WITH LOW GRADE GLIOMA","authors":"Piyush Ostwal, Shanbhag Nandan","doi":"10.21776/ub.mnj.2021.007.01.12","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.12","url":null,"abstract":"Seizures are a common presentation of pediatric brain tumors. The incidence of pediatric brain tumor (Age 0-19 years) ranges from 1.12–5.26 cases per 100,000 persons. Low grade gliomas are an important subgroup of pediatric brain tumors causing epilepsy. Low-grade gliomas are largely slow-growing tumors and the manifestations are dependent on age, location, tumor type, size of tumor and rate of tumor growth. Seizures have been reported in up to 38 % of children with supratentorial tumors. The tumors are identified when work up of patients for epilepsy includes electrophysiological and imaging studies. The primary treatment modality remains surgical excision. Antiepileptic medications are used for control of seizures. Subsequent histopathological diagnosis is important for prognostication. The tumors commonly associated with long-term epilepsy in various studies were ganglioglioma, dysembryoplastic neuroepithelial tumor, pilocytic astrocytoma and pilocytic xanthoastrocytoma. The outcome of surgery with regards to seizure control is generally good. Though concomitantly antiepileptic medications will be needed for most of them. An attempt is made in this review to summarize the epidemiology, clinical features, pathology and treatment aspects of pediatric low grade gliomas presenting with seizures.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Wardani, Sirin Salsabila, Arizal Novrianto Rahman, R. Rakhmatiar
{"title":"EFFECTIVITY OF NINTENDO WII AS REHABILITATION THERAPY IN POST STROKE PATIENTS: A SYSTEMATIC REVIEW","authors":"R. Wardani, Sirin Salsabila, Arizal Novrianto Rahman, R. Rakhmatiar","doi":"10.21776/ub.mnj.2021.007.01.11","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.11","url":null,"abstract":"Post stroke patients need medical rehabilitation to live an independent life. Nintendo Wii technology presents an alternative choice that is quite safe, feasible, and has a high potential in rehabilitating & restoring motor function in post stroke patients. Although it has been widely used as adjunct therapy in stroke rehabilitation facilities throughout the world, only a few acknowledge its effectivity in post-stroke patients. This study aims to conduct a systematic review in order to identify and assess the results used in evaluating Nintendo Wii technology as rehabilitation therapy for stroke patients. Thus, the study used for this research is systematic review. Materials included in this study are research/studies found in NCBI, PubMed, Cochrane and other relevant online databases. From this research, it is found that Virtual Reality (VR) such as Nintendo Wii considered as an additional rehabilitation therapy that provides a significant improvement in various aspects of exercise therapy, such as; balance; walking ability; statistical and dynamic strengths; motivation as well as socialization; and recovery of physical function in stroke patients. Nintendo Wii can also be used safely in stroke patients and there have been no reports of side effects from this therapy.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"7 1","pages":"56-59"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A CASE REPORT OF ACUTE NONTRAUMATIC SPONTANEOUS SUBDURAL HAEMATOMA DUE TO PSEUDOANEURYSM OF MIDDLE MENINGEAL ARTERY","authors":"F. Makkiyah, Rahma Nida Nurrahmah","doi":"10.21776/ub.mnj.2021.007.01.13","DOIUrl":"https://doi.org/10.21776/ub.mnj.2021.007.01.13","url":null,"abstract":"Acute subdural bleeding is blood collection in subdural space, usually caused by laceration of the bridging vein that runs from cortex to meningeal layer. On the other hand, the acute epidural hematoma is a collection of blood above the dura mater, usually caused by tearing of the middle meningeal artery. Subdural hematoma acute more likely happen in elderly than young adult. This case report discusses acute spontaneous subdural hematoma that was caused by a pseudoaneurysm of the middle meningeal artery. Seventeen years old boy came with symptoms of high intracranial pressure because of massive subdural bleeding. He was undergone craniotomy. After the clot removal operation, Digital Subtraction Angiography revealed vascular blush and pseudoaneurysm of the middle meningeal artery. Onyx embolization was delivered to proximal to a distal branch of the middle meningeal artery. The patient recovered in good condition, and no rebleeding in two years. Conclusion. Acute spontaneous subdural bleeding even though it is quite rare, but the chance of fatal rebleeding is high. As a result, one still has to look for the source of bleeding and manage comprehensively with embolization.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"7 1","pages":"66-69"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68324918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}