THE EFFECT OF INFECTION OF MYCOBACTERIUM TUBERCULOSIS STRAIN H37RV TOWARDS THE EXPRESSION OF TNF- α IN THE BRAIN

Malang Neurology Journal Pub Date : 2017-01-01 DOI:10.21776/UB.MNJ.2017.003.01.3

G. Santoso, H. Sujuti, D. Hidayati

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引用次数: 1

Abstract

Background. Tuberculosis caused by mycobacterium tuberculosis. The support of these inflamated factors contained in this focus determine the prognosis of TB towards Central Nervous System. One of the inflammation factors is TNF-α. Objective. To find the expression of TNF-α on the brain which are infected by M. tuberculosis. Methods. Experimental study, Wild Mus musculus to compare the group which has got infected before. The similiar study has been conducted by Laksmi Wulandari, pulmonologist. The observation towards the expression of TNF-a into a mouse’s brain was done by using the imunohistokimia method. It is marked by the brown color in the core, sitoplasma and the cell with upgrading size 100x times 20. Results. This is evident that significanly corelation (P = 0.000) between independent Mycobacterium tuberculosis infection at incubation periode 8 and 16 weeks) and dependent variabel (TNF-α expression on brain winstar tissue that infected by Mycobacterium tuberculosis for 8 and 16 weeks). Conclusion. Strong relationship between expression of TNF-a and the M. Tuberculosis’ infection.

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结核分枝杆菌H37RV感染对脑组织TNF-α表达的影响

背景。由结核分枝杆菌引起的肺结核。这些炎症因子的支持包含在这个焦点决定了结核对中枢神经系统的预后。炎症因子之一是TNF-α。目标。目的探讨结核分枝杆菌感染脑组织中TNF-α的表达。方法。实验研究，野生小家鼠与以前感染过的小家鼠组比较。肺病学家Laksmi Wulandari也进行了类似的研究。利用免疫组织学方法观察TNF-a在小鼠脑内的表达。在核心，原体和升级尺寸为100 × 20的细胞中以棕色为标志。结果。这表明，独立结核分枝杆菌感染(潜伏期8和16周)与因变量(结核分枝杆菌感染8和16周的脑组织TNF-α表达)之间存在显著相关(P = 0.000)。结论。TNF-a表达与结核分枝杆菌感染有密切关系。

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来源期刊

Malang Neurology Journal

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审稿时长

48 weeks