Caspian Journal of Neurological Sciences最新文献_第6页

Functional Balance Tests for Patients with Multiple Sclerosis: A Review Study 多发性硬化症患者的功能平衡测试:一项综述研究

Caspian Journal of Neurological Sciences Pub Date : 2022-07-01 DOI: 10.32598/cjns.8.30.7

Parisa Sedaghti Sedaghti, Gita Asgharzadeh, H. Zarei

{"title":"Functional Balance Tests for Patients with Multiple Sclerosis: A Review Study","authors":"Parisa Sedaghti Sedaghti, Gita Asgharzadeh, H. Zarei","doi":"10.32598/cjns.8.30.7","DOIUrl":"https://doi.org/10.32598/cjns.8.30.7","url":null,"abstract":"Background: Knowledge of the functional balance tests for the patients with Multiple Sclerosis (PwMS) may provide useful and accurate information about the balance function of these patients under different situations. Objectives: This study aims to review the functional balance tests for PwMS. Materials and Methods: This is a systematic review. The search was conducted in PubMed, Scopus, LILACS, CINAHL, CENTRAL, Web of Science, PEDro, and Google Scholar databases on relevant studies published until November 2021. Results: Twenty-five articles and 25 different tests were found to evaluate the functional balance of PwMS. It was found that the studies used 6 tests to assess the static balance, 13 tests to assess dynamic balance, and 6 multi-item tests to assess functional balance in PwMS. Single-leg stance test, balance error scoring system test and steady stance test is a test battery for static balance; six-spot step test, timed up and go test, and figure-of-8 hop test are better for dynamic balance, and the balance evaluation systems test is a better multiitem test to assess the balance of PwMS by examining the postural control components. Conclusion: Single-limb standing test, balance error scoring system (BESS) test and steady stance test provide accurate data on static balance; six spot step test, Timed Get up and go test and figure-of-8 hop test provide valuable data on the dynamic balance and Balance Evaluation Systems Test (BESTest) is a valid test to assess the balance of PwMS from the perspective of the review of posture control components.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"135 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86734546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atracurium as an Alternative to Succinylcholine in Electroconvulsive Therapy: A Randomized Clinical Trial 阿曲库铵在电休克治疗中替代琥珀胆碱:一项随机临床试验

Caspian Journal of Neurological Sciences Pub Date : 2022-07-01 DOI: 10.32598/cjns.8.30.2

Abbas Sedighinejad, H. Khoshrang, S. Soltanipour, S. M. Rezvani, R. Soleimani, M. Haghighi, S. Rimaz, Gelareh Biazar

{"title":"Atracurium as an Alternative to Succinylcholine in Electroconvulsive Therapy: A Randomized Clinical Trial","authors":"Abbas Sedighinejad, H. Khoshrang, S. Soltanipour, S. M. Rezvani, R. Soleimani, M. Haghighi, S. Rimaz, Gelareh Biazar","doi":"10.32598/cjns.8.30.2","DOIUrl":"https://doi.org/10.32598/cjns.8.30.2","url":null,"abstract":"Background: Electroconvulsive Therapy (ECT) is a successful treatment option for various psychiatric disorders. It is performed under general anesthesia where succinylcholine is the preferred muscle relaxant in this process. However its several contraindications and potential adverse effects, and the fact that it is not always available should be considered. Therefore, finding an effective and safe alternative is crucial. Objectives: This study aims to assess the safety and efficacy of atracurium in ECT. Materials & Methods: This single-blind clinical trial was conducted at Shafa hospital affiliated to Guilan University of Medical Sciences from November 2020 to April 2021. Participants were 67 eligible patients with ECT, randomly assigned into two groups receiving succinylcholine (0.5 mg/ kg), and atracurium (0.2 mg/kg). Seizure duration, hemodynamic parameters, the time to return to spontaneous breathing, and recovery time were assessed and compared between the two groups. Results: Seizure duration was longer in the succinylcholine group (P=0.071), while the time to return to spontaneous breathing (P=0.0001) and the recovery time (P=0.0001) were significantly longer in the atracurium group. The trend of changes in the Mean Arterial Pressure (MAP) and Heart Rate (HR) were significant over time; however, the difference between the two groups was significant only in HR one minute after the seizure induction (P=0.001). None of patients was reported serious adverse effects. Conclusion: When succinylcholine can't be used, atracurium can be a safe alternative in the ECT process.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85197203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Affecting the Outcome of Lumbar Canal Stenosis Surgery: A Two-year Follow-up Study 影响腰椎管狭窄手术结果的因素:一项为期两年的随访研究

Caspian Journal of Neurological Sciences Pub Date : 2022-07-01 DOI: 10.32598/cjns.8.30.4

B. Mirzashahi, Furqan Mohammed Yaseen Khan, S. Besharaty, Nima Bagheri, A. Moaveni, Sadegh Hasani Satehi, M. Zarei

{"title":"Factors Affecting the Outcome of Lumbar Canal Stenosis Surgery: A Two-year Follow-up Study","authors":"B. Mirzashahi, Furqan Mohammed Yaseen Khan, S. Besharaty, Nima Bagheri, A. Moaveni, Sadegh Hasani Satehi, M. Zarei","doi":"10.32598/cjns.8.30.4","DOIUrl":"https://doi.org/10.32598/cjns.8.30.4","url":null,"abstract":"Background: Lumbar Canal Stenosis (LCS) is the most common reason for spinal surgery in older patients. Identifying factors influencing the outcome of surgical management is important in clinical research. Objectives: This study aims to identify the factors affecting the outcome of surgical management for LCS. Materials & Methods: This prospective non-randomized cohort study was conducted at the spine center of Imam Khomeini Hospital in Tehran, Iran from March 2017 to January 2019 on 135 patients with symptomatic LCS, confirmed by MRI. Clinical and functional outcomes were measured using the 12-Item Short form Health Survey (SF-12), Oswestry Disability Index (ODI) and Visual Analogue Scale (VAS) the day before surgery, and 12 and 24 months after surgery. Radiographical parameters was assessed by measuring lumbar lordosis, sacral slope, pelvic tilt and pelvic incidence. Results: Of 135 patients, 120 completed the follow-up. Patients treated surgically had significantimprovement in SF-12, ODI and VAS scores after 2 years of follow-up. Higher values of BMI(P=0.031), symptom duration >1 year (P=0.045 for SF-12, P=0.031 for ODI), and smoking(P=0.033 for SF-12, P=0.028 for ODI) were associated with poor outcome. Patients with higher pre-operative SF-12, ODI and VAS scores (P=0.007 for SF-12, P=0.003 for ODI, P=0.050 for VAS) and lower lumbar lordosis (P=0.055) showed significant improvement after surgery. Conclusion: Patients with LCS showed significant improvement in outcomes afterdecompression surgery. Higher values of BMI, symptom duration >1 year, and smokingare associated with poor outcome, while higher pre-operative disability score and lowerlumbar lordosis are associated with better outcome after surgery.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82389920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfactory Dysfunction and Phantosmia in Patients With COVID-19 in Northern Iran 伊朗北部地区新冠肺炎患者嗅觉功能障碍和幻影症

Caspian Journal of Neurological Sciences Pub Date : 2022-07-01 DOI: 10.32598/cjns.8.30.8

S. Nemati, Ali Faghih Habibi, Makan Shalchizadeh, Tofigh Yaghubi Kalurazi, H. A. Balou, Mehryar Mashouf, S. H. Bagheri, Vahid Aghsaghloo, Yasaman Hosseinzadeh Lakhani

{"title":"Olfactory Dysfunction and Phantosmia in Patients With COVID-19 in Northern Iran","authors":"S. Nemati, Ali Faghih Habibi, Makan Shalchizadeh, Tofigh Yaghubi Kalurazi, H. A. Balou, Mehryar Mashouf, S. H. Bagheri, Vahid Aghsaghloo, Yasaman Hosseinzadeh Lakhani","doi":"10.32598/cjns.8.30.8","DOIUrl":"https://doi.org/10.32598/cjns.8.30.8","url":null,"abstract":"Background: One of the most common symptoms of COVID-19 infection is Olfactory Dysfunction (OD). Objectives: This study aims to investigate OD and phantosmia in COVID-19 cases from northern Iran. Materials & Methods: In this cross-sectional study, participants were 400 patients with COVID-19 infection in Rasht, Iran from March 2019 to September 2020. All the patients were evaluated in terms of OD and then followed up for 3 months face-to-face, by telephone call, or online. Results: Among 400 patients, 37.75% had OD (19% hyposmia, 10.75% primary phantosmia, and 8% anosmia) during the initiation of the disease, but 121 (30.25%) including nearly 65% of anosmic and/or hyposmic cases reported phantosmia at different time intervals of followup visits. Moreover, 65.38% of patients reported acute onset of OD. The prevalence of OD was significantly higher in patients aged <40 years (P=0.001) and in females (P=0.002). OD improved in about 90% of patients within 3 months. Peripheral oxygen saturation was better in anosmic cases and C-reactive protein level was higher in normosmic cases at their first visit. No significant difference was found in terms of other laboratory results. Conclusion: OD is a common complication of COVID-19 infection, but seems not to be permanent. It is more common in young patients, females, and those with mild COVID-19 infection.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81843317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Serum Electrolyte Disturbances and Glasgow Coma Scale Score in Patients With Diffuse Axonal Injury 弥漫性轴索损伤患者血清电解质紊乱与格拉斯哥昏迷评分的关系

Caspian Journal of Neurological Sciences Pub Date : 2022-07-01 DOI: 10.32598/cjns.8.30.9

H. Behzadnia, Mesbah Dibavand, M. Emamhadi, S. Andalib, Mahsa Pakseresht Mogharab, Naghmeh Khoshsima, Z. Reihanian

{"title":"Association Between Serum Electrolyte Disturbances and Glasgow Coma Scale Score in Patients With Diffuse Axonal Injury","authors":"H. Behzadnia, Mesbah Dibavand, M. Emamhadi, S. Andalib, Mahsa Pakseresht Mogharab, Naghmeh Khoshsima, Z. Reihanian","doi":"10.32598/cjns.8.30.9","DOIUrl":"https://doi.org/10.32598/cjns.8.30.9","url":null,"abstract":"Background: Appropriate clinical measures to prevent secondary brain damage in traumatic brain injury are of critical importance. Objectives: This study aims to investigate the relationships between serum electrolyte disturbances and Glasgow Coma Scale (GCS) score in patients with Diffuse Axonal Injury (DAI) at the time of admission and discharge. Materials & Methods: In this retrospective cross-sectional study, we evaluated 101 patients with DAI having GCS score <15 admitted to Poursina Hospital in Rasht, Iran from 2019 to 2020. Based on the presence or absence of serum potassium (K), sodium (Na), magnesium (Mg), and zinc (Zn), disturbances on the first day of hospitalization, patients were divided into two study groups of with and without abnormal electrolyte levels. The GCS scores of the two groups at the time of admission and discharge were recorded and the relationship between electrolyte disturbances and GCS score was evaluated. Results: There were no significant differences in the mean GCS score at the time of admission and discharge between patients with and without disturbances in serum Na, K, Zn and Mg levels based on the crude analysis. Regarding the simultaneous effects of the study variables on the GCS score, only Mg serum level exerted a significant impact on the GCS score at the time of admission (P=0.041) and discharge (P=0.017). Conclusion: The GCS score in patients with DAI at the time of admission and discharge has an association with the Mg serum level but not with Na, K, and Zn levels.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84937680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Cognitive Function in Different Trimesters of Pregnancy 不同妊娠期认知功能的比较

Caspian Journal of Neurological Sciences Pub Date : 2022-07-01 DOI: 10.32598/cjns.8.30.3.5

R. Soleimani, M. Asgharnia, M. Jalali, Fatemeh Eslamdoust-Siahestalkhi, Seyyed Mousa Kafi Masule, Rahman Iranidoost-Haghighi, M. Kousha

{"title":"Comparison of Cognitive Function in Different Trimesters of Pregnancy","authors":"R. Soleimani, M. Asgharnia, M. Jalali, Fatemeh Eslamdoust-Siahestalkhi, Seyyed Mousa Kafi Masule, Rahman Iranidoost-Haghighi, M. Kousha","doi":"10.32598/cjns.8.30.3.5","DOIUrl":"https://doi.org/10.32598/cjns.8.30.3.5","url":null,"abstract":"Background: Although pregnancy is a normal function in women, it is considered as a stressful experience which is associated with many psychological and physical changes in pregnant women. Objectives: This study aims to investigate and compare cognitive function in different trimesters of pregnancy. Materials & Methods: This was a longitudinal cohort study. Participants were 76 pregnantwomen with a mean age of 30.09±6.23 years referred to Al-Zahra Hospital in Rasht, Iran during 2019-2020. Participants were assessed in three trimesters of pregnancy using the Wechsler Memory Scale (WMS) and Mini-Mental State Exam (MMSE). The multilevel mixed-effects linear regression and repeated measures ANOVA were used for data analysis. All analyses were done in SPSS software v. 19 and Stata v. 14. Results: The mean score of WMS was significantly lower in the third trimester (84.95±12.07) than in the first and second trimesters (89.34±13.13 and 88.72±13.24, respectively) (P=0.001). The results of linear regression analysis showed no significant difference in MMSE score between different trimesters of pregnancy (P>0.05), while the WMS score was significantly different between different pregnancy trimesters; the change in WMS score was statistically significant only in the third trimester (P= 0.04). Conclusion: No impairment in general cognitive function occur during pregnancy, but memory impairment may occur. In the third trimester, pregnant women have the poorest memory function.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85128728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune-mediated Necrotizing Myopathy With Increased Creatine Phosphokinase and Positive Signal Recognition Particle: A Case Report 免疫介导的坏死性肌病伴肌酸磷酸激酶升高和阳性信号识别颗粒:1例报告

Caspian Journal of Neurological Sciences Pub Date : 2022-07-01 DOI: 10.32598/cjns.8.30.1

Seyed Mohammad Masoud Hojati, P. Saadat, S. Alijanpour

{"title":"Immune-mediated Necrotizing Myopathy With Increased Creatine Phosphokinase and Positive Signal Recognition Particle: A Case Report","authors":"Seyed Mohammad Masoud Hojati, P. Saadat, S. Alijanpour","doi":"10.32598/cjns.8.30.1","DOIUrl":"https://doi.org/10.32598/cjns.8.30.1","url":null,"abstract":"Background: Knowledge about Immune-Mediated Necrotizing Myopathy (IMNM) has received significantly attention in recent years. In this study, we report a rare case of IMNM with increased Creatine Phosphokinase (CPK) and positive Signal Recognition Particle (SRP). Clinical Presentation and Intervention: The case was a 67-year-old male patient referred to Firozgar hospital affiliated to the Iran University of Medical Science, Tehran, Iran in June 2018 with a chief complaint of pain in the proximal lower extremity. According to Medical Research Council Scale for muscle strength, the motor function of proximal upper extremities was 4/5 and for the proximal of the lower extremities, it was 3/5. Laboratory findings showed an increase in CPK, CK-MB, lactate dehydrogenase, creatinine, alanine aminotransferase, aspartate aminotransferase and aldolase levels. Six days after admission, autoantibody test was requested which showed positive SRP. In muscle biopsy, the myopathic atrophy with multiple necrotic and many degenerative/regenerative fibers was associated with mild endomysial fibrosis, and no inflammation was observed. Two g/kg dose of Intravenous Immunoglobulin (IVIG) was administrated after diagnosis of IMNM. Prednisone 50 mg/day orally, calcium vitamin D daily, pantoprazole 40 mg/day, physiotherapy, and occupational therapy were administrated for after discharge. Conclusion: Reporting a case of anti-SRP associated IMNM and reviewing its pathophysiology, diagnosis and treatment options can help increase the physicians’ knowledge of this rare and debilitating condition.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88385405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychological Distress in Patients With Multiple Sclerosis and Epilepsy in the COVID-19 Pandemic: A Systematic Review COVID-19大流行期间多发性硬化症和癫痫患者的心理困扰:一项系统综述

Caspian Journal of Neurological Sciences Pub Date : 2022-04-21 DOI: 10.32598/cjns.8.29.7

Farzin Bagheri-Sheykhangafshe, Mina Fathi-Ashtiani, A. Fathi-Ashtiani

{"title":"Psychological Distress in Patients With Multiple Sclerosis and Epilepsy in the COVID-19 Pandemic: A Systematic Review","authors":"Farzin Bagheri-Sheykhangafshe, Mina Fathi-Ashtiani, A. Fathi-Ashtiani","doi":"10.32598/cjns.8.29.7","DOIUrl":"https://doi.org/10.32598/cjns.8.29.7","url":null,"abstract":"Background: The COVID-19 pandemic can cause various anxiety, fear, and tension in society. The negative impact of the pandemic is not limited to physical health problems. It can generate serious consequences, such as anxiety, depression, and stress, especially neurological diseases. Objectives: The present study investigated depression, anxiety, and stress in patients with MS and epilepsy during the COVID-19 pandemic. Materials & Methods: In this study, the keywords depression, anxiety, stress, multiple sclerosis, epilepsy, and COVID-19 in the title and abstract of articles published in 2020 (May) and 2021 (July) in reputable international scientific databases, including Google Scholar, PubMed, Scopus, EMBASE, and PsycINFO were searched. The PRISMA checklist was used to review and control the quality of articles. Results: Overall, 394 English articles were retrieved. Finally, 27 final articles were selected for comprehensive review and data extraction. The obtained results suggested that patients with MS and epilepsy experienced depression, anxiety, stress, fear, poor sleep quality, mental fatigue, and poor quality of life during the COVID-19 pandemic. Quarantine has limited patients’ access to medication and treatment, resulting in increased seizures and disease severity. Conclusion: The COVID-19 pandemic reduced patients’ mental health with MS and epilepsy. The psychological consequences of the outbreak of COVID-19 might be associated with patients with MS and epilepsy for years; thus, it is necessary to adopt psychological interventions to reduce psychological distress in these patients.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90035335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 and its Outcomes in Multiple Sclerosis Patients COVID-19及其在多发性硬化症患者中的预后

Caspian Journal of Neurological Sciences Pub Date : 2022-04-21 DOI: 10.32598/cjns.8.29.5

Masood Najafi, S. Eskandarieh, Nasim Rezaeemanesh, Hora Heydari, M. Moosavi, M. Harirchian

{"title":"COVID-19 and its Outcomes in Multiple Sclerosis Patients","authors":"Masood Najafi, S. Eskandarieh, Nasim Rezaeemanesh, Hora Heydari, M. Moosavi, M. Harirchian","doi":"10.32598/cjns.8.29.5","DOIUrl":"https://doi.org/10.32598/cjns.8.29.5","url":null,"abstract":"Background: Coronavirus Disease 2019 (COVID-19) is a highly contagious disease that resulted in 4533645 deaths until September first, 2021. Multiple Sclerosis (MS) patients receive immunosuppressive drugs. Thus, there is a concern that these drugs will reduce the patient’s immune system resistance against COVID19. Objectives: This study aimed to evaluate the epidemiology of COVID19 and its impact on MS patients in our university hospital in Tehran City, Iran. Materials & Methods: A cross-sectional study was conducted based on hospital-based registry data from May 2020 to March 2021. Among more than 500 registered MS patients in Imam Khomeini Hospital in Tehran City, Iran, referring within our study period, 84 patients reported SARS-COV2 infection. The diagnosis of MS was confirmed by the McDonald criteria. Moreover, the diagnosis of COVID-19 in MS patients was established by the real-time-PCR technique and chest computed tomography. Results: Out of 84 MS patients with SARS-COV2 infection, 55(65.5%) were women, and their mean age was 37.48 years. The most commonly used medications by MS patients were Rituximab 20 (26.3%) and Dimethyl Fumarate 14(18.4%). Totally, 9(10.8%) of the patients needed to be hospitalized due to COVID-19, with a mean hospitalization duration of 5.88 days. A total of 1 (1.2%) death was reported. Conclusion: Compared to the healthy population, COVID-19 is not more serious in MS patients. Most MS patients with COVID-19 infection were not hospitalized and continued their medication during the infection.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90773453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Combined Effect of Aerobic Exercise and α-Pinene on Pentylenetetrazole-Induced Seizure in Male Rats 有氧运动和α-蒎烯对戊四唑致雄性大鼠癫痫发作的联合作用

Caspian Journal of Neurological Sciences Pub Date : 2022-04-21 DOI: 10.32598/cjns.8.29.9

Sadegh Lotfinesab, A. Doulah, M. Rafieirad

{"title":"The Combined Effect of Aerobic Exercise and α-Pinene on Pentylenetetrazole-Induced Seizure in Male Rats","authors":"Sadegh Lotfinesab, A. Doulah, M. Rafieirad","doi":"10.32598/cjns.8.29.9","DOIUrl":"https://doi.org/10.32598/cjns.8.29.9","url":null,"abstract":"Background: Seizure is due to the abnormal electric activity of neurons in the brain. Because of the side effects of synthetic drugs, plant medicines can be used instead to control seizures. Objectives: This study aimed to investigate the effect of aerobic exercise and α-pinene on pentylenetetrazole-induced seizures in mature male rats. Materials & Methods: A total of 40 Wistar male rats (weight: 200-250 g) were divided into five groups: control (receiving normal saline), positive control (receiving 1 mg/kg diazepam as an antiepileptic drug), aerobic exercise (receiving five sessions of exercise per week, each session for 30 min), α-pinene (receiving 200 mg/kg for 4 weeks), and aerobic exercise plus α-pinene. Thirty minutes after the intervention, 85 mg/kg Pentylenetetrazole (PTZ) was intraperitoneally administered to the rats in all experimental groups, and their seizure-related behaviors were observed and recorded. Results: Combined use of α-pinene and aerobic exercise significantly increased the delay of onset of seizure (P<0.05) and decreased the duration of the tonic-clonic seizure (P<0.001) and the total duration of seizure P<0.001) compared to the control group. Conclusion: The findings showed that the use of α-pinene together with exercise can have preventive effects against pentylenetetrazole-induced seizures in mature male rats through their antioxidant activity.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79400771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0