Caspian Journal of Neurological Sciences最新文献

{"title":"Prevalence of Heart Failure in Patients With Ischemic Stroke: A Descriptive Study","authors":"Seyyed Mahdi Zia Ziabari, Seyyed Aboozar Fakhrmousavi, Maryam Nasseri Alavi, Amir Noyani, Rasoul Tabari-Khomeiran, M. Ghasemi, Zahra Shokri Bafrajard","doi":"10.32598/cjns.7.26.3","DOIUrl":"https://doi.org/10.32598/cjns.7.26.3","url":null,"abstract":"Background: Cerebrovascular Accident (CVA) is the second cause of death and disability in the world. Heart failure can co-occur with CVA and increases the risk of death and disability in patients. Objectives: This study aimed to evaluate the prevalence of heart failure in patients with ischemic stroke. Materials & Methods: In this cross-sectional study, the information of patients with ischemic stroke was collected in 2016 from their files. They were referred to the Emergency Department of Poursina Hospital. Statistical analysis of data was performed by using descriptive statistical methods. Estimation of mean and frequency was done by SPSS v. 22. Results: A total of 291 patients were recruited in the study. Also, 157 patients (54%) were male, and 134 (46%) were female. The Mean±SD age of patients was 61.68 (12.98) years. Systolic heart failure prevalence was 59.8%, and diastolic heart failure was 65.7%. Conclusion: Based on the findings, more than half of the patients with ischemic stroke also develop heart failure. Therefore, it is recommended that the patient be evaluated and treated for heart failure when faced with ischemic stroke.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"37 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72542240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Serum Dehydroepiandrosterone Concentration and Memory Function in the Elderly","authors":"E. Abdollahi, Golsa Olia, Fatemeh Eslamdoust-Siahestalkhi, R. Soleimani","doi":"10.32598/cjns.7.26.2","DOIUrl":"https://doi.org/10.32598/cjns.7.26.2","url":null,"abstract":"Background: World population is rapidly aging, and the elderly are most at risk of cognitive impairment. Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEAS) have an essential effect on neuroprotection and might effectively improve cognition and memory. Objectives: This study aimed to investigate the relationship between the level of DHEA and memory function in the elderly. Materials & Methods: The present study was a cross-sectional analytical study, and the study population included the elderly (age 60 years and older) living in Rasht City, the north of Iran, in 2020. The participants completed a demographic questionnaire and Wechsler Memory Scale (WMS), and their serum DHEA levels were measured by the hormonal automation method. The data were analyzed by SPSS v. 23, using t-test, the one-way Analysis of Variance (ANOVA), Pearson and Spearman correlation coefficient. Results: The participants included 100 older people (57 females and 43 males) with a Mean±SD age of 67.38±5.39 years. There was no correlation between serum DHEA concentrations with a total score of the WMS (r=0.117, P=0.247). However, the correlation between the DHEA level and the scores of personal and current information and visual reproduction subscales were statistically significant (r=0.219, P=0.029; r=0.206, P=0.04). Conclusion: The study indicates that the total memory score was not associated with the level of serum DHEA.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"12 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72430593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-Related Quality of Life of Mothers of Children With Phenylketonuria","authors":"Zahra Mortazavi, Leili Tapak, S. Mortazavi, M. Golchin","doi":"10.32598/cjns.6.22.4","DOIUrl":"https://doi.org/10.32598/cjns.6.22.4","url":null,"abstract":"Background: Quality of life is one of the pivotal notions of the World Health Organization’s perspective. Regarding the complications of Phenylketonuria (PKU) disease in children, it seems that this disease affects the quality of life of these mothers. Objectives: Investigating the quality of life of mothers with PKU children and to compare it with that of mothers of normal children. Materials & Methods: This case-control study was conducted on 65 mothers with PKU children and 122 mothers with normal children in Hamadan City, Iran, in 2018 (selected randomly from the general population). For data collection, mothers filled a demographic profile questionnaire and the Iranian version of the World Health Organization Quality of Life-Brief. The obtained data were analyzed using the independent t test and univariate analysis of variance (α=0.05) in SPSS V. 16. Results: The Mean±SD total scores of quality of life of mothers with PKU children and mothers with normal children were 11.74±1.91 and 14.37±1.58, respectively and the difference between the two groups was statistically significant (P<0.001). There was also a significant relationship between the quality of life of mothers with PKU children and the age of the child at the onset of treatment (P<0.05). Conclusion: According to the current study results that indicated the low quality of life of the mothers of PKU children, it is recommended that rehabilitation and psychological interventions be included in pediatric treatment programs to improve the quality of life of mothers.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78332581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Determinants of Delayed Gratification among American Children.","authors":"Shervin Assari","doi":"10.32598/cjns.6.22.2","DOIUrl":"10.32598/cjns.6.22.2","url":null,"abstract":"<p><strong>Background: </strong>A wide array of socioeconomic status (SES) indicators tend to show differential effects for members of diverse social groups. Limited knowledge exists on ethnic variation in the effects of family income on delay discounting which is predictor of risk behaviors.</p><p><strong>Objectives: </strong>This study tested whether the effect of family income on delayed gratification differs between Latino and non-Latino children.</p><p><strong>Methods and materials: </strong>In this cross-sectional analytical study, data came from wave one of the Adolescent Brain Cognitive Development (ABCD) study which included 3903 non-Latino or Latino Black or White American children between ages 9 and 10 years old. The predictor was family income. Data were collected in 21 sits in the US in 2018. The outcome was children's delay discounting. We measured delay discounting, which reflected individuals' tendency to assign less value to remote outcomes and rewards (inversely correlated with delayed gratification). Using SPSS 22.0, linear regression was used for data analysis.</p><p><strong>Results: </strong>According to our pooled sample regression, higher family income was associated with lower children delay discounting (Beta= -0.05, p = .021). We found a significant interaction between family income and ethnicity, suggesting that the association between family income and delay discounting is stronger for Latino than non-Latino children (Beta= -0.09, p = .043).</p><p><strong>Conclusions: </strong>Not all ethnic disparities are due to SES gaps; differential returns of socioeconomic status indicators, such as family income, across diverse social groups also contribute to ethnic disparities in health.</p>","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"6 3","pages":"181-189"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9483746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic Effect of Apotel Versus Pethidine After Hemilaminectomy","authors":"M. Emamhadi, H. Behzadnia, S. Jafari, M. Zamanidoust, S. Andalib","doi":"10.32598/CJNS.5.19.185","DOIUrl":"https://doi.org/10.32598/CJNS.5.19.185","url":null,"abstract":"Background: Postoperative pain is a common phenomenon, and its management affects considerably on the recovery process, and patients’ satisfaction. Apotel and pethidine are two conventional medicines used to relieve pain after operation. Objectives: The present study aimed to compare the effect of intravenous injection of Apotel and intramuscular injection of pethidine in relieving pain after hemilaminectomy. Materials & Methods: In the present cross-sectional study, 150 patients who underwent hemilaminectomy were recruited between May 2015 and November 2015. They were taking either Apotel (n=75) or pethidine (n=75) after the operation, which was done at Poursina Hospital affiliated to Guilan University of Medical Sciences, Rasht City, Iran. The patients’ pain levels were measured using visual analog scale (VAS), and the results were compared between the 2 groups. Results: There was no significant difference in the total VAS score between the Apotel and pethidine groups (P=0.189). However, there was a significant reduction in VAS score hours 2 (P=0.03) and 4 (P=0.004) hours after the injection of Apotel in this group, compared with those scores in the pethidine group. Also, VAS scores at other times (8, 12, 20, 28 hours after the injection) were lower than those in the pethidine group, but the difference was not significant. Conclusion: Apotel was better pain-killer in the early hours after the first injection compared to pethidine. But its effect was similar to pethidine at the late hours after the first injection. Therefore it seems that Apotel is better painkiller after laminectomy, especially in the early hours after the operation.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82318532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Cognitive and Motor Dual-task Training on Improvement of Balance and Some Spatiotemporal Gait Parameters in People With Idiopathic Parkinson's Disease","authors":"Tahereh Pourkhani, H. Daneshmandi, A. Norasteh, B. Bakhshayesh Eghbali, P. Sedaghati","doi":"10.32598/CJNS.5.19.190","DOIUrl":"https://doi.org/10.32598/CJNS.5.19.190","url":null,"abstract":"Background: Parkinson disease (PD) is characterized by motor and non-motor symptoms that affect patients’ functions, especially while performing dual-tasks a critical factor in everyday living. However, many controversies exist about the benefits of dual-task training in patients with PD. Objectives: This study assessed the efficacy of motor and cognitive dual-task training in improving balance and gait parameters in people with idiopathic PD. Materials & Methods: A single-blind controlled trial was conducted on PD patients living in Guilan Province of Iran, in 2018-2019. A total of 30 PD patients (Hoehn and Yahr stage II-III while on medication) were assigned to the cognitive dual-task training group (n=10), motor dual-task training group (n=10), and single-task control group (n=10). All groups received 30 sessions of different exercises for 10 consecutive weeks. The patients’ balance and some spatiotemporal gait parameters were respectively assessed with timed up and go test and HD VideoCam-Kinovea before and after training and then 1 month later. Results: Both dual-task and single-task trainings improved the outcome measures (timed up and go test (F=535.54; P=0.000), stride length (F=87.41; P=0.00), stride time (F=102.11; P=0.00), cadence (F=286.36; P=0.00), swing time (F=48.90; P=0.00), and stance time (F=40.56; P=0.00)). These improvements were maintained at 1-month follow-up, although the effect slightly reduced. No significant differences were found between the study groups (P>0.05). Conclusion: Motor/cognitive dual-task training and single-task training were found to be significantly and equally effective in improving balance and gait parameters in people with PD.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82336474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Epigallocatechin Gallate and Catechin on Overexpression of GSK-3β and IR Genes Induced by Streptozotocin in Rat Brain","authors":"M. Zamani, K. Rohampour, Samira Rashtiani, M. Dolati, F. Fallahian, N. Kalhor","doi":"10.32598/CJNS.5.18.161","DOIUrl":"https://doi.org/10.32598/CJNS.5.18.161","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) is one of the significant risk factors for Alzheimer disease (AD). Defects in insulin signaling pathway induce AD hallmarks mainly through activation of glycogen synthase kinase-3β (GSK-3β) pathway. Objectives: In this study, we investigated the expression of GSK-3β and insulin receptor (IR) genes in the hippocampi of an animal model of sporadic AD and assessed the preventive effect of Catechin (CAT) and epigallocatechin gallate (EGCG) on their expression. Materials & Methods: Adult male Wistar rats were treated by intracerebroventricular streptozotocin (STZ) injection (3 mg/kg) at day 1 and 3 after cannulation. CAT was administered at a dose of 40 mg/kg for 10 days per gavage, and EGCG was administered at a dose of 3 mg/kg for 14 days into drinking water. Then the animals were decapitated, and their hippocampi were removed. Real-time Polymerase Chain Reaction (PCR) was used to evaluate the alteration in gene expression. Results: There was overexpression in GSK-3β gene in STZ-treated rats (P≤0.05), which was brought back to normalcy by EGCG (P≤0.01). The IR gene also increased after STZ treatment, but CAT reduced IR expression (P≤0.05). However, the suppressive effect of EGCG on IR expression was stronger (P≤0.01). Conclusion: The neuroprotective activity of EGCG might be due to its influence on IR and GSK-3β expression.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90365527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Oprm1 Gene Promoter Methylation in the Lymphocytes of Male Rats Addicted to Nicotine, Morphine, Methadone, and Buprenorphine","authors":"Maedeh Mohammad Alizadeh, S. R. Kazemi Nezhad, P. Babaei, P. Keshavarz","doi":"10.32598/CJNS.5.19.168","DOIUrl":"https://doi.org/10.32598/CJNS.5.19.168","url":null,"abstract":"Background: Addiction is a polygenic disorder caused by genetic and environmental factors. The opioid material can act as an epigenetic element, like DNA methylation. Objectives: The present study aimed to examine the effect of epigenetic drugs such as nicotine, morphine, methadone, and buprenorphine on the methylation of two CpG sites in promoter of Oprm1 gene in male Wistar rats. Materials & Methods: In this case-control study, 48 male Wistar rats with Mean±SD (200±30) g were divided into 6 groups: These are five groups only The control (intact) group, nicotine (0.4 mg/kg, SC injection for 5 days), morphine (10 mg/kg on days 1-3 and 20 mg/kg on days 4-6 and 40 mg/kg, IP injection on days 7-9), methadone (0.5 mg/kg, IP injection for 15 days), buprenorphine (0.05 mg/kg, SC injection for 6 days) and finally saline for each respected group. After the treatment, genomic DNA was extracted from the whole blood of the rats. Then, the extracted DNA was treated with sodium bisulfate. To identify the selected methylated areas of Oprm1 promoter sites (CpG-107 and CpG+33), we used methylation-specific PCR (MSP). Results: Our results showed no methylation in the two CpG sites of Oprm1 promoter in all of the treated groups. Conclusion: Addiction with nicotine, morphine, methadone, and buprenorphine in doses and duration used in this study was not associated with the methylation of the Oprm1 promoter sites in the male Wistar rats.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"139 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77991296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Quality of Life in Patients With Multiple Sclerosis Consuming Fingolimod and Cinnovex","authors":"A. Saberi, H. Hatamian, A. Ghayeghran, Fatemeh Mola Hosseini, Sama Noroozi Guilandehi, S. Rezaei, F. Shafaei","doi":"10.29252/CJNS.5.19.151","DOIUrl":"https://doi.org/10.29252/CJNS.5.19.151","url":null,"abstract":"Background: Multiple Sclerosis (MS) is a chronic demyelinating, inflammatory, and degenerative disease of the central nervous system. MS gradually limits and deteriorates the patients’ quality of life. Objectives: This study aimed to evaluate and compare the quality of life in patients with MS consuming Fingolimod and Cinnovex. Materials & Methods: In an analytical cross-sectional study, 106 patients with Relapsing-Remitting MS (RRMS) referred to specialized neurology clinics of Guilan University of Medical Sciences were selected for the study using a convenience sampling method (52 patients consuming Fingolimod and 54 patients consuming Cinnovex). Then, we collected their demographic information and medical profile. The patients were assessed by the Hamburg quality of life questionnaire in MS. The obtained data were analyzed in SPSS V. 22 using the Chi-square test, independent t-test, Mann-Whitney U, one-way and multivariate analysis of covariance. Results: There was a significant difference between the two groups in terms of age, number of attacks in the last 6 months, and educational level (P<0.05). After controlling confounding variables, it was found that consumers of Fingolimod had a better quality of life. At the subscales level, this difference was significant only in the mood dimension (F=6.931, P=0.011, η=0.12). Conclusion: Patients consuming Fingolimod reported a better quality of life compared to consumers of Cinnovex. This improvement was mainly found in mood scores.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82050027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Adolescent-centered Mindfulness Training and Cognitive Behavioral Therapy on Depression and Suicidal Ideation in Adolescent Girls With Bipolar II Disorder","authors":"Bahar Shayegh Borojeni, Gholamreza Manshaee, I. Sajjadian","doi":"10.29252/CJNS.5.19.175","DOIUrl":"https://doi.org/10.29252/CJNS.5.19.175","url":null,"abstract":"Background: Cognitive behavioral therapy has provided the most empirical evidence concerning the treatment of mood disorders, especially depression. However, the findings have not confirmed the definitive efficacy of this treatment so far. Objectives: This study aimed to compare the effectiveness of adolescent-centered mindfulness training with cognitive behavioral therapy on depression and suicidal ideation in adolescent girls with bipolar II disorder. Materials & Methods: This was a quasi-experimental with pre-test, post-test design, a control group, and a 45-day follow-up. The study population consisted of all adolescent girls with bipolar II disorder referred to Al-Zahra Hospital in Isfahan. Using a convenience sampling method, we recruited 45 female patients with depression based on inclusion and exclusion criteria and then randomly divided into one control and two experimental groups (15 patients in each group). The subjects answered the research questionnaires, including depression and suicidal ideation of Beck version II before and after the intervention and 45 days later. One experimental group received Bourdick-based mindfulness training and one experimental group received, and another experimental group received cognitive behavioral therapy. Results: The results of covariance analysis showed that adolescent-centered mindfulness training and cognitive behavioral therapy were effective in reducing depression tested at post-test (F=64.94; P<0.001) and follow-up (F=28.35; P<0.001). Also, there was a significant effect on suicidal ideation reduction in the post-test (F=84.72; P<0.001) and follow-up (F=45.54; P<0.001). Cognitive-behavioral therapy results have been more effective in reducing both depression and suicidal ideation than adolescent-centered mindfulness training. Conclusion: Cognitive behavioral therapy has reduced depression and suicidal ideation by challenging negative self-thoughts and dysfunctional core beliefs, as well as changing patterns, and lifestyle.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86445102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}