Caspian Journal of Neurological Sciences最新文献

Anxiolytic Effect of Anethum Graveolens Seed Extract Combined With the Antagonist of Estrogen Receptor in Female Rats With Anxiety 鹅掌楸籽提取物与雌激素受体拮抗剂联合使用对焦虑症雌性大鼠的抗焦虑作用

Caspian Journal of Neurological Sciences Pub Date : 2024-04-01 DOI: 10.32598/cjns.10.37.302.2

Rana Shahabi, Mohammad Rostampour, B. Khakpour, Edris Mahdavi Fekjur, Farshid Saadat

{"title":"Anxiolytic Effect of Anethum Graveolens Seed Extract Combined With the Antagonist of Estrogen Receptor in Female Rats With Anxiety","authors":"Rana Shahabi, Mohammad Rostampour, B. Khakpour, Edris Mahdavi Fekjur, Farshid Saadat","doi":"10.32598/cjns.10.37.302.2","DOIUrl":"https://doi.org/10.32598/cjns.10.37.302.2","url":null,"abstract":"Background: Anxiety as an important psychological disorder that has affected many people and has made them to spend a lot of money for its treatment. Objectives: This study aims to assess the anxiolytic effect of the hydro-alcoholic extract of Anethum Graveolens L. seed (AGS) combined with the antagonist of estrogen receptor in female rats with anxiety. Materials & Methods: In this study, 66 female Wistar rats were divided into eight groups as follow as: Negative control (10 ml/kg saline), positive control (0.6 mg/kg diazepam), five groups of AGS extract (0.1, 1, 10, 100 and 1000 mg/kg) and tamoxifen+AGS extract (10 mg/kg). Anxiety indicators were measured by the elevated plus maze (EPM) test. Results: The percentage of time spent open arms (%OAT) and percentage open arms entry (%OAE) significantly increased after using 10 mg/Kg dose of AGS extract compared to control group. Tamoxifen could significantly reduce this increase caused by AGS extract on anxiety indices. Conclusion: Considering the anxiolytic effect of the hydro-alcoholic extract of AGS and the reduction of this effect by the antagonist of estrogen receptor (tamoxifen), it can be concluded that the extract’s anxiolytic effect may be due to interaction with estrogen receptor.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140354872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Reliability of the Rehabilitative Ultrasound Imaging Method for Assessing Pelvic Floor Muscles Function in Pregnant Women 评估孕妇盆底肌肉功能的康复超声波成像方法的可靠性

Caspian Journal of Neurological Sciences Pub Date : 2024-04-01 DOI: 10.32598/cjns.10.37.467.1

Parisa Ghadiri Harati, Seyed Majid Hosseini, A. Javaheri, Farideh Dehghan Manshadi, Alireza Akbarzadeh Baghban

{"title":"The Reliability of the Rehabilitative Ultrasound Imaging Method for Assessing Pelvic Floor Muscles Function in Pregnant Women","authors":"Parisa Ghadiri Harati, Seyed Majid Hosseini, A. Javaheri, Farideh Dehghan Manshadi, Alireza Akbarzadeh Baghban","doi":"10.32598/cjns.10.37.467.1","DOIUrl":"https://doi.org/10.32598/cjns.10.37.467.1","url":null,"abstract":"Background: To our knowledge, there is scant research on the use of rehabilitative ultrasound imaging (RUSI) method for evaluating bladder base displacement in pregnant women. The RUSI is a non-invasive and simple method that assesses the function of pelvic floor muscles (PFM) based on the movement of the bladder base. Objectives: This study aims to assess the reliability of the RUSI for the assessment of PFM function in pregnant women during voluntary muscle contractions. Materials & Methods: In this cross-sectional study, 18 pregnant women with different gestational ages participated. The amount of bladder base displacement during PFM contraction was assessed in all women and considered an indicator of PFM function. The test re-test reliability was evaluated using the intraclass correlation coefficient (ICC) and Bland-Altman plot. The percentages of standard error of measurement (SEM%) and minimal detectable change (MDC%) were also calculated. Results: The mean amount of bladder base displacement during PFM contraction at time points 1 and 2 was 4.89±1.43 and 4.81±1.41, respectively. The ICC was 0.989 (95% CI, 0.969%, 0.996%), which indicates excellent reliability. The Bland-Altman plot showed that all the points were within the 95% limits of agreement with no considerable trend or bias. The SEM% and MDC% were 3.09% and 8.41%, respectively. Conclusion: The intra-rater reliability of the RUSI to assess PFM function in pregnant women is high, and can be useful for further studies on the PFMs in pregnant women.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140356648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Fluvoxamine on Electrophysiological and Behavioral Alterations of Rats With Depression 氟伏沙明对抑郁症大鼠电生理和行为变化的影响

Caspian Journal of Neurological Sciences Pub Date : 2024-04-01 DOI: 10.32598/cjns.10.37.177.2

Mahsa Rahimi, I. Goudarzi, K. Rohampour

{"title":"Effect of Fluvoxamine on Electrophysiological and Behavioral Alterations of Rats With Depression","authors":"Mahsa Rahimi, I. Goudarzi, K. Rohampour","doi":"10.32598/cjns.10.37.177.2","DOIUrl":"https://doi.org/10.32598/cjns.10.37.177.2","url":null,"abstract":"Background: Depression is a serious mental illness with symptoms such as worry, disturbed sleep and appetite, lack of interest or pleasure, and persistent sorrow. Objectives: This study aims to assess the effect of fluvoxamine (FLX) on behavioral and electrophysiological alterations of the posterior cingulate cortex (PCC) and the hippocampus in rats with depression. Materials & Methods: Thirty-two albino rats (weighing 250–300 g) were divided into four groups; control (sham), chronic mild stress (CMS), FLX, and CMS+FLX. The CMS was induced by applying different stressors for 3 weeks. Intraperitoneal injection of FLX (25 mg/Kg) was performed daily for 14 days in the treatment group. Depressive-like behaviors were assessed, and local field potentials (LFP) from the hippocampus and the PCC were recorded. Results: FLX effectively reduced depressive-like behaviors in rats with CMS (P≤0.05). Additionally, depression-induced alterations in LFP were observed in the hippocampus and the PCC. Depression reduced the power of delta and theta bands and increased the hippocampal low-gamma band power (P≤0.05). In the PCC, depression increased the power of delta and low-gamma bands and reduced the power of the alpha band (P≤0.05). Conclusion: FLX reduce depression-like behaviors in the animal model, possibly through affecting electrophysiological activity of the hippocampus and the PCC.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"1 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140354654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alexithymia and Suicidal Ideation in Iranian Patients With Psoriasis 伊朗银屑病患者的自闭症和自杀意念

Caspian Journal of Neurological Sciences Pub Date : 2024-04-01 DOI: 10.32598/cjns.10.37.440.1

Ali Pourramzani, Kaveh Gharaei Nejad, Soheila Sayar

{"title":"Alexithymia and Suicidal Ideation in Iranian Patients With Psoriasis","authors":"Ali Pourramzani, Kaveh Gharaei Nejad, Soheila Sayar","doi":"10.32598/cjns.10.37.440.1","DOIUrl":"https://doi.org/10.32598/cjns.10.37.440.1","url":null,"abstract":"Background: Evidence highlighted the high prevalence of some mental problems among individuals with psoriasis, including alexithymia and suicidal ideation. Objectives: The present study aims to investigate the prevalence and comorbidity of alexithymia and suicidal ideation in individuals with psoriasis in Iran. Materials & Methods: This cross-sectional study was conducted on 100 patients with psoriasis referred to Razi Dermatology Clinic and Beesat Clinic of hospitals affiliated to Guilan University of Medical Sciences, Rasht, Iran, in 2020. Psoriasis was diagnosed by a dermatologist, and the demographic and clinical characteristics of patients were recorded. The Toronto alexithymia scale (TAS-20) and the Beck scale for suicidal ideation (BSSI) were used to assess alexithymia and suicidal thoughts. Results: The mean age of patients was 37.56±10.58 years, and 51% were female. Among patients, 52% had alexithymia, 23% were at high risk of suicide, and 6% were at very high risk of suicide. The moderate severity of psoriasis had a significant association with suicidal thoughts (P<0.05). The TAS-20 score had a significant association with the male gender and younger age, and the BSSI score had a significant association with the psoriasis area (P=0.003). The highest score of BSSI was seen in those with psoriasis in the face and limb/trunk (10±4.36 and 8.56±8.52, respectively). Conclusion: Patients with psoriasis exhibit a significant prevalence of alexithymia and suicidal thoughts. Additionally, younger age and male gender were identified as factors associated with alexithymia in this population.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140356376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of Ocular Trauma in Patients Referred to a Tertiary Center in Northern Iran 伊朗北部一家三级医疗中心转诊患者的眼外伤流行病学

Caspian Journal of Neurological Sciences Pub Date : 2024-04-01 DOI: 10.32598/cjns.10.37.465.1

Yousef Alizadeh, Ghazaleh Mohammadi-manesh, A. Medghalchi, Hasan Behboudi, Reza Soltani-Moghadam, M. Akbari, Ebrahim Azaripour, S. Kianmehr, Narges Pour Deylami, Haleh Alizadeh, Ehsan Kazemnezhad Leyli, Maryam Dourandeesh

{"title":"Epidemiology of Ocular Trauma in Patients Referred to a Tertiary Center in Northern Iran","authors":"Yousef Alizadeh, Ghazaleh Mohammadi-manesh, A. Medghalchi, Hasan Behboudi, Reza Soltani-Moghadam, M. Akbari, Ebrahim Azaripour, S. Kianmehr, Narges Pour Deylami, Haleh Alizadeh, Ehsan Kazemnezhad Leyli, Maryam Dourandeesh","doi":"10.32598/cjns.10.37.465.1","DOIUrl":"https://doi.org/10.32598/cjns.10.37.465.1","url":null,"abstract":"Background: Ocular trauma is a debilitating condition and one of the most important and leading causes of visual impairments that have high socioeconomic consequences. Objectives: This study aims to investigate the epidemiology of ocular trauma in patients referred to a tertiary center in northern Iran. Materials & Methods: This cross-sectional study was carried out on 476 patients with ocular trauma referred to the eye emergency department of a teaching hospital in Guilan Province, north of Iran, in 2020-21. Personal and trauma-related information was extracted from the patient’s medical records using a checklist. Results: Most patients were in the 31-40 age group (28.8%), with a mean age of 41.5±17.4 years. Most of the injuries occurred at home (57.1%). Few of the patients had used eye safety glasses (5.3%). Most of the patients were living in the city. Closed globe injuries were the common types of traumas (96%), and the prevalence of open globe injuries was at a very low level (4%). Conclusion: Closed globe injuries are the most common types of ocular traumas in northern Iran. Most of the ocular traumas are preventable using eye protection equipment.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"42 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140357764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Mechanisms Involved in the Anticonvulsant Effect of Recombinant Human VEGF on Maximal Electroshock-induced Seizure 重组人血管内皮生长因子对最大电击诱发癫痫的抗惊厥作用的潜在机制

Caspian Journal of Neurological Sciences Pub Date : 2024-04-01 DOI: 10.32598/cjns.10.37.48.1

Morteza Fathi, Majid Hassanpourezatti

{"title":"Potential Mechanisms Involved in the Anticonvulsant Effect of Recombinant Human VEGF on Maximal Electroshock-induced Seizure","authors":"Morteza Fathi, Majid Hassanpourezatti","doi":"10.32598/cjns.10.37.48.1","DOIUrl":"https://doi.org/10.32598/cjns.10.37.48.1","url":null,"abstract":"Background: Vascular endothelial growth factor (VEGF) signaling pathway plays an important role in the pathogenesis of seizure. The oxidant/antioxidant factors and miRNA expression in the brain are differentially regulated in seizure. Objectives: We aim to investigate the potential mechanism of action for the recombinant human VEGF (rhVEGF) in mice with maximal electroshock (MES)-induced seizure. Materials & Methods: A total of 40 male mice (weight: 20-25 g) were treated intraperitoneally with normal saline, or rhVEGF (50, 100, and 150 µg/kg, daily for 4 consecutive days). One hour after the last injection, seizures were induced in each animal by MES. The latency for the onset of the first clonus and the duration of hind limb extension (HLE) were recorded. The levels of nitric oxide (NO), total antioxidant capacity (TAC), and micoRNA-142-5p expression were determined in the hippocampus of mice. Blood-brain barrier (BBB) permeability was also estimated by Evans blue dye extravasation method. Results: The administration of rhVEGF at all doses significantly reduced the HLE duration. However, latency for the seizure onset increased after administration of 50 and 150 μg/kg rhVEGF and decreased after administration of 100 μg/kg rhVEGF. In the brain, the NO level decreased, while TAC level and microRNA-142-5p expression increased by rhVEGF treatment in mice with MES-induced seizure. Pretreatment with rhVEGF at doses of 100 and 150 μg/kg reversed the increase in BBB leakage induced by MES-induced seizures. Conclusion: The rhVEGF administration can prevent MES-induced seizures by regulating NO, TAC, and miR-142-5 expression levels in the hippocampus and reducing BBB leakage in mice.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"5 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140353789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic Intracranial Hypertension With Unusual Presentation in an Adolescent Girl: A Case Report 特发性颅内高压症在一名少女身上的异常表现：病例报告

Caspian Journal of Neurological Sciences Pub Date : 2024-04-01 DOI: 10.32598/cjns.10.37.469.1

Afagh Hassanzadeh Rad, V. Aminzadeh

引用次数: 0

Suprasellar Immature Teratoma in A 20-year-old Male: A Case Report 一名 20 岁男性的小脑上未成熟畸胎瘤：病例报告

Caspian Journal of Neurological Sciences Pub Date : 2024-04-01 DOI: 10.32598/cjns.10.37.464.1

Nyoman Golden, Kevin Kristian Putra, Steven Awyono, Christopher Lauren

引用次数: 0

Protective Effect of Gum Arabic on Spinal Cord Ischemia-reperfusion Injury in Rats 阿拉伯胶对大鼠脊髓缺血再灌注损伤的保护作用

Caspian Journal of Neurological Sciences Pub Date : 2024-01-01 DOI: 10.32598/cjns.10.36.447.1

Hesam Yahak, G. Farjah, B. Pourheydar, M. Karimipour

引用次数: 0

Upregulation of Metabolic Defense System After Short-term Exposure to Formulated Insecticide 短期接触配方杀虫剂后代谢防御系统的上调

Caspian Journal of Neurological Sciences Pub Date : 2024-01-01 DOI: 10.32598/cjns.10.36.442.1

Princewill Sopuluchukwu Udodi, Oluoma Vivian Aneke, Roseline Ebube Udodi

引用次数: 0