Caspian Journal of Neurological Sciences最新文献

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Borderline Personality Traits in Patients With Epilepsy 癫痫患者的边缘性人格特征
Caspian Journal of Neurological Sciences Pub Date : 2023-01-11 DOI: 10.32598/cjns.9.32.389.1
Sara Shoja, Nikoo Saeedi, Seyed Mehran Homam
{"title":"Borderline Personality Traits in Patients With Epilepsy","authors":"Sara Shoja, Nikoo Saeedi, Seyed Mehran Homam","doi":"10.32598/cjns.9.32.389.1","DOIUrl":"https://doi.org/10.32598/cjns.9.32.389.1","url":null,"abstract":"Background: Although much research on patients with epilepsy (PWE) has focused on psychiatric disorders such as depression, anxiety, and psychotic disorders, the relationship between epilepsy and personality disorders has not been frequently studied. Objectives: The study aimed to evaluate borderline personality traits in PWE. Materials & Methods: In this case-control study, we evaluated 211 PWE who were consecutively referred to 22 Bahman Hospital, Mashhad, Iran, in 2021. We also compared the patients with an age-matched and gender-matched control group. The Borderline personality traits were assessed by the second subscale of the schizotypal questionnaire (STB) which is known as the borderline personality scale questionnaire. Data were coded and analyzed by SPSS software, version 20. Results: Epilepsy group had significantly higher borderline personality features in comparison with the control group (P=0.029). PWE had significantly higher scores in hopelessness (P=0.017) and impulsivity factors (P=0.046) on the STB questionnaire. Our results revealed that PWE who were married (P=0.011) and who had epilepsy for more than 10 years, had significantly higher borderline personality traits (P=0.04). Conclusion: PWE are more likely to have borderline personality traits. Therefore, it is important to screen epileptic patients to detect it earlier to avoid further consequences and its possible effects on therapeutic responses.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86476507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational Pattern Separation Models of Dentate Gyrus Neural Subpopulation in the Hippocampus 海马齿状回神经亚群的计算模式分离模型
Caspian Journal of Neurological Sciences Pub Date : 2022-10-01 DOI: 10.32598/cjns.4.31.286.1
Nazal Modhej, A. Bastanfard, M. Teshnehlab, S. Raiesdana
{"title":"Computational Pattern Separation Models of Dentate Gyrus Neural Subpopulation in the Hippocampus","authors":"Nazal Modhej, A. Bastanfard, M. Teshnehlab, S. Raiesdana","doi":"10.32598/cjns.4.31.286.1","DOIUrl":"https://doi.org/10.32598/cjns.4.31.286.1","url":null,"abstract":"Hippocampus is a part of the brain that has an essential role in memory and learning. It is involved in many cognitive and behavioral phenomena, including the pattern separation process: the ability to distinguish patterns with very high similarity. The present study compared the models of pattern separation in the dentate gyrus of the hippocampus and aimed to investigate the significant cells and factors affecting pattern separation. In this review, we intend to describe the anatomy of the dentate gyrus as a part of the hippocampus, which has an essential role in pattern separation. Other adjacent neural populations are further addressed, too. Models of the dentate gyrus, including neurocomputation and functional, that represent the process of separating patterns in the dentate gyrus are reviewed and analyzed. In this regard, five major models were highlighted and compared from several perspectives. While some models are based on the entorhinal cortex and dentate gyrus regions, others point to the mediation of cornu ammonis (CA3) as well. Models with the lowest cells for pattern separation are addressed first. Finally, inhibition is discussed in the comparison of pattern separation models.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77559397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoperative Awareness During Cesarean Delivery Under General Anesthesia 全身麻醉下剖宫产术中意识的研究
Caspian Journal of Neurological Sciences Pub Date : 2022-10-01 DOI: 10.32598/cjns.4.31.2
M. M. Ghanaie, Fatemeh Hosseinzadeh, S. Soltanipour, Zahra Rafiei Sorouri, Zahra Hamidi Madani, Gelareh Biazar, Haniye Dalir, Mahin Tayefeh Ashrafiyeh
{"title":"Intraoperative Awareness During Cesarean Delivery Under General Anesthesia","authors":"M. M. Ghanaie, Fatemeh Hosseinzadeh, S. Soltanipour, Zahra Rafiei Sorouri, Zahra Hamidi Madani, Gelareh Biazar, Haniye Dalir, Mahin Tayefeh Ashrafiyeh","doi":"10.32598/cjns.4.31.2","DOIUrl":"https://doi.org/10.32598/cjns.4.31.2","url":null,"abstract":"Background: General anesthesia (GA) for caesarean section (CS) has distinctive characteristics that may increase the risk of awareness during GA (AGA). Objectives: The aim of this study was to investigate the incidence of unintended awareness during GA (AGA) in CS. Materials & Methods: This cross-sectional descriptive study was performed in Alzahra Hospital in Rasht City, Iran. Eligible women with term pregnancy candidates for CS under GA were enrolled in this survey from May 2018 to August 2021. After delivery, a questionnaire including demographic data and questions related to different stages of anesthesia was completed via a faceto- face interview. The collected data were analyzed using repeated measurement, the Chi-square, Fisher exact, and t-test in SPSS v. 21. Results: The data from 174 women were analyzed, and 12 (6.9%) experienced AGA. Among them, dreaming and feeling the manipulation of the surgical area (27.8%) were the most common reported awareness states. Body mass index had a significant (P=0.034) relationship with AGA, but age (P=0.843), the level of education (P=0.714), history of anesthesia (P=0.552), 5-minute Apgar score (P=0.49), and surgery time (P=0.686) had no significant relationship with AGA. Conclusion: The incidence of AGA during CS was almost close to the high limit established by the credible evidence, and a significant number of the women were not in completely acceptable conditions. Therefore, the management of GA for CS should be revised in this academic hospital.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74923433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Sulpiride on Dopaminergic Synapse of Dorsal Hippocampus of Morphine-Treated Rats 舒必利对吗啡治疗大鼠海马背侧多巴胺能突触的影响
Caspian Journal of Neurological Sciences Pub Date : 2022-10-01 DOI: 10.32598/cjns.4.31.330.1
Marziyeh-Sadat Hashemi, M. Karami, Mahdiyeh Jafarpour Fard
{"title":"Effect of Sulpiride on Dopaminergic Synapse of Dorsal Hippocampus of Morphine-Treated Rats","authors":"Marziyeh-Sadat Hashemi, M. Karami, Mahdiyeh Jafarpour Fard","doi":"10.32598/cjns.4.31.330.1","DOIUrl":"https://doi.org/10.32598/cjns.4.31.330.1","url":null,"abstract":"Background: As previous studies show, several effects of morphine are induced by the dopaminergic system. Sulpiride is a dopamine D2 receptor (DAD2) antagonist widely used in clinics to treat DArelated disorders. DAD2 receptors are abundant at hippocampal cornu ammonis (CA1). Objectives: This study aimed to investigate the possible interaction of morphine and sulpiride on DA synapses in CA1. Materials & Methods: In this study, 48 Wistar rats weighing 220 to 250 g were used. These animals were classified into eight groups (6 rats per group): saline control group (1 mL/kg), morphine group (5 mg/kg), sulpiride groups alone (1, 2, and 4 mg/kg) and sulpiride groups (1, 2, and 4 mg/ kg)+morphine (5 mg/kg). Saline or substances were injected once intraperitoneally. After 48 h, the animals’ brains were removed under anesthesia and placed in 10% formalin for fixation. Then, 3- to 4-μm slices were cut from these tissues, and the DA synapse was examined by histochemistry and immunohistochemistry techniques. The data were statistically analyzed by the analysis of variance. Results: The control group had DA synapses and healthy neurons. A relative increase in DA synapses compared to the control group was observed in the morphine and single sulpiride groups. However, in sulpiride+morphine groups, DA synapses were reduced compared to morphine or sulpiride alone, but neurons were not destroyed. Conclusion: The interaction effect of sulpiride and morphine in the CA1 region may decrease DA synapses.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79401393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physicians’ Skills in Breaking Bad News to Patients With Cancer Using SPIKES Protocol 医生使用尖峰协议向癌症患者传达坏消息的技能
Caspian Journal of Neurological Sciences Pub Date : 2022-10-01 DOI: 10.32598/cjns.4.31.96.5
Bahram Naderi Nabi, Zahra Rafiei Sorouri, Ali Pourramzani, Seyyed Hossein Mirpour, Gelareh Biazar, Zahra Atrkarroushan, M. Mortazavi, M. Ahmadi
{"title":"Physicians’ Skills in Breaking Bad News to Patients With Cancer Using SPIKES Protocol","authors":"Bahram Naderi Nabi, Zahra Rafiei Sorouri, Ali Pourramzani, Seyyed Hossein Mirpour, Gelareh Biazar, Zahra Atrkarroushan, M. Mortazavi, M. Ahmadi","doi":"10.32598/cjns.4.31.96.5","DOIUrl":"https://doi.org/10.32598/cjns.4.31.96.5","url":null,"abstract":"Background: Breaking bad news is an unpleasant task for physicians, especially for patients with cancer. In this regard, the SPIKES protocol, which is prevalent in several countries, has not been discussed in Iran. Objectives: This study evaluated how the SPIKES protocol was followed by physicians. Materials & Methods: This descriptive cross-sectional study was conducted at Guilan academic hospitals from December 2021 to April 2022. Patients with cancer participated in the survey who were referred to the oncology academic centers for follow-ups or radiotherapy and chemotherapy. They were over 18 years old with the ability of proper communication. The SPIKES questionnaire consists of 12 questions with 6 subscales (settings, invitation, perception, knowledge, emotion, and strategy). It was filled out through a direct interview. Results: The data from 280 patients were analyzed. Everyone stated that at the time of receiving the diagnosis, the doctor was not in a hurry and made appropriate eye contact. About 61.1% believed they were emotionally supported, and 65.4% were satisfied with their final knowledge about the disease and treatment planning. Patients with older ages and lower levels of education were significantly more likely to state that physicians’ language was not comprehensive; physicians did not understand them, and the patients were not emotionally supported (P=0.0001). Conclusion: This study showed that more attention should be paid to older patients with lower levels of education. They needed more time for conversation and simpler dialect. Some areas, such as “invitation” are required to be improved","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73976383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Safety and Efficacy of Memantine in Improving Cognitive Function of Patients with Epilepsy 美金刚改善癫痫患者认知功能的安全性和有效性
Caspian Journal of Neurological Sciences Pub Date : 2022-10-01 DOI: 10.32598/cjns.8.31.6
P. Balali, Seyedeh Sajedeh Marashi, Elmira Agah, Mahdi Shafiei Sabet, N. Rahimian, S. Shafiee, V. Aghamollaii, A. Tafakhori
{"title":"Safety and Efficacy of Memantine in Improving Cognitive Function of Patients with Epilepsy","authors":"P. Balali, Seyedeh Sajedeh Marashi, Elmira Agah, Mahdi Shafiei Sabet, N. Rahimian, S. Shafiee, V. Aghamollaii, A. Tafakhori","doi":"10.32598/cjns.8.31.6","DOIUrl":"https://doi.org/10.32598/cjns.8.31.6","url":null,"abstract":"Background: The prevalence of cognitive impairment among patients with epilepsy is about 70%. There is still no approved medication for the treatment of this problem. Objectives: The present study aims to assess the safety and efficacy of memantine in improving the cognitive function of patients with epilepsy. Materials & Methods: This is a pilot, randomized, double-blind, placebo-controlled, parallel-group clinical trial, conducted in a hospital in Tehran, Iran during 2018-2019. Participants were randomly allocated to receive memantine (5 mg/day in the first eight weeks and 10 mg/day in the second eight weeks) or placebo in a 1:1 ratio. Participants underwent the mini-mental state examination (MMSE), montreal cognitive assessment (MoCA), and frontal assessment battery (FAB) before and after the intervention. The primary and secondary measures were safety and change in the cognitive test scores, respectively. Results: Out of 53 allocated participants, 33 completed the study. Drug intolerance including headache, somnolence, and dizziness was not significantly different between the two groups. The Intention-to-Treat analyses demonstrated no significant change in MoCA and FAB scores between the two groups after the intervention, but a significant improvement in the MMSE score of the memantine group (P=0.047) was observed. After controlling confounding factors, there was no significant difference in scores of any cognitive tests between the two groups. Conclusion: Memantine is a safe drug for patients with epilepsy, but it may not exert a beneficial effect on the cognitive function of these patients.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90054195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traumatic Supratrochlear Artery Pseudoaneurysm With Spontaneous Resolution 外伤性滑车上动脉假性动脉瘤自发性消退
Caspian Journal of Neurological Sciences Pub Date : 2022-10-01 DOI: 10.32598/cjns.4.31.351.1
M. Akbarpour, S. Yousefnejad
{"title":"Traumatic Supratrochlear Artery Pseudoaneurysm With Spontaneous Resolution","authors":"M. Akbarpour, S. Yousefnejad","doi":"10.32598/cjns.4.31.351.1","DOIUrl":"https://doi.org/10.32598/cjns.4.31.351.1","url":null,"abstract":"Background: Traumatic pseudoaneurysm of the supratrochlear artery is a rare lesion. It manifests, as a painless mass, in the frontal region following trauma. The unusual incidence and confusing presentation require the clinicians to thoroughly understand its presentation and diagnosis. Diagnosis is typically made on history and physical examination, but it can be confirmed by duplex ultrasound. Definitive treatment is surgical resection of the aneurysm after proximal and distal ligation of the vessel. However, in some cases, follow-up is recommended because there is a possibility of spontaneous relapse. Case Presentation: We present a case of traumatic pseudoaneurysm of the supratrochlear artery, which developed a few weeks after blunt trauma to the forehead. The radiologist reported a pseudoaneurysm originating with a narrow stalk of the supratrochlear artery. In the patient’s followup after three months, the patient’s mass became very small, and in the follow-up after five months, the mass completely disappeared. Conclusion: Pulsatile and or soft-tissue masses that are continuous with an artery with a history of trauma should be considered pseudoaneurysm. Color Doppler sonography is a convenient and noninvasive modality in diagnosis. If the pseudoaneurysm of the supratrochlear artery is small and contains thrombosis, waiting and seeing might be an effective option.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77209940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive Evolution of the “Human” Concept and Its Adaptation to Piaget’s Theory “人”概念的认知演变及其对皮亚杰理论的适应
Caspian Journal of Neurological Sciences Pub Date : 2022-10-01 DOI: 10.32598/cjns.4.31.355.1
Amir Qorbanpoor Lafmejani
{"title":"Cognitive Evolution of the “Human” Concept and Its Adaptation to Piaget’s Theory","authors":"Amir Qorbanpoor Lafmejani","doi":"10.32598/cjns.4.31.355.1","DOIUrl":"https://doi.org/10.32598/cjns.4.31.355.1","url":null,"abstract":"Background: Cognitions and attitudes, especially anthropological attitudes, are influential in human behavior. Objectives: The present study was conducted to investigate the cognitive evolution of the human concept in elementary school female students and its adaptation to Piaget’s theory of cognitive development. Materials & Methods: The present research method is qualitative of deductive-inductive type. Participants were first (n=12), second (n=13), and third-grade (n=12) elementary female students selected through the available sampling method. Semi-structured interviews were conducted with them to the point of theoretical saturation. Consistent with the research method, the findings were analyzed by theme analysis. Results: The findings showed that regarding human nature, students of all three grades have concrete thinking. Regarding the distinction between humans and animals, first and second grade students have concrete thinking, and third-grade students have concrete-abstract thinking. Regarding the purpose of life, students of all three grades have concrete thinking. Regarding the end of life, students of all three grades have abstract thinking. Regarding the beginning of human life, first-grade students have abstract thinking, and second- and third-grade students have concreteabstract thinking. Conclusion: Research findings consistent with some studies have shown that students can achieve abstract cognitive growth at younger ages than what Piaget stated, which can be a function of cultural, religious, and social factors.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82281071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mortality Rate of Acute Stroke in Iran: A Systematic Review and Meta-Analysis 伊朗急性中风死亡率:系统回顾和荟萃分析
Caspian Journal of Neurological Sciences Pub Date : 2022-10-01 DOI: 10.32598/cjns.4.31.338.1
Hossein-Ali Nikbakht, Layla Shojaie, Nasim Niknejad, Soheil Hassanipour, H. Soleimanpour, Sohrab Heidari, S. Afrashteh, E. Sarbazi, S. Ghaffari-fam
{"title":"Mortality Rate of Acute Stroke in Iran: A Systematic Review and Meta-Analysis","authors":"Hossein-Ali Nikbakht, Layla Shojaie, Nasim Niknejad, Soheil Hassanipour, H. Soleimanpour, Sohrab Heidari, S. Afrashteh, E. Sarbazi, S. Ghaffari-fam","doi":"10.32598/cjns.4.31.338.1","DOIUrl":"https://doi.org/10.32598/cjns.4.31.338.1","url":null,"abstract":"Background: There is limited data about the short-term stroke mortality rates for patients in treatment settings. Objectives: This study aimed to estimate the short-term stroke (in hospital, one month, one year) mortality rates in Iran through a systematic review and meta-analysis. Materials & Methods: We searched electronic databases, including three national (IranDoc, Megiran, SID) and four international (Scopus, PubMed, Web of Science, Google Scholar), from January 1990 to March 2020. We considered all observational studies on stroke mortality, such as cohort and crosssectional studies. Furthermore, the sub-group analyses were performed based on each province and metaregression analysis based on the study’s year and patients’ mean age. Results: Among 143 studies, 28 were eligible (11 cohort and 17 cross-sectional studies). Based on the random model, the mortality rates for in-hospital, 1-month, and 1-year mortality were reported as 18.71% (95% CI: 15.09%-22.34%), 23.43% (95% CI: 20.08%-26.78%), and 34.44% (95% CI: 32.02%- 36.85%), respectively. The results also revealed that mortality rates were neither related to the year studies conducted nor to the patient’s age. Conclusion: Approximately one-fifth of stroke patients in Iran die in the hospital after admission. The mortality rate increased in the one-month and one-year period, and about one-third of the patients died in the first year. Therefore, it is cardinal to focus on programs and solutions in which we can ameliorate mortality in the short-term period after stroke by performing primary specific treatments on patients.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"2020 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90420223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Multiple Sclerosis Diagnosed in a Woman With Von-Willebrand Disease: A Case Report 多发性硬化症诊断的妇女与范氏血友病:一个病例报告
Caspian Journal of Neurological Sciences Pub Date : 2022-07-01 DOI: 10.32598/cjns.8.30.3
Mohsen Farjoud Kouhanjani, Shirin Haghighat, M. Poursadeghfard
{"title":"Multiple Sclerosis Diagnosed in a Woman With Von-Willebrand Disease: A Case Report","authors":"Mohsen Farjoud Kouhanjani, Shirin Haghighat, M. Poursadeghfard","doi":"10.32598/cjns.8.30.3","DOIUrl":"https://doi.org/10.32598/cjns.8.30.3","url":null,"abstract":"Background: Von-Willebrand Disease (VWD) is the most common inherited bleeding disorder with an autosomal inheritance pattern. Multiple Sclerosis (MS) is a neurological disease, causing neurodegeneration and demyelination of the central nervous system through autoimmune mechanisms, and is a major cause of non-traumatic disabilities in youths. Some studies have shown the higher plasma activity of Von-Willebrand Factor in the active phase of MS. However, we could not find any study reporting co-occurrence of VWD and MS. Case Presentation and Intervention: In this case report, we present a woman with VWD who had optic neuritis 8 years ago and a new onset right-side hemiparesis. She was finally diagnosed as a new case of MS. Conclusion: There is a case of both VWD and MS; however, further investigation is needed regarding the association of VWD and MS","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73672598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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