Caspian Journal of Neurological Sciences最新文献_第4页

Potential Anti-inflammatory Activity of Brown Propolis Against Brain Ischemia Damage in Mice 褐蜂胶对小鼠脑缺血损伤的潜在抗炎作用

Caspian Journal of Neurological Sciences Pub Date : 2023-04-01 DOI: 10.32598/cjns.9.33.396.1

Mohammad Allahtavakoli, Z. Kamiab, M. Zamanian, M. Kujawska, M. Boroushaki, M. Rahmani, Mohammadreza Gholamrezapour, Fatemeh Pakvojoud, Gholamreza Bazmandegan

{"title":"Potential Anti-inflammatory Activity of Brown Propolis Against Brain Ischemia Damage in Mice","authors":"Mohammad Allahtavakoli, Z. Kamiab, M. Zamanian, M. Kujawska, M. Boroushaki, M. Rahmani, Mohammadreza Gholamrezapour, Fatemeh Pakvojoud, Gholamreza Bazmandegan","doi":"10.32598/cjns.9.33.396.1","DOIUrl":"https://doi.org/10.32598/cjns.9.33.396.1","url":null,"abstract":"Background: Inflammation plays a major part in brain ischemia. Propolis is a polyphenol-rich hive product with a set of pharmaceutical properties. Objectives: This research aims to investigate the impact of water extracts of brown propolis (WEPs) on stroke outcomes and inflammatory responses in a rat model of permanent middle cerebral artery occlusion (MCAO). Materials & Methods: This experimental study was conducted in Rafsanjan, Iran, in 2017. WEPs were experimentally prepared from two regions in Iran. Gas chromatography–mass spectrometry and Folin–Ciocalteu assays were used to determine chemical portrayal and the total polyphenol content, respectively. A total of 66 male adult mice were divided randomly into the surgical sham, control (vehicle-treated), and four WEPs-treated animal groups. WEPs-treated groups received doses of 100 and 200 (mg/kg, IP) four times, and their behavioral tests, brain edema, infarct volume, and tumor necrosis factor-alpha (TNF-α) level were evaluated. Results: The samples were not significantly different in terms of the concentration of the total polyphenol content. Compared to the control, WEPs led to a substantial decrease in the TNF-α level (P<0.05) as well as a subsequent reduction in the brain edema and infarct volume (P<0.001) in all treatment groups. Furthermore, there was a significant improvement in neurological deficits and sensory-motor impairments level (P<0.05). Conclusion: According to the study findings, WEPs reduce brain ischemia damage, perhaps by exerting a neuroprotective effect on stroke-induced neuroinflammatory responses","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87520754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Interactive Variation Between Brain and Heart Signals While Listening to the Holy Quran by Fusion Technique 用融合技术研究听古兰经时大脑和心脏信号的交互变化

Caspian Journal of Neurological Sciences Pub Date : 2023-04-01 DOI: 10.32598/cjns.9.33.269.2

Roya Sheibani, Ghasem SADEGHI BAJESTANI, A. Goshvarpour

{"title":"Study of Interactive Variation Between Brain and Heart Signals While Listening to the Holy Quran by Fusion Technique","authors":"Roya Sheibani, Ghasem SADEGHI BAJESTANI, A. Goshvarpour","doi":"10.32598/cjns.9.33.269.2","DOIUrl":"https://doi.org/10.32598/cjns.9.33.269.2","url":null,"abstract":"Background: In recent years, much attention has been paid to the impact of spirituality on people’s health. Some signals can alter brain function and affects the autonomic nervous system to reduce blood pressure, heart rate, and anxiety levels. Objectives: This study aimed to investigate the effect of listening to the Holy Quran on the electrocardiogram (ECG) and electroencephalogram (EEG) signals of healthy people with the fusion technique. Materials & Methods: Cardiac signal recording and two brain signal channels in the C3 and C4 areas of 25 female students between 20 and 23 years old were performed in three stages: silence, listening to the Holy Quran, and silence again. We used standard complementary plots, then we matched the circles with different radii (0.1 to 1) on the complementary diagram and extracted the number of intersection points with the hypothetical lines of the complementary plot as a feature. We then examined all possible modes with the support vector machine classifier. A new data fusion technique was used to study the interactions between the heart and the brain. Results: The best accuracy of 98.75% was obtained for a distinction between pre and no-voice using the brain signal. Conclusion: The results of the present study show the effect of listening to the Holy Quran on physiological signals with the fusion technique.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89921162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Ketamine or Nasal Midazolam for Sedation in Pediatric Upper Gastrointestinal Endoscopy 口服氯胺酮或鼻用咪达唑仑用于小儿上消化道内窥镜的镇静

Caspian Journal of Neurological Sciences Pub Date : 2023-04-01 DOI: 10.32598/cjns.9.33.392.1

Shohreh Maleknejad, F. Farzi, A. Heidarzadeh, A. Safaei Asl, Afagh Hasanzadeh Rad, Seyyedeh Azade Hoseini Nouri

{"title":"Oral Ketamine or Nasal Midazolam for Sedation in Pediatric Upper Gastrointestinal Endoscopy","authors":"Shohreh Maleknejad, F. Farzi, A. Heidarzadeh, A. Safaei Asl, Afagh Hasanzadeh Rad, Seyyedeh Azade Hoseini Nouri","doi":"10.32598/cjns.9.33.392.1","DOIUrl":"https://doi.org/10.32598/cjns.9.33.392.1","url":null,"abstract":"Background: There is no agreement on the route of administration and the drug of choice for providing adequate sedation for pediatric invasive procedures. Objectives: We compared the utility, safety, and sedation effects of intranasal midazolam and oral ketamine. Materials & Methods: This double-blind clinical trial was performed on 100 children aged 2 to 14 years who were candidates for upper gastrointestinal (GI) endoscopy. Patients were randomly assigned to two groups: ketamine (4 mg/kg orally) and midazolam (0.1 mg/ kg intranasal). Sedation score, fear levels, children’s behavior at the time of separation from parents, and vital signs were recorded. Results: Higher systolic blood pressure was seen in children who received ketamine (P=0.012) and lower arterial oxygen saturation in the midazolam group (P=0.023). Also, the level of sedation showed no significant difference between the groups. Conclusion: Based on the results, administering oral ketamine or intranasal midazolam before endoscopy induced a similar sedation score in children. Also, both methods could be safe and non-invasive modalities for sedation.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80849179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Helicobacter Pylori Infection and Seronegative Neuromyelitis Optica Spectrum Disorder 幽门螺杆菌感染与血清阴性神经脊髓炎视谱障碍的关系

Caspian Journal of Neurological Sciences Pub Date : 2023-01-11 DOI: 10.32598/cjns.9.32.143.8

Mahdi Barzegar, H. Nouri, O. Mirmosayyeb, H. Motedayyen, N. Nehzat, V. Shaygannejad

{"title":"Association Between Helicobacter Pylori Infection and Seronegative Neuromyelitis Optica Spectrum Disorder","authors":"Mahdi Barzegar, H. Nouri, O. Mirmosayyeb, H. Motedayyen, N. Nehzat, V. Shaygannejad","doi":"10.32598/cjns.9.32.143.8","DOIUrl":"https://doi.org/10.32598/cjns.9.32.143.8","url":null,"abstract":"Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disease in the central nervous system. Association between NMOSD and Helicobacter pylori (H. pylori) infection has been investigated, but few studies have assessed the relationship between H. pylori and seronegative AQP4-Ab NMOSD. Objectives: This study aimed to survey the association between H. pylori infection and NMOSD patients with seronegative AQP4-Ab status, as well as the possible relationship between the presence of H. pylori and clinical characteristics. Materials & Methods: This cross-sectional study was carried out in Kashani Hospital affiliated with the Isfahan University of Medical Sciences, Isfahan, Iran, from October 2017 to May 2019. A total of 35 consecutive seronegative AQP4-Ab NMOSD patients and 37 sex and age-matched healthy controls participated in the study. Demographic and clinical characteristics were obtained from all participants. We assessed participants’ seroprevalence of IgG and IgM antibodies against H. pylori. The Association of H. pylori with NMOSD was determined. Results: The frequency of IgG and IgM Ab H. pylori seropositivity in NMOSD patients was 22.9% and 40.0%, respectively. Among HC, 11(29.7%) and 20(54.1%) were positive for IgG and IgM Ab H. pylori. Although the rate of H. pylori IgG (OR=0.700, 95%, CI=0.243, 2.017, P=0.420) and IgM Ab (OR=0.567, 95%, CI=0.222, 1.444, P=0.233) seropositivity in NMOSD were lower than NMOSD, these differences were not statistically different. No clinical variables associated with H. pylori IgG and IgM seropositivity infection seropositivity. Conclusion: These findings show that possibly there is no relationship between H. pylori infection and seronegative AQP4-Ab NMOSD.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86342954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Case of Recovered Severe Rhino-Orbito-Cerebral Mucormycosis 重度鼻-眶-脑毛霉菌病痊愈1例

Caspian Journal of Neurological Sciences Pub Date : 2023-01-11 DOI: 10.32598/CJNS.9.32.316.1

L. Mahfoozi, P. Karimian

{"title":"A Case of Recovered Severe Rhino-Orbito-Cerebral Mucormycosis","authors":"L. Mahfoozi, P. Karimian","doi":"10.32598/CJNS.9.32.316.1","DOIUrl":"https://doi.org/10.32598/CJNS.9.32.316.1","url":null,"abstract":"Background: Mucormycosis is a rare disease with high morbidity and mortality, and its diagnosis is difficult and often delayed. Also, the disease tends to progress rapidly. Therefore, urgent surgical and medical intervention is lifesaving. Case Presentation: A 24-year-old woman with diabetes since 3 months ago presented with excessive tearing in her left eye, unilateral headache with epistaxis, and loss of consciousness at Razi Hospital, Rasht City, Iran, in June 2021. A clinical and pathologic diagnosis of mucormycosis was established. Imaging the head and paranasal sinuses revealed extensive involvement of the brain, paranasal sinuses, and left orbit. Treatment with liposomal amphotericin B (5 mg/kg) was administered for about 50 days until discharge. During the treatment period, the patient underwent several surgical procedures, such as enucleation of the left eye, surgery on soft and hard palates, sinuses, and neurosurgery for debridement of necrotizing tissues. After 50 days of intensive medical and surgical treatments, the patient was recovered and discharged. Conclusion: In the era of the COVID-19 pandemic, many diabetic patients acquire that infection. Physicians caring for these patients should be alert to mucormycosis as a complication of severe or mild COVID-19 infection. Early diagnostic and therapeutic interventions could be lifesaving for these patients.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"538 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88530034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Determiners of Temporal Lobe Epilepsy Surgery Outcome in a Developing Country 发展中国家颞叶癫痫手术结果的决定因素

Caspian Journal of Neurological Sciences Pub Date : 2023-01-11 DOI: 10.32598/cjns.9.32.262.1

Marjan Asadollahi, M. Samadian, Zeinab Sadat Hasheminezhad, Leila Simani

{"title":"The Determiners of Temporal Lobe Epilepsy Surgery Outcome in a Developing Country","authors":"Marjan Asadollahi, M. Samadian, Zeinab Sadat Hasheminezhad, Leila Simani","doi":"10.32598/cjns.9.32.262.1","DOIUrl":"https://doi.org/10.32598/cjns.9.32.262.1","url":null,"abstract":"Background: Epilepsy surgery has become a successful treatment option for patients with drug-resistant epilepsies. Objectives: This study aimed to assess temporal lobe epilepsy (TLE) surgery outcome and its association with epilepsy duration, the presence of pre-surgical generalized tonic-clonic seizure (GTCS), and brain MRI findings. Materials & Methods: This retrospective study was performed from 2016 to 2020 at Loghman-Hakim Hospital, Tehran, Iran. The patients’ demographic data, epilepsy type, duration, frequency, brain image findings, the selected surgical approaches, and histopathological findings were collected. The post-operative seizure outcome was expressed one year according to the proposed International League Against Epilepsy (ILAE) classification system. The independent sample t-test, chi-square, and one-way analysis of variance were applied to analyze the differences between variables in terms of quantitative and categorical data. Results: A total number of 69 TLE surgeries were enrolled in our study. No differences were found in the surgical outcome base on the ILAE classification system of patients with lesional vs non-lesional MRIs (P=0.834). In patients with mesial temporal sclerosis, no correlation was found between the surgical approaches including selective amygdalohippocampectomy, anterior temporal lobectomy, and post-operative seizure outcome (P=0.142). Seven patients (10.1%) developed post-operative functional seizures. Conclusion: In our study, the epilepsy duration and the presence of GTCSs before surgery had no effect on the surgery outcome. In patients with mesial temporal sclerosis, amygdalohippocampectomy, and anterior temporal lobectomy did not confer different surgical outcomes. TLE patients with normal MRI showed similar surgical outcomes as lesional patients. A significantly high proportion of our patients developed functional seizures, postoperatively.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"37 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72403426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 Infection and Seropositivity in Multiple Sclerosis Patients in Guilan in 2021 桂兰县2021年多发性硬化症患者COVID-19感染及血清阳性分析

Caspian Journal of Neurological Sciences Pub Date : 2023-01-11 DOI: 10.32598/CJNS.9.32.8.29

A. Ghayeghran, Elaheh Ghahramani, A. Saberi, H. Hatamian, Enayattollah Homaie Rad, Samaneh Ghorbani Shirkouhi, Rita Khayami, Mehri Fallahi, F. Shafaei, Parisa Shahshahani, Z. Reihanian

{"title":"COVID-19 Infection and Seropositivity in Multiple Sclerosis Patients in Guilan in 2021","authors":"A. Ghayeghran, Elaheh Ghahramani, A. Saberi, H. Hatamian, Enayattollah Homaie Rad, Samaneh Ghorbani Shirkouhi, Rita Khayami, Mehri Fallahi, F. Shafaei, Parisa Shahshahani, Z. Reihanian","doi":"10.32598/CJNS.9.32.8.29","DOIUrl":"https://doi.org/10.32598/CJNS.9.32.8.29","url":null,"abstract":"Background: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. COVID-19 has presented a significant challenge to the care providers of patients with MS. Objectives: The present study aimed to investigate the frequency of COVID-19 infection and its seropositivity in MS patients in Guilan, Iran, in 2021. Materials & Methods: In this analytical-cross-sectional study, all patients with relapsing-remitting MS registered in the Guilan MS Association with an expanded disability status scale of less than 5 who were referred for evaluation participated in the study. Information related to the clinical and serological symptoms of COVID-19 infection, changes in drug use, and the occurrence of new attacks were collected. Serological results of COVID-19 (IgG) among them were registered. Results: In total, 260 patients with MS (78.8% women, and 21.2% men) with a Mean±SD age of 38.7±9.9 years, and a Mean±SD duration of MS of 8.9±4.9 years were investigated. The most commonly used drugs were Dimethyl fumarate, Interferon, and Rituximab, respectively. Thirty-three patients (12.6%) had a clinical COVID-19 infection, of which 32 people had a mild and only one had a critical infection. Eight patients (1.3%) had positive COVID-19 IgG tests. No significant relationship was found between the COVID-19 infection with the type of medication, medication change, clinical attack of MS, and co-morbidities (P>0.05). Conclusion: A few patients had positive COVID-19 IgG tests and clinical COVID-19 infection. The vast majority had mild disease, and the clinical attack was not related to COVID-19 infection.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"33 8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89639323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychometrics and Validation of the Intensive Care Unit Memory Assessment Tool in the Iranian Population 伊朗人群重症监护病房记忆评估工具的心理测量学和验证

Caspian Journal of Neurological Sciences Pub Date : 2023-01-11 DOI: 10.32598/cjns.9.32.391.1

Sara Ghafouri, Simin Jahani, E. Maraghi, Somayeh Biparva Haghighi

{"title":"Psychometrics and Validation of the Intensive Care Unit Memory Assessment Tool in the Iranian Population","authors":"Sara Ghafouri, Simin Jahani, E. Maraghi, Somayeh Biparva Haghighi","doi":"10.32598/cjns.9.32.391.1","DOIUrl":"https://doi.org/10.32598/cjns.9.32.391.1","url":null,"abstract":"Background: The intensive care unit memory (ICUM) assessment tool is a practical tool for memory monitoring after the discharge from ICU. Objectives: This psychometric study purported to validate ICUM for a sample population of Iranian patients hospitalized in ICU. Materials & Methods: This research was a descriptive-analytical study that was conducted at Ahvaz University of Medical Sciences in 2022. A total of 96 patients were selected through the convenience sampling method and were asked to complete the questionnaire 2 weeks and 8 weeks after their discharge from the hospital. Exploratory factor analysis was run to validate the tool’s structure. The reliability of the ICUM tool was checked by the testretest method and the Cronbach alpha coefficient for memory subscales. Results: To increase the qualitative face and content validity of the tool in Persian, some vague items were modified according to the suggestions of the participants, language, and nursing experts. For the quantitative face validity, the item coefficient was calculated, and the minimum score obtained was 4.4. For the quantitative content validity, the content validity ratio (CVR) and content validity index (CVI) were calculated. The minimum obtained scores were CVI=0.7 and CVR=0.6. Thus, all the items were confirmed. The implementation of the factor analysis was confirmed with KMO=0.65. The highest Cronbach alpha coefficient for delusional memory was 0.62 and the highest test-retest correlation for factual memory was 0.95. Conclusion: The Persian version of ICUM has strong test-retest reliability, but weak internal consistency reliability. It is recommended that future studies evaluate the tool’s reliability over an extended period.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91255909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unusual Presentation of Neuronal Ceroid Lipofuscinosis With CLN6 Mutation 罕见的神经元类脂褐变伴CLN6突变

Caspian Journal of Neurological Sciences Pub Date : 2023-01-11 DOI: 10.32598/cjns.9.32.232.5

Shahin Koohmanaee, Seyyedeh Azadeh Hoseini Nouri, V. Aminzadeh, Manijeh Tabrizi, Reza Bayat, Fatemeh Kharaee, M. Shahrokhi, A. Hassanzadeh Rad, Saber Najafi Chakoosari, Setila Dalili, Ehsan Kazemnejad Leili

{"title":"An Unusual Presentation of Neuronal Ceroid Lipofuscinosis With CLN6 Mutation","authors":"Shahin Koohmanaee, Seyyedeh Azadeh Hoseini Nouri, V. Aminzadeh, Manijeh Tabrizi, Reza Bayat, Fatemeh Kharaee, M. Shahrokhi, A. Hassanzadeh Rad, Saber Najafi Chakoosari, Setila Dalili, Ehsan Kazemnejad Leili","doi":"10.32598/cjns.9.32.232.5","DOIUrl":"https://doi.org/10.32598/cjns.9.32.232.5","url":null,"abstract":"Background: Neuronal ceroid lipofuscinoses (NCL) is a rare progressive neurodegenerative disorder caused by more than 530 mutations of at least 13 different genes (CLN 1-14). NCL is a part of the lysosomal disease characterized by the presence of neuronal and extraneural autofluorescent lipopigment accumulations that leads to motor and mental deterioration, developmental regression, seizure, vision loss, and premature death. NCL is classified into four main groups based on the different clinical manifestations and age of presentation. In this study, we aimed to report an unusual presentation of NCL with CLN6 mutation without retina involvement. Case Presentation: We reported a 10-year-old boy with mixed types of seizures, developmental delay, cognitive problems, unsteady gait, and speech disorders. Although after a thorough assessment, CLN6 mutation was diagnosed, he had all symptoms of this mutation, except the visual impairment. Conclusion: According to recent NCL case reports from Asia, full familiarity with its presentation by pediatricians and neurologists is obligatory. Children with developmental regression or refractory seizures, who also have visual or other neurological symptoms such as ataxia and other cerebellar symptoms, even at older ages, should be evaluated for NCL. Attention to ophthalmological examinations and neurological signs and confirming the diagnosis by biopsy or genetic analysis is desirable to prevent missed diagnosis.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88554065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Side Effects of First and Second Doses of Inactivated COVID-19 Vaccine in Multiple Sclerosis 1、2剂COVID-19灭活疫苗对多发性硬化症的毒副作用

Caspian Journal of Neurological Sciences Pub Date : 2023-01-11 DOI: 10.32598/CJNS.9.32.373.1

N. Razazian, M. Sahraian, M. Rezaei, S. Eskandarieh, Seyedeh Elham Mousavi, Negin Fakhri

{"title":"Side Effects of First and Second Doses of Inactivated COVID-19 Vaccine in Multiple Sclerosis","authors":"N. Razazian, M. Sahraian, M. Rezaei, S. Eskandarieh, Seyedeh Elham Mousavi, Negin Fakhri","doi":"10.32598/CJNS.9.32.373.1","DOIUrl":"https://doi.org/10.32598/CJNS.9.32.373.1","url":null,"abstract":"Background: It is currently recommended to vaccinate against SARS CoV-2 for people with multiple sclerosis (MS), but it is uncertain what effect it will have on people with MS (PwMS). Objectives: We aimed to compare the side effects of the first and second doses of the Sinopharm vaccine in PwMS. Materials & Methods: This descriptive-analytical follow-up study was conducted on PwMS patients in Kermanshah province, Iran, who received the Sinopharm vaccine using the nationwide MS registry of Iran (NMSRI) by available methods between May and August 2021. Using a researcher-made questionnaire, demographic and clinical information about PwMS, as well as side effects from the Sinopharm vaccine were collected by telephone 5-14 days after the first and second doses. Data were analyzed using SPSS software version 25. Results: Study participants included 188 PwMS, including 148 females (78.7%) and 40 males (21.3%). PwMS had Median age of 42.66±11.1 years and Median 9.57±7.0 for disease duration. In the 1st dose, the prevalence of side effects was significantly higher than in the second dose (58.5% vs 47.0%, P=0.012). Fatigue (30.1%), myalgia (29.8%), fever (25.0%), and headache (22.3%) were the most common in the first dose, and fatigue (27.1%), headache (18.6%), myalgia (17.5%) and fever (14.9%) were the most common in the second dose. COVID-19 was present in 51 people (27.3%) before vaccination. Conclusion: Sinopharm vaccine side effects were significantly more prevalent in the first dose than in the second dose. Most side effects are moderate in severity and transient.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74967737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1