Proceedings of 5th International Electronic Conference on Medicinal Chemistry最新文献

{"title":"Phosphorylation of breast-milk αS1-casein induced conformational changes and abolished TLR4-agonisticity as well as formation of fibril structure","authors":"T. Saenger, Marten F. Schulte, F. Herrmann, Marius Pattberg, S. Vordenbäumen, E. Bleck, Matthias Schneider, J. Jose","doi":"10.3390/ecmc2019-06290","DOIUrl":"https://doi.org/10.3390/ecmc2019-06290","url":null,"abstract":"Breast-milk αS1-casein is a Toll-like receptor (TLR4) agonist which induced proinflammatory cytokine secretion. Phosphorylated αS1-casein (P- αS1-casein) is non-agonistic.1,2 The objective of this study was to analyze structural characteristics underlying these observations. \u0000 Recombinant αS1-casein was shown to exist in two conformations, an α-helical TLR4-agonistic conformation and a non-agonistic conformation with lower α‑helical and higher random coil content. TLR4-agonstic αS1-casein conformation was found at a pH-range between 7.4 and 2. αS1-Casein bound itself (KD-value: 2 µM) formed large aggregates (between O 73 nm [pH7] and O 826.2 nm [pH2]). Using Thioflavin T assay and atomic force microscopy showed that αS1-casein adopted fibril-like structure. P-αS1-casein was observed in a less α‑helical conformation, not inducing IL-8 secretion. P-αS1-casein bound itself stronger (KD-value: 0.5 µM) than αS1-casein and did not form fibrils. \u0000 In conclusion, TLR4-agonistic and non-agonistic conformations of αS1-casein could be differentiated. It was demonstrated that human caseins are able to adopt fibril structure. These kind of structures are often disease related. We postulate, that phosphorylation could be a switch of two conformations regulating immunomodulatory effects of human αS1-casein especially in immune system development. \u0000 \u0000Vordenbaumen, S. et al. Human casein alpha s1 induces proinflammatory cytokine expression in monocytic cells by TLR4 signaling. Mol Nutr Food Res 60, 1079-89 (2016). \u0000Saenger, T. et al. Human αS1-casein induces IL-8 secretion by binding to the ecto-domain of the TLR4/MD2 receptor complex. Biochim Biophys Acta Gen Subj 1863, 632-643 (2019).","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132457664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin C and E contents and antioxidant, antibacterial, and antiproliferative activities of Citrus suhuiensis peel","authors":"Jesmine Khan, Wan Mohamad Zain, Nurul Suhaili Amirah Mamat, Raja Nurfirzanah Syaza Raja Sharin, Noor Masyitah Jumahat, J. Houssaini","doi":"10.3390/ecmc2019-06296","DOIUrl":"https://doi.org/10.3390/ecmc2019-06296","url":null,"abstract":"Citrus suhuiensis is a citrus fruit with greenish yellow peel. It is consumed fresh but the peels are discarded as waste whereas they might also contain biological potentials. This study aimed to determine the vitamin C and E contents as well as the antioxidant, antibacterial, and antiproliferative properties of Citrus suhuiensis peel crude extract. Vitamin C and E contents were measured following the AOAC method. The total phenolic content was evaluated using Folin-Ciocalteau assay. Capability of the extract to scavenge free radical was elucidated using DPPH assay. Agar disk diffusion method was used to evaluate its antibacterial effect against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The antiproliferative effects of Citrus suhuiensis crude extract on MCF-7 (estrogen-dependent breast cancer), MDA-MB-231 (non-estrogen-dependent breast cancer), T84 (colon cancer) and MCF10a (normal fibroblast) cell lines were assessed via MTS assay. Vitamin C (19.18±0.14 mg/100 g) in C. suhuiensis peel was significantly higher than vitamin E (0.018±0.00 mg/100 g) (p<0.001). The total phenolic content was 108.00±1.00 mg GAEs/g sample. However, Citrus suhuiensis crude extract was unable to scavenge 50% of DPPH free radicals. The extract did not have antimicrobial effect against the bacterial strains tested. It inhibited 50% MCF-7 estrogen-dependent breast cancer and T84 colon cancer cell growth at 90.03±0.18 and 50.11±1.46 µg/ml, respectively. No inhibition was observed on MDA-MB-231 non-estrogen-dependent breast cancer and MCF10a normal fibroblast cell growth. In conclusion, although C. suhuiensis peel has very limited antibacterial and DPPH radical scavenging activities, it exhibited antiproliferative effect against estrogen-dependent breast cancer and colon cancer cell growth, what could be due to its vitamin C and E and total phenolic contents. Nevertheless, further investigations are required to increase understanding on the underlying mechanisms.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130900161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, biological evaluation and membranotropic properties of quinoline-antimicrobial peptide conjugates as antibacterial drugs","authors":"P. Laumaillé, A. Dassonville-Klimpt, S. Nascimento, C. Mullié, F. Peltier, C. Andrejak, S. Castelain, S. Morandat, K. E. Kirat, P. Sonnet","doi":"10.3390/ecmc2019-06320","DOIUrl":"https://doi.org/10.3390/ecmc2019-06320","url":null,"abstract":"","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124055794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel approach for ER+ breast cancer treatment: A new compound that modulates aromatase and ER","authors":"C. Almeida, Ana Oliveira, P. Fernandes, G. Correia-da-Silva, M. Ramos, T. Augusto, N. Teixeira, C. Amaral","doi":"10.3390/ecmc2019-06337","DOIUrl":"https://doi.org/10.3390/ecmc2019-06337","url":null,"abstract":"Introduction: Estrogen receptor-positive (ER+) breast cancer is the most common subtype of breast cancer worldwide. Estrogens, after being synthetized by aromatase, bind to ERα promoting breast cancer proliferation (1). Therefore, the therapies already approved act either by inhibiting aromatase or by modulating ERα. However, besides their therapeutic success, they induce several side effects (2), reason why it is crucial to discover novel therapeutic approaches.\u0000Aim: Considering that aromatase activity and ERα activation display important roles in this type of cancer, our goal is to discover multi-target compounds able to simultaneously inhibit aromatase and modulate ERα.\u0000Methods: We used the ChEMBL Database to retrieve all the known aromatase inhibitors (AIs) and ERα antagonists. Using the ChemAxon software we computed two types of chemical descriptors: extended connectivity fingerprints and the pharmacophore fingerprints of each compound. After this, clusters were constructed and the selected compounds were analyzed by molecular docking. Anti-aromatase activity was evaluated in human placental microsomes and ERα expression was assessed by Western-Blot in ER+ an aromatase-overexpressing breast cancer cell line (MCF-7aro).\u0000Results: Based on clusters and after docking studies one compound (MT1) was selected to be studied in microsomes and in MCF-7aro cells. Although MT1 binds to key residues in aromatase important for its inhibition, unexpectedly, MT1 was not able to inhibit this enzyme in microsomes. However, as Exemestane, the steroidal AI used in clinic (1), MT1 induced a decrease in aromatase protein levels in MCF-7aro cells. Furthermore, MT1 impaired ERα activation, acting as an ERα antagonist.\u0000Discussion: To the best of our knowledge, this is the first attempt to discover multi-target compounds for ER+ breast cancer, using this type of approach. In fact, the compound MT1 was able to modulate aromatase and ERα, two key targets of this type of cancer, which represents a great advantage over other molecules used in breast cancer treatment.\u0000Acknowledgments: The authors are grateful to Fundacao para a Ciencia e Tecnologia (FCT) for CA Post-doc grant (SFRH/BPD/98304/2013) and for the financial support (UID/MULTI/04378/2019).\u0000References:\u0000\u0000Amaral C, Varela CL, Mauricio J, Sobral AF, Costa SC, Roleira FMF, et al. Anti-tumor efficacy of new 7alpha-substituted androstanes as aromatase inhibitors in hormone-sensitive and resistant breast cancer cells. J Steroid Biochem Mol Biol. 2017;171:218-28.\u0000\u00002. Augusto TV, Correia-da-Silva G, Rodrigues CMP, Teixeira N, Amaral C. Acquired resistance to aromatase inhibitors: where we stand! Endocr Relat Cancer. 2018;25(5):R283-R301.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"918 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123048618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro antimicrobial effect of curcumin","authors":"T. Karpiński, A. Adamczak, M. Ożarowski","doi":"10.3390/ecmc2019-06322","DOIUrl":"https://doi.org/10.3390/ecmc2019-06322","url":null,"abstract":"Curcumin is a major phenolic constituent of Curcuma longa L. The purpose of the present work was comparative analysis of the antimicrobial activity of curcumin using CLSI recommendations. In the study, there were tested six Gram(+) bacteria (Enterococcus faecalis, Staphylococcus aureus, MRSA, S. epidermidis, Streptococcus agalactiae, S. pyogenes), five Gram(-) (Acinetobacter lwoffii, Escherichia coli, Klebsiella oxytoca, Proteus mirabilis, Pseudomonas aeruginosa) and fungus Candida albicans. The minimal inhibitory concentrations (MICs) of curcumin were determined by the micro-dilution method. Curcumin was dissolved in 40% water solution of DMSO. Curcumin did not inhibit the growth of C. albicans, MRSA, S. agalactiae, and P. mirabilis (MICs >1000 μg/mL), while it demonstrated very strong effect on strains of S. epidermidis (MICs 15.6-31.25 μg/mL) and S. pyogenes (62.5-125 μg/mL). Curcumin sensitivity was also observed for A. lwoffii (125-250 μg/mL), P. aeruginosa (250-500 μg/mL) as well as E. coli and K. oxytoca (500-1000 μg/mL). Among S. aureus and E. faecalis strains, we found both resistant (MICs >1000 μg/mL) and sensitive (500 μg/mL) bacteria. Summarizing our study, curcumin belongs to the potent natural antibacterial agents of plant origin, but its activity varies greatly depending on the species and even the bacterial strain.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132734990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of oligoribonucleotide complexes with D-mannitol on tumor formation in a murine model of B16 melanoma","authors":"I. Kraievska, Z. Tkachuk, I. Vagina, G. Gerashchenko, T. Yakovenko, V. Kashuba","doi":"10.3390/ecmc2019-06329","DOIUrl":"https://doi.org/10.3390/ecmc2019-06329","url":null,"abstract":"One of the ways of effective treatment of melanoma is based on strategies to enhance the body's immune response. OligoribonucleotidesD-mannitol (ORNs-D-M) complexes possess immunotherapeutic actions due to the activation of immune responses. Adult male mice of a C57BL/6J line were injected once by the ORNs-D-M solution at concentrations of 1.4; 0.7; 0.35; 0.175 mg. In the group where animals received 1.4 mg of ORNs-D-M, the formation of the solid tumors was not observed; however, in the group with 0.7 mg dose, the average tumor volume was 97% lower than the non-drug group. Also, the mRNA expression levels of markers of T-cell counts CD3, CD4, CD8, and CD247 approached those of healthy animals. Immunosuppressive state was decreased which reflect in the increased expression of CD274, PDCD1, and IFNB1.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132059041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of partially hydrogenated pyridines (derivatives of cyanothioacetamide) on blood indicators of rats with acute tetrachloromethane hepatitis","authors":"Anna A. Burdeynaya, E. Bibik, B. S. Krivokolysko, K. Frolov, V. Dotsenko, S. Krivokolysko","doi":"10.3390/ecmc2019-06304","DOIUrl":"https://doi.org/10.3390/ecmc2019-06304","url":null,"abstract":": Currently, a focused search for new and safe hepatoprotective agents is highly relevant. An experimental study was conducted on 80 male rats after intragastric infiltration of carbon tetrachloride (CCl 4 ) in a 50% solution of refined sunflower oil intragastrically once a day at a dose of 4 ml/kg for 3 days. Screening researches of six partially hydrogenated pyridines, derivatives of cyanothioacetamide, on a model of acute tetracycline hepatitis at a dose of 5 mg/kg showed a high hepatoprotective and detoxifying activity in all compounds. They stabilize the level of biochemical blood parameters, keeping them at the normal level in terms of hepatotoxicity induced by the use of high dosages of CCl 4 in vivo. A compound CV146 (benzyl 4- (4-chlorophenyl) -5-cyano-6 - ({2 - [(3,4-dimethylphenyl) amino] -2-oxoethyl} thio) -2-methyl-1,4-dihydropyridine -3-carboxylate) should be considered as an perspective in terms of further preclinical studies in order to find new highly effective and safe agents for the pharmacocorrection of acute toxic liver damages. cyanothioacetamide, tetrachloromethane hepatitis model. named after St. Luke. liver damage was in once a day at dose 4 ml/kg For research, we used substituted di- tetrahydropyridines with the codes CV042, CV043, CV046, CV047, CV080, CV146 compound CV146 with those in intact animals, a decrease of 25.6% is seen. The activity of transaminases in the blood of rats of this experimental group was reduced by 25.5% (ALT) and 39.2% (AST) compared with the control group. Alkaline phosphatase activity was at the level recorded in the group of intact animals. these properties be considered as an further find new highly effective","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125260260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel menthone derivatives with anticonvulsant effect","authors":"M. Nesterkina, D. Barbalat, Ivan Zheltvay, I. Rakipov, M. Atakay, B. Salih, I. Kravchenko","doi":"10.3390/ecmc2019-06294","DOIUrl":"https://doi.org/10.3390/ecmc2019-06294","url":null,"abstract":"Nowadays, a significant number of antiepileptic drugs aimed at influencing the main inhibitory transmitter – gamma-aminobutyric acid (GABA). Compounds with various chemical structures, binding to different GABAA sites, potentiate the action of amino acid. Recent studies have reported that terpenoids such as l-menthone and its derivatives were found to act as modulators of GABAA receptors, thereby demonstrating anticonvulsant activity. On the other hand, neuroprotective and anticonvulsant potentialities were revealed in phenoxyacetic acid derivatives. Based on the foregoing, the combination of l-menthone and phenoxyacetic acid residues into one molecule is feasible for obtaining the pharmacological agents with antiseizure action. In order to achieve the above-mentioned goal, l-menthone hydrazones were synthesized via condensation of terpenoid with 4-R-phenoxyacetic acid hydrazides in the presence of a catalytic amount of glacial acetic acid. The structure of the target compounds has been established by FTIR-ATR, Raman, 1H-NMR and 13C-NMR spectral analysis and EI/FAB/ESI mass spectrometry. Thermal properties of hydrazones were elucidated by DSC and their purity ‒ by HPLC coupled to mass spectrometry. Synthesized compounds were found to exist as Z/E geometrical isomers about C=N bond and cis/trans amide conformers. At the present study, the influence of obtained derivatives on the central nervous system was reliably confirmed by evaluating their anticonvulsant activity. The present findings indicate that all aforementioned compounds possess antiseizure action after oral administration on PTZ-induced convulsion and maximal electroshock-induced (MES) seizures.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125259750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The in silico identification of potent natural bioactive anti-dengue agents by targeting the human hexokinase 2 enzyme","authors":"F. A. A. Fuad, F. Ahammad","doi":"10.3390/ecmc2019-06342","DOIUrl":"https://doi.org/10.3390/ecmc2019-06342","url":null,"abstract":"Background: Hexokinase 2 (HKII) is a rate-limiting and the first key enzyme of glycolysis, responsible for the biosynthesis of glucose-6-phospate (G6P) and is upregulated in dengue virus (DENV) infected cells. During DENV infections, the glycolytic pathway of the host is activated by the pathogens, and inhibition of glycolysis by targeting HKII enzyme can significantly block the infectious DENV production. Objectives: The main aim of this study was to computer-aided identification of natural bioactive antidengue agents that can inhibit the activity of human HKII enzyme. Methods: A ligand-based pharmacophore model (LBPM) was developed using previously known inhibitors of HKII enzymes to ensure the optimal molecular interactions with the specific target. Virtual screening (VS), molecular docking (MD) and the absorption, distribution, metabolism, excretion, and toxicity (ADMET) approaches were used to identify potential and specific natural human HKII inhibitors. Result: Based on MD results and binding interaction analysis, four compounds D-Glucose hydrate, (2R,3R,4S,5S)-2,3,4,5,6-Pentahydroxyhexanal, (S)-2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl) propanehydrazide hydrochloride, (2S)-2-Amino-3-hydroxy-N’, N'-bis[(2,3,4-trihydroxyphenyl)methyl] propanehydrazide were predicted to be the basis for lead optimization. They bind to the active site of human HKII and virtually behave as strong competitive inhibitors. Conclusion: The results demonstrated 4 hits compatible with the active site of HKII enzymes. The current results will be further evaluated in the wet lab by both in vitro and in vivo testing for the development of potential DENV inhibitor.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115187408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactose-based Fatty Acid Monoesters: Synthesis, antimicrobial activity and permeability enhancement studies","authors":"S. Lucarini","doi":"10.3390/ecmc2019-06340","DOIUrl":"https://doi.org/10.3390/ecmc2019-06340","url":null,"abstract":"We present the synthesis and the in vitro assaying of a series of lactose-based non-ionic surfactants, highlighting the relationship between their structure and biological effect. Using tensiometric measurements the critical micelle concentrations (CMCs) of the surfactants were determined and demonstrate that increasing hydrophobic chain length reduces surfactant CMC. In vitro testing on Caco-2 intestinal and Calu-3 airway epithelia revealed that cytotoxicity is present, for most of the surfactants, at concentrations greater than their CMCs. Importantly, through the culture of epithelial monolayers on Transwell® supports, the surfactants demonstrate the ability to reversibly modulate transepithelial electrical resistance (TEER), and thus open tight junctions, at non-toxic concentrations. The surfactants were then tested for their ability to improve the in vitro permeability of Ovalbumin and Dextran, confirming their potential application as safe permeability enhancers in vivo. Moreover, the synthesized compounds exhibit antimicrobial activity versus eight pathogenic species belonging to Gram-positive, Gram-negative microorganisms and fungi.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125719503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}