The influence of oligoribonucleotide complexes with D-mannitol on tumor formation in a murine model of B16 melanoma

I. Kraievska, Z. Tkachuk, I. Vagina, G. Gerashchenko, T. Yakovenko, V. Kashuba
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Abstract

One of the ways of effective treatment of melanoma is based on strategies to enhance the body's immune response. OligoribonucleotidesD-mannitol (ORNs-D-M) complexes possess immunotherapeutic actions due to the activation of immune responses. Adult male mice of a C57BL/6J line were injected once by the ORNs-D-M solution at concentrations of 1.4; 0.7; 0.35; 0.175 mg. In the group where animals received 1.4 mg of ORNs-D-M, the formation of the solid tumors was not observed; however, in the group with 0.7 mg dose, the average tumor volume was 97% lower than the non-drug group. Also, the mRNA expression levels of markers of T-cell counts CD3, CD4, CD8, and CD247 approached those of healthy animals. Immunosuppressive state was decreased which reflect in the increased expression of CD274, PDCD1, and IFNB1.
寡核苷酸复合物与d -甘露醇对B16黑色素瘤小鼠模型肿瘤形成的影响
有效治疗黑色素瘤的方法之一是基于增强人体免疫反应的策略。寡核苷酸甘露醇(ORNs-D-M)复合物由于激活免疫反应而具有免疫治疗作用。给C57BL/6J系成年雄性小鼠一次性注射浓度为1.4的ORNs-D-M溶液;0.7;0.35;0.175毫克。在接受1.4 mg ORNs-D-M的组中,没有观察到实体瘤的形成;但在0.7 mg剂量组,平均肿瘤体积比非药物组小97%。t细胞计数标志物CD3、CD4、CD8和CD247 mRNA表达水平接近健康动物。免疫抑制状态降低,反映在CD274、PDCD1和IFNB1的表达增加。
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