Influence of partially hydrogenated pyridines (derivatives of cyanothioacetamide) on blood indicators of rats with acute tetrachloromethane hepatitis

Abstract

: Currently, a focused search for new and safe hepatoprotective agents is highly relevant. An experimental study was conducted on 80 male rats after intragastric infiltration of carbon tetrachloride (CCl 4 ) in a 50% solution of refined sunflower oil intragastrically once a day at a dose of 4 ml/kg for 3 days. Screening researches of six partially hydrogenated pyridines, derivatives of cyanothioacetamide, on a model of acute tetracycline hepatitis at a dose of 5 mg/kg showed a high hepatoprotective and detoxifying activity in all compounds. They stabilize the level of biochemical blood parameters, keeping them at the normal level in terms of hepatotoxicity induced by the use of high dosages of CCl 4 in vivo. A compound CV146 (benzyl 4- (4-chlorophenyl) -5-cyano-6 - ({2 - [(3,4-dimethylphenyl) amino] -2-oxoethyl} thio) -2-methyl-1,4-dihydropyridine -3-carboxylate) should be considered as an perspective in terms of further preclinical studies in order to find new highly effective and safe agents for the pharmacocorrection of acute toxic liver damages. cyanothioacetamide, tetrachloromethane hepatitis model. named after St. Luke. liver damage was in once a day at dose 4 ml/kg For research, we used substituted di- tetrahydropyridines with the codes CV042, CV043, CV046, CV047, CV080, CV146 compound CV146 with those in intact animals, a decrease of 25.6% is seen. The activity of transaminases in the blood of rats of this experimental group was reduced by 25.5% (ALT) and 39.2% (AST) compared with the control group. Alkaline phosphatase activity was at the level recorded in the group of intact animals. these properties be considered as an further find new highly effective