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Serbian Journal of Dermatology and Venereology最新文献

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Familial Hypercholesterolemia with Tendinous Xanthomas and Achilles Tendinitis – A Forgotten Dermato-Rheumatologic Association 家族性高胆固醇血症伴腱黄瘤和跟腱炎——一个被遗忘的皮肤-风湿病学关联
Serbian Journal of Dermatology and Venereology Pub Date : 2019-03-01 DOI: 10.2478/sjdv-2019-0004
Puspanjuli Sahu, S. Mohanan, C. Udayshankar, S. Sinhasan, R. Bhat
{"title":"Familial Hypercholesterolemia with Tendinous Xanthomas and Achilles Tendinitis – A Forgotten Dermato-Rheumatologic Association","authors":"Puspanjuli Sahu, S. Mohanan, C. Udayshankar, S. Sinhasan, R. Bhat","doi":"10.2478/sjdv-2019-0004","DOIUrl":"https://doi.org/10.2478/sjdv-2019-0004","url":null,"abstract":"Abstract Familial hypercholesterolemia (FH) is a disorder of lipoprotein metabolism with dermatological and rhematological manifestations. Tendinous xanthomata (TX) are a hallmark of this disease. They are associated with recurrent tendinitis and tendon damage, an aspect of the clinical presentation, which is not well-known among dermatologists. We report two cases of heterozygous familial hypercholesterolemia, where the patients started developing tendinous xanthomata early in their life, with progressive increase in the number and size of lesions. However, they presented late, only when the recurrent attacks of tendinitis became severe. We present these cases to highlight the rheumatologic features, which may be the first symptom of heterozygous familial hypercholesterolemia.","PeriodicalId":30659,"journal":{"name":"Serbian Journal of Dermatology and Venereology","volume":"11 1","pages":"25 - 29"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45329243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rosmarinus Improved Skin Flap Survival Through mTOR Dependent Pathway 迷迭香通过mTOR依赖通路改善皮瓣存活
Serbian Journal of Dermatology and Venereology Pub Date : 2018-12-01 DOI: 10.2478/sjdv-2018-0016
Z. Javid, A. Norouzy, Zahra Bangaleh, Mahdi Shadnoush
{"title":"Rosmarinus Improved Skin Flap Survival Through mTOR Dependent Pathway","authors":"Z. Javid, A. Norouzy, Zahra Bangaleh, Mahdi Shadnoush","doi":"10.2478/sjdv-2018-0016","DOIUrl":"https://doi.org/10.2478/sjdv-2018-0016","url":null,"abstract":"Abstract Introduction: Skin flap application in the clinical practice is restricted due to the ischemic damage and flap necrosis. Rosmarinus oil has been shown to improve a skin flap survival. In the present work we studied the role of mammalian target of rapamycin (mTOR) signaling on rosmarinus-induced flap protection. Methods: A flap surgery was performed on Sprauge-Dawley rats (8 cm in by 3 cm). A week before and a week after the surgery the flaps were treated with topical rosmarinus oil (twice per day). Rapamycin (m-TOR inhibitor) was administered 30 minutes before the flap surgery in rosmarinus-treated or not treated groups. A week after the surgery the malondialdehyde (MDA) contents, myeloperoxidase (MPO) and superoxide dismutase (SOD) activities, expression of Bax, Bcl-2, mTOR and p-mTOR were measured in the flap tissue. Results: Topical application of the rosmarinus increased the flap survival (p<0.05), anti-oxidative enzyme activity (SOD, p<0.05) and anti-apoptotic protein Bcl-2 expression. Rosmarinus treatment decreased the flap MDA content, MPO activity, and pro-apoptotic protein Bax expression (p<0.05). Rosmarinus topical application did not change mTOR expression and phosphorylation in the flap tissue. Expression of p-mTOR in rosmarinus treated group was suppressed by rapamycin pre-treatment, which also abolished rosmarinus effects on the flap survival (p<0.05). Conclusion: These data suggested p-mTOR dependent mechanism in rosmarinus-induced flap survival.","PeriodicalId":30659,"journal":{"name":"Serbian Journal of Dermatology and Venereology","volume":"10 1","pages":"113 - 118"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44008148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dermoscopy of the Month Dermoscopic Features of Sebaceous Nevus - a Report of 4 Cases 皮脂腺痣的皮肤镜特征——附4例报告
Serbian Journal of Dermatology and Venereology Pub Date : 2018-12-01 DOI: 10.2478/sjdv-2018-0020
Tanja Tirnanić, Z. Mijuskovic
{"title":"Dermoscopy of the Month Dermoscopic Features of Sebaceous Nevus - a Report of 4 Cases","authors":"Tanja Tirnanić, Z. Mijuskovic","doi":"10.2478/sjdv-2018-0020","DOIUrl":"https://doi.org/10.2478/sjdv-2018-0020","url":null,"abstract":"Abstract Sebaceous nevus is a congenital hamartoma commonly associated with the development of secondary neoplasms. It has a predilection for the scalp and less commonly manifests on the face, the neck, and the trunk. The lesions presented in our cases are from the trunk of a 19-year old man, the forehead of a 25-year old man, the scalp of a 22-year old woman and from the face of a 45-year old man. Two of four cases were associated with secondary neoplasms, syringoma and basal cell carcinoma. Dermoscopy of nevus sebaceous demonstrated yellowish-brown globular structures, presenting either singly or in clusters and pink-brown-grey papillary appearance. The specific dermoscopic findings in our case associated with basal cell carcinoma were fine arborizing and serpiginous vessels at the periphery of the lesion and exophytic grey papillary structures. Dermoscopy can be a useful diagnostic tool for diagnosing and monitoring nevus sebaceous in order to detect different tumors associated with nevus sebaceous and avoid unnecessary excisions and scars in aesthetically sensitive locations.","PeriodicalId":30659,"journal":{"name":"Serbian Journal of Dermatology and Venereology","volume":"10 1","pages":"133 - 137"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45291040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leukemia Cutis – A Case Report 皮肤白血病1例报告
Serbian Journal of Dermatology and Venereology Pub Date : 2018-12-01 DOI: 10.2478/sjdv-2018-0017
D. Mihajlović, M. Dinić, Z. Mijuskovic, N. Petrov, O. Tasić, Marija Elez, L. K. Sekulovic
{"title":"Leukemia Cutis – A Case Report","authors":"D. Mihajlović, M. Dinić, Z. Mijuskovic, N. Petrov, O. Tasić, Marija Elez, L. K. Sekulovic","doi":"10.2478/sjdv-2018-0017","DOIUrl":"https://doi.org/10.2478/sjdv-2018-0017","url":null,"abstract":"Abstract Leukemia cutis is a specific skin lesion which is characterized by diffuse infiltration of neoplastic cells and can occur in all types of leukemia. Leukemia cutis can have varied cutaneous presentations such as papules, macules, nodules, plaques and ulcers. We report a case of 52-year-old woman who presented with erythematous macules and papules over her trunk, thighs and upper arms. A skin punch biopsy showed monomorphic, perivascular and periadnexal infiltration by the cells positive for CD45, CD15, CD68 and lysozyme. According to the subsequent bone marrow biopsy and immunophenotypic analysis of peripheral blood cells, the diagnosis of acute monocytic leukemia (FAB AML-M5b) was made. In our case, the first clinical sign suggestive of the diagnosis of leukemia was the presence of erythematous macules and papules. Therefore, we believe that leukemia cutis should be taken into consideration in the differential diagnosis of maculopapular rush on the trunk, upper arms and leg","PeriodicalId":30659,"journal":{"name":"Serbian Journal of Dermatology and Venereology","volume":"10 1","pages":"119 - 123"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43532957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrence of Bullous Pemphigoid and Psoriasis: A Case Report 大疱性类天疱疮并发银屑病1例
Serbian Journal of Dermatology and Venereology Pub Date : 2018-12-01 DOI: 10.2478/sjdv-2018-0018
O. Suwarsa, Lengga Herlina, E. Sutedja, H. Dharmadji, R. Hindritiani, H. Gunawan
{"title":"Concurrence of Bullous Pemphigoid and Psoriasis: A Case Report","authors":"O. Suwarsa, Lengga Herlina, E. Sutedja, H. Dharmadji, R. Hindritiani, H. Gunawan","doi":"10.2478/sjdv-2018-0018","DOIUrl":"https://doi.org/10.2478/sjdv-2018-0018","url":null,"abstract":"Abstract Bullous pemphigoid (BP) and psoriasis are chronic recurrent inflammatory skin diseases. The pathogenesis of concurrence of BP with psoriasis is still unknown. A 39-year-old male with a five-year history of chronic plaque psoriasis developed itchy large tense bullae on the trunk and upper extremities after he had been receiving narrow band ultraviolet B (NBUVB) therapy over five months. Skin biopsy from bulla on the trunk showed typical histological features of BP. Direct immunofluorescent staining showed deposit of immunoglobulin G and C3 in the basement membrane zone (BMZ) which supported the diagnosis of BP. It has been postulated that the autoimmune process responsible for BP lesions might be induced by ultraviolet light therapy and/or the inflammatory processes that occur in psoriasis.","PeriodicalId":30659,"journal":{"name":"Serbian Journal of Dermatology and Venereology","volume":"10 1","pages":"124 - 128"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68917698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Radiodermatitis - review of treatment options 放射性皮炎-治疗方案综述
Serbian Journal of Dermatology and Venereology Pub Date : 2018-09-01 DOI: 10.2478/sjdv-2018-0011
B. Spasic, M. Jovanović, Z. Golušin, O. Ivanov, D. Tešanović
{"title":"Radiodermatitis - review of treatment options","authors":"B. Spasic, M. Jovanović, Z. Golušin, O. Ivanov, D. Tešanović","doi":"10.2478/sjdv-2018-0011","DOIUrl":"https://doi.org/10.2478/sjdv-2018-0011","url":null,"abstract":"Abstract Radiation dermatitis is one of the commonest side effects of ionizing radiation which is applied in radiotherapy of carcinoma of all localizations, most frequently of tumors of breast, head and neck region, lungs and soft tissue sarcomas. It usually occurs as a complication of breast radiotherapy and thus it is more often recorded in female patients on the skin in the region of breast subjected to radiation. Clinical manifestations of radiation dermatitis can be divided into four phases: acute phase (erythema, dry desquamation, moist desquamation, ulceration and necrosis with resulting re-epithelialization, residual post-inflammatory hyperpigmentation, reduction and suppression of sebaceous and sweat glands and epilation); subacute phase (hyperpigmentation and hypopigmentation, telangiectasia, skin atrophy, even ulceration); chronic phase (skin atrophy, dermal fibrosis and permanent skin epilation) and late phase (increased risk of skin cancer). In order to prevent radiation dermatitis, skin care products should be applied throughout radiotherapy that will decrease the frequency of skin reactions or block them and thus improve life quality. Although the therapy includes not only topical corticosteroids but numerous other products with active ingredients such as aloe vera, calendula, hyaluronic acid, sucralfat, sorbolene, mineral and olive oil, honey, vitamin C, zinc, antimicrobials and silver, common therapeutic consensus has not been reached on their application in radiation dermatitis. Therefore, the treatment should be conducted according to the basic guidelines but tailor-made for each individual patient.","PeriodicalId":30659,"journal":{"name":"Serbian Journal of Dermatology and Venereology","volume":"10 1","pages":"71 - 81"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43963802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Evolving Pattern Of Primary Skin Cancers in Ile-Ife, Nigeria 尼日利亚Ile-Ife地区原发性皮肤癌的演变模式
Serbian Journal of Dermatology and Venereology Pub Date : 2018-09-01 DOI: 10.2478/sjdv-2018-0013
M. Oripelaye, A. O. Oladele, F. Olanrewaju, O. Olaofe
{"title":"The Evolving Pattern Of Primary Skin Cancers in Ile-Ife, Nigeria","authors":"M. Oripelaye, A. O. Oladele, F. Olanrewaju, O. Olaofe","doi":"10.2478/sjdv-2018-0013","DOIUrl":"https://doi.org/10.2478/sjdv-2018-0013","url":null,"abstract":"Abstract Background. The increasing solar intensity and HIV epidemic have progressively eroded the protective effects of melanin among black race. This study was aimed at evaluating the pattern of primary skin cancers in Ile-Ife, Nigeria. Methods. This retrospective study, which was conducted at the Obafemi Awolowo University Teaching Hospital, Ile-Ife, included the patients diagnosed with primary skin cancers between January 2008 and December 2017. The data were analyzed using SPSS version20. Results. The frequency of primary skin cancers was 1.0%. Females (58.3%) outnumbered the males (41.7%), the ratio being 1.4:1. The spectrum of primary skin cancers documented by this study are squamous cell carcinoma (33.3%), malignant melanoma (25%), Kaposi sarcoma (15.3%), basal cell carcinoma (9.7%), and cutaneous lymphoma (6.9%). Conclusion. Melanin remains a major protective factor for skin cancers among negroids. Albinism and high burden of HIV were identified risk groups for skin cancers. The eradication of HIV and enhanced sun protection will reduce the prevalence of skin cancers.","PeriodicalId":30659,"journal":{"name":"Serbian Journal of Dermatology and Venereology","volume":"10 1","pages":"90 - 95"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46528561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Genotyping of Mycobacterium leprae in a Son-and-Father Pair of Patients Indicated the Possible Mode of Leprosy Transmission: a Case Report 一对父子患者的麻风分枝杆菌基因分型表明麻风传播的可能模式：一例报告
Serbian Journal of Dermatology and Venereology Pub Date : 2018-09-01 DOI: 10.2478/sjdv-2018-0014
H. Gunawan, Irma Fakhrosa, Nia Ayu Saraswati, Muljaningsih Sasmojo, R. Hindritiani, O. Suwarsa
{"title":"Genotyping of Mycobacterium leprae in a Son-and-Father Pair of Patients Indicated the Possible Mode of Leprosy Transmission: a Case Report","authors":"H. Gunawan, Irma Fakhrosa, Nia Ayu Saraswati, Muljaningsih Sasmojo, R. Hindritiani, O. Suwarsa","doi":"10.2478/sjdv-2018-0014","DOIUrl":"https://doi.org/10.2478/sjdv-2018-0014","url":null,"abstract":"Abstract One of the success indicators of the World Health Organization (WHO) leprosy eradication program is the decreasing number of new cases of pediatric leprosy with a grade 2 disability. A case of borderline lepromatous (BL) leprosy with partial claw hand in a 13-year-old boy was reported. On physical examination, we found claw fingers on the fourth and fifth fingers of the left hand accompanied by hypoesthetic erythematous plaques on both cheeks. The patient also presented with the enlargement of bilateral great auricular, ulnar, and peroneal nerves. The bacteriological examination showed the bacterial index 3+ and morphological index 35%. The results of histopathological and serological anti-phenolic glycolipid-I examinations supported the diagnosis of BL type of leprosy. Genotyping of Mycobacterium leprae by variable number tandem repeat of the patient showed 24 copies thymine-thymine-cytosine that were similar to his father, who had been diagnosed with leprosy 12 years before, without adequate therapy. The result indicated the possibility of leprosy transmission from the father to a son. This case report revealed the presence of leprosy in children with a multibacillary infection who have been living with leprosy family members. Genotyping seems to be feasible for epidemiological analysis of leprosy transmission.","PeriodicalId":30659,"journal":{"name":"Serbian Journal of Dermatology and Venereology","volume":"10 1","pages":"100 - 96"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48999924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant Basal Cell Carcinoma – a Case Report 基底细胞巨癌一例报告
Serbian Journal of Dermatology and Venereology Pub Date : 2018-09-01 DOI: 10.2478/sjdv-2018-0012
I. Kapetanovic, V. Reljić, Martina Bosic, S. Popadic
{"title":"Giant Basal Cell Carcinoma – a Case Report","authors":"I. Kapetanovic, V. Reljić, Martina Bosic, S. Popadic","doi":"10.2478/sjdv-2018-0012","DOIUrl":"https://doi.org/10.2478/sjdv-2018-0012","url":null,"abstract":"Abstract Basal cell carcinoma is the most common form of cutaneous cancer. In majority of cases it is locally invasive with slow growth, ranging in size from a couple of milimeters to a couple of centimeters and located primarily on sun-exposed regions. Giant basal cell carcinoma, defined as a tumor that is larger than 5 cm in diameter, is a very rare type of cutaneous malignancy accounting for 0.5-1% of all basal cell carcinomas. We present a case of a 74-year-old man with a 17 x 14 cm giant basal cell carcinoma in the right supraclavicular region. Detailed history revealed that the lesion had started as a papule 15 years before presentation. Despite its growth, the lesion was neglected until admission. Histological examination of skin lesion confirmed superficial and focally infiltrative types of basal cell carcinoma. Electron radiotherapy was administered with 54 Gy total dose delivered in 20 daily fractions which resulted in healing of lesions and adequate response. Thus, definitive radiotherapy can be just as effective as excision when the criteria are met.","PeriodicalId":30659,"journal":{"name":"Serbian Journal of Dermatology and Venereology","volume":"10 1","pages":"83 - 89"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42679562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermoscopy of the Month 本月皮肤镜
Serbian Journal of Dermatology and Venereology Pub Date : 2018-09-01 DOI: 10.2478/sjdv-2018-0015
A. Jović, D. Tiodorovic, D. Popović, H. Kocic, Zorana Zlatanović, M. Kostić, G. Damiani
{"title":"Dermoscopy of the Month","authors":"A. Jović, D. Tiodorovic, D. Popović, H. Kocic, Zorana Zlatanović, M. Kostić, G. Damiani","doi":"10.2478/sjdv-2018-0015","DOIUrl":"https://doi.org/10.2478/sjdv-2018-0015","url":null,"abstract":"Abstract Melanonychia refers to a brown or black coloration of the nail plate caused by numerous factors. Regarding the arrangement of pigmentation, we can differentiate between total melanonychia, when pigmentation involves the whole nail plate, or transverse or longitudinal melanonychia, when pigmentation involves the nail in a form of transverse or longitudinal band of pigmentation, respectively. Since longitudinal melanonychia can be a sign of numerous benign and malignant lesions, it often poses a diagnostic challenge for a dermatologist. Herein, we report a case of a 13-year-old girl who developed longitudinal melanonychia on multiple nails after receiving a therapy with azithromycin.","PeriodicalId":30659,"journal":{"name":"Serbian Journal of Dermatology and Venereology","volume":"10 1","pages":"101 - 104"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47451397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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